Dr Johannes Koehbach
Postdoctoral Research Officer
Institute for Molecular Bioscience
+61 7 336 52299
Journal Articles
Koehbach, Johannes and Craik, David J. (2019) The vast structural diversity of antimicrobial peptides. Trends in Pharmacological Sciences, 40 7: 517-528. doi:10.1016/j.tips.2019.04.012
Pinto, Meri Emili F., Najas, Jhenny Z. G., Magalhães, Luma G., Bobey, Antonio F., Mendonça, Jacqueline N., Lopes, Norberto P., Leme, Flávia M., Teixeira, Simone P., Trovó, Marcelo, Andricopulo, Adriano D., Koehbach, Johannes, Gruber, Christian W., Cilli, Eduardo Maffud and Bolzani, Vanderlan S. (2018) Inhibition of breast cancer cell migration by cyclotides isolated from Pombalia calceolaria. Journal of Natural Products, 81 5: 1203-1208. doi:10.1021/acs.jnatprod.7b00969
Rodriguez-Valle, Manuel, Moolhuijzen, Paula, Barrero, Roberto A., Ong, Chian Teng, Busch, Greta, Karbanowicz, Thomas, Booth, Mitchell, Clark, Richard, Koehbach, Johannes, Ijaz, Hina, Broady, Kevin, Agnew, Kim, Knowles, Aleta G., Bellgard, Matthew I. and Tabor, Ala E. (2018) Transcriptome and toxin family analysis of the paralysis tick, Ixodes holocyclus. International journal for parasitology, 48 1: 71-82. doi:10.1016/j.ijpara.2017.07.007
Koehbach, Johannes (2017) Structure-activity relationships of insect defensins. Frontiers in Chemistry, 5 JUL: . doi:10.3389/fchem.2017.00045
Liutkeviciute, Zita, Koehbach, Johannes, Eder, Thomas, Gil-Mansilla, Esther and Gruber, Christian W. (2016) Global map of oxytocin/vasopressin-like neuropeptide signalling in insects. Scientific Reports, 6 1: 55-61. doi:10.1038/srep39177
Koehbach, Johannes and Clark, Richard J. (2016) Unveiling the diversity of cyclotides by combining peptidome and transcriptome analysis. Biopolymers, 106 6: 774-783. doi:10.1002/bip.22858
Chand, Kirat K., Lee, Kah Meng, Lavidis, Nickolas A., Rodriguez-Valle, Manuel, Ijaz, Hina, Koehbach, Johannes, Clark, Richard J., Lew-Tabor, Ala and Noakes, Peter G. (2016) Tick holocyclotoxins trigger host paralysis by presynaptic inhibition. Scientific Reports, 6 29446. doi:10.1038/srep29446
Koehbach, Johannes, Gruber, Christian W., Becker, Christian, Kreil, David P. and Jilek, Alexander (2016) MALDI TOF/TOF-based approach for the identification of d-amino acids in biologically active peptides and proteins. Journal of Proteome Research, 15 5: 1487-1496. doi:10.1021/acs.jproteome.5b01067
Hellinger, Roland, Koehbach, Johannes, Soltis, Douglas E., Carpenter, Eric J., Wong, Gane Ka-Shu and Gruber, Christian W. (2015) Peptidomics of circular cysteine-rich plant peptides: Analysis of the diversity of cyclotides from viola tricolor by transcriptome and proteome mining. Journal of Proteome Research, 14 11: 4851-4862. doi:10.1021/acs.jproteome.5b00681
Hellinger, Roland, Koehbach, Johannes, Puigpinos, Albert, Clark, Richard J., Tarrago, Teresa, Giralt, Ernest and Gruber, Christian W. (2015) Inhibition of human prolyl oligopeptidase activity by the cyclotide psysol 2 isolated from Psychotria solitudinum. Journal of Natural Products, 78 5: 1073-1082. doi:10.1021/np501061t
Koehbach, Johannes and Jackson, Kathryn A. V. (2015) Unravelling peptidomes by in silico mining. Peptidomics, 2 1: 17-25. doi:10.1515/ped-2015-0002
Pinto, Meri Emili F., Batista, Joao M., Koehbach, Johannes, Gaur, Pratibha, Sharma, Abhinay, Nakabashi, Myna, Cilli, Eduardo Maffud, Giesel, Guilherme M., Verli, Hugo, Gruber, Christian W., Blanch, Ewan W., Tavares, Joseam F., da Silva, Marcelo S., Garcia, Celia R. S. and Bolzani, Vanderlan S. (2015) Ribifolin, an orbitide from jatropha ribifolia, and its potential antimalarial activity. Journal of Natural Products, 78 3: 374-380. doi:10.1021/np5007668
