Dr Alysha Elliott Aparicio

Matiadis, Dimitris, Tsironis, Dimitrios, Stefanou, Valentina, Elliott, Alysha G., Kordatos, Konstantinos, Zahariou, Georgia, Ioannidis, Nikolaos, McKee, Vickie, Panagiotopoulou, Angeliki, Igglessi-Markopoulou, Olga and Markopoulos, John (2019) Synthesis, characterization and antimicrobial activity of N-acetyl-3-acetyl-5-benzylidene tetramic acid-metal complexes. X-ray analysis and identification of the Cd(II) complex as a potent antifungal agent. Journal of Inorganic Biochemistry, 194 65-73. doi:10.1016/j.jinorgbio.2019.02.008

Zhang, Alan H., Edwards, Ingrid A., Mishra, Biswa P., Sharma, Gagan, Healy, Michael D., Elliott, Alysha, Blaskovich, Mark A. T., Cooper, Matthew A., Collins, Brett M., Jia, Xinying and Mobli, Mehdi (2019) Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs. Frontiers in Chemistry, 7 MAR: . doi:10.3389/fchem.2019.00238

Gallardo-Godoy, Alejandra, Hansford, Karl, Muldoon, Craig, Becker, Bernd, Elliott, Alysha, Huang, Johnny, Pelingon, Ruby, Butler, Mark, Blaskovich, Mark and Cooper, Matthew (2019) Structure-function studies of polymyxin B lipononapeptides. Molecules, 24 3: 553. doi:10.3390/molecules24030553

Chen, Ao, Er, Gerald, Zhang, Cheng, Tang, Joyce, Alam, Mahbub, T. Ta, Hang, Elliott, Alysha G., Cooper, Matthew A., Perera, Janesha, Swift, Simon, Blakey, Idriss, Whittaker, Andrew K. and Peng, Hui (2019) Antimicrobial anilinium polymers: The properties of poly(N,N‐dimethylaminophenylene methacrylamide) in solution and as coatings. Journal of Polymer Science Part A: Polymer Chemistry, . doi:10.1002/pola.29314

Chen, Ao, Er, Gerald, Zhang, Cheng, Tang, Joyce, Alam, Mahbub, Ta, Hang T., Elliott, Alysha G., Cooper, Matthew A., Perera, Janesha, Swift, Simon, Blakey, Idriss, Whittaker, Andrew K. and Peng, Hui (2019) Antimicrobial anilinium polymers: the properties of poly(N,N‐dimethylaminophenylene methacrylamide) in solution and as coatings. Journal of Polymer Science Part A: Polymer Chemistry, . doi:10.1002/pola.29314

James, Amy M., Haywood, Joel, Leroux, Julie, Ignasiak, Katarzyna, Elliott, Alysha G., Schmidberger, Jason W., Fisher, Mark F., Nonis, Samuel G., Fenske, Ricarda, Bond, Charles S. and Mylne, Joshua S. (2019) The macrocyclizing protease butelase 1 remains autocatalytic and reveals the structural basis for ligase activity. Plant Journal, . doi:10.1111/tpj.14293

Hickey, Shane M., Ashton, Trent D., Boer, Gareth, Bader, Christie A., Thomas, Michael, Elliott, Alysha G., Schmuck, Carsten, Yu, Heidi Y., Li, Jian, Nation, Roger L., Cooper, Matthew A., Plush, Sally E., Brooks, Douglas A. and Pfeffer, Frederick M. (2018) Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane. European Journal of Medicinal Chemistry, 160 9-22. doi:10.1016/j.ejmech.2018.09.072

Grace, James L., Schneider-Futschik, Elena K., Elliott, Alysha G., Amado, Maite, Truong, Nghia P., Cooper, Matthew A., Li, Jian, Davis, Thomas P., Quinn, John F., Velkov, Tony and Whittaker, Michael R. (2018) Exploiting macromolecular design to optimize the antibacterial activity of alkylated cationic oligomers. Biomacromolecules, 19 12: 4629-4640. doi:10.1021/acs.biomac.8b01317

Blaskovich, Mark A. T., Pitt, Miranda E., Elliott, Alysha G. and Cooper, Matthew A. (2018) Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria?. Expert Review of Anti-infective Therapy, 16 6: 485-499. doi:10.1080/14787210.2018.1483240

