Associate Professor Michael Landsberg
Affiliate Research Fellow
Institute for Molecular Bioscience
Researcher biography
A/Prof Landsberg's undergraudate and Honours studies, majoring in Chemistry, were completed at Central Queensland University and the CSIRO (JM Rendel laboratories) before he moved to the University of Queensland to study a PhD in Biochemistry (awarded 2003). He then moved to a postdoctoral position at the Institute for Molecular Bioscience, spending time as a Visiting Scientist at Harvard Medical School (2008) and securing promotion to Senior Research Officer upon his return to IMB in 2009. He additioanlly spent time as a Visiting Scientist at the Victor Chang Cardiac Research Institute in 2010 and 2011.
In 2016, he joined UQ's School of Chemistry and Molecular Biosciences as a Group Leader in Cryo-EM and Macromolecular Structure and Senior Lecturer in Biochemistry and Biophysics, where he was promoted to Associate Professor in 2019. He has secured >$13.5M in competitive research funding since 2012, including major grants from the Australian Research Council and National Health and Medical Research Council. He his research has been presented at over 70 national and international conferences and research institutions.
Book Chapters
Brillault, Lou and Landsberg, Michael J. (2019). Preparation of proteins and macromolecular assemblies for cryo-electron microscopy. Protein Nanotechnology: Protocols, Instrumentation, and Applications. (pp. 221-246) New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-9869-2_13
Chassagnon, Irene R., Piper, Sarah J. and Landsberg, Michael J. (2019). ABC toxins: self-assembling nanomachines for the targeted cellular delivery of bioactive proteins. Comprehensive nanoscience and nanotechnology. (pp. 279-298) edited by David L. Andrews, Gregory D. Scholes and Gary P. Wiederrecht. London, United Kingdom: Academic Press. doi: 10.1016/b978-0-12-803581-8.10513-2
Journal Articles
Arvindekar, Shreyas M., Jackman, Matthew J., Low, Jason K.K., Landsberg, Michael J., Mackay, Joel P. and Viswanath, Shruthi (2023). Molecular architecture of nucleosome remodeling and deacetylase sub-complexes by integrative structure determination. Biophysical Journal, 122 (3), 472a. doi: 10.1016/j.bpj.2022.11.2531
Manik, Mohammad K., Shi, Yun, Li, Sulin, Zaydman, Mark A., Damaraju, Neha, Eastman, Samuel, Smith, Thomas G., Gu, Weixi, Masic, Veronika, Mosaiab, Tamim, Weagley, James S., Hancock, Steven J., Vasquez, Eduardo, Hartley-Tassell, Lauren, Kargios, Nestoras, Maruta, Natsumi, Lim, Bryan Y. J., Burdett, Hayden, Landsberg, Michael J., Schembri, Mark A., Prokes, Ivan, Song, Lijiang, Grant, Murray, DiAntonio, Aaron, Nanson, Jeffrey D., Guo, Ming, Milbrandt, Jeffrey, Ve, Thomas and Kobe, Bostjan (2022). Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling. Science, 377 (6614) eadc8969, eadc8969-+. doi: 10.1126/science.adc8969
Arvindekar, Shreyas, Jackman, Matthew J., Low, Jason K. K., Landsberg, Michael J., Mackay, Joel P. and Viswanath, Shruthi (2022). Molecular architecture of nucleosome remodeling and deacetylase sub‐complexes by integrative structure determination. Protein Science, 31 (9) e4387, 1-19. doi: 10.1002/pro.4387
