Dr Alysha Elliott Aparicio
Research Fellow
Institute for Molecular Bioscience
+61 7 334 62745
Researcher biography
Doctor Alysha Elliott is a Research Fellow at the Centre for Superbug Solutions in the Institute for Molecular Bioscience at The University of Queensland. Alysha began her research career in 2007 and has since been dedicated to multi-disciplinary drug discovery with a specific passion for anti-infective targeted research. Alysha is highly experienced in infectious disease microbiology, structural biology of peptides, and molecular biology. Developing new antibiotics to treat drug resistant pathogens and investigating mechanisms of resistance in bacteria are Alysha's core research activities.
Dr Elliott is the Program Coordinator for Microbiology and Screening for the Community for Open Antimicrobial Drug Discovery (CO-ADD), a global antibiotic discovery initiative that has screened >300,000 unique compounds via high throughput screening technologies for antimicrobial activity from over 270 research groups from 47 countries. Alysha's antimicrobial drug development research has been funded by NHMRC, CARB-X (Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator), the Wellcome Trust and the Queensland Government (Advance Queensland). She has published more than sixty research articles and is active in collaborating with industry and public private partnerships for translational outcomes.
Dr Elliott's current core research focus is on alternative therapies to treat extensively drug resistant Gram-negative bacterial infections, in particular the use of potentiators (inactive or inefficient compounds when used alone as an antimicrobial) to restore activity of traditional antibiotics that are no longer effective due to the development of antimicrobial resistance.
Journal Articles
Baker, Jennifer R., Cossar, Peter J., Blaskovich, Mark A. T., Elliott, Alysha G., Zuegg, Johannes, Cooper, Matthew A., Lewis, Peter J. and McCluskey, Adam (2022). Amino alcohols as potential antibiotic and antifungal leads. Molecules, 27 (7) 2050. doi: 10.3390/molecules27072050
Boer, Gareth E., Hickey, Shane M., Elliott, Alysha G. and Pfeffer, Frederick M. (2022). Synthesis of 2-[2-(tert-butoxycarbonyl)-3-(acyl)guanidino]ethylamine salts for convergent introduction of acyl guanidines. New Journal of Chemistry, 46 (17), 8131-8137. doi: 10.1039/d2nj01510b
Demchenko, Sergii, Lesyk, Roman, Yadlovskyi, Oleh, Zuegg, Johannes, Elliott, Alysha G., Drapak, Iryna, Fedchenkova, Yuliia, Suvorova, Zinaida and Demchenko, Anatolii (2021). Synthesis, antibacterial and antifungal activity of new 3-Aryl-5H-pyrrolo[1,2-a]imidazole and 5H-Imidazo[1,2-a]azepine quaternary salts. Molecules, 26 (14) 4253, 1-13. doi: 10.3390/molecules26144253
Semenov, Victor V., Raihstat, Mikhail M., Konyushkin, Leonid D., Semenov, Roman V., Blaskovich, Mark A. T., Zuegg, Johannes, Elliott, Alysha G., Hansford, Karl A. and Cooper, Matthew A. (2021). Antimicrobial screening of a historical collection of over 140 000 small molecules. Mendeleev Communications, 31 (4), 484-487. doi: 10.1016/j.mencom.2021.07.015
Braga Emidio, Nayara, Meli, Rajeshwari, Tran, Hue N. T., Baik, Hayeon, Morisset-Lopez, Séverine, Elliott, Alysha G., Blaskovich, Mark A. T., Spiller, Sabrina, Beck-Sickinger, Annette G., Schroeder, Christina I. and Muttenthaler, Markus (2021). Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite. Journal of Medicinal Chemistry, 64 (13) acs.jmedchem.1c00767, 9484-9495. doi: 10.1021/acs.jmedchem.1c00767
