Professor David Hume

Eichmann, Klaus, Avery, Oswald T., Baltimore, David, Von Behring, Emil, Benacerraf, Baruj, Bloor, David, Bordet, Jules J.B.V., Bona, Constantin A., Boyse, Edward A., Burnet, F. Macfarlane, Cantor, Harvey, Cazenave, Pierre A., Claman, Henry N., Cohn, Melvin, Coutinho, Antonio, Davis, Mark M., Crick, Francis H., Dobzhansky, Theodosius G., Doherty, Peter C., Eco, Umberto, Edelman, Gerald M., Ehrlich, Paul, Feyerabend, Paul, Fleck, Ludwik, Fujimura, Joan, Gershon, Richard K., Germain, Ronald N., Gowans, James L., Greene, Mark I. ... Zinkernagel, Rolf M. (2008). The network collective: Rise and fall of a scientific paradigm. Birkhauser Verlag AG. doi: 10.1007/978-3-7643-8373-2

Hume, David A., Summers, Kim M. and Rehli, Michael (2017). Transcriptional regulation and macrophage differentiation. Myeloid Cells in Health and Disease: A Synthesis. (pp. 119-139) Washington, DC United States: Wiley-Blackwell. doi: 10.1128/9781555819194.ch8

Hume, David A., Schroder, Kate and Irvine, Katharine M. (2009). The impact of CAGE data on understanding macrophage transcriptional biology. Cap-Analysis Gene Expression (CAGE): The Science of Decoding Genes Transcription. (pp. 227-243) Pan Stanford Publishing Pte. Ltd.. doi: 10.4032/9789814241359

Hume, D. A., Irvine, K. M. and Schroder, K. (2009). The impact of CAGE data on the understanding of macrophage transcriptional biology. Cap- Analysis Gene Expression (Cage): The Science of Decoding Gene Transcription. (pp. 227-244) edited by Piero Carninci. Singapore: Pan Stanford Publishing.

Robin, G., Cowieson, N.P., Guncar, G., Forwood, J.K., Listwan, P., Hume, D.A., Kobe, B., Martin, J.L. and Huber, T.L. (2008). A general target selection method for crystallographic proteomics. Structural Proteomics: High-Throughput Methods. (pp. 27-35) edited by Kobe, B., Guss, M. and Huber, T.L.. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_2

Mouradov, Dmitri, King. Gordon, Ross, Ian L., Forwood, Jade K., Hume, David A., Sinz, Andrea, Martin, Jennifer L., Kobe, Bostjan and Huber, Thomas L. (2008). Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling. Structural Proteomics: High Throughput Methods. (pp. 459-474) edited by Bostjan Kobe, Mitchell Guss and Thomas L. Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_31

Meng, Weining, Forwood, Jade K., Guncar, Gregor, Robin, Gautier, Cowieson, Nathan P., Listwan, Pawel, Mouradov, Dmitri, King, Gordon, Ross, lan L., Robinson, Jodie, Puri, Munish, Hill, Justine M., Kellie, Stuart, Huber, Thomas, Hume, David A., Martin, Jennifer L. and Kobe, Bostjan (2008). Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland. Structural proteomics: High-throughput methods. (pp. 577-587) edited by B. Kobe, M. Guss and T. L. Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_38

Cowieson, N. P., Wensley, B., Robin, G., Guncar, G., Forwood, J. K., Hume, D. A., Kobe, B. and Martin, J. L. (2008). A medium or high throughput protein refolding assay. Structural Proteomics: High throughput Methods. (pp. 269-275) edited by Bostjan Kobe, Mitchell Guss and Thomas Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_17

Hume, David A., Wells, Christine A. and Ravasi, Timothy (2007). Transcriptional Regulatory Networks in Macrophages. Decoding the Genomic Control of Immune Reactions. (pp. 2-24) Chichester, UK: wiley. doi: 10.1002/9780470062128.ch2

Ravasi, T. and Hume, D. A. (2005). Noncoding RNA's in mammals. Encyclopedia of Genetics, Genomics, Proteomics and Bioformatics. (pp. xx-xx) edited by Michael J. Dunn, Lynn B. Jorde, Peter F. R. Little and Shankar Subramaniam. USA: John Wiley & Sons, Inc.. doi: 10.1002/047001153X.g203204

B.Tse B.TseBrendanB.Tse B.TseBrendanhttps://api.elsevier.com/content/author/author_id/56055692200 (2005). Pattern matching for motifs. Bioinformatics Technologies. (pp. 299-312) Berlin/Heidelberg: Springer Berlin Heidelberg. doi: 10.1007/3-540-26888-X_10

Sasmono, R.T. and Hume, D. A. (2004). The Biology of Macrophages. The Innate Immune Response to Infection. (pp. 71-94) edited by Kaufmann, SE.; Medzhitov, R.; Gordon and S.. Washington, DC, USA: ASM Press.

Stacey, K. J., Sester, D. P., Naik, S., Roberts, T., Sweet, M. J. and Hume, D. A. (2002). Phosphorothioate backbone modification changes the pattern of responses to CpG. Microbial DNA and host immunity. (pp. 63-77) Totowa, New Jersey: Humana Press. doi: 10.1007/978-1-59259-305-7_6

Hume, D. A., Stacey, K. J., Cassady, A. ., Browne, C. M., Sweet, M. J. and Bertoncello, I. (1996). Growth and differentiation of murine macrophages. Handbook of experimental immunology. (pp. 160.1-160.10) Boston: Wiley-Blackwell.