Pitt, Miranda E., Elliott, Alysha G., Cao, Minh Duc, Ganesamoorthy, Devika, Karaiskos, Ilias, Giamarellou, Helen, Abboud, Cely S., Blaskovich, Mark A. T., Cooper, Matthew A. and Coin, Lachlan J. M. (2018) Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae. Microbial Genomics, 4 3: . doi:10.1099/mgen.0.000158

Velkov, Tony, Gallardo-Godoy, Alejandra, Swarbrick, James D., Blaskovich, Mark A. T., Elliott, Alysha G., Han, Meiling, Thompson, Philip E., Roberts, Kade D., Huang, Johnny X., Becker, Bernd, Butler, Mark S., Lash, Lawrence H., Henriques, Sónia Troeira, Nation, Roger L., Sivanesan, Sivashangarie, Sani, Marc-Antoine, Separovic, Frances, Mertens, Haydyn, Bulach, Dieter, Seemann, Torsten, Owen, Jeremy, Li, Jian and Cooper, Matthew A. (2018) Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria. Cell Chemical Biology, 25 4: 380-391.e5. doi:10.1016/j.chembiol.2018.01.005

Edwards, Ingrid A, Elliott, Alysha G, Kavanagh, Angela M, Blaskovich, Mark A T and Cooper, Matthew A (2017) Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS infectious diseases, 3 12: 917-926. doi:10.1021/acsinfecdis.7b00123

Scott, Fraser J., Nichol, Ryan J. O., Khalaf, Abedawn I., Giordani, Federica, Gillingwater, Kirsten, Ramu, Soumya, Elliott, Alysha, Zuegg, Johannes, Duffy, Paula, Rosslee, Michael-Jon, Hlaka, Lerato, Kumar, Santosh, Ozturk, Mumin, Brombacher, Frank, Barrett, Michael, Guler, Reto and Suckling, Colin J. (2017) An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics. European Journal of Medicinal Chemistry, 136 561-572. doi:10.1016/j.ejmech.2017.05.039

Henriques, Sónia Troeira, Lawrence, Nicole, Chaousis, Stephanie, Ravipati, Anjaneya S., Cheneval, Olivier, Benfield, Aurélie H., Elliott, Alysha G., Kavanagh, Angela Maria, Cooper, Matthew A., Chan, Lai Yue, Huang, Yen-Hua and Craik, David J. (2017) Redesigned spider peptide with improved antimicrobial and anticancer properties. ACS Chemical Biology, 12 9: 2324-2334. doi:10.1021/acschembio.7b00459

Dekan, Zoltan, Headey, Stephen J., Scanlon, Martin, Baldo, Brian A., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Deuis, Jennifer R., Vetter, Irina, Elliott, Alysha G., Amado, Maite, Cooper, Matthew A., Alewood, Dianne and Alewood, Paul F. (2017) Δ-Myrtoxin-Mp1a is a helical heterodimer from the venom of the jack jumper ant that has antimicrobial, membrane-disrupting, and nociceptive activities. Angewandte Chemie, 129 29: 8615-8619. doi:10.1002/ange.201703360

Hussein, Maytham H., Schneider, Elena K., Elliott, Alysha G., Han, Meiling, Reyes-Ortega, Felisa, Morris, Faye, Blaskovich, Mark A. T., Jasim, Raad, Currie, Bart, Mayo, Mark, Baker, Mark, Cooper, Matthew A., Li, Jian and Velkov, Tony (2017) From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators. Microbial Drug Resistance, 23 5: 640-650. doi:10.1089/mdr.2016.0196

Dekan, Zoltan, Headey, Stephen J. , Scanlon, Martin, Baldo, Brian A. , Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Deuis, Jennifer R. , Vetter, Irina, Elliott, Alysha G. , Amado, Maite, Cooper, Matthew A. , Alewood, Dianne and Alewood, Paul F. (2017) Δ-Myrtoxin-Mp1a is a helical heterodimer from the venom of the jack jumper ant that has antimicrobial, membrane-disrupting, and nociceptive activities. Angewandte Chemie, 56 29: 8495-8499. doi:10.1002/anie.201703360

Becker, Bernd, Butler, Mark S., Hansford, Karl A., Gallardo-Godoy, Alejandra, Elliott, Alysha G., Huang, Johnny X., Edwards, David J., Blaskovich, Mark A. T. and Cooper, Matthew A. (2017) Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria. Bioorganic and Medicinal Chemistry Letters, 27 11: 2407-2409. doi:10.1016/j.bmcl.2017.04.027