Shi, Yun, Kerry, Philip S., Nanson, Jeffrey D., Bosanac, Todd, Sasaki, Yo, Krauss, Raul, Saikot, Forhad K., Adams, Sarah E., Mosaiab, Tamim, Masic, Veronika, Mao, Xianrong, Rose, Faith, Vasquez, Eduardo, Furrer, Marieke, Cunnea, Katie, Brearley, Andrew, Gu, Weixi, Luo, Zhenyao, Brillault, Lou, Landsberg, Michael J., DiAntonio, Aaron, Kobe, Bostjan, Milbrandt, Jeffrey, Hughes, Robert O. and Ve, Thomas (2022). Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Molecular Cell, 82 (9), 1643-1659.e10. doi: 10.1016/j.molcel.2022.03.007
McMillan, Christopher L. D., Azuar, Armira, Choo, Jovin J. Y., Modhiran, Naphak, Amarilla, Alberto A., Isaacs, Ariel, Honeyman, Kate E., Cheung, Stacey T. M., Liang, Benjamin, Wurm, Maria J., Pino, Paco, Kint, Joeri, Fernando, Germain J. P., Landsberg, Michael J., Khromykh, Alexander A., Hobson-Peters, Jody, Watterson, Daniel, Young, Paul R. and Muller, David A. (2022). Dermal delivery of a SARS-CoV-2 subunit vaccine induces immunogenicity against variants of concern. Vaccines, 10 (4) 578, 578. doi: 10.3390/vaccines10040578
McMillan, Christopher L. D., Choo, Jovin J. Y., Idris, Adi, Supramaniam, Aroon, Modhiran, Naphak, Amarilla, Alberto A., Isaacs, Ariel, Cheung, Stacey T. M., Liang, Benjamin, Bielefeldt-Ohmann, Helle, Azuar, Armira, Acharya, Dhruba, Kelly, Gabrielle, Fernando, Germain J. P., Landsberg, Michael J., Khromykh, Alexander A., Watterson, Daniel, Young, Paul R., McMillan, Nigel A. J. and Muller, David A. (2021). Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine. Science Advances, 7 (44) eabj8065, eabj8065. doi: 10.1126/sciadv.abj8065
Rathbone, Harry W., Michie, Katharine A., Landsberg, Michael J., Green, Beverley R. and Curmi, Paul M. G. (2021). Scaffolding proteins guide the evolution of algal light harvesting antennas. Nature Communications, 12 (1) 1890. doi: 10.1038/s41467-021-22128-w
Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron and Ve, Thomas (2021). SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration. Neuron, 109 (7), 1-19. doi: 10.1016/j.neuron.2021.02.009
Modhiran, Naphak, Song, Hao, Liu, Lidong, Bletchly, Cheryl, Brillault, Lou, Amarilla, Alberto A., Xu, Xiaoying, Qi, Jianxun, Chai, Yan, Cheung, Stacey T. M., Traves, Renee, Setoh, Yin Xiang, Bibby, Summa, Scott, Connor A. P., Freney, Morgan E., Newton, Natalee D., Khromykh, Alexander A., Chappell, Keith J., Muller, David A., Stacey, Katryn J., Landsberg, Michael J., Shi, Yi, Gao, George F., Young, Paul R. and Watterson, Daniel (2021). A broadly protective antibody that targets the flavivirus NS1 protein. Science, 371 (6525), 190-194. doi: 10.1126/science.abb9425
Low, Jason K. K., Silva, Ana P. G., Sharifi Tabar, Mehdi, Torrado, Mario, Webb, Sarah R., Parker, Benjamin L., Sana, Maryam, Smits, Callum, Schmidberger, Jason W., Brillault, Lou, Jackman, Matthew J., Williams, David C., Blobel, Gerd A., Hake, Sandra B., Shepherd, Nicholas E., Landsberg, Michael J. and Mackay, Joel P. (2020). The nucleosome remodeling and deacetylase complex has an asymmetric, dynamic, and modular architecture. Cell Reports, 33 (9) 108450, 108450. doi: 10.1016/j.celrep.2020.108450
Lonhienne, Thierry, Low, Yu Shang, Garcia, Mario D., Croll, Tristan, Gao, Yan, Wang, Quan, Brillault, Lou, Williams, Craig M., Fraser, James A., McGeary, Ross P., West, Nicholas P., Landsberg, Michael J., Rao, Zihe, Schenk, Gerhard and Guddat, Luke W. (2020). Structures of fungal and plant acetohydroxyacid synthases. Nature, 586 (7828), 317-321+. doi: 10.1038/s41586-020-2514-3
Ilsley, Melissa D., Huang, Stephen, Magor, Graham W., Landsberg, Michael J., Gillinder, Kevin R. and Perkins, Andrew C. (2019). Corrupted DNA-binding specificity and ectopic transcription underpin dominant neomorphic mutations in KLF/SP transcription factors. BMC Genomics, 20 (1) 417, 417. doi: 10.1186/s12864-019-5805-z
