Dr Lin Luo
Research Officer
Institute for Molecular Bioscience
+61 7 334 62035
+61 7 334 62332
Researcher biography
Dr Lin Luo (PhD) is an ARC DECRA fellow. He graduated with a PhD supervised by Prof Phil Robinson at Children's Medical Research Institute, Sydney University in late 2012. He has been appointed as a senior postdoctoral researcher in the laboratory of Prof Jenny Stow, IMB, The University of Queensland. His training has included acquiring advanced skills in a wide array of techniques, including structural biology, proteomics, and cell biology, and his research output is building a reputation in cell biology, immunology and inflammation.
| Featured projects | Duration |
|---|---|
| Controlling inflammation in chronic disease |
Book Chapter
Tong, Samuel J., Lucas, Richard M., Xiao, Zhijian, Luo, Lin and Stow, Jennifer L. (2021). Detecting Endogenous Rab8 Activation. Rab GTPases: Methods and Protocols. (pp. 45-56) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-1346-7_4
Journal Articles
Liu, Liping, Lucas, Richard M., Nanson, Jeffrey D., Li, Yan, Whitfield, Jason, Curson, James E. B., Tuladhar, Neeraj, Alexandrov, Kirill, Mobli, Mehdi, Sweet, Matthew J., Kobe, Bostjan, Stow, Jennifer and Luo, Lin (2022). The transmembrane adaptor SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs. Journal of Biological Chemistry, 298 (5) 101857, 101857. doi: 10.1016/j.jbc.2022.101857
Curson, James E.B., Luo, Lin, Liu, Liping, Burgess, Belinda J., Bokil, Nilesh J., Wall, Adam A, Brdicka, Tomas, Kapetanovic, Ronan, Stow, Jennifer L and Sweet, Matthew J (2022). An alternative downstream translation start site in the non‐TIR adaptor Scimp enables selective amplification of CpG DNA responses in mouse macrophages. Immunology and Cell Biology, 100 (4), 267-284. doi: 10.1111/imcb.12540
Lucas, Richard M., Liu, Liping, Curson, James E.B., Koh, Yvette W.H., Tuladhar, Neeraj, Condon, Nicholas D., Das Gupta, Kaustav, Burgener, Sabrina S., Schroder, Kate, Ingley, Evan, Sweet, Matthew J., Stow, Jennifer L. and Luo, Lin (2021). SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages. Cell Reports, 36 (10) 109662, 1-20. doi: 10.1016/j.celrep.2021.109662
Das Gupta, Kaustav, Shakespear, Melanie R., Curson, James E.B., Murthy, Ambika M.V., Iyer, Abishek, Hodson, Mark P., Ramnath, Divya, Tillu, Vikas A., von Pein, Jessica B., Reid, Robert C., Tunny, Kathryn, Hohenhaus, Daniel M., Moradi, Shayli Varasteh, Kelly, Gregory M., Kobayashi, Takumi, Gunter, Jennifer H., Stevenson, Alexander J., Xu, Weijun, Luo, Lin, Jones, Alun, Johnston, Wayne A., Blumenthal, Antje, Alexandrov, Kirill, Collins, Brett M., Stow, Jennifer L., Fairlie, David P. and Sweet, Matthew J. (2020). Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2. Cell Reports, 30 (8), 2712-2728.e8. doi: 10.1016/j.celrep.2020.02.007
Luo, Lin, Lucas, Richard M., Liu, Liping and Stow, Jennifer L. (2019). Signalling, sorting and scaffolding adaptors for Toll-like receptors. Journal of Cell Science, 133 (5), jcs239194. doi: 10.1242/jcs.239194
Luo, Lin, Curson, James E. B., Liu, Liping, Wall, Adam A., Tuladhar, Neeraj, Lucas, Richard M., Sweet, Matthew J. and Stow, Jennifer L. (2019). SCIMP is a universal Toll‐like receptor adaptor in macrophages. Journal of Leukocyte Biology, 107 (2) JLB.2MA0819-138RR, 251-262. doi: 10.1002/jlb.2ma0819-138rr