Desselle, Mathilde R., Neale, Ruth, Hansford, Karl A., Zuegg, Johannes, Elliott, Alysha G., Cooper, Matthew A. and Blaskovich, Mark A. T. (2017) Institutional profile: Community for Open Antimicrobial Drug Discovery - crowdsourcing new antibiotics and antifungals. Future Science OA, 3 2: FSO171. doi:10.4155/fsoa-2016-0093

Galappathie, Savithri, Edwards, David J., Elliott, Alysha G., Cooper, Matthew A., Palombo, Enzo A., Butler, Mark S. and Mahon, Peter J. (2017) Antibacterial nerol cinnamates from the Australian plant Eremophila longifolia. Journal of Natural Products, 80 4: 1178-1181. doi:10.1021/acs.jnatprod.6b00888

Cao, Minh Duc, Nguyen, Son Hoang, Ganesamoorthy, Devika, Elliott, Alysha G., Cooper, Matthew A. and Coin, Lachlan J. M. (2017) Scaffolding and completing genome assemblies in real-time with nanopore sequencing. Nature Communications, 8 14515. doi:10.1038/ncomms14515

Möhler, Jasper S., Kolmar, Theresa, Synnatschke, Kevin, Hergert, Marcel, Wilson, Liam A., Ramu, Soumya, Elliott, Alysha G., Blaskovich, Mark A.T., Sidjabat, Hanna E., Paterson, David L., Schenk, Gerhard, Cooper, Matthew A. and Ziora, Zyta M. (2017) Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies. Journal of Inorganic Biochemistry, 167 134-141. doi:10.1016/j.jinorgbio.2016.11.028

Grace, James L., Elliott, Alysha G., Huang, Johnny X., Schneider, Elena K., Truong, Nghia P., Cooper, Matthew A., Li, Jian, Davis, Thomas P., Quinn, John F., Velkov, Tony and Whittaker, Michael R. (2016) Cationic acrylate oligomers comprising amino acid mimic moieties demonstrate improved antibacterial killing efficiency. Journal of Materials Chemistry B, 5 3: 531-536. doi:10.1039/C6TB02787C

Yousfi, Tarek, Elliott, Alysha, Hanane, Messiad, Merdes, Rachid and Moyano, Albert (2016) Expedient organocatalytic syntheses of 4-substituted pyrazolidines and isoxazolidines. Molecules, 21 12: 1655. doi:10.3390/molecules21121655

Kumar, Rohitesh, Lu, Yuting, Elliott, Alysha G., Kavanagh, Angela M., Cooper, Matthew A. and Davis, Rohan A. (2016) Semi-synthesis and NMR spectral assignments of flavonoid and chalcone derivatives. Magnetic Resonance in Chemistry, 54 11: 880-886. doi:10.1002/mrc.4482

Cao, Minh Duc, Ganesamoorthy, Devika, Elliott, Alysha G., Zhang, Huihui, Cooper, Matthew A. and Coin, Lachlan J. M. (2016) Streaming algorithms for identification of pathogens and antibiotic resistance potential from real-time MinION (TM) sequencing. Gigascience, 5 1: 32. doi:10.1186/s13742-016-0137-2

Elliott, Alysha G., Ganesamoorthy, Devika, Coin, Lachlan, Cooper, Matthew A. and Cao, Minh Duc (2016) Complete Genome Sequence of Klebsiella quasipneumoniae subsp. similipneumoniae Strain ATCC 700603. Genome Announcements, 4 3: . doi:10.1128/genomeA.00438-16

Cao, Minh Duc, Nguyen, Hoang Son, Ganesamoorthy, Devika, Elliott, Alysha, Cooper, Matthew and Coin, Lachlan J. M. (2016) Scaffolding and completing genome assemblies in real-time with nanopore sequencing. bioRxiv, . doi:10.1101/054783

Azmi, Fazren, Elliott, Alysha G., Marasini, Nirmal, Ramu, Soumya, Ziora, Zyta, Kavanagh, Angela M., Blaskovich, Mark A. T., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2016) Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation. Bioorganic and Medicinal Chemistry, 24 10: 2235-2241. doi:10.1016/j.bmc.2016.03.053

Edwards, Ingrid A., Elliott, Alysha G., Kavanagh, Angela M., Zuegg, Johannes, Blaskovich, Mark A. T. and Cooper, Matthew A. (2016) Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptides. ACS Infectious Diseases, 2 6: 442-450. doi:10.1021/acsinfecdis.6b00045