Piper, Sarah J., Brillault, Lou, Rothnagel, Rosalba, Croll, Tristan I., Box, Joseph K., Chassagnon, Irene, Scherer, Sebastian, Goldie, Kenneth N, Jones, Sandra A, Schepers, Femke, Hartley-Tassell, Lauren, Ve, Thomas, Busby, Jason N, Dalziel, Julie E, Lott, J Shaun, Hankamer, Ben, Stahlberg, Henning, Hurst, Mark R H and Landsberg, Michael J (2019). Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin. Nature Communications, 10 (1) 1952, 1952. doi: 10.1038/s41467-019-09890-8
Ali, Rubbiya A., Mehdi, Ahmed M., Rothnagel, Rosalba, Hamilton, Nicholas A., Gerle, Christoph, Landsberg, Michael J. and Hankamer, Ben (2017). RAZA: A Rapid 3D z-crossings algorithm to segment electron tomograms and extract organelles and macromolecules. Journal of Structural Biology, 200 (2), 73-86. doi: 10.1016/j.jsb.2017.10.002
Ve, Thomas, Vajjhala, Parimala, Hedger, Andrew, Croll, Tristan, DiMaio, Frank, Horsefield, Shane, Yu, Xiong, Lavrencic, Peter, Hassan, Zahid, Morgan, Garry P., Mansell, Ashley, Mobli, Mehdi, O'Carroll, Ailis, Chauvin, Brieuc, Gambin, Yann, Sierecki, Emma, Landsberg, Michael J., Stacey, Katryn, Egelman, Edward H. and Kobe, Bostjan (2017). Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling. Nature Structural and Molecular Biology, 24 (9), 743-751. doi: 10.1038/nsmb.3444
Brillault, Lou, Jutras, Philippe V., Dashti, Noor , Thuenemann, Eva C., Morgan, Garry, Lomonossoff, George P., Landsberg, Michael J. and Sainsbury, Frank (2017). Engineering recombinant virus-like nanoparticles from plants for cellular delivery. ACS Nano, 11 (4), 3476-3484. doi: 10.1021/acsnano.6b07747
Mackay, Joel P., Landsberg, Michael J., Whitten, Andrew E. and Bond, Charles S. (2017). Whaddaya know: A guide to uncertainty and subjectivity in structural biology. Trends In Biochemical Sciences, 42 (2), 155-167. doi: 10.1016/j.tibs.2016.11.002
Gillinder, Kevin R., Ilsley, Melissa D., Nébor, Danitza, Sachidanandam, Ravi, Lajoie, Mathieu, Magor, Graham W., Tallack, Michael R., Bailey, Timothy, Landsberg, Michael J., Mackay, Joel P., Parker, Michael W., Miles, Luke A., Graber,Joel H., Peters, Luanne L., Bieker, James J. and Perkins, Andrew C. (2016). Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability. Nucleic Acids Research, 45 (3), 1130-1143. doi: 10.1093/nar/gkw1014
Ringsmuth, Andrew K., Landsberg, Michael J. and Hankamer, Ben (2016). Can photosynthesis enable a global transition from fossil fuels to solar fuels, to mitigate climate change and fuel-supply limitations?. Renewable and Sustainable Energy Reviews, 62, 134-163. doi: 10.1016/j.rser.2016.04.016
Schmidberger, Jason W., Sharifi Tabar, Mehdi, Torrado, Mario, Silva, Ana P. G., Landsberg, Michael J., Brillault, Lou, AlQarni, Saad, Zeng, Yi Cheng, Parker, Benjamin L., Low, Jason K. K. and Mackay, Joel P. (2016). The MTA1 subunit of the nucleosome remodeling and deacetylase complex can recruit two copies of RBBP4/7. Protein Science, 25 (8), 1472-1482. doi: 10.1002/pro.2943
Chi, Gamma, Rohde, Paul R., Ridone, Pietro, Hankamer, Ben, Martinac, Boris and Landsberg, Michael J. (2015). Functional similarities between heterogeneously and homogenously expressed MscL constructs. European Biophysics Journal, 44 (7), 589-598. doi: 10.1007/s00249-015-1062-5
