Dr Bruce Wyse
Deputy Director (Operations)
Institute for Molecular Bioscience
+61 7 334 62197
Journal Articles
Smith, Maree T., Wyse, Bruce D., Edwards, Stephen R., El-Taminy, Mahmoud, Gaetano, Giacinto and Gavin, Paul (2015) Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture, TPM) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure. Journaal of Pharmaceutical Sciences, 104 7: 2388-2396. doi:10.1002/jps.24502
Huang, Lillian Y., Tsui, Debbie Y., Williams, Craig M., Wyse, Bruce D. and Smith, Maree T. (2015) The Furoxan Nitric Oxide Donor, PRG150, Evokes Dose-Dependent Analgesia in a Rat Model of Painful Diabetic Neuropathy (PDN). Clinical and Experimental Pharmacology and Physiology, 42 9: 921-929. doi:10.1111/1440-1681.12442
Han, Felicity Yaqin, Wyse, Bruce D. and Smith, Maree T. (2014) Optimization and pharmacological characterization of a refined cisplatin-induced rat model of peripheral neuropathic pain. Behavioural Pharmacology, 25 8: 732-740. doi:10.1097/FBP.0000000000000090
Cai, Jun, Song, Bowen, Cai, Yunxin, Ma, Yu, Lam, Ai-leen, Magiera, Julia, Sekar, Sunder, Wyse, Bruce D., Ambo, Akihiro, Sasaki, Yusuke, Lazarus, Lawrence H., Smith, Maree T. and Li, Tingyou (2014) Endomorphin analogues with mixed mu-opioid (MOP) receptor agonism/delta-opioid (DOP) receptor antagonism and lacking beta-arrestin2 recruitment activity. Biorganic and Medicinal Chemistry, 22 7: 2208-2219. doi:10.1016/j.bmc.2014.02.015
Smith, Maree T., Lau, Tanya, Wallace, Victoria C. J., Wyse, Bruce D. and Rice, Andrew S. C. (2014) Analgesic efficacy of small-molecule angiotensin II type 2 receptor antagonists in a rat model of antiretroviral toxic polyneuropathy. Behavioural Pharmacology, 25 2: 137-146. doi:10.1097/FBP.0000000000000025
Kuo, A., Wyse, B. D., Meutermans, W. and Smith, M. T. (2014) In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile. British Journal of Pharmacology, Accepted Article 2: 1-48. doi:10.1111/bph.12696
Muralidharan, Arjun, Wyse, Bruce D. and Smith, Maree T. (2014) Analgesic efficacy and mode of action of a selective small molecule angiotensin II type 2 receptor antagonist in a rat model of prostate cancer-induced bone pain. Pain Medicine, 15 1: 93-110. doi:10.1111/pme.12258
Smith, Maree T., Woodruff, Trent M., Wyse, Bruce D., Muralidharan, Arjun and Walther, Thomas (2013) A small molecule angiotensin II type 2 receptor (AT2R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia. Pain Medicine, 14 10: 1557-1568. doi:10.1111/pme.12157
Smith, Maree T., Wyse, Bruce D. and Edwards, Stephen R. (2013) Small molecule angiotensin II type 2 receptor (AT2R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in rats. Pain Medicine, 14 5: 692-705. doi:10.1111/pme.12063
Varamini, Pegah, Goh, Wei Huang, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2013) Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation. Bioorganic & Medicinal Chemistry, 21 7: 1898-1904. doi:10.1016/j.bmc.2013.01.044
Muralidharan, Arjun, Wyse, Bruce D. and Smith, Maree T. (2013) Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioural, pharmacological, radiological, histological and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 106 33-46. doi:10.1016/j.pbb.2013.02.020
Varamini, Pegah, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2012) Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation. PLoS One, 7 8 Article. No.e41909: . doi:10.1371/journal.pone.0041909
Varamini, Pegah, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2012) Synthesis and biological evaluation of an orally active glycosylated endomorphin-1. Journal of Medicinal Chemistry, 55 12: 5859-5867. doi:10.1021/jm300418d