Muller, Jessica A. I., Lawrence, Nicole, Chan, Lai Yue, Harvey, Peta J., Elliott, Alysha G., Blaskovich, Mark A. T., Gonçalves, Jacqueline C., Galante, Priscilla, Mortari, Marcia R., Toffoli-Kadri, Mônica C., Koehbach, Johannes and Craik, David (2021). Antimicrobial and anticancer properties of synthetic peptides derived from the wasp Parachartergus fraternus. Chembiochem , 22 (8) cbic.202000716, 1415-1423. doi: 10.1002/cbic.202000716
Frei, Angelo, King, A. Paden, Lowe, Gabrielle J., Cain, Amy K., Short, Francesca L., Dinh, Hue, Elliott, Alysha G., Zuegg, Johannes, Wilson, Justin J. and Blaskovich, Mark A. T. (2021). Cover feature: nontoxic cobalt(III) schiff base complexes with broad‐spectrum antifungal activity (Chem. Eur. J. 6/2021). Chemistry – A European Journal, 27 (6), 1861-1861. doi: 10.1002/chem.202004912
Frei, Angelo, King, A. Paden, Lowe, Gabrielle J., Cain, Amy K., Short, Francesca L., Dinh, Hue, Elliott, Alysha G., Zuegg, Johannes, Wilson, Justin J. and Blaskovich, Mark A. T. (2021). Nontoxic cobalt(III) schiff base complexes with broad‐spectrum antifungal activity. Chemistry – A European Journal, 27 (6), 2021-2029. doi: 10.1002/chem.202003545
Blaskovich, Mark A. T., Kavanagh, Angela M., Elliott, Alysha G., Zhang, Bing, Ramu, Soumya, Amado, Maite, Lowe, Gabrielle J., Hinton, Alexandra O., Pham, Do Minh Thu, Zuegg, Johannes, Beare, Neil, Quach, Diana, Sharp, Marc D., Pogliano, Joe, Rogers, Ashleigh P., Lyras, Dena, Tan, Lendl, West, Nicholas P., Crawford, David W., Peterson, Marnie L., Callahan, Matthew and Thurn, Michael (2021). The antimicrobial potential of cannabidiol. Communications Biology, 4 (1) 7, 1-18. doi: 10.1038/s42003-020-01530-y
Frei, Angelo, Ramu, Soumya, Lowe, Gabrielle J., Dinh, Hue, Semenec, Lucie, Elliott, Alysha G., Zuegg, Johannes, Deckers, Anke, Jung, Nicole, Bräse, Stefan, Cain, Amy K. and Blaskovich, Mark A. T. (2021). Platinum cyclooctadiene complexes with activity against gram-positive bacteria. ChemMedChem, 16 (20) cmdc.202100157, 1-8. doi: 10.1002/cmdc.202100157
Fuller, Amelia A., Dounay, Amy B., Schirch, Douglas, Rivera, Daniel G., Hansford, Karl A., Elliott, Alysha G., Zuegg, Johannes, Cooper, Matthew A., Blaskovich, Mark A. T., Hitchens, Jacob R., Burris-Hiday, Sarah, Tenorio, Kristiana, Mendez, Yanira, Samaritoni, J. Geno, O’Donnell, Martin J. and Scott, William L. (2020). Multi-institution research and education collaboration identifies new antimicrobial compounds. ACS Chemical Biology, 15 (12), 3187-3196. doi: 10.1021/acschembio.0c00732
Peacock, Hayden, Henriques, Sónia Troeira, Benfield, Aurélie H., Elliott, Alysha G., Luo, Jinghui, Luccarelli, James, Nagano, Masanobu, Craik, David J. and Hamilton, Andrew D. (2020). Antimicrobial peptide mimetics based on a diphenylacetylene scaffold: synthesis, conformational analysis, and activity. ChemMedChem, 15 (20) cmdc.202000474, 1932-1939. doi: 10.1002/cmdc.202000474
Demchenko, Sergii, Lesyk, Roman, Zuegg, Johannes, Elliott, Alysha G., Fedchenkova, Yuliia, Suvorova, Zinaida and Demchenko, Anatolii (2020). Synthesis, antibacterial and antifungal activity of new 3-biphenyl-3H-Imidazo[1,2-a]azepin-1-ium bromides. European Journal of Medicinal Chemistry, 201 112477, 112477. doi: 10.1016/j.ejmech.2020.112477
Braga Emidio, Nayara, Baik, Hayeon, Lee, David, Stürmer, René, Heuer, Jörn, Elliott, Alysha G, Blaskovich, Mark A T, Haupenthal, Katharina, Tegtmeyer, Nicole, Hoffmann, Werner, Schroeder, Christina I and Muttenthaler, Markus (2020). Correction: Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical communications (Cambridge, England), 56 (51), 7049-7049. doi: 10.1039/d0cc90250k