Stacey, K. J., Cassady, A. I., Nimmo, K. A., Murphy, K. M., von der Ahe, D., Pearson, D., Botteri, F., Nagamine, Y. and Hume, D. A. (1992). The regulation of urokinase plasminogen activator gene expression in macrophages. Mononuclear Phagocytes: Biology of Monocytes and Macrophages. (pp. 233-240) edited by van Furth, R.. Dordrecht , Netherlands: Kluwer Academic Publishers. doi: 10.1007/978-94-015-8070-0

Grootveld, Abigail K., Kyaw, Wunna, Panova, Veera, Lau, Angelica W.Y., Ashwin, Emily, Seuzaret, Guillaume, Dhenni, Rama, Bhattacharyya, Nayan Deger, Khoo, Weng Hua, Biro, Maté, Mitra, Tanmay, Meyer-Hermann, Michael, Bertolino, Patrick, Tanaka, Masato, Hume, David A., Croucher, Peter I., Brink, Robert, Nguyen, Akira, Bannard, Oliver and Phan, Tri Giang (2023). Apoptotic cell fragments locally activate tingible body macrophages in the germinal center. Cell, 186 (6), 1144-1161. doi: 10.1016/j.cell.2023.02.004

Summers, Kim M., Bush, Stephen J., Davis, Margaret R., Hume, David A., Keshvari, Sahar and West, Jennifer A. (2023). Fibrillin-1 and asprosin, novel players in metabolic syndrome. Molecular Genetics and Metabolism, 138 (1) 106979, 106979. doi: 10.1016/j.ymgme.2022.106979

Grapotte, Mathys, Saraswat, Manu, Bessière, Chloé, Menichelli, Christophe, Ramilowski, Jordan A., Severin, Jessica, Hayashizaki, Yoshihide, Itoh, Masayoshi, Tagami, Michihira, Murata, Mitsuyoshi, Kojima-Ishiyama, Miki, Noma, Shohei, Noguchi, Shuhei, Kasukawa, Takeya, Hasegawa, Akira, Suzuki, Harukazu, Nishiyori-Sueki, Hiromi, Frith, Martin C., Abugessaisa, Imad, Aitken, Stuart, Aken, Bronwen L., Alam, Intikhab, Alam, Tanvir, Alasiri, Rami, Alhendi, Ahmad M. N., Alinejad-Rokny, Hamid, Alvarez, Mariano J., Andersson, Robin, Arakawa, Takahiro ... Lecellier, Charles-Henri (2022). Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7). Nature Communications, 13 (1) 1200. doi: 10.1038/s41467-022-28758-y

Ferrari-Cestari, Michelle, Okano, Satomi, Patel, Preya J., Horsfall, Leigh U., Keshvari, Sahar, Hume, David A., Williams, Suzanne, Russell, Anthony, Powell, Elizabeth E. and Irvine, Katharine M (2022). Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD). Digestive Diseases. doi: 10.1159/000527784

Paolicelli, Rosa C., Sierra, Amanda, Stevens, Beth, Tremblay, Marie-Eve, Aguzzi, Adriano, Ajami, Bahareh, Amit, Ido, Audinat, Etienne, Bechmann, Ingo, Bennett, Mariko, Bennett, Frederick, Bessis, Alain, Biber, Knut, Bilbo, Staci, Blurton-Jones, Mathew, Boddeke, Erik, Brites, Dora, Brône, Bert, Brown, Guy C., Butovsky, Oleg, Carson, Monica J., Castellano, Bernardo, Colonna, Marco, Cowley, Sally A., Cunningham, Colm, Davalos, Dimitrios, De Jager, Philip L., de Strooper, Bart, Denes, Adam ... Wyss-Coray, Tony (2022). Microglia states and nomenclature: A field at its crossroads. Neuron, 110 (21), 3458-3483. doi: 10.1016/j.neuron.2022.10.020

Hume, David A., Batoon, Lena, Sehgal, Anuj, Keshvari, Sahar and Irvine, Katharine M. (2022). CSF1R as a Therapeutic Target in Bone Diseases: Obvious but Not so Simple. Current Osteoporosis Reports, 20 (6), 516-531. doi: 10.1007/s11914-022-00757-4

Freeman, Tom C., Horsewell, Sebastian, Patir, Anirudh, Harling-Lee, Josh, Regan, Tim, Shih, Barbara B., Prendergast, James, Hume, David A. and Angus, Tim (2022). Graphia: a platform for the graph-based visualisation and analysis of high dimensional data. PLOS Computational Biology, 18 (7) e1010310, 1-17. doi: 10.1371/journal.pcbi.1010310

Hume, David A., Offermanns, Stefan and Bonnavion, Remy (2022). Contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells. Immunity, 55 (7), 1139-1140. doi: 10.1016/j.immuni.2022.06.010

Kiani Shabestari, Sepideh, Morabito, Samuel, Danhash, Emma Pascal, McQuade, Amanda, Sanchez, Jessica Ramirez, Miyoshi, Emily, Chadarevian, Jean Paul, Claes, Christel, Coburn, Morgan Alexandra, Hasselmann, Jonathan, Hidalgo, Jorge, Tran, Kayla Nhi, Martini, Alessandra C., Chang Rothermich, Winston, Pascual, Jesse, Head, Elizabeth, Hume, David A., Pridans, Clare, Davtyan, Hayk, Swarup, Vivek and Blurton-Jones, Mathew (2022). Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice. Cell Reports, 39 (11) 110961, 1-30. doi: 10.1016/j.celrep.2022.110961

Laviron, Marie, Petit, Maxime, Weber-Delacroix, Eléonore, Combes, Alexis J., Arkal, Arjun Rao, Barthélémy, Sandrine, Courau, Tristan, Hume, David A., Combadière, Christophe, Krummel, Matthew F. and Boissonnas, Alexandre (2022). Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer. Cell Reports, 39 (8) 110865, 110865. doi: 10.1016/j.celrep.2022.110865

Summers, Kim M., Bush, Stephen J., Wu, Chunlei and Hume, David A. (2022). Generation and network analysis of an RNA-seq transcriptional atlas for the rat. NAR Genomics and Bioinformatics, 4 (1) lqac017, lqac017. doi: 10.1093/nargab/lqac017

Lisowski, Zofia M., Lefevre, Lucas, Mair, Tim S., Clark, Emily L., Hudson, Neil P. H., Hume, David A. and Pirie, R. Scott (2022). Use of quantitative real‐time PCR to determine the local inflammatory response in the intestinal mucosa and muscularis of horses undergoing small intestinal resection. Equine Veterinary Journal, 54 (1), 52-62. doi: 10.1111/evj.13429

Pettit, Allison R, Batoon, Lena, Heng, Ostyn, Hume, David, Irvine, Kate, Kaur, Simranpreet, Levesque, Jean-Pierre, Magor, Graham, Millard, Susan, Noll, Jacqueline, Perkins, Andrew, Raggatt, Liza, Sandrock, Cheyenne, Sehgal, Anuj, Sester, David, Opperman, Khatora Shanae, Summers, Kim, Wu, Andy and Zannettino, Andrew (2022). 1015 – APPEARANCES CAN BE DECEIVING: MACROPHAGE FRAGMENTATION CONFOUNDS EX VIVO HAEMATOPOIETIC TISSUE ANALYSIS. Experimental Hematology, 111, S23. doi: 10.1016/j.exphem.2022.07.018