Foo, Alexander, Battle, Andrew R., Chi, Gamma, Hankamer, Ben, Landsberg, Michael J. and Martinac, Boris (2015). Inducible release of particulates from liposomes using the mechanosensitive channel of large conductance and l-α-lysophosphatidylcholine. European Biophysics Journal, 44 (7), 521-530. doi: 10.1007/s00249-015-1055-4
Sawyer, Anne L., Landsberg, Michael J., Ross, Ian L., Kruse, Olaf, Mobli, Mehdi and Hankamer, Ben (2015). Solution structure of the RNA-binding cold shock domain of the Chlamydomonas reinhardtii NAB1 protein and insights into RNA recognition. Biochemical Journal, 469 (1), 97-106. doi: 10.1042/BJ20150217
Martinac, Boris, Nomura, Takeshi, Chi, Gamma, Petrov, Evgeny, Rohde, Paul R., Battle, Andrew R., Foo, Alexander, Constantine, Maryrose, Rothnagel, Rosalba, Carne, Sonia, Deplazes, Evelyne, Cornell, Bruce, Cranfield, Charles G., Hankamer, Ben and Landsberg, Michael J. (2014). Bacterial mechanosensitive channels: models for studying mechanosensory transduction. Antioxidants and Redox Signaling, 20 (6), 952-969. doi: 10.1089/ars.2013.5471
Friend, Lexie R., Landsberg, Michael J., Nouwens, Amanda S., Wei, Ying, Rothnagel, Joseph A. and Smith, Ross (2013). Arginine methylation of hnRNP A2 does not directly govern its subcellular localization. PLoS One, 8 (9) e75669, e75669.1-e75669.12. doi: 10.1371/journal.pone.0075669
Busby, Jason N., Panjikar, Santosh, Landsberg, Michael J., Hurst, Mark R. H. and Lott, J. Shaun (2013). The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device. Nature, 501 (7468), 547-550. doi: 10.1038/nature12465
Muller, David A., Landsberg, Michael J., Bletchly, Cheryl, Rothnagel, Rosalba, Waddington, Lynne, Hankamer, Ben and Young, Paul R. (2012). Structure of the dengue virus glycoprotein non-structural protein 1 by electron microscopy and single-particle analysis. Journal of General Virology, 93 (4), 771-779. doi: 10.1099/vir.0.039321-0
Ali, Rubbiya A., Landsberg, Michael J., Knauth, Emily, Morgan, Garry P., Marsh, Brad J. and Hankamer, Ben (2012). A 3D image filter for parameter-free segmentation of macromolecular structures from electron tomograms. Plos One, 7 (3) e33697, e33697-1-e33697-12. doi: 10.1371/journal.pone.0033697
Busby, Jason N., Landsberg, Michael J., Simpson, Robert M., Jones, Sandra A., Hankamer, Ben, Hurst, Mark R. H. and Lott, J. Shaun (2012). Structural analysis of Chi1 Chitinase from Yen-tc: The multisubunit insecticidal ABC toxin complex of Yersinia entomophaga. Journal of Molecular Biology, 415 (2), 359-371. doi: 10.1016/j.jmb.2011.11.018
Landsberg, Michael J., Jones, Sandra A., Rothnagel, Rosalba, Busby, Jason N., Marshall, Sean D. G., Simpson, Robert M., Lott, J. Shaun, Hankamer, Ben and Hurst, Mark R. H. (2011). 3D structure of the Yersinia entomophaga toxin complex and implications for insecticidal activity. Proceedings of the National Academy of Sciences of the United States of America, 108 (51), 20544-20549. doi: 10.1073/pnas.1111155108
Maco, B, Ross, IL, Landsberg, MJ, Mouradov, D, Saunders, NFW, Hankamer, B and Kobe, B (2011). Proteomic and electron microscopy survey of large assemblies in macrophage cytoplasm. Molecular and Cellular Proteomics, 10 (6) M111.008763, M111.008763. doi: 10.1074/mcp.M111.008763
Landsberg, MJ, Ruggles, JL, Hussein, WM, McGeary, RP, Gentle, IR and Hankamer, B (2010). Molecular packing of functionalized fluorinated lipids in langmuir mono layers. Langmuir, 26 (24), 18868-18873. doi: 10.1021/la103743e