Elliott, Alysha G., Huang, Johnny X., Neve, Søren, Zuegg, Johannes, Edwards, Ingrid A., Cain, Amy K., Boinett, Christine J., Barquist, Lars, Lundberg, Carina Vingsbo, Steen, Jason, Butler, Mark S., Mobli, Mehdi, Porter, Kaela M., Blaskovich, Mark A. T., Lociuro, Sergio, Strandh, Magnus and Cooper, Matthew A. (2020). An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria. Nature Communications, 11 (1) 3184, 3184. doi: 10.1038/s41467-020-16950-x
Zuegg, Johannes, Hansford, Karl A., Elliott, Alysha G., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). How to stimulate and facilitate early stage antibiotic discovery. ACS Infectious Diseases, 6 (6), 1302-1304. doi: 10.1021/acsinfecdis.0c00163
Frei, Angelo, Zuegg, Johannes, Elliott, Alysha G., Baker, Murray, Braese, Stefan, Brown, Christopher, Chen, Feng, Dowson, Christopher G., Dujardin, Gilles, Jung, Nicole, King, A. Paden, Mansour, Ahmed M., Massi, Massimiliano, Moat, John, Mohamed, Heba A., Renfrew, Anna K., Rutledge, Peter J., Sadler, Peter J., Todd, Matthew H., Willans, Charlotte E., Wilson, Justin J., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). Correction: Metal complexes as a promising source for new antibiotics (vol 11, pg 2627, 2020). Chemical Science, 11 (17), 4531-4531. doi: 10.1039/d0sc90075c
Rineh, Ardeshir, Soren, Odel, McEwan, Timothy, Ravikumar, Vikashini, Poh, Wee Han, Azamifar, Fereshteh, Naimi-Jamal, M. Reza, Cheung, Chen-Yi, Elliott, Alysha G., Zuegg, Johannes, Blaskovich, Mark A. T., Cooper, Matthew A., Dolange, Victoria, Christodoulides, Myron, Cook, Gregory M., Rice, Scott A., Faust, Saul N., Webb, Jeremy S. and Kelso, Michael J. (2020). Discovery of cephalosporin-3′-diazeniumdiolates that show dual antibacterial and antibiofilm effects against Pseudomonas aeruginosa clinical cystic fibrosis isolates and efficacy in a murine respiratory infection model. ACS Infectious Diseases, 6 (6) acsinfecdis.0c00070, 1460-1479. doi: 10.1021/acsinfecdis.0c00070
Frei, Angelo, Zuegg, Johannes, Elliott, Alysha G., Baker, Murray V., Braese, Stefan, Brown, Christopher, Chen, Feng, Dowson, Christopher Gerard, Dujardin, Gilles, Jung, Nicole, King, A. Paden, Mansour, Ahmed Moustafa, Massi, Massimiliano, Moat, John, Mohamed, Heba A., Renfrew, Anna, Rutledge, Peter, Sadler, Peter J., Todd, Matthew Houghton, Willans, Charlotte E., Wilson, Justin Jeff, Cooper, Matthew Allister and Blaskovich, Mark (2020). Metal complexes as a promising source for new antibiotics. Chemical Science, 11 (10), 2627-2639. doi: 10.1039/c9sc06460e
Barbon, Stephanie M., Truong, Nghia P., Elliott, Alysha G., Cooper, Matthew A., Davis, Thomas P., Whittaker, Michael R., Hawker, Craig J. and Anastasaki, Athina (2020). Elucidating the effect of sequence and degree of polymerization on antimicrobial properties for block copolymers. Polymer Chemistry, 11 (1), 84-90. doi: 10.1039/c9py01435g
Braga Emidio, Nayara, Baik, Hayeon, Lee, David, Stürmer, René, Heuer, Jörn, Elliott, Alysha G., Blaskovich, Mark A. T., Haupenthal, Katharina, Tegtmeyer, Nicole, Hoffmann, Werner, Schroeder, Christina I. and Muttenthaler, Markus (2020). Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical Communications, 56 (47), 6420-6423. doi: 10.1039/d0cc02321c
Grace, James L., Amado, Maite, Reid, Janet C., Elliott, Alysha G., Landersdorfer, Cornelia B., Truong, Nghia P., Kempe, Kristian, Cooper, Matthew A., Davis, Thomas P., Montembault, Véronique, Pascual, Sagrario, Fontaine, Laurent, Velkov, Tony, Quinn, John F. and Whittaker, Michael R. (2019). An optimised Cu(0)-RDRP approach for the synthesis of lipidated oligomeric vinyl azlactone: toward a versatile antimicrobial materials screening platform. Journal of Materials Chemistry B, 7 (43), 6796-6809. doi: 10.1039/c9tb01624d