Hume, David A. (2022). Letter to the editor: Questioning the existence of Aif1+, Csf1r+ mesenchymal stem cells. Hepatology, n/a-n/a. doi: 10.1002/hep.32809

Keshvari, Sahar, Genz, Berit, Teakle, Ngari, Caruso, Melanie, Cestari, Michelle F., Patkar, Omkar L., Tse, Brian W. C., Sokolowski, Kamil A., Ebersbach, Hilmar, Jascur, Julia, MacDonald, Kelli P. A., Miller, Gregory, Ramm, Grant A., Pettit, Allison R., Clouston, Andrew D., Powell, Elizabeth E., Hume, David A. and Irvine, Katharine M. (2022). Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease. Disease Models and Mechanisms, 15 (4) dmm049387, 1-15. doi: 10.1242/dmm.049387

Psifidi, Androniki, Kranis, Andreas, Rothwell, Lisa M., Bremner, Abi, Russell, Kay, Robledo, Diego, Bush, Stephen J., Fife, Mark, Hocking, Paul M., Banos, Georgios, Hume, David A., Kaufman, Jim, Bailey, Richard A., Avendano, Santiago, Watson, Kellie A., Kaiser, Pete and Stevens, Mark. P. (2021). Quantitative trait loci and transcriptome signatures associated with avian heritable resistance to Campylobacter. Scientific Reports, 11 (1) 1623. doi: 10.1038/s41598-020-79005-7

Patkar, Omkar L., Mohamed, Abdalla Z., Narayanan, Ashwin, Mardon, Karine, Cowin, Gary, Bhalla, Rajiv, Stimson, Damion H. R., Kassiou, Michael, Beecher, Kate, Belmer, Arnauld, Alvarez Cooper, Ignatius, Morgan, Michael, Hume, David A., Irvine, Katharine M., Bartlett, Selena E., Nasrallah, Fatima and Cumming, Paul (2021). A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity. Scientific Reports, 11 (1) 11252, 11252. doi: 10.1038/s41598-021-90817-z

Millard, Susan M., Heng, Ostyn, Opperman, Khatora S., Sehgal, Anuj, Irvine, Katharine M., Kaur, Simranpreet, Sandrock, Cheyenne J., Wu, Andy C., Magor, Graham W., Batoon, Lena, Perkins, Andrew C., Noll, Jacqueline E., Zannettino, Andrew C.W., Sester, David P., Levesque, Jean-Pierre, Hume, David A., Raggatt, Liza J., Summers, Kim M. and Pettit, Allison R. (2021). Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues. Cell Reports, 37 (8) 110058, 110058. doi: 10.1016/j.celrep.2021.110058

Wu, Zhiguang, Hu, Tuanjun, Chintoan-Uta, Cosmin, Macdonald, Joni, Stevens, Mark P., Sang, Helen, Hume, David A., Kaiser, Pete and Balic, Adam (2021). Development of novel reagents to chicken FLT3, XCR1 and CSF2R for the identification and characterization of avian conventional dendritic cells. Immunology, 165 (2), 171-194. doi: 10.1111/imm.13426

Sehgal, Anuj, Irvine, Katharine M. and Hume, David A. (2021). Functions of macrophage colony-stimulating factor (CSF1) in development, homeostasis, and tissue repair. Seminars in Immunology, 54 101509, 101509. doi: 10.1016/j.smim.2021.101509

Batoon, Lena, Millard, Susan M., Raggatt, Liza J., Sandrock, Cheyenne, Pickering, Edmund, Williams, Kyle, Sun, Lucas W.H., Wu, Andy C., Irvine, Katharine M., Pivonka, Peter, Glatt, Vaida, Wullschleger, Martin E., Hume, David A. and Pettit, Allison R. (2021). Treatment with a long-acting chimeric CSF1 molecule enhances fracture healing of healthy and osteoporotic bones. Biomaterials, 275 120936, 120936. doi: 10.1016/j.biomaterials.2021.120936

Keshvari, Sahar, Caruso, Melanie, Teakle, Ngari, Batoon, Lena, Sehgal, Anuj, Patkar, Omkar L., Ferrari-Cestari, Michelle, Snell, Cameron E., Chen, Chen, Stevenson, Alex, Davis, Felicity M., Bush, Stephen J., Pridans, Clare, Summers, Kim M., Pettit, Allison R., Irvine, Katharine M. and Hume, David A. (2021). CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genetics, 17 (6) e1009605, e1009605. doi: 10.1371/journal.pgen.1009605

Abbott, Carolyn R. and Hume, David (2021). Actions of small cancellation groups on hyperbolic spaces. Geometriae Dedicata, 212 (1), 325-363. doi: 10.1007/s10711-020-00561-3

Gažová, Iveta, Lefevre, Lucas, Bush, Stephen J., Rojo, Rocio, Hume, David A., Lengeling, Andreas and Summers, Kim M. (2021). CRISPR-Cas9 editing of human histone deubiquitinase gene USP16 in human monocytic leukemia cell line THP-1. Frontiers in Cell and Developmental Biology, 9 679544. doi: 10.3389/fcell.2021.679544

Hume, David A., Caruso, Melanie, Keshvari, Sahar, Patkar, Omkar L., Sehgal, Anuj, Bush, Stephen J., Summers, Kim M., Pridans, Clare and Irvine, Katharine M. (2021). The mononuclear phagocyte system of the rat. The Journal of Immunology, 206 (10), 2251-2263. doi: 10.4049/jimmunol.2100136

Patkar, Omkar L., Caruso, Melanie, Teakle, Ngari, Keshvari, Sahar, Bush, Stephen J., Pridans, Clare, Belmer, Arnauld, Summers, Kim M., Irvine, Katharine M. and Hume, David A. (2021). Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations. Neurobiology of Disease, 151 105268, 105268. doi: 10.1016/j.nbd.2021.105268