Otto, Kathleen J., Wyse, Bruce D., Cabot, Peter J. and Smith, Maree T. (2011) Insulin implants prevent the temporal development of mechanical allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic wistar rats. Pain Medicine, 12 5: 782-793. doi:10.1111/j.1526-4637.2011.01102.x
Otto, Kathleen J., Wyse, Bruce D., Cabot, Peter J. and Smith, Maree T. (2011) Longitudinal study of painful diabetic neuropathy in the Zucker diabetic fatty rat model of type 2 diabetes: Impaired basal G-protein activity appears to underpin marked morphine hyposensitivity at 6 months. Pain Medicine, 12 3: 437-450. doi:10.1111/j.1526-4637.2011.01067.x
Vetter, Irina, Cheung, Wei, Peiris, Madusha, Wyse, Bruce D., Roberts-Thomson, Sarah J., Zheng, Jie, Monteith, Gregory R. and Cabot, Peter J (2008) Rapid, Opiod-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization. Journal of Biological Chemistry, 283 28: 19540-19550. doi:10.1074/jbc.M707865200
Chan, S., Edwards, S. R., Wyse, B. D. and Smith, M. T. (2008) Sex differences in the pharmacokinetics, oxidative metabolism and oral bioactivity of oxycodone in the sprague-dawley rat. Clinical and Experimental Pharmacology and Physiology, 35 3: 295-302. doi:10.1111/j.1440-1681.2007.04821.x
Vetter, Irina, Wyse, Bruce D., Roberts-Thomson, Sarah J., Monteith, Gregory R. and Cabot, Peter J. (2008) Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol. European Journal of Pain, 12 4: 441-454. doi:10.1016/j.ejpain.2007.07.001
Vetter, Irina, Wyse, Bruce D., Monteith, Gregory R., Roberts-Thomson, Sarah J. and Cabot, Peter J. (2006) The μ opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase A pathway. Molecular Pain, 2 22: 1-16. doi:10.1186/1744-8069-2-22
Wyse, B. D., Prior, I. A., Qian, H. W., Morrow, I. C., Nixon, S., Muncke, C., Kurzchalia, T. V., Thomas, W. G., Parton, R. G. and Hancock, J. F. (2003) Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. Journal of Biological Chemistry, 278 26: 23738-23746. doi:10.1074/jbc.M212892200
Wyse, B., Ali, N. and Ellison, D. H. (2002) Interaction with grp58 increases the activity of the thiazide-sensitive Na-Cl cotransporter. American Journal of Physiology - Renal Physiology, 282 3: F424-F430.
Roy, S., Wyse, B. and Hancock, J. F. (2002) H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis. Molecular And Cellular Biology, 22 14: 5128-5140. doi:10.1128/MCB.22.14.5128-5140.2002
Carozzi, A. J., Roy, S., Morrow, I. C., Pol, A., Wyse, B., Clyde-Smith, J., Prior, I. A., Nixon, S. J., Hancock, J. F. and Parton, R. G. (2002) Inhibition of lipid raft-dependent signaling by a dystrophy-associated mutant of caveolin-3. Journal of Biological Chemistry, 277 20: 17944-17949. doi:10.1074/jbc.M110879200
Abdallah, J. G., Schrier, R. W., Edelstein, C., Jennings, S. D., Wyse, B. and Ellison, D. H. (2001) Loop diuretic infusion increases thiazide-sensitive Na+/Cl--cotransporter abundance: Role of aldosterone. Journal of The American Society of Nephrology, 12 7: 1335-1341.
Conference Papers
Huang, L., Smith, M. T. and Wyse, B. D. (2008). Mechanistic insight into the anti-allodynic effects of PRG100. In: Abstracts of the 12th World Congress on Pain. 12th World Congress on Pain, Glasgow, Scotland, U. K., (). 17-22 August 2008.
Hemstapat, K., Kuo, A., Smith, M.T. and Wyse, B.D. (2008). Comparative profiles of the antinociceptive and constipating effects of single intracerebroventricular (i.c.v.) bolus doses of morphine, morphine-6-glucuronide and fentanyl in rats Kuo A, Hemstapat K, Wyse BD, Smith MT. In: Proceedings of the 4th Scientific Meeting of the Australian Health and Medical Research Congress. 4th Scientific Meeting of the Australian Health and Medical Research Congress, Brisbane, Australia, (389-389). 16 - 21 November, 2008.