Blaskovich, Mark A. T., Elliott, Alysha G., Kavanagh, Angela M., Ramu, Soumya and Cooper, Matthew A. (2019). In vitro antimicrobial activity of acne drugs against skin-associated bacteria. Scientific Reports, 9 (1) 14658, 14658. doi: 10.1038/s41598-019-50746-4
Chen, Ao, Er, Gerald, Zhang, Cheng, Tang, Joyce, Alam, Mahbub, T. Ta, Hang, Elliott, Alysha G., Cooper, Matthew A., Perera, Janesha, Swift, Simon, Blakey, Idriss, Whittaker, Andrew K. and Peng, Hui (2019). Antimicrobial anilinium polymers: The properties of poly(N,N‐dimethylaminophenylene methacrylamide) in solution and as coatings. Journal of Polymer Science Part A: Polymer Chemistry, 57 (18), 1908-1921. doi: 10.1002/pola.29314
James, Amy M., Haywood, Joel, Leroux, Julie, Ignasiak, Katarzyna, Elliott, Alysha G., Schmidberger, Jason W., Fisher, Mark F., Nonis, Samuel G., Fenske, Ricarda, Bond, Charles S. and Mylne, Joshua S. (2019). The macrocyclizing protease butelase 1 remains autocatalytic and reveals the structural basis for ligase activity. Plant Journal, 98 (6) tpj.14293, 988-999. doi: 10.1111/tpj.14293
Matiadis, Dimitris, Tsironis, Dimitrios, Stefanou, Valentina, Elliott, Alysha G., Kordatos, Konstantinos, Zahariou, Georgia, Ioannidis, Nikolaos, McKee, Vickie, Panagiotopoulou, Angeliki, Igglessi-Markopoulou, Olga and Markopoulos, John (2019). Synthesis, characterization and antimicrobial activity of N-acetyl-3-acetyl-5-benzylidene tetramic acid-metal complexes. X-ray analysis and identification of the Cd(II) complex as a potent antifungal agent. Journal of Inorganic Biochemistry, 194, 65-73. doi: 10.1016/j.jinorgbio.2019.02.008
Zhang, Alan H., Edwards, Ingrid A., Mishra, Biswa P., Sharma, Gagan, Healy, Michael D., Elliott, Alysha, Blaskovich, Mark A. T., Cooper, Matthew A., Collins, Brett M., Jia, Xinying and Mobli, Mehdi (2019). Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs. Frontiers in Chemistry, 7 (MAR) 238, 238. doi: 10.3389/fchem.2019.00238
Gallardo-Godoy, Alejandra, Hansford, Karl, Muldoon, Craig, Becker, Bernd, Elliott, Alysha, Huang, Johnny, Pelingon, Ruby, Butler, Mark, Blaskovich, Mark and Cooper, Matthew (2019). Structure-function studies of polymyxin B lipononapeptides. Molecules, 24 (3) 553, 553. doi: 10.3390/molecules24030553
Hickey, Shane M., Ashton, Trent D., Boer, Gareth, Bader, Christie A., Thomas, Michael, Elliott, Alysha G., Schmuck, Carsten, Yu, Heidi Y., Li, Jian, Nation, Roger L., Cooper, Matthew A., Plush, Sally E., Brooks, Douglas A. and Pfeffer, Frederick M. (2018). Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane. European Journal of Medicinal Chemistry, 160, 9-22. doi: 10.1016/j.ejmech.2018.09.072
Grace, James L., Schneider-Futschik, Elena K., Elliott, Alysha G., Amado, Maite, Truong, Nghia P., Cooper, Matthew A., Li, Jian, Davis, Thomas P., Quinn, John F., Velkov, Tony and Whittaker, Michael R. (2018). Exploiting macromolecular design to optimize the antibacterial activity of alkylated cationic oligomers. Biomacromolecules, 19 (12) acs.biomac.8b01317, 4629-4640. doi: 10.1021/acs.biomac.8b01317
Blaskovich, Mark A. T., Pitt, Miranda E., Elliott, Alysha G. and Cooper, Matthew A. (2018). Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria?. Expert Review of Anti-infective Therapy, 16 (6), 485-499. doi: 10.1080/14787210.2018.1483240