Tong, Samuel J., Wall, Adam A., Hung, Yu, Luo, Lin and Stow, Jennifer L. (2019). Guanine nucleotide exchange factors activate Rab8a for Toll-like receptor signalling. Small GTPases, 12 (1), 1-17. doi: 10.1080/21541248.2019.1587278
Wall, Adam A., Condon, Nicholas D., Luo, Lin and Stow, Jennifer L. (2019). Rab8a localisation and activation by Toll-like receptors on macrophage macropinosomes. Philosophical Transactions of the Royal Society B: Biological Sciences, 374 (1765) 20180151, 20180151. doi: 10.1098/rstb.2018.0151
Luo, Lin, Wall, Adam A., Tong, Samuel J., Hung, Yu, Xiao, Zhijian, Tarique, Abdullah A., Sly, Peter D., Fantino, Emmanuelle, Marzolo, María-Paz and Stow, Jennifer L. (2018). TLR crosstalk activates LRP1 to recruit Rab8a and PI3Kγ for suppression of inflammatory responses. Cell Reports, 24 (11), 3033-3044. doi: 10.1016/j.celrep.2018.08.028
Condon, Nicholas D., Heddleston, John M., Chew, Teng-Leong, Luo, Lin, McPherson, Peter S., Ioannou, Maria S., Hodgson, Louis, Stow, Jennifer L. and Wall, Adam A. (2018). Macropinosome formation by tent pole ruffling in macrophages. The Journal of Cell Biology, 217 (11), 3873-3885. doi: 10.1083/jcb.201804137
Curson, James E. B., Luo, Lin, Sweet, Matthew J. and Stow, Jennifer L. (2018). pTRAPs: Transmembrane adaptors in innate immune signaling. Journal of Leukocyte Biology, 103 (6), 1011-1019. doi: 10.1002/JLB.2RI1117-474R
Schuelein, Ralf, Spencer, Hugh, Dagley, Laura F, Li, Peng Fei, Luo, Lin, Stow, Jennifer L, Abraham, Gilu, Naderer, Thomas, Gomez-Valero, Laura, Buchrieser, Carmen, Sugimoto, Chihiro, Yamagishi, Junya, Webb, Andrew I, Pasricha, Shivani and Hartland, Elizabeth L (2018). Targeting of RNA Polymerase II by a nuclear Legionella pneumophila Dot/Icm effector SnpL. Cellular Microbiology, 20 (9) e12852, e12852. doi: 10.1111/cmi.12852
Tarique, Abdullah A., Sly, Peter D., Cardenas, Diana G., Luo, Lin, Stow, Jennifer L., Bell, Scott C., Wainwright, Claire E. and Fantino, Emmanuelle (2018). Differential expression of genes and receptors in monocytes from patients with cystic fibrosis. Journal of Cystic Fibrosis, 18 (3), 342-348. doi: 10.1016/j.jcf.2018.07.012
Teo, Wei Xuan, Yang, Zhe, Kerr, Markus Charles, Luo, Lin, Guo, Zhong, Alexandrov, Kirill, Stow, Jenny Lea and Teasdale, Rohan David (2017). Salmonella effector SopD2 interferes with Rab34 function. Cell Biology International, 41 (4), 433-446. doi: 10.1002/cbin.10739
Luo, Lin, Tong, Samuel J., Wall, Adam A., Khromykh, Tatiana, Sweet, Matthew J. and Stow, Jennifer L. (2017). Development of SH2 probes and pull-down assays to detect pathogen-induced, site-specific tyrosine phosphorylation of the TLR adaptor SCIMP. Immunology and Cell Biology, 95 (6), 564-570. doi: 10.1038/icb.2017.10
Wall, Adam A., Luo, Lin, Hung, Yu, Tong, Samuel J., Condon, Nicholas D., Blumenthal, Antje, Sweet, Matthew J. and Stow, Jennifer L. (2017). Small GTPase Rab8a-recruited phosphatidylinositol 3-kinase γ regulates signaling and cytokine outputs from endosomal toll-like receptors. Journal of Biological Chemistry, 292 (11), 4411-4422. doi: 10.1074/jbc.M116.766337
Luo, Lin, Bokil, Nilesh J., Wall, Adam A., Kapetanovic, Ronan, Lansdaal, Natalie M., Marceline, Faustine, Burgess, Belinda J., Tong, Samuel J., Guo, Zhong, Alexandrov, Kirill, Ross, Ian L., Hibbs, Margaret L., Stow, Jennifer L. and Sweet, Matthew J. (2017). SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages. Nature Communications, 8 (1) 14133, 14133. doi: 10.1038/ncomms14133