Wiener, Pamela, Robert, Christelle, Ahbara, Abulgasim, Salavati, Mazdak, Abebe, Ayele, Kebede, Adebabay, Wragg, David, Friedrich, Juliane, Vasoya, Deepali, Hume, David A., Djikeng, Appolinaire, Watson, Mick, Prendergast, James G D, Hanotte, Olivier, Mwacharo, Joram M. and Clark, Emily L. (2021). Whole-genome sequence data suggest environmental adaptation of Ethiopian sheep populations. Genome Biology and Evolution, 13 (3) evab014, 1-18. doi: 10.1093/gbe/evab014

Karagianni, Anna E., Lisowski, Zofia M., Hume, David A. and Scott Pirie, R. (2021). The equine mononuclear phagocyte system: the relevance of the horse as a model for understanding human innate immunity. Equine Veterinary Journal, 53 (2), 231-249. doi: 10.1111/evj.13341

Pridans, Clare, Irvine, Katharine M, Davis, Gemma M, Lefevre, Lucas, Bush, Stephen J and Hume, David A (2021). Transcriptomic analysis of rat macrophages. Frontiers in Immunology, 11 594594. doi: 10.3389/fimmu.2020.594594

Green, Kim N. and Hume, David A. (2021). On the utility of CSF1R inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 118 (4) e2019695118, 1-2. doi: 10.1073/pnas.2019695118

Kaur, Simranpreet, Sehgal, Anuj, Wu, Andy C., Millard, Susan M., Batoon, Lena, Sandrock, Cheyenne J., Ferrari-Cestari, Michelle, Levesque, Jean-Pierre, Hume, David A., Raggatt, Liza J. and Pettit, Allison R. (2021). Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice. Journal of Hematology and Oncology, 14 (1) 3, 1-19. doi: 10.1186/s13045-020-00997-w

Munro, David A.D., Bradford, Barry M., Mariani, Samanta A., Hampton, David W., Vink, Chris S., Chandran, Siddharthan, Hume, David A., Pridans, Clare and Priller, Josef (2020). CNS macrophages differentially rely on an intronic Csf1r enhancer for their development. Development, 147 (23) dev194449, 1-9. doi: 10.1242/dev.194449

Dutta, Prasun, Talenti, Andrea, Young, Rachel, Jayaraman, Siddharth, Callaby, Rebecca, Jadhav, Santosh Kumar, Dhanikachalam, Velu, Manikandan, Mayakannan, Biswa, Bhim B., Low, Wai Y., Williams, John L., Cook, Elizabeth, Toye, Phil, Wall, Eileen, Djikeng, Appolinaire, Marshall, Karen, Archibald, Alan L., Gokhale, Suresh, Kumar, Satish, Hume, David A. and Prendergast, James G. D. (2020). Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication. Nature Communications, 11 (1) 4739. doi: 10.1038/s41467-020-18550-1

Grabert, Kathleen, Sehgal, Anuj, Irvine, Katharine M., Wollscheid-Lengeling, Evi, Ozdemir, Derya D., Stables, Jennifer, Luke, Garry A., Ryan, Martin D., Adamson, Antony, Humphreys, Neil E., Sandrock, Cheyenne J., Rojo, Rocio, Verkasalo, Veera A., Mueller, Werner, Hohenstein, Peter, Pettit, Allison R., Pridans, Clare and Hume, David A. (2020). A transgenic line that reports CSF1R protein expression provides a definitive marker for the mouse mononuclear phagocyte system. Journal of Immunology, 205 (11), 3154-3166. doi: 10.4049/jimmunol.2000835

Hume, David and Mackay, John M. (2020). Poorly connected groups. Proceedings of the American Mathematical Society, 148 (11), 4653-4664. doi: 10.1090/proc/15128

Summers, Kim M., Bush, Stephen J. and Hume, David A. (2020). Network analysis of transcriptomic diversity amongst resident tissue macrophages and dendritic cells in the mouse mononuclear phagocyte system. PLoS Biology, 18 (10) e3000859, 1-45. doi: 10.1371/journal.pbio.3000859

Gow, Deborah J., Jackson, Hilary, Forsythe, Peter, Nuttall, Tim, Gow, Adam G., Mellanby, Richard J. and Hume, David A. (2020). Measurement of serum Interleukin 34 (IL-34) and correlation with severity and pruritus scores in client-owned dogs with atopic dermatitis. Veterinary Dermatology, 31 (5), 359-e94. doi: 10.1111/vde.12873

Tsang, Hiu-Gwen, Clark, Emily L., Markby, Greg R., Bush, Stephen J., Hume, David A., Corcoran, Brendan M., MacRae, Vicky E. and Summers, Kim M. (2020). Expression of calcification and extracellular matrix genes in the cardiovascular system of the healthy domestic sheep (Ovis aries). Frontiers in Genetics, 11 919. doi: 10.3389/fgene.2020.00919

Lisowski, Zofia M., Sauter, Kristin A., Waddell, Lindsey A., Hume, David A., Pirie, R. Scott and Hudson, Neil P.H. (2020). Immunohistochemical study of morphology and distribution of CD163+ve macrophages in the normal adult equine gastrointestinal tract. Veterinary Immunology and Immunopathology, 226 110073, 110073. doi: 10.1016/j.vetimm.2020.110073

Bush, Stephen J., McCulloch, Mary E. B., Lisowski, Zofia M., Muriuki, Charity, Clark, Emily L., Young, Rachel, Pridans, Clare, Prendergast, James G. D., Summers, Kim M. and Hume, David A. (2020). Species-specificity of transcriptional regulation and the response to lipopolysaccharide in mammalian macrophages. Frontiers in Cell and Developmental Biology, 8 661. doi: 10.3389/fcell.2020.00661

Gažová, Iveta, Lefevre, Lucas, Bush, Stephen J., Clohisey, Sara, Arner, Erik, de Hoon, Michiel, Severin, Jessica, van Duin, Lucas, Andersson, Robin, Lengeling, Andreas, Hume, David A. and Summers, Kim M. (2020). The transcriptional network that controls growth arrest and macrophage differentiation in the human myeloid leukemia cell line THP-1. Frontiers in Cell and Developmental Biology, 8 498. doi: 10.3389/fcell.2020.00498