Pitt, Miranda E., Elliott, Alysha G., Cao, Minh Duc, Ganesamoorthy, Devika, Karaiskos, Ilias, Giamarellou, Helen, Abboud, Cely S., Blaskovich, Mark A. T., Cooper, Matthew A. and Coin, Lachlan J. M. (2018). Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae. Microbial Genomics, 4 (3) 000158. doi: 10.1099/mgen.0.000158
Velkov, Tony, Gallardo-Godoy, Alejandra, Swarbrick, James D., Blaskovich, Mark A. T., Elliott, Alysha G., Han, Meiling, Thompson, Philip E., Roberts, Kade D., Huang, Johnny X., Becker, Bernd, Butler, Mark S., Lash, Lawrence H., Henriques, Sónia Troeira, Nation, Roger L., Sivanesan, Sivashangarie, Sani, Marc-Antoine, Separovic, Frances, Mertens, Haydyn, Bulach, Dieter, Seemann, Torsten, Owen, Jeremy, Li, Jian and Cooper, Matthew A. (2018). Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria. Cell Chemical Biology, 25 (4), 380-391.e5. doi: 10.1016/j.chembiol.2018.01.005
Blaskovich, Mark A T, Hansford, Karl A., Gong, Yujing, Butler, Mark S., Muldoon, Craig, Huang, Johnny X., Ramu, Soumya, Silva, Alberto B., Cheng, Mu, Kavanagh, Angela M., Ziora, Zyta, Premraj, Rajaratnam, Lindahl, Fredrik, Bradford, Tanya A., Lee, June C., Karoli, Tomislav, Pelingon, Ruby, Edwards, David J., Amado, Maite, Elliott, Alysha G, Phetsang, Wanida, Daud, Noor Huda, Deecke, Johan E, Sidjabat, Hanna E, Ramaologa, Sefetogi, Zuegg, Johannes, Betley, Jason R, Beevers, Andrew P G, Smith, Richard A G ... Cooper, Matthew A. (2018). Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria. Nature Communications, 9 (1) 02123, 22. doi: 10.1038/s41467-017-02123-w
Edwards, Ingrid A, Elliott, Alysha G, Kavanagh, Angela M, Blaskovich, Mark A T and Cooper, Matthew A (2017). Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS infectious diseases, 3 (12), 917-926. doi: 10.1021/acsinfecdis.7b00123
Henriques, Sónia Troeira, Lawrence, Nicole, Chaousis, Stephanie, Ravipati, Anjaneya S., Cheneval, Olivier, Benfield, Aurélie H., Elliott, Alysha G., Kavanagh, Angela Maria, Cooper, Matthew A., Chan, Lai Yue, Huang, Yen-Hua and Craik, David J. (2017). Redesigned spider peptide with improved antimicrobial and anticancer properties. ACS Chemical Biology, 12 (9), 2324-2334. doi: 10.1021/acschembio.7b00459
Scott, Fraser J., Nichol, Ryan J. O., Khalaf, Abedawn I., Giordani, Federica, Gillingwater, Kirsten, Ramu, Soumya, Elliott, Alysha, Zuegg, Johannes, Duffy, Paula, Rosslee, Michael-Jon, Hlaka, Lerato, Kumar, Santosh, Ozturk, Mumin, Brombacher, Frank, Barrett, Michael, Guler, Reto and Suckling, Colin J. (2017). An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics. European Journal of Medicinal Chemistry, 136, 561-572. doi: 10.1016/j.ejmech.2017.05.039
Hussein, Maytham H., Schneider, Elena K., Elliott, Alysha G., Han, Meiling, Reyes-Ortega, Felisa, Morris, Faye, Blaskovich, Mark A. T., Jasim, Raad, Currie, Bart, Mayo, Mark, Baker, Mark, Cooper, Matthew A., Li, Jian and Velkov, Tony (2017). From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators. Microbial Drug Resistance, 23 (5), 640-650. doi: 10.1089/mdr.2016.0196
Dekan, Zoltan, Headey, Stephen J., Scanlon, Martin, Baldo, Brian A., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Deuis, Jennifer R., Vetter, Irina, Elliott, Alysha G., Amado, Maite, Cooper, Matthew A., Alewood, Dianne and Alewood, Paul F. (2017). Δ-Myrtoxin-Mp1a is a helical heterodimer from the venom of the jack jumper ant that has antimicrobial, membrane-disrupting, and nociceptive activities. Angewandte Chemie, 56 (29), 8495-8499. doi: 10.1002/anie.201703360