Beattie, Karren D., Ellwood, Nicola, Kumar, Rohitesh, Yang, Xinzhou, Healy, Peter C., Choomuenwai, Vanida, Quinn, Ronald J., Elliott, Alysha G., Huang, Johnny X., Chitty, Jessica L., Fraser, James A., Cooper, Matthew A. and Davis, Rohan A. (2016) Antibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D-F. Phytochemistry, 124 79-85. doi:10.1016/j.phytochem.2015.12.014

Gallardo-Godoy, Alejandra, Muldoon, Craig, Becker, Bernd, Elliott, Alysha G., Lash, Lawrence H, Huang, Johnny X., Butler, Mark S., Pelingon, Ruby, Kavanagh, Angela M., Ramu, Soumya, Phetsang, Wanida, Blaskovich, Mark A. T. and Cooper, Matthew A (2016) Activity and predicted nephrotoxicity of synthetic antibiotics based on polymyxin B. Journal of Medicinal Chemistry, 59 3: 1068-1077. doi:10.1021/acs.jmedchem.5b01593

Elliott, Alysha G., Franke, Bastian, Armstrong, David A., Craik, David J., Mylne, Joshua S. and Rosengren, K. Johan (2016) Natural structural diversity within a conserved cyclic peptide scaffold. Amino Acids, 49 1: 1-14. doi:10.1007/s00726-016-2333-x

Huang, Johnny X., Blaskovich, Mark A.T., Pelingon, Ruby, Ramu, Soumya, Kavanagh, Angela, Elliott, Alysha G., Butler, Mark S., Montgomery, A. Bruce and Cooper, Matthew A. (2015) Mucin binding reduces colistin antimicrobial activity. Antimicrobial Agents and Chemotherapy, 59 10: 5925-5931. doi:10.1128/AAC.00808-15

Rees, Karlee A., Bermudez, Cindy, Edwards, David J., Elliott, Alysha G., Ripen, Jovita E., Seta, Cynthia, Huang, Johnny X., Cooper, Matthew A., Fraser, James A., Yeo, Tiong C. and Butler, Mark S. (2015) Flemingin-type prenylated chalcones from the sarawak rainforest plant desmodium congestum. Journal of Natural Products, 78 8: 2141-2144. doi:10.1021/acs.jnatprod.5b00410

Jarrad, Angie M., Karoli, Tomislav, Anjan, Debnath, Tay, Chin Yen, Huang, Johnny X., Kaeslin, Geraldine, Elliott, Alysha G., Miyamoto, Yukiko, Ramu, Soumya, Kavanagh, Angela M., Zuegg, Johannes, Eckmann, Lars, Blaskovich, Mark A. and Cooper, Matthew A. (2015) Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites. European Journal of Medicinal Chemistry, 101 96-102. doi:10.1016/j.ejmech.2015.06.019

Zuegg, Johannes, Muldoon, Craig, Adamson, George, McKeveney, Declan, Le Thanh, Giang, Premraj, Rajaratnam, Becker, Bernd, Cheng, Mu, Elliott, Alysha G., Huang, Johnny X., Butler, Mark S., Bajaj, Megha, Seifert, Joachim, Singh, Latika, Galley, Nicola F., Roper, David I., Lloyd, Adrian J., Dowson, Christopher G., Cheng, Ting-Jen, Cheng, Wei-Chieh, Demon, Dieter, Meyer, Evelyne, Meutermans, Wim and Cooper, Matthew A. (2015) Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nature Communications, 6 1: 1-11. doi:10.1038/ncomms8719

Hickey, Shane M., Ashton, Trent D., Khosa, Simren K., Robson, Ryan N., White, Jonathan M., Li, Jian, Nation, Roger L., Yu, Heidi Y., Elliott, Alysha G., Butler, Mark S., Huang, Johnny X., Cooper, Matthew A. and Pfeffer, Frederick M. (2015) Synthesis and evaluation of cationic norbornanes as peptidomimetic antibacterial agents. Organic and Biomolecular Chemistry, 13 22: 6225-6241. doi:10.1039/c5ob00621j

Blaskovich, Mark A. T., Zuegg, Johannes, Elliott, Alysha G. and Cooper, Matthew (2015) Helping chemists discover new antibiotics. ACS Infectious Diseases, 1 7: 285-287. doi:10.1021/acsinfecdis.5b00044