Warr, Amanda, Affara, Nabeel, Aken, Bronwen, Beiki, Hamid, Bickhart, Derek M., Billis, Konstantinos, Chow, William, Eory, Lel, Finlayson, Heather A., Flicek, Paul, Girón, Carlos G., Griffin, Darren K., Hall, Richard, Hannum, Greg, Hourlier, Thibaut, Howe, Kerstin, Hume, David A., Izuogu, Osagie, Kim, Kristi, Koren, Sergey, Liu, Haibou, Manchanda, Nancy, Martin, Fergal J., Nonneman, Dan J., O'Connor, Rebecca E., Phillippy, Adam M., Rohrer, Gary A., Rosen, Benjamin D., Rund, Laurie A. ... Archibald, Alan L. (2020). An improved pig reference genome sequence to enable pig genetics and genomics research. GigaScience, 9 (6) GIAA051. doi: 10.1093/gigascience/giaa051

Clohisey, Sara, Parkinson, Nicholas, Wang, Bo, Bertin, Nicolas, Wise, Helen, Tomoiu, Andru, Summers, Kim M., Hendry, Ross W., Carninci, Piero, Forrest, Alistair R. R., Hayashizaki, Yoshihide, Digard, Paul, Hume, David A. and Baillie, J. Kenneth (2020). Comprehensive characterization of transcriptional activity during influenza A virus infection reveals biases in cap-snatching of host RNA sequences. Journal of Virology, 94 (10) e01720-19. doi: 10.1128/JVI.01720-19

Wu, Zhiguang, Harne, Rakhi, Chintoan-Uta, Cosmin, Hu, Tuan-Jun, Wallace, Robert, MacCallum, Amanda, Stevens, Mark P., Kaiser, Pete, Balic, Adam and Hume, David A. (2020). Regulation and function of macrophage colony-stimulating factor (CSF1) in the chicken immune system. Developmental and Comparative Immunology, 105 103586. doi: 10.1016/j.dci.2019.103586

Hume, David, Mackay, John M. and Tessera, Romain (2020). Poincaré profiles of groups and spaces. Revista Matematica Iberoamericana, 36 (6), 1835-1886. doi: 10.4171/RMI/1184

Summers, Kim M., Bush, Stephen J., Wu, Chunlei, Su, Andrew I., Muriuki, Charity, Clark, Emily L., Finlayson, Heather A., Eory, Lel, Waddell, Lindsey A., Talbot, Richard, Archibald, Alan L. and Hume, David A. (2020). Functional annotation of the transcriptome of the pig, Sus scrofa, based upon network analysis of an RNAseq transcriptional atlas. Frontiers in Genetics, 10 1355. doi: 10.3389/fgene.2019.01355

Wragg, D., Liu, Q., Lin, Z., Riggio, V., Pugh, C. A., Beveridge, A. J., Brown, H., Hume, D. A., Harris, S. E., Deary, I. J., Tenesa, A. and Prendergast, J. G.D. (2020). Using regulatory variants to detect gene-gene interactions identifies networks of genes linked to cell immortalisation. Nature Communications, 11 (1) 343. doi: 10.1038/s41467-019-13762-6

Abbott, Carolyn R. and Hume, David (2020). The geometry of generalized loxodromic elements. Annales de l'Institut Fourier, 70 (4), 1689-1713. doi: 10.5802/AIF.3379

Banos, Georgios, Clark, Emily L., Bush, Stephen J., Dutta, Prasun, Georgios Bramis, D., Arsenos, Georgios, Hume, David A. and Psifidi, Androniki (2019). Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep. PLoS One, 14 (11) e0214346, e0214346. doi: 10.1371/journal.pone.0214346

Halachev, Mihail, Meynert, Alison, Taylor, Martin S., Vitart, Veronique, Kerr, Shona M., Klaric, Lucija, Consortium, S. G.P., Aitman, Timothy J., Haley, Chris S., Prendergast, James G., Pugh, Carys, Hume, David A., Harris, Sarah E., Liewald, David C., Deary, Ian J., Semple, Colin A. and Wilson, James F. (2019). Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions. PLoS Genetics, 15 (11) e1008480, e1008480. doi: 10.1371/journal.pgen.1008480

Freem, Lucy, Summers, Kim M., Gheyas, Almas A., Psifidi, Androniki, Boulton, Kay, MacCallum, Amanda, Harne, Rakhi, O’Dell, Jenny, Bush, Stephen J. and Hume, David A. (2019). Analysis of the progeny of sibling matings reveals regulatory variation impacting the transcriptome of immune cells in commercial chickens. Frontiers in Genetics, 10 1032. doi: 10.3389/fgene.2019.01032

Muriuki, Charity, Bush, Stephen J., Salavati, Mazdak, McCulloch, Mary E.B., Lisowski, Zofia M., Agaba, Morris, Djikeng, Appolinaire, Hume, David A. and Clark, Emily L. (2019). A mini-atlas of gene expression for the domestic goat (Capra hircus). Frontiers in Genetics, 10 1080, 1080. doi: 10.3389/fgene.2019.01080

Stewart, Teneale A., Hughes, Katherine, Hume, David A. and Davis, Felicity M. (2019). Developmental stage-specific distribution of macrophages in mouse mammary gland. Frontiers in Cell and Developmental Biology, 7 250, 250. doi: 10.3389/fcell.2019.00250

Balic, Adam, Chintoan-Uta, Cosmin, Vohra, Prerna, Sutton, Kate M., Cassady-Cain, Robin L., Hu, Tuan, Donaldson, David S., Stevens, Mark P., Mabbott, Neil A., Hume, David A., Sang, Helen M. and Vervelde, Lonneke (2019). Antigen sampling CSF1R-expressing epithelial cells are the functional equivalents of mammalian m cells in the avian follicle-associated epithelium. Frontiers in Immunology, 10 (OCT) 2495, 2495. doi: 10.3389/fimmu.2019.02495

Salavati, Mazdak, Bush, Stephen J., Palma-Vera, Sergio, McCulloch, Mary E. B., Hume, David A. and Clark, Emily L. (2019). Elimination of reference mapping bias reveals robust immune related allele-specific expression in crossbred sheep. Frontiers in Genetics, 10 863, 863. doi: 10.3389/fgene.2019.00863