Becker, Bernd, Butler, Mark S., Hansford, Karl A., Gallardo-Godoy, Alejandra, Elliott, Alysha G., Huang, Johnny X., Edwards, David J., Blaskovich, Mark A. T. and Cooper, Matthew A. (2017). Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria. Bioorganic and Medicinal Chemistry Letters, 27 (11), 2407-2409. doi: 10.1016/j.bmcl.2017.04.027
Desselle, Mathilde R., Neale, Ruth, Hansford, Karl A., Zuegg, Johannes, Elliott, Alysha G., Cooper, Matthew A. and Blaskovich, Mark A. T. (2017). Institutional profile: Community for Open Antimicrobial Drug Discovery - crowdsourcing new antibiotics and antifungals. Future Science OA, 3 (2) FSO171, FSO171. doi: 10.4155/fsoa-2016-0093
Galappathie, Savithri, Edwards, David J., Elliott, Alysha G., Cooper, Matthew A., Palombo, Enzo A., Butler, Mark S. and Mahon, Peter J. (2017). Antibacterial nerol cinnamates from the Australian plant Eremophila longifolia. Journal of Natural Products, 80 (4), 1178-1181. doi: 10.1021/acs.jnatprod.6b00888
Cao, Minh Duc, Nguyen, Son Hoang, Ganesamoorthy, Devika, Elliott, Alysha G., Cooper, Matthew A. and Coin, Lachlan J. M. (2017). Scaffolding and completing genome assemblies in real-time with nanopore sequencing. Nature Communications, 8 (1) 14515, 14515. doi: 10.1038/ncomms14515
Möhler, Jasper S., Kolmar, Theresa, Synnatschke, Kevin, Hergert, Marcel, Wilson, Liam A., Ramu, Soumya, Elliott, Alysha G., Blaskovich, Mark A.T., Sidjabat, Hanna E., Paterson, David L., Schenk, Gerhard, Cooper, Matthew A. and Ziora, Zyta M. (2017). Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies. Journal of Inorganic Biochemistry, 167, 134-141. doi: 10.1016/j.jinorgbio.2016.11.028
Grace, James L., Elliott, Alysha G., Huang, Johnny X., Schneider, Elena K., Truong, Nghia P., Cooper, Matthew A., Li, Jian, Davis, Thomas P., Quinn, John F., Velkov, Tony and Whittaker, Michael R. (2016). Cationic acrylate oligomers comprising amino acid mimic moieties demonstrate improved antibacterial killing efficiency. Journal of Materials Chemistry B, 5 (3), 531-536. doi: 10.1039/C6TB02787C
Yousfi, Tarek, Elliott, Alysha, Hanane, Messiad, Merdes, Rachid and Moyano, Albert (2016). Expedient organocatalytic syntheses of 4-substituted pyrazolidines and isoxazolidines. Molecules, 21 (12) 21121655, 1655. doi: 10.3390/molecules21121655
Kumar, Rohitesh, Lu, Yuting, Elliott, Alysha G., Kavanagh, Angela M., Cooper, Matthew A. and Davis, Rohan A. (2016). Semi-synthesis and NMR spectral assignments of flavonoid and chalcone derivatives. Magnetic Resonance in Chemistry, 54 (11), 880-886. doi: 10.1002/mrc.4482
Cao, Minh Duc, Ganesamoorthy, Devika, Elliott, Alysha G., Zhang, Huihui, Cooper, Matthew A. and Coin, Lachlan J. M. (2016). Streaming algorithms for identification of pathogens and antibiotic resistance potential from real-time MinION (TM) sequencing. Gigascience, 5 (1) 32, 32. doi: 10.1186/s13742-016-0137-2
Elliott, Alysha G., Ganesamoorthy, Devika, Coin, Lachlan, Cooper, Matthew A. and Cao, Minh Duc (2016). Complete Genome Sequence of Klebsiella quasipneumoniae subsp. similipneumoniae Strain ATCC 700603. Genome Announcements, 4 (3) e00438-16. doi: 10.1128/genomeA.00438-16
Azmi, Fazren, Elliott, Alysha G., Marasini, Nirmal, Ramu, Soumya, Ziora, Zyta, Kavanagh, Angela M., Blaskovich, Mark A. T., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2016). Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation. Bioorganic and Medicinal Chemistry, 24 (10), 2235-2241. doi: 10.1016/j.bmc.2016.03.053