Bernath-Levin, Kalia, Nelson, Clark, Elliott, Alysha G., Jayasena, Achala S., Millar, A. Harvey, Craik, David J. and Mylne, Joshua S. (2015) Peptide macrocyclization by a bifunctional endoprotease. Chemistry and Biology, 22 5: 571-582. doi:10.1016/j.chembiol.2015.04.010

Azmi, Fazren, Elliott, Alysha G., Khalil, Zeinab G., Hussein, Waleed M., Kavanagh, Angela, Huang, Johnny X., Quezada, Michelle, Blaskovich, Mark A. T., Capon, Robert J., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2015) Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains. Nanomedicine, 10 22: 3359-3371. doi:10.2217/nnm.15.137

Hickey, Shane M., Ashton, Trent D., White, Jonathan M., Li, Jian, Nation, Roger L., Yu, Heidi Y., Elliott, Alysha G., Butler, Mark S., Huang, Johnny X., Cooper, Matthew A. and Pfeffer, Frederick M. (2015) Synthesis of norbornane bisether antibiotics via silver-mediated alkylation. Rsc Advances, 5 36: 28582-28596. doi:10.1039/c5ra03321g

Elliott, Alysha G., Delay, Christina, Liu, Huanle, Phua, Zaiyang, Rosengren, K. Johan, Benfield, Aurelie H., Panero, Jose L., Colgrave, Michelle L., Jayasena, Achala S., Dunse, Kerry M., Anderson, Marilyn A., Schilling, Edward E., Ortiz-Barrientos, Daniel, Craik, David J. and Mylne, Joshua S. (2014) Evolutionary origins of a bioactive peptide buried within preproalbumin. The Plant Cell, 26 3: 981-995. doi:10.1105/tpc.114.123620

Koehbach, Johannes, O'Brien, Margaret, Muttenthaler, Markus, Miazzo, Marion, Akcan, Muharrem, Elliott, Alysha G., Daly, Norelle L., Harvey, Peta J., Arrowsmith, Sarah, Gunasekera, Sunithi, Smith, Terry J., Wray, Susan, Göransson, Ulf, Dawson, Philip E., Craik, David J., Freissmuth, Michael and Gruber, Christian W. (2013) Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences of the United States of America, 110 52: 21183-21188. doi:10.1073/pnas.1311183110

Mylne, Joshua S., Colgrave, Michelle L., Daly, Norelle L., Chanson, Aurelie H., Elliott, Alysha G., McCallum, Emily J., Jones, Alun and Craik, David J. (2011) Albumins and their processing machinery are hijacked for cyclic peptides in sunflower. Nature Chemical Biology, 7 5: 257-259. doi:10.1038/nchembio.542

Gruber, Christian W., Elliott, Alysha G., Ireland, David C., Delprete, Piero G., Dessein, Steven, Goransson, Ulf, Trabi, Manuela, Wang, Conan K., Kinghorn, Andrew B., Robbrecht, Elmar and Craik, David J. (2008) Distribution and evolution of circular miniproteins in flowering plants. The Plant Cell, 20 9: 2471-2483. doi:10.1105/tpc.108.062331

Edwards, I., Elliott, A., Blaskovich, M. and Cooper, M. (2016). Contribution of physicochemical parameters to the antimicrobial activity / toxicity index of B-Hairpin peptides. In: 34th European Peptide Symposium, Leipzig, Germany, (S122-S122). 4‐9 September 2016. doi:10.1002/psc.2950

Rosengren, K. J., Elliott, A. G., Franke, B. and Mylne, J. S. (2014). Structural Diversity of a Novel Family of Cyclic Plant Peptides. In: Journal of Peptide Science. 33rd European Peptide Symposium, Sofia Bulgaria, (S67-S67). August 31 – September 5 2014.

Elliott, Alysha G., Craik, David J. and Mylne, Joshua S. (2011). Sunflower trypsin inhibitor-1: chemical v. biological synthesis. In: Michal Lebl, Peptides: Building Bridges: Proceedings of the Twenty-Second American Peptide Symposium. 22nd American Peptide Symposium, San Diego, United States, (86-87). 25-30 June 2011.

Elliott, Alysha Gai (2013). A new class of daisy seed peptides PhD Thesis, The Institute for Molecular Bioscience, The University of Queensland.

Dr Alysha Elliott Aparicio

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Thesis