Hume, David A., Gutowska‐Ding, Maria W., Garcia‐Morales, Carla, Kebede, Adebabay, Bamidele, Oladeji, Trujillo, Adriana Vallejo, Gheyas, Almas A. and Smith, Jacqueline (2019). Functional evolution of the colony‐stimulating factor 1 receptor (CSF1R) and its ligands in birds. Journal of Leukocyte Biology, 107 (2) JLB.6MA0519-172R, 237-250. doi: 10.1002/jlb.6ma0519-172r

Irvine, Katharine M., Caruso, Melanie, Cestari, Michelle Ferrari, Davis, Gemma M., Keshvari, Sahar, Sehgal, Anuj, Pridans, Clare and Hume, David A. (2019). Analysis of the impact of CSF‐1 administration in adult rats using a novel Csf1r ‐mApple reporter gene. Journal of Leukocyte Biology, 107 (2) JLB.MA0519-149R, 221-235. doi: 10.1002/jlb.ma0519-149r

Giotti, Bruno, Chen, Sz-Hau, Barnett, Mark W., Regan, Tim, Ly, Tony, Wiemann, Stefan, Hume, David A. and Freeman, Tom C. (2019). Assembly of a parts list of the human mitotic cell cycle machinery. Journal of Molecular Cell Biology, 11 (8), 703-718. doi: 10.1093/jmcb/mjy063

Hume, David A., Caruso, Melanie, Ferrari‐Cestari, Michelle, Summers, Kim M., Pridans, Clare and Irvine, Katharine M. (2019). Phenotypic impacts of CSF1R deficiencies in humans and model organisms. Journal of Leukocyte Biology, 107 (2) JLB.MR0519-143R, 205-219. doi: 10.1002/jlb.mr0519-143r

Chundru, V. Kartik, Marioni, Riccardo E., Prendergast, James G. D., Vallerga, Costanza L., Lin, Tian, Berveridge, Allan J., SGPD Consortium, Gratten, Jacob, Hume, David A., Deary, Ian J., Wray, Naomi R., Visscher, Peter M. and McRae, Allan F. (2019). Examining the impact of imputation errors on fine-mapping using DNA methylation QTL as a model trait. Genetics, 212 (3), 577-586. doi: 10.1534/genetics.118.301861

Gow, Debbie J., Jackson, Hilary, Forsythe, Peter, Gow, Adam G., Mellanby, Richard J., Hume, David A. and Nuttall, Tim (2019). Measurement of serum macrophage migration inhibitory factor (MIF) and correlation with severity and pruritus scores in client owned dogs with atopic dermatitis. Veterinary Dermatology, 30 (2), 115-e32. doi: 10.1111/vde.12721

Karagianni, Anna E., Summers, Kim M., Couroucé, Anne, Depecker, Marianne, McGorum, Bruce C., Hume, David A. and Pirie, R. Scott (2019). The effect of race training on the basal gene expression of alveolar macrophages derived from Standardbred racehorses. Journal of Equine Veterinary Science, 75, 48-54. doi: 10.1016/j.jevs.2019.01.010

Prendergast, James G D, Pugh, Carys, Harris, Sarah E., Hume, David A., Deary, Ian J. and Beveridge, Allan (2019). Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution. Genome Biology and Evolution, 11 (3), 759-775. doi: 10.1093/gbe/evz014

Cordes, Matthew and Hume, David (2019). Relatively hyperbolic groups with fixed peripherals. Israel Journal of Mathematics, 230 (1), 443-470. doi: 10.1007/s11856-019-1830-5

Dunning, Jake, Blankley, Simon, Hoang, Long T., Cox, Mike, Graham, Christine M., James, Philip L., Bloom, Chloe I., Chaussabel, Damien, Banchereau, Jacques, Brett, Stephen J., Habibi, Maximillian S., Johnston, Sebastian L., Hansel, Trevor T., Levin, Mike, Thwaites, Ryan S., Warner, John O., Cookson, William O., Gazzard, Brian G., Hay, Alan, McCauley, John, Aylin, Paul, Ashby, Deborah, Barclay, Wendy S., Elderfield, Ruth A., Nadel, Simon, Herberg, Jethro A., Drumright, Lydia N., Garcia-Alvarez, Laura, Holmes, Alison H. ... Openshaw, Peter J. M. (2019). Correction to: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (Nature Immunology, (2018), 19, 6, (625-635), 10.1038/s41590-018-0111-5). Nature Immunology, 20 (3), 373-373. doi: 10.1038/s41590-019-0328-y

Irvine, Katharine Margaret, Ratnasekera, Isanka, Powell, Elizabeth E. and Hume, David Arthur (2019). Causes and consequences of innate immune dysfunction in cirrhosis. Frontiers in Immunology, 10 (FEB) 293, 293. doi: 10.3389/fimmu.2019.00293

Hu, Tuanjun, Wu, Zhiguang, Bush, Stephen J., Freem, Lucy, Vervelde, Lonneke, Summers, Kim M., Hume, David A., Balic, Adam and Kaiser, Pete (2019). Characterization of subpopulations of chicken mononuclear phagocytes that express TIM4 and CSF1R. The Journal of Immunology, 202 (4), 1186-1199. doi: 10.4049/jimmunol.1800504

Bush, Stephen J., McCulloch, Mary E. B., Muriuki, Charity, Salavati, Mazdak, Davis, Gemma M., Farquhar, Iseabail L., Lisowski, Zofia M., Archibald, Alan L., Hume, David A. and Clark, Emily L. (2019). Comprehensive transcriptional profiling of the gastrointestinal tract of ruminants from birth to adulthood reveals strong developmental stage specific gene expression. G3: Genes, Genomes, Genetics, 9 (2), 359-373. doi: 10.1534/g3.118.200810

Hume, David A., Irvine, Katharine M. and Pridans, Clare (2019). The mononuclear phagocyte system: the relationship between monocytes and macrophages. Trends in Immunology, 40 (2), 98-112. doi: 10.1016/j.it.2018.11.007

Low, Wai Yee, Tearle, Rick, Bickhart, Derek M., Rosen, Benjamin D., Kingan, Sarah B., Swale, Thomas, Thibaud-Nissen, Françoise, Murphy, Terence D., Young, Rachel, Lefevre, Lucas, Hume, David A., Collins, Andrew, Ajmone-Marsan, Paolo, Smith, Timothy P. L. and Williams, John L. (2019). Chromosome-level assembly of the water buffalo genome surpasses human and goat genomes in sequence contiguity. Nature Communications, 10 (1) 260. doi: 10.1038/s41467-018-08260-0