Edwards, Ingrid A., Elliott, Alysha G., Kavanagh, Angela M., Zuegg, Johannes, Blaskovich, Mark A. T. and Cooper, Matthew A. (2016). Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptides. ACS Infectious Diseases, 2 (6), 442-450. doi: 10.1021/acsinfecdis.6b00045
Beattie, Karren D., Ellwood, Nicola, Kumar, Rohitesh, Yang, Xinzhou, Healy, Peter C., Choomuenwai, Vanida, Quinn, Ronald J., Elliott, Alysha G., Huang, Johnny X., Chitty, Jessica L., Fraser, James A., Cooper, Matthew A. and Davis, Rohan A. (2016). Antibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D-F. Phytochemistry, 124, 79-85. doi: 10.1016/j.phytochem.2015.12.014
Gallardo-Godoy, Alejandra, Muldoon, Craig, Becker, Bernd, Elliott, Alysha G., Lash, Lawrence H, Huang, Johnny X., Butler, Mark S., Pelingon, Ruby, Kavanagh, Angela M., Ramu, Soumya, Phetsang, Wanida, Blaskovich, Mark A. T. and Cooper, Matthew A (2016). Activity and predicted nephrotoxicity of synthetic antibiotics based on polymyxin B. Journal of Medicinal Chemistry, 59 (3), 1068-1077. doi: 10.1021/acs.jmedchem.5b01593
Elliott, Alysha G., Franke, Bastian, Armstrong, David A., Craik, David J., Mylne, Joshua S. and Rosengren, K. Johan (2016). Natural structural diversity within a conserved cyclic peptide scaffold. Amino Acids, 49 (1), 1-14. doi: 10.1007/s00726-016-2333-x
Huang, Johnny X., Blaskovich, Mark A.T., Pelingon, Ruby, Ramu, Soumya, Kavanagh, Angela, Elliott, Alysha G., Butler, Mark S., Montgomery, A. Bruce and Cooper, Matthew A. (2015). Mucin binding reduces colistin antimicrobial activity. Antimicrobial Agents and Chemotherapy, 59 (10), 5925-5931. doi: 10.1128/AAC.00808-15
Rees, Karlee A., Bermudez, Cindy, Edwards, David J., Elliott, Alysha G., Ripen, Jovita E., Seta, Cynthia, Huang, Johnny X., Cooper, Matthew A., Fraser, James A., Yeo, Tiong C. and Butler, Mark S. (2015). Flemingin-type prenylated chalcones from the sarawak rainforest plant desmodium congestum. Journal of Natural Products, 78 (8), 2141-2144. doi: 10.1021/acs.jnatprod.5b00410
Jarrad, Angie M., Karoli, Tomislav, Anjan, Debnath, Tay, Chin Yen, Huang, Johnny X., Kaeslin, Geraldine, Elliott, Alysha G., Miyamoto, Yukiko, Ramu, Soumya, Kavanagh, Angela M., Zuegg, Johannes, Eckmann, Lars, Blaskovich, Mark A. and Cooper, Matthew A. (2015). Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites. European Journal of Medicinal Chemistry, 101 7946, 96-102. doi: 10.1016/j.ejmech.2015.06.019
Zuegg, Johannes, Muldoon, Craig, Adamson, George, McKeveney, Declan, Le Thanh, Giang, Premraj, Rajaratnam, Becker, Bernd, Cheng, Mu, Elliott, Alysha G., Huang, Johnny X., Butler, Mark S., Bajaj, Megha, Seifert, Joachim, Singh, Latika, Galley, Nicola F., Roper, David I., Lloyd, Adrian J., Dowson, Christopher G., Cheng, Ting-Jen, Cheng, Wei-Chieh, Demon, Dieter, Meyer, Evelyne, Meutermans, Wim and Cooper, Matthew A. (2015). Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nature Communications, 6 (1) 7719, 1-11. doi: 10.1038/ncomms8719
Hickey, Shane M., Ashton, Trent D., Khosa, Simren K., Robson, Ryan N., White, Jonathan M., Li, Jian, Nation, Roger L., Yu, Heidi Y., Elliott, Alysha G., Butler, Mark S., Huang, Johnny X., Cooper, Matthew A. and Pfeffer, Frederick M. (2015). Synthesis and evaluation of cationic norbornanes as peptidomimetic antibacterial agents. Organic and Biomolecular Chemistry, 13 (22), 6225-6241. doi: 10.1039/c5ob00621j
Blaskovich, Mark A. T., Zuegg, Johannes, Elliott, Alysha G. and Cooper, Matthew (2015). Helping chemists discover new antibiotics. ACS Infectious Diseases, 1 (7), 285-287. doi: 10.1021/acsinfecdis.5b00044