Landsberg, Michael J., Vajjhala, Parimala Rao, Rothnagel, Rosalba, Munn, Alan Leslie and Hankamer, Ben (2009). Three-dimensional structure of AAA ATPase Vps4: Advancing structural insights into the mechanisms of endosomal sorting and enveloped virus budding. Structure, 17 (3), 427-437. doi: 10.1016/j.str.2008.12.020
Hussein, Waleed M., Ross, Benjamin P., Landsberg, Michael J., Levy, Daniel, Hankamer, Ben and McGeary, Ross P. (2009). Synthesis of nickel-chelating fluorinated lipids for protein monolayer crystallizations. Journal of Organic Chemistry, 74 (4), 1473-1479. doi: 10.1021/jo802651p
Hussein. Waleed M., Ross, Benjamin P., Landsberg, M. J., Hankamer, B and McGeary, Ross P. (2009). Synthetic approaches to functionalized lipids for protein monolayer crystallizations. Current Organic Chemistry, 13 (14), 1378-1405. doi: 10.2174/138527209789055081
Vajjhala, P. R., Nguyen , C. H., Landsberg, M. J., Kistler, C., Gan, A. L., King, G. F., Hankamer, B. and Munn, A. L. (2008). The Vps4 C-terminal helix is a critical determinant for assembly and ATPase activity and has elements conserved in other members of the meiotic clade of AAA ATPases.. Febs Journal, 275 (7), 1427-1449. doi: 10.1111/j.1742-4658.2008.06300.x
Landsberg, M. J. and Hankamer, B. (2007). Symmetry: A guide to its application in 2D electron crystallography. Journal of Structural Biology, 160 (3), 332-343. doi: 10.1016/j.jsb.2007.07.002
Woolford, D. S., Ericksson, G. B., Rothnagel, R., Muller, D., Landsberg, M. J., Pantelic, R., McDowall, A. W., Pailthorpe, B., Young, P. R., Hankamer, B. and Banks, J. (2007). SwarmPS: Rapid, semi-automated single particle selection software. Journal of Structural Biology, 157 (1), 174-188. doi: 10.1016/j.jsb.2006.04.006
Pantelic, R. S., Rothnagel, A. R., Huang, C. Y., Muller, D. A., Woolford, D., Landsberg, M. J., McDowall, A. W., Pailthorpe, B., Young, P. R., Banks, J. E., Hankamer, B. and Ericksson, G. B. (2006). The discriminative bilateral filter: An enhanced denoising filter for electron microscopy data. Journal Of Structural Biology, 155 (3), 395-408. doi: 10.1016/j.jsb.2006.03.030
Landsberg, Michael J., Moran-Jones, Kim and Smith, Ross (2006). Molecular recognition of an RNA trafficking element by heterogeneous nuclear ribonucleoprotein A2. Biochemistry, 45 (12), 3943-3951. doi: 10.1021/bi052440e
Landsberg, M. J., Bond, J., Gee, C. L., Martin, J. L. and Hankamer, B. (2006). A method for screening the temperature dependence of three-dimensional crystal formation. Acta Crystallographica Section D: Biological Crystallography, 62 (Pt 5), 559-562. doi: 10.1107/s0907444906006093
Conference Papers
Jeon, Yujung, Ross, Ian, Landsberg, Michael, Hankamer, Ben and Kobe, Bostjan (2017). Structural characterization of pseudo-dihyroorotase domain in yeast URA2. XXIV IUCr Congress, Hyderabad, India, 21-28 August 2017. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1107/s2053273317090325
Low, Jason K. K., Silva, Ana P. G., Sharifitabar, Medhi, Torrado, Mario, Schmidberger, Jason, Webb, Sarah R., Saathoff, Hinnerk, Parker, Benjamin L., Paudel, Bishnu, van Oijen, Antoine, Landsberg, Michael J., Shepherd, Nicholas E. and Mackay, Joel P. (2017). Architecture of the Nucleosome Remodeling and Deacetylase (NuRD) Complex. Annual Meeting of the American-Society-for-Pharmacology-and-Experimental-Therapeutics (ASPET) at Experimental Biology Meeting, Chicago IL United States, 22-26 April 2017. BETHESDA: Federation of American Societies for Experimental Biology.