Koehbach, Johannes and Gruber, Christian W. (2015) Cyclotides in the Rubiaceae. Advances in Botanical Research, 76 51-78. doi:10.1016/bs.abr.2015.09.002
Hellinger, Roland, Koehbach, Johannes, Fedchuk, Halyna, Sauer, Barbara, Huber, Roman, Gruber, Christian W. and Gruendemann, Carsten (2014) Immunosuppressive activity of an aqueous Viola tricolor herbal extract. Journal of Ethnopharmacology, 151 1: 299-306. doi:10.1016/j.jep.2013.10.044
Koehbach, Johannes and Gruber, Christian W. (2014) Biosynthesis and molecular effects of cyclic plant peptides Biosynthese und molekulare Wirkung von zyklischen Pflanzenpeptiden. BioSpektrum, 20 7: 724-736.
Koehbach, Johannes and Gruber, Christian W. (2014) Biosynthese und molekulare Wirkung von zyklischen Pflanzenpeptiden. BioSpektrum, 20 7: 741-743. doi:10.1007/s12268-014-0511-5
Koehbach, Johannes and Gruber, Christian W. (2013) From ethnopharmacology to drug design. Communicative and Integrative Biology, 6 6: . doi:10.4161/cib.27583
Koehbach, Johannes, O'Brien, Margaret, Muttenthaler, Markus, Miazzo, Marion, Akcan, Muharrem, Elliott, Alysha G., Daly, Norelle L., Harvey, Peta J., Arrowsmith, Sarah, Gunasekera, Sunithi, Smith, Terry J., Wray, Susan, Göransson, Ulf, Dawson, Philip E., Craik, David J., Freissmuth, Michael and Gruber, Christian W. (2013) Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences of the United States of America, 110 52: 21183-21188. doi:10.1073/pnas.1311183110
Koehbach, Johannes, Attah, Alfred F., Berger, Andreas, Hellinger, Roland, Kutchan, Toni M., Carpenter, Eric J., Rolf, Megan, Sonibare, Mubo A., Moody, Jones O., Wong, Gane Ka-Shu, Dessein, Steven, Greger, Harald and Gruber, Christian W. (2013) Cyclotide discovery in Gentianales revisited—identification and characterization of cyclic cystine-knot peptides and their phylogenetic distribution in Rubiaceae plants. Biopolymers, 100 5: 438-452. doi:10.1002/bip.22328
Hashempour, Hossein, Koehbach, Johannes, Daly, Norelle L., Ghassempour, Alireza and Gruber, Christian W. (2013) Characterizing circular peptides in mixtures: sequence fragment assembly of cyclotides from a violet plant by MALDI-TOF/TOF mass spectrometry. Amino Acids, 44 2: 581-595. doi:10.1007/s00726-012-1376-x
Gruber, Christian W., Koehbach, Johannes and Muttenthaler, Markus (2012) Exploring bioactive peptides from natural sources for oxytocin and vasopressin drug discovery. Future Medicinal Chemistry, 4 14: 1791-1798. doi:10.4155/FMC.12.108
Attah, Alfred F., O'Brien, Margaret, Koehbach, Johannes, Sonibare, Mubo A., Moody, Jones O., Smith, Terry J. and Gruber, Christian W. (2012) Uterine contractility of plants used to facilitate childbirth in Nigerian ethnomedicine. Journal of Ethnopharmacology, 143 1: 377-382. doi:10.1016/j.jep.2012.06.042
Hicks, C., Jorgensen, W., Brown, C., Fardell, J., Koehbach, J., Gruber, C. W., Kassiou, M., Hunt, G. E. and McGregor, I. S. (2012) The nonpeptide oxytocin receptor agonist WAY 267,464: receptor-binding profile, prosocial effects and distribution of c-Fos expression in adolescent rats. Journal of Neuroendocrinology, 24 7: 1012-1029. doi:10.1111/j.1365-2826.2012.02311.x
Gruendemann, Carsten, Koehbach, Johannes, Huber, Roman and Gruber, Christian W. (2012) Do plant cyclotides have potential as immunosuppressant peptides?. Journal of Natural Products, 75 2: 167-174. doi:10.1021/np200722w
Conference Papers
Liutkeviciute, Z., Koehbach, J., Gil-Mansilla, E., Eder, T. and Gruber, C. W. (2016). Discovery of Novel Oxytocin-Like Neuropeptides in Insects. In: Journal of Peptide Science. , , (S40-S40). .