Bernath-Levin, Kalia, Nelson, Clark, Elliott, Alysha G., Jayasena, Achala S., Millar, A. Harvey, Craik, David J. and Mylne, Joshua S. (2015). Peptide macrocyclization by a bifunctional endoprotease. Chemistry and Biology, 22 (5), 571-582. doi: 10.1016/j.chembiol.2015.04.010
Azmi, Fazren, Elliott, Alysha G., Khalil, Zeinab G., Hussein, Waleed M., Kavanagh, Angela, Huang, Johnny X., Quezada, Michelle, Blaskovich, Mark A. T., Capon, Robert J., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2015). Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains. Nanomedicine, 10 (22), 3359-3371. doi: 10.2217/nnm.15.137
Hickey, Shane M., Ashton, Trent D., White, Jonathan M., Li, Jian, Nation, Roger L., Yu, Heidi Y., Elliott, Alysha G., Butler, Mark S., Huang, Johnny X., Cooper, Matthew A. and Pfeffer, Frederick M. (2015). Synthesis of norbornane bisether antibiotics via silver-mediated alkylation. Rsc Advances, 5 (36), 28582-28596. doi: 10.1039/c5ra03321g
Elliott, Alysha G., Delay, Christina, Liu, Huanle, Phua, Zaiyang, Rosengren, K. Johan, Benfield, Aurelie H., Panero, Jose L., Colgrave, Michelle L., Jayasena, Achala S., Dunse, Kerry M., Anderson, Marilyn A., Schilling, Edward E., Ortiz-Barrientos, Daniel, Craik, David J. and Mylne, Joshua S. (2014). Evolutionary origins of a bioactive peptide buried within preproalbumin. The Plant Cell, 26 (3), 981-995. doi: 10.1105/tpc.114.123620
Koehbach, Johannes, O'Brien, Margaret, Muttenthaler, Markus, Miazzo, Marion, Akcan, Muharrem, Elliott, Alysha G., Daly, Norelle L., Harvey, Peta J., Arrowsmith, Sarah, Gunasekera, Sunithi, Smith, Terry J., Wray, Susan, Göransson, Ulf, Dawson, Philip E., Craik, David J., Freissmuth, Michael and Gruber, Christian W. (2013). Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences of the United States of America, 110 (52), 21183-21188. doi: 10.1073/pnas.1311183110
Mylne, Joshua S., Colgrave, Michelle L., Daly, Norelle L., Chanson, Aurelie H., Elliott, Alysha G., McCallum, Emily J., Jones, Alun and Craik, David J. (2011). Albumins and their processing machinery are hijacked for cyclic peptides in sunflower. Nature Chemical Biology, 7 (5), 257-259. doi: 10.1038/nchembio.542
Gruber, Christian W., Elliott, Alysha G., Ireland, David C., Delprete, Piero G., Dessein, Steven, Goransson, Ulf, Trabi, Manuela, Wang, Conan K., Kinghorn, Andrew B., Robbrecht, Elmar and Craik, David J. (2008). Distribution and evolution of circular miniproteins in flowering plants. The Plant Cell, 20 (9), 2471-2483. doi: 10.1105/tpc.108.062331
Conference Papers
Edwards, I., Elliott, A., Blaskovich, M. and Cooper, M. (2016). Contribution of physicochemical parameters to the antimicrobial activity / toxicity index of B-Hairpin peptides. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2950
Rosengren, K. J., Elliott, A. G., Franke, B. and Mylne, J. S. (2014). Structural Diversity of a Novel Family of Cyclic Plant Peptides. 33rd European Peptide Symposium, Sofia Bulgaria, August 31 – September 5 2014. United Kingdom: John Wiley & Sons.
Elliott, Alysha G., Craik, David J. and Mylne, Joshua S. (2011). Sunflower trypsin inhibitor-1: chemical v. biological synthesis. 22nd American Peptide Symposium, San Diego, United States, 25-30 June 2011. San Diego, United States: Prompt Scientific Publishing.
Patent
Gallardo-Goday, Alejandra, Cooper, Matthew, Blaskovich, Mark, Hansford, Karl and Elliott, Alysha (2019). Peptide antibiotics. WO2019084628.
Preprint
Thesis
Elliott, Alysha Gai (2013). A new class of daisy seed peptides. PhD Thesis, The Institute for Molecular Bioscience, The University of Queensland.