Perkins, Andrew C., Gillinder, Kevin R., Magor, Graham, Lajoie, Mathieu, Bailey, Timothy L., Tallack, Michael R., Ilsley, Melissa, Landsberg, Michael, Mackay, Joel P., Bieker, James J. and Peters, Luanne L. (2014). New Insights into the Mechanism of Dominant Anemia Caused By Zinc Finger Mutations in KLF1. 56th Annual Meeting of the American Society of Hematology, San Francisco, CA United States, 06-09 December 2014. Washington, DC United States: American Society of Hematology.
Gillinder, Kevin R., Lajoie, Mathieu, Ilsley, Melissa, Tallack, Michael R., Magor, Graham, Landsberg, Michael, Bailey, Timothy L. and Perkins, Andrew C. (2013). Mutations In The Zinc Finger Domain Of Human and Mouse KLF1 Cause Congenital Dyserythropoietic Anemia (CDA) Via Promiscuous DNA Binding and Ectopic Target Gene Expression. 55th Annual Meeting of the American-Society-of-Hematology, New Orleans La, Dec 07-10, 2013. WASHINGTON: AMER SOC HEMATOLOGY.
Foo, Alexander F. -W., Landsberg, Michael J., Battle, Andrew R., Marsh, Brad J., Hankamer, Ben and Martinac, Boris (2011). Mscl Channels as Nanovales for the Controlled Release of Liposome-Encapsulated Compounds. 55th Annual Meeting of the Biophysical Society, Baltimore, MD United States, 5 - 9 March 2011. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2010.12.1724
Friend, Lexie, Landsberg, Michael, Nouwens, Amanda, Rothnagel, J., Smith, R. and Toki, Naoko (2010). Mass spectrometric detection of differential methylation of hnRNP A2/B1 paralogs in neuronal cells and cell lines. Human Proteome World Congress (HUPO 2010), Darling Harbour Convention Centre, Sydney, Australia, 19 - 23 September 2010.
Landsberg, M.J., Hatfield, J.T., Friend, L., Dunphy, J., Cowan, D.W., Maggipinto, M. and Smith, R. W. (2006). The role of alternative splicing and post-translational modifications of hnRNP A/B proteins and their subcellular localization. ComBio 2006, Brisbane, Australia, 25-28 Sept, 2006. Kent Town, Australia: Australian Society for Biochemistry and Molecular Biology.
Landsberg, M. J. and Smith, R. W. (2002). HnRNP A2 - a multifunctional nucleic acid-binding protein. ComBio 2002, Sydney, 29 September - 3 October, 2002.
Landsberg, M., Guddat, L. W., Hawkins, B. L. and Smith, R. W. (2001). Structural analysis of the hnRNP A proteins: Understanding the interaction between hnRNP A2 and the A2RE trafficking element. ASBMB, Canberra, 31 Sept-4 Oct, 2001.
Thesis
Landsberg, Michael. (2003). Structural studies on the cytoplasmic RNA transport factor, hnRNP A2. PhD Thesis, School of Molecular and Microbial Sciences, The University of Queensland.