Yeo, Jeremy C., Wall, Adam A., Luo, Lin, Condon, Nicholas D. and Stow, Jennifer L. (2016). Distinct roles for APPL1 and APPL2 in regulating toll-like receptor 4 signaling in macrophages. Traffic, 17 (9), 1014-1026. doi: 10.1111/tra.12415
Luo, Lin, Xue, Jing, Kwan, Ann, Gamsjaeger, Roland, Wielens, Jerome, von Kleist, Lisa, Cubeddu, Liza, Guo, Zhong, Stow, Jennifer L., Parker, Michael W., Mackay, Joel P. and Robinson, Phillip J. (2016). The binding of syndapin SH3 domain to dynamin proline-rich domain involves short and long distance elements. Journal of Biological Chemistry, 291 (18), 9411-+. doi: 10.1074/jbc.M115.703108
Yeo, Jeremy C., Wall, Adam A., Luo, Lin and Stow, Jennifer L. (2016). Sequential recruitment of Rab GTPases during early stages of phagocytosis. Cellular Logistics, 6 (1) e1140615, e1140615.1-e1140615.12. doi: 10.1080/21592799.2016.1140615
Yeo, Jeremy C., Wall, Adam A., Luo, Lin and Stow, Jennifer L. (2015). Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages. Molecular Biology of the Cell, 26 (5), 952-965. doi: 10.1091/mbc.E14-10-1457
King, Nathan P., Newton, Patrice, Schuelein, Ralf, Brown, Darren L., Petru, Marketa, Zarsky, Vojtech, Dolezal, Pavel, Luo, Lin, Bugarcic, Andrea, Stanley, Amanda C., Murray, Rachael Z., Collins, Brett M., Teasdale, Rohan D., Hartland, Elizabeth L. and Stow, Jennifer L. (2015). Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophila Dot/Icm effector. Cellular Microbiology, 17 (6), 767-784. doi: 10.1111/cmi.12405
Luo, Lin, Wall, Adam A., Yeo, Jeremy C., Condon, Nicholas D., Norwood, Suzanne J., Schoenwaelder, Simone, Chen, Kaiwen W., Jackson, Shaun, Jenkins, Brendan J., Hartland, Elizabeth L., Schroder, Kate, Collins, Brett M., Sweet, Matthew J. and Stow, Jennifer L. (2014). Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling. Nature Communications, 5 (1) 4407, 4407.1-4407.13. doi: 10.1038/ncomms5407
Luo, Lin, King, Nathan P., Yeo, Jeremy C., Jones, Alun and Stow, Jennifer L. (2013). Single-step protease cleavage elution for identification of protein-protein interactions from GST pull-down and mass spectrometry. Proteomics, Accepted Article (1), 1-15. doi: 10.1002/pmic.201300315
Rao, Yijian, Ma, Qingjun, Vahedi-Faridi, Ardeschir, Sundborger, Anna, Pechstein, Arndt, Puchkov, Dmytro, Luo, Lin, Shupliakov, Oleg, Saenger, Wolfram and Haucke, Volker (2010). Molecular basis for SH3 domain regulation of F-BAR-mediated membrane deformation. Proceedings of the National Academy of Sciences , 107 (18), 8213-8218. doi: 10.1073/pnas.1003478107
Luo, Lin, Tong, XingZhang and Farley, Peter C. (2007). The Candida albicans gene HGT12 (orf19.7094) encodes a hexose transporter. FEMS Immunology and Medical Microbiology, 51 (1), 14-17. doi: 10.1111/j.1574-695X.2007.00274.x
Conference Paper
Luo, L., Bokil, N., Lansdaal, N., Wall, A., Marceline, F., Guo, Z., Alexandrov, K., Ross, I, Hibbs, M., Stow, J. and Sweet, M. (2016). A new Toll-like receptor adaptor protein that provides specificity to inflammatory cytokine production from macrophages. International Congress of Immunology (ICI), Melbourne Australia, 21-26 August 2016. HOBOKEN: Wiley-Blackwell.