Dr Nikita Abraham
Adjunct Research Fellow
Institute for Molecular Bioscience
Journal Articles
Ho, Thao NT, Abraham, Nikita and Lewis, Richard J. (2023). Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors. Frontiers in Pharmacology, 14 1170514. doi: 10.3389/fphar.2023.1170514
Ho, Thao N. T., Abraham, Nikita and Lewis, Richard J. (2022). Synthesis of full-length homodimer αD-VxXXB that targets human α7 nicotinic acetylcholine receptors. RSC Medicinal Chemistry, 13 (11), 1410-1419. doi: 10.1039/d2md00188h
Wilhelm, Patrick, Luna-Ramirez, Karen, Chin, Yanni K.-Y., Dekan, Zoltan, Abraham, Nikita, Tae, Han-Shen, Chow, Chun Yuen, Eagles, David A., King, Glenn F., Lewis, Richard J., Adams, David J. and Alewood, Paul F. (2022). Cysteine-rich α-conotoxin SII displays novel interactions at the muscle nicotinic acetylcholine receptor. ACS Chemical Neuroscience, 13 (8), 1245-1250. doi: 10.1021/acschemneuro.1c00857
Ho, Thao N.T., Abraham, Nikita and Lewis, Richard J. (2021). Unique pharmacological properties of α-Conotoxin OmIA at α7 nAChRs. Frontiers in Pharmacology, 12 803397, 803397. doi: 10.3389/fphar.2021.803397
Ho, Thao N. T., Abraham, Nikita and Lewis, Richard J. (2021). Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of α-conotoxin AusIA. Scientific Reports, 11 (1) 21928, 21928. doi: 10.1038/s41598-021-01277-4
Katz, Dana, DiMattia, Michael A., Sindhikara, Dan, Li, Hubert, Abraham, Nikita and Leffler, Abba E. (2021). Potency- and selectivity-enhancing mutations of conotoxins for nicotinic acetylcholine receptors can be predicted using accurate free-energy calculations. Marine Drugs, 19 (7) 367, 367. doi: 10.3390/md19070367
Ho, Thao N. T., Abraham, Nikita and Lewis, Richard J. (2020). Structure-function of neuronal nicotinic acetylcholine receptor inhibitors derived from natural toxins. Frontiers in Neuroscience, 14 609005, 1-23. doi: 10.3389/fnins.2020.609005
Mohan, Madhan Kumar, Abraham, Nikita, Rajesh, R. P., Jayaseelan, Benjamin Franklin, Ragnarsson, Lotten, Lewis, Richard J. and Sarma, Siddhartha P. (2020). Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 295 (20), 7096-7112. doi: 10.1074/jbc.RA119.012098
Abraham, Nikita and Lewis, Richard J. (2018). Neuronal nicotinic acetylcholine receptor modulators from cone snails. Marine Drugs, 16 (6) 208;, 208. doi: 10.3390/md16060208
Abraham, Nikita, Healy, Michael, Ragnarsson, Lotten, Brust, Andreas, Alewood, Paul F. and Lewis, Richard J. (2017). Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor. Scientific Reports, 7 (1) 45466, 45466. doi: 10.1038/srep45466
Abraham, Nikita, Paul, Blessy, Ragnarsson, Lotten and Lewis, Richard J. (2016). Escherichia coli protein expression system for Acetylcholine Binding Proteins (AChBPs). PLoS One, 11 (6) e0157363, e0157363. doi: 10.1371/journal.pone.0157363
Wan, Jingjing, Huang, Johnny X., Vetter, Irina, Mobli, Mehdi, Lawson, Joshua, Tae, Han-Shen, Abraham, Nikita, Paul, Blessy, Cooper, Matthew A., Adams, David J., Lewis, Richard J. and Alewood, Paul F. (2015). α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors. Journal of the American Chemical Society, 137 (9), 3209-3212. doi: 10.1021/jacs.5b00244
Jin, Ai-Hua, Vetter, Irina, Dutertre, Sébastien, Abraham, Nikita, Emidio, Nayara B., Inserra, Marco, Murali, Swetha S., Christie, MacDonald J., Alewood, Paul F. and Lewis, Richard J. (2014). MrIC, a novel alpha-conotoxin agonist in the presence of PNU at endogenous alpha-7 nicotinic acetylcholine receptors. Biochemistry, 53 (1), 1-3. doi: 10.1021/bi400882s
Conference Papers
Hasan, Mahadhi, Abraham, Nikita, Cardoso, Fernanda C., Ragnarsson, Lotten, Starobova, Hana, Mueller, Alexander, Vetter, Irina and Lewis, Richard J. (2021). Subcutaneous analgesic actions and mode of action of binding of ω-conotoxins at Cav2.2. Venom to Drugs, Daydream Island, QLD Australia, 15 - 19 March 2021.
Hassan, Mahadhi, Abraham, Nikita, Ragnarsson, Lotten K.N., Cardoso, Fernanda C. and Lewis, Richard J. (2017). Defining ω-conotoxin binding site and delineating the role of the α2δ1 subunit in ω-conotoxin binding. Venom to Drugs Conference 2017, Noosa Heads, QLD Australia, 9-14 October 2017.
Thesis
Abraham, Nikita (2016). Investigating nAChR structure and function using AChBP and α-conotoxins. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/uql.2016.313