Arzhantseva, Goulnara N., Cashen, Christopher H., Gruber, Dominik and Hume, David (2019). Negative curvature in graphical small cancellation groups. Groups, Geometry, and Dynamics, 13 (2), 579-632. doi: 10.4171/GGD/498

Irvine, Katharine Margaret, Ratnasekera, Isanka, Powell, Elizabeth E. and Hume, David Arthur (2019). Corrigendum: Causes and consequences of innate immune dysfunction in cirrhosis (Frontiers in Immunology (2019) 10 (293) DOI: 10.3389/fimmu.2019.00293). Frontiers in Immunology, 10 (APR) 818, 818. doi: 10.3389/fimmu.2019.00818

Young, Rachel, Lefevre, Lucas, Bush, Stephen J., Joshi, Akshay, Singh, Salam H., Jadhav, Santosh K., Lisowski, Zofia M., Iamartino, Daniela, Summers, Kim M., Williams, John L., Archibald, Alan L., Gokhale, Suresh, Kumar, Satish and Hume, David A. (2019). A gene expression atlas of the domestic water buffalo (Bubalus bubalis). Frontiers in Genetics, 10 (JUN) 668. doi: 10.3389/fgene.2019.00668

Herron, Lissa R., Pridans, Clare, Turnbull, Matthew L., Smith, Nikki, Lillico, Simon, Sherman, Adrian, Gilhooley, Hazel J., Wear, Martin, Kurian, Dominic, Papadakos, Grigorios, Digard, Paul, Hume, David A., Gill, Andrew C. and Sang, Helen M. (2018). A chicken bioreactor for efficient production of functional cytokines. BMC Biotechnology, 18 (1) 82. doi: 10.1186/s12896-018-0495-1

Boulton, Kay, Nolan, Matthew J., Wu, Zhiguang, Riggio, Valentina, Matika, Oswald, Harman, Kimberley, Hocking, Paul M., Bumstead, Nat, Hesketh, Pat, Archer, Andrew, Bishop, Stephen C., Kaiser, Pete, Tomley, Fiona M., Hume, David A., Smith, Adrian L., Blake, Damer P. and Psifidi, Androniki (2018). Dissecting the genomic architecture of resistance to Eimeria maxima parasitism in the chicken. Frontiers in Genetics, 9 528, 528. doi: 10.3389/fgene.2018.00528

Boulton, Kay, Nolan, Matthew J., Wu, Zhiguang, Psifidi, Androniki, Riggio, Valentina, Harman, Kimberley, Bishop, Stephen C., Kaiser, Pete, Abrahamsen, Mitchell S., Hawken, Rachel, Watson, Kellie A., Tomley, Fiona M., Blake, Damer P. and Hume, David A. (2018). Phenotypic and genetic variation in the response of chickens to Eimeria tenella induced coccidiosis. Genetics Selection Evolution, 50 (1) 63, 63. doi: 10.1186/s12711-018-0433-7

Nirmal, Ajit J., Regan, Tim, Shih, Barbara B., Hume, David A., Sims, Andrew H. and Freeman, Tom C. (2018). Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors. Cancer Immunology Research, 6 (11), 1388-1400. doi: 10.1158/2326-6066.CIR-18-0342

Waddell, Lindsey A., Lefevre, Lucas, Bush, Stephen J., Raper, Anna, Young, Rachel, Lisowski, Zofia M., McCulloch, Mary E.B., Muriuki, Charity, Sauter, Kristin A., Clark, Emily L., Irvine, Katharine M., Pridans, Clare, Hope, Jayne C. and Hume, David A. (2018). ADGRE1 (EMR1, F4/80) is a rapidly-evolving gene expressed in mammalian monocyte-macrophages. Frontiers in Immunology, 9 (OCT) 2246. doi: 10.3389/fimmu.2018.02246

Pridans, Clare, Raper, Anna, Davis, Gemma M., Alves, Joana, Sauter, Kristin A., Lefevre, Lucas, Regan, Tim, Meek, Stephen, Sutherland, Linda, Thomson, Alison J., Clohisey, Sara, Bush, Stephen J, Rojo, Rocío, Lisowski, Zofia M., Wallace, Robert, Grabert, Kathleen, Upton, Kyle R., Tsai, Yi Ting, Brown, Deborah, Smith, Lee B., Summers, Kim M., Mabbott, Neil A., Piccardo, Pedro, Cheeseman, Michael T., Burdon, Tom and Hume, David A. (2018). Pleiotropic impacts of macrophage and microglial deficiency on development in rats with targeted mutation of the Csf1r locus. Journal of Immunology, 201 (9), 2683-2699. doi: 10.4049/jimmunol.1701783

Brown, S. M., Bush, S. J., Summers, K. M., Hume, D. A. and Lawrence, A. B. (2018). Environmentally enriched pigs have transcriptional profiles consistent with neuroprotective effects and reduced microglial activity. Behavioural Brain Research, 350, 6-15. doi: 10.1016/j.bbr.2018.05.015

Bush, Stephen J., Freem, Lucy, MacCallum, Amanda J., O'Dell, Jenny, Wu, Chunlei, Afrasiabi, Cyrus, Psifidi, Androniki, Stevens, Mark P., Smith, Jacqueline, Summers, Kim M. and Hume, David A. (2018). Combination of novel and public RNA-seq datasets to generate an mRNA expression atlas for the domestic chicken. BMC Genomics, 19 (1) 594. doi: 10.1186/s12864-018-4972-7

Kaur, Simranpreet, Raggatt, Liza J., Millard, Susan M., Wu, Andy C., Batoon, Lena, Jacobsen, Rebecca N., Winkler, Ingrid G., MacDonald, Kelli P., Perkins, Andrew C., Hume, David A., Levesque, Jean-Pierre and Pettit, Allison R. (2018). Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment. Blood, 132 (7), 735-749. doi: 10.1182/blood-2018-01-829663