Kuo, A., Hemstapat, K., Wyse, B. D., South, S. M. and Smith, M. T. (2008). Comparative profiles of the antinociceptive and constipating effects of single intracerebroventricular (i.c.v.) bolus doses of morphine and oxycodone in rats. In: Abstracts of the 12th World Congress on Pain. 12th World Congress on Pain, Glasgow, UK, (). 17-22 August 2008.
Cabot, P.J., Otto, K., Smith, M.T., South, S.M. and Wyse, B.D. (2008). Influence of diet on the longitudinal temporal development of opioid hyposensitivity and tactile allodynia in the Zucker Diabetic Fatty (ZDF) rat. In: Proceedings of the 28th National Scientific Meeting of the Australian Pain Society: The Spectrum of Pain. 28th Annual Scientific Meeting of the Australian Pain Society: The Spectrum of Pain, Perth, Australia, (36-36). 30 March – 2 April, 2008.
Huang, L., Wyse, B. D. and Smith, M. T. (2008). Mechanistic insight into the anti-allodynic effects of PRG150. In: Abstracts of the 12th World Congress on Pain. 12th World Congress on Pain, Glasgow, Scotland, (). 17-22 August 2008.
Wyse, B., Rogers, H., O'Hagan, S., Dao, C. B., Weerasinghe, G., Smith, M. T. and South, S. M. (2007). 2',3'-Dideoxycytidine-Induced Neuropathy: Comparison With Other Neuropathic Pain Models. In: C. G. Sobey and S. Smid, 41st Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and 10th Southeast Asian Western Pacific Regional Meeting of Pharmacologists, Adelaide South Australia, (Poster 3 - 82). 2-6 December 2007.
South, S. M., Dao, C. B., Wyse, B. and Smith, M. T. (2007). Additive Antinociception Following Co-administration of a NR2B-Selective NMDA Antagonist with BDNF. In: 41st Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and 10th Southeast Asian Western Pacific Regional Meeting of Pharmacologists, Adelaide, South Australia, (Poster 2 - 72). 2-6 December 2007.
Cabot, P. J., Otto, K. J., Smith, M. T., South, S. M. and Wyse, B. D. (2007). Influence of diet on the temporal development of tactile allodynia and opioid hyposensitivity for 22-wks in the Zucker Diabetic Fatty (ZDF) rat. In: Abstracts of the Second International Congress on Neuropathic Pain (NeuPSIG). Second International Congress on Neuropathic Pain, Berlin, Germany, (). 7- 10 June 2007. doi:10.1016/j.ejpain.2007.03.177
Smith, M. T., Wyse, B., Hall, H., Moisan, A., LeMontagne, S., Wolliez, A., Weerasinghe, G. and South, S. M. (2007). Modelling Parkinson's Disease in rats. In: Proceedings of the 41st annual scientific meeting of Australian Society of Clinical and Experimental Pharmacologists and Toxicologists & South-East Asian Western Pacific Regional Meeting of Pharmacologists. 41st Annual Scientific Meeting of Australian Society of Clinical and Experimental Pharmacologists and Toxicologists & South-East Asian Western Pacific Regional Meeting of Pharmacologists, Adelaide, Australia, (). 2-6 December 2007.
Tsui, D. Y., Monteith, G. R., Wyse, B. D. and Smith, M. T. (2006). Preliminary evaluation of cultured embryonic rat midbrain neurons as an in vitro model of diabetic neuropathy. In: H. Flor, Abstracts, 11th World Congress on Pain. 11th World Congress on Pain, Sydney, Australia, (89-89). 21-26 August 2005.
Tsui, D. Y. Y., Wyse, B D and Smith, M T (2006). The novel compound PRG100 reverses tactile allodynia in STZ-induced diabetic rats. In: Neuroscience 2006 abstracts. 2006 Neuroscience Meeting, Atlanta, (1-1). 14-18 October, 2006.
Otto, K. J., Wyse, B. D., Cabot, P. J. and Smith, M. T. (2006). Insulin implants prevent the temporal development of tactile allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic wistar rats. In: Proceedings of the 26th National Scientific Meeting of the Australian Pain Society. 26th Annual Scientific Meeting of the Australian Pain Society, Melbourne / Grand Hyatt Hotel, (46). 9-12 April 2006.
