Molecular Biodiscovery: learning from nature
Key publications
-
Exploring natural product artifacts: The polyketide enterocin warms to a ballet of isomers. Org. Letts. 2020, 22 (12), 4828-4832. DOI: 10.1021/acs.orglett.0c01629
-
Extracting value: Mechanistic insights into the formation of natural product artifacts - case studies in marine natural products, Nat. Prod. Reports 2020, 37; p.55-79. DOI: 10.1039/C9NP00013E
-
A tetrapeptide class of biased analgesics from an Australian fungus targets the m-opioid receptor. PNAS 2019, 116 (44); p. 22353-22358. DOI: 10.1073/pnas.1908662116
-
Chrysosporazines A-E: P-glycoprotein inhibitory piperazines from an Australian marine fish gastrointestinal tract-derived fungus, Chrysosporium sp. CMB-F214. Org. Lett. 2019, 21 (19): 8097-8100. DOI: 10.1021/acs.orglett.9b03094
-
Inter-Kingdom beach warfare: Microbial chemical communication activates natural chemical defenses. The ISME Journal 2019, 13: p. 147-158. DOI: 10.1038/s41396-018-0265-z
-
Prolinimines: N-amino-L-Pro-methyl ester (hydrazine) Schiff bases from a fish gastrointestinal tract-derived fungus, Trichoderma sp. CMB-F563. Org. Lett. 2018. 20 (2): p. 377-380. DOI: 10.1021/acs.orglett.7b03666
Citizen Science
-
Cane Toad Challenge (CTC)
An IMB Citizen Science initiative provides the public with patented pheromonal tadpole trapping technology, and enlists their support in the largescale capture and eradication of poisonous invasive cane toads tadpoles from local waterways.
More information -
Soils for Science (S4S)
An IMB Citizen Science initiative that informs the public about antibiotics and antimicrobial resistance, and enlists their support to collect soil samples from across Qld – to help discover new and improved antibiotics.
More information
Key projects
-
Microbes Australia
A living library of Australian microbes, rich in new bioactive chemical diversity ideally positioned to fuel the search for new and improved therapeutics and agrochemicals.
More information -
Preclinical validation of a novel drug lead to treat tuberculosis
Developing the cyclic peptide wollamides, first reported in 2014 by our lab from a far north Qld soil Streptomyces, as a new class of antibiotic effective against multidrug resistant tuberculosis.
More information -
Marine Bioproducts Cooperative Research Centre (MB-CRC)
Growing Australia’s emerging marine bioproducts sector into a globally competitive industry, transforming marine seaweeds, microalgae and microbes into new high value human foods, animal feeds, nutritional supplements, nutraceuticals, cosmeceuticals, fertilizers, agrochemicals, bioplastics, biomaterials, and much more….
More information -
New antiparasitics to safeguard Australian livestock
Exploring microbes isolated from Australian sheep faeces and pastures heavily infected with drug resistant worms, to discover new classes of antiparasitic to safeguard animal health.
More information