Pandit, Ramesh J., Hinsu, Ankit T., Patel, Namrata V., Koringa, Prakash G., Jakhesara, Subhash J., Thakkar, Jalpa R., Shah, Tejas M., Limon, Georgina, Psifidi, Androniki, Guitian, Javier, Hume, David A., Tomley, Fiona M., Rank, Dharamshibhai N., Raman, M., Tirumurugaan, K. G., Blake, Damer P. and Joshi, Chaitanya G. (2018). Microbial diversity and community composition of caecal microbiota in commercial and indigenous Indian chickens determined using 16s rDNA amplicon sequencing. Microbiome, 6 (1) 115. doi: 10.1186/s40168-018-0501-9

Lisowski, Z. M., Pirie, R. S., Blikslager, A. T., Lefebvre, D., Hume, D. A. and Hudson, N. P. H. (2018). An update on equine postoperative ileus: definitions, pathophysiology and management. Equine Veterinary Journal, 50 (3), 292-303. doi: 10.1111/evj.12801

Bush, Stephen J., Muriuki, Charity, McCulloch, Mary E. B., Farquhar, Iseabail L., Clark, Emily L. and Hume, David A. (2018). Cross-species inference of long non-coding RNAs greatly expands the ruminant transcriptome. Genetics Selection Evolution, 50 (1) 20. doi: 10.1186/s12711-018-0391-0

Jubb, Alasdair W., Hofer, Thomas P., Hume, David A. and Ziegler-Heitbrock, Loems (2018). The preterm labor associated ADAMTS2 gene is induced by glucocorticoids. American Journal of Obstetrics and Gynecology, 219 (1), 122-123. doi: 10.1016/j.ajog.2018.03.024

Sehgal, Anuj, Donaldson, David S., Pridans, Clare, Sauter, Kristin A., Hume, David A. and Mabbott, Neil A. (2018). The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche. Nature Communications, 9 (1) 1272, 1272. doi: 10.1038/s41467-018-03638-6

Hawley, Catherine A., Rojo, Rocio, Raper, Anna, Sauter, Kristin A., Lisowski, Zofia M., Grabert, Kathleen, Bain, Calum C., Davis, Gemma M., Louwe, Pieter A., Ostrowski, Michael C., Hume, David A., Pridans, Clare and Jenkins, Stephen J. (2018). Csf1r-mApple transgene expression and ligand binding in vivo reveal dynamics of CSF1R expression within the mononuclear phagocyte system. Journal of Immunology, 200 (6), 2209-2223. doi: 10.4049/jimmunol.1701488

Pridans, Clare, Sauter, Kristin A., Irvine, Katharine M., Davis, Gemma M., Lefevre, Lucas, Raper, Anna, Rojo, Rocio, Nirmal, Ajit J., Beard, Philippa, Cheeseman, Michael and Hume, David A. (2018). Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats. American Journal of Physiology - Gastrointestinal and Liver Physiology, 314 (3), G388-G398. doi: 10.1152/ajpgi.00343.2017

Baillie, J. Kenneth, Bretherick, Andrew, Haley, Christopher S., Clohisey, Sara, Gray, Alan, Neyton, Lucile P. A., Barrett, Jeffrey, Stahl, Eli A., Tenesa, Albert, Andersson, Robin, Brown, J. Ben, Faulkner, Geoffrey J., Lizio, Marina, Schaefer, Ulf, Daub, Carsten, Itoh, Masayoshi, Kondo, Naoto, Lassmann, Timo, Kawai, Jun, IIBDGC Consortium, Mole, Damian, Bajic, Vladimir B., Heutink, Peter, Rehli, Michael, Kawaji, Hideya, Sandelin, Albin, Suzuki, Harukazu, Satsangi, Jack, Wells, Christine A. ... Hume, David A. (2018). Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease. PL o S Computational Biology, 14 (3) e1005934, e1005934. doi: 10.1371/journal.pcbi.1005934

Regan, Tim, Gill, Andrew C., Clohisey, Sara M., Barnett, Mark W., Pariante, Carmine M., Harrison, Neil A., Hume, David A., Bullmore, Edward T. and Freeman, Tom C. (2018). Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophages. Journal of Leukocyte Biology, 103 (4), 681-692. doi: 10.1002/JLB.3A0617-261R

Young, Rachel, Bush, Stephen J., Lefevre, Lucas, McCulloch, Mary E.B., Lisowski, Zofia M., Muriuki, Charity, Waddell, Lindsey A., Sauter, Kristin A., Pridans, Clare, Clark, Emily L. and Hume, David A. (2018). Species-specific transcriptional regulation of genes involved in nitric oxide production and arginine metabolism in macrophages. ImmunoHorizons, 2 (1), 27-37. doi: 10.4049/immunohorizons.1700073

Jubb, Alasdair W., Boyle, Shelagh, Hume, David A. and Bickmore, Wendy A. (2017). Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci. Cell Reports, 21 (11), 3022-3031. doi: 10.1016/j.celrep.2017.11.053

Hume, David A., Wollscheid-Lengeling, Evi, Rojo, Rocio and Pridans, Clare (2017). The evolution of the macrophage-specific enhancer (Fms intronic regulatory element) within the CSF1R locus of vertebrates. Scientific Reports, 7 (1) 17115, 1-10. doi: 10.1038/s41598-017-15999-x

Farro, Giovanna, Stakenborg, Michelle, Gomez-Pinilla, Pedro J., Labeeuw, Evelien, Goverse, Gera, Giovangiulio, Martina Di, Stakenborg, Nathalie, Meroni, Elisa, D'Errico, Francesca, Elkrim, Yvon, Laoui, Damya, Lisowski, Zofia M., Sauter, Kristin A., Hume, David A., Van Ginderachter, Jo A., Boeckxstaens, Guy E. and Matteoli, Gianluca (2017). CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus. Gut, 66 (12), 2098-2109. doi: 10.1136/gutjnl-2016-313144

Hume, David and Sisto, Alessandro (2017). Groups with no coarse embeddings into hyperbolic groups. New York Journal of Mathematics, 23, 1657-1670. doi: 10.48550/arXiv.1702.03789

Batoon, Lena, Millard, Susan Marie, Wullschleger, Martin Eduar, Preda, Corina, Wu, Andy Chiu-Ku, Kaur, Simranpreet, Tseng, Hsu-Wen, Hume, David Arthur, Levesque, Jean-Pierre, Raggatt, Liza Jane and Pettit, Allison Robyn (2017). CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair. Biomaterials, 196, