Membrane trafficking at atomic resolution

We study protein structures, using methods including X-ray crystallography, cryo electron microscopy (cryoEM), and nuclear magnetic resonance spectroscopy (NMR).

Our work is focused on understanding how membrane-associated protein complexes are assembled to control receptor transport and the homeostasis of endocytic organelles.

We are primarily interested in the fundamental molecular mechanisms that underpin these processes in healthy cells.

But we also hope that by better understanding how these essential protein machineries function we may be able to develop drugs or therapies that target them in various diseases.

Most notably the dysfunction of membrane trafficking is a common hallmark of neurodegenerative disorders including Parkinson’s and Alzheimer’s diseases.