Koehbach, J. and Clark, R. J. (2016). Discovery, Synthesis and Characterization of Novel Cysteine-Rich Peptides From Insects. In: , , (S130-S130). .
Koehbach, Johannes and Clark, Richard J. (2015). Exploring the chemistry and pharmacological potential of bioactive peptides from insects. In: 14th International Congress on Amino Acids, Peptides and Proteins, Vienna, Austria, (1653-1653). August 3–7, 2015. doi:10.1007/s00726-015-2016-z
Gruber, C., Koehbach, J. and Freissmuth, M. (2014). Exploring Bioactive Peptides as Pharmacological Tools for Oxytocin and Vasopressin Ligand Design. In: Basic & Clinical Pharmacology & Toxicology. , , (120-120). .
Koehbach, J., O'Brien, M., Muttenthaler, M., Akcan, M., Smith, T. J., Craik, D. J., Freissmuth, M. and Gruber, C. W. (2013). Peptide GPCRs as molecular targets for plant cyclotides. In: Biopolymers. 23rd American Peptide Symposium, Waikoloa Hi, (252-252). Jun 22-27, 2013.
Koehbach, Johannes, Stockner, Thomas, Bergmayr, Christian, Muttenthaler, Markus and Gruber, Christian W. (2013) Insights into the molecular evolution of oxytocin receptor ligand binding. Biochemical Society Transactions, 41 1: 197-204. doi:10.1042/BST20120256
Hashempour, H., Koehbach, J., Ghassempour, A. and Gruber, C. W. (2012). Characterizing circular peptides in mixtures: sequence fragment assembly of cyclotides from a violet plant by MALDI-TOF/TOF mass spectrometry. In: Journal of Peptide Science. , , (S71-S71). .
Gruber, C. W., Gruendemann, C., Koehbach, J. and Huber, R. (2012). Combinatorial library of natural cyclic peptides with immunosuppressive properties. In: Journal of Peptide Science. , , (S49-S49). .
Koehbach, J., O'Brien, M., Miazzo, M., Muttenthaler, M., Akcan, M., Smith, T. J., Craik, D. J., Freissmuth, M. and Gruber, C. W. (2012). Pharmacological characterization of circular plant peptides with oxytocin-like activity. In: Proceedings of the 32nd European Peptide Symposium. 32nd European Peptide Symposium "Peptides 2012", Athens, Greece, (S98-S98). 02-07 September 2012. doi:10.1002/psc.2449
Koehbach, J., Dessein, S., Greger, H. and Gruber, C. W. (2011). Improved peptidomics screening protocol for the identification of cyclotide-containing plants. In: Planta Medica. 59th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research, Antalya Turkey, (1233-1233). Sep 04-09, 2011.
Kinsella, Marie, Koehbach, Johannes, Smith, Terry J., Gruber, Christian W. and O'Brien, Margaret (2011). Modulation of Myometrial Smooth Muscle Cell Contractility by Plant Cyclotides. In: Reproductive Sciences. , , (133A-133A). .
Gruber, Christian W., Koehbach, Johannes and O'Brien, Margaret (2011). Discovery of circular disulfide-rich peptides in plants with oxytocin-like activity. In: Biopolymers. 22nd American Peptide Symposium, San Diego Ca, (494-494). Jun 25-30, 2011.