Vetter, I., Wyse, B. D., Monteith, G. R., Roberts-Thomson, S. J. and Cabot, P. J. (2006). Effects of the Mu opioid receptor agonist morphine on TRPV1-mediated capsaicin responses potentiated through PKC and cAMP-dependent PKA pathways. In: 2006 Neuroscience. 2006 Neuroscience, Georgia World Congress Center / Altana, Georgia, U.S.A., (). 11-18 October, 2006.
Tsui, D. Y. Y., Wyse, B. D., Monteith, G. R. and Smith, M. T. (2006). PRG100, a novel anti-allodynic agent. In: Abstracts of the 26th Annual Scientific Meeting of the Australian Pain Society. 26th Annual Scientific Meeting of the Australian Pain Society, Melbourne, Australia, (61-61). 9-12 April, 2006.
Vetter, I., Wyse, B. D., Monteith, G. R., Roberts-Thomson, S. J. and Cabot, P. J. (2006). Modulation of TRPV1-mediated capsaicin responses potentiated through PKC and camp-dependent PKA pathways by the Mu opioid receptor agonist morphine. In: Combined conference abstracts: ComBio 2006. ComBio 2006, Brisbane Convention Centre, Brisbane, Australia, (183-183). 24-28 September, 2006.
Tan, S., Wyse, B. D., Duffull, S. B. and Smith, M. T. (2005). Investigation of temporal changes in the anti-allodynic effectiveness of chronically administered gabapentin in a rat model of neuropathic pain. In: Abstract book of 11th World Congress on Pain. 11th World Congress on Pain, Sydney, (74-P51). 21-26 August 2005.
Vetter, I., Wyse, B. D., Monteith, G. R., Roberts-Thomson, S. J. and Cabot, P. J. (2005). Opioid inhibition of TRPV1-mediated calcium currents in cultured dorsal root ganglion neurones and a HEK293 cell line stably expressing TRPV1 and MOR. In: Abstracts: 11th World Congress on Pain. 11th World Congress on Pain, Sydney, NSW, Australia, (286-286). 21-26 August, 2005.
Otto, K. J., Wyse, B. D., Cabot, P. J. and Smith, M. T. (2005). Insulin implants prevent the temporal development of tactile allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic Wistar rats. In: Abstracts: 11th World Congress on Pain. 11th World Congress on Pain, Sydney, (75-P52). 21-26 Aug. 2005.
Smith, M. T., Nielsen, C. K., Hwang, J. C., Kydd, S., Wyse, B. D., Lewis, R. J. and Drinkwater, R. D. (2005). Intrathecal XEN2174 produces significant anti-allodynia in morphine-tolerant rats using the CCI-model of persistent neuropathic pain. In: Abstracts, 11th World Congress on Pain. 11th World Congress on Pain, Sydney, Australia, (265-265). 21-26 August 2005.
Wyse, B. D., Hwang, J. C., Kydd, S., Patterson, M., Nielsen, C. K., Belyea, C., McIntosh, D. and Smith, M. T. (2005). Investigation of the anti-allodynic and anti-hyperalgesics effects of ACV1 in a rat model of neuropathic pain. In: H. Flor, Abstracts, 11th World Congress on Pain. 11th World Congress on Pain, Sydney, Australia, (). 21-26 August 2005.
Otto, K. J., Wyse, B. D., Cabot, P. J. and Smith, M. T. (2004). Effect of insulin treatment on diabetic characteristics in the STZ-diabetic rat. In: Building a healthier future through research. 4th Annual Queensland Health and Medical Scientific Meeting, Brisbane, (260-260). 30 Nov - 1 Dec 2004.
Conference Item
Otto, K., Wyse, B. D., South, S. M., Cabot, P. J. and Smith, M. T. (2008). Influence of diet on the longitudinal temporal development of opioid hyposensitivity and tactile allodynia in the Zucker Diabetic Fatty (ZDF) rat. In: 12th World Congress on Pain, Glasgow, Scotland, (). 17-22 August 2008.
Patents
Smith, Maree and Wyse, Bruce (2007). Method of treatment or prophylaxis. WO/2006/066361.
Smith, Maree Therese and Wyse, Bruce Douglas (2006). Method of treatment or prophylaxis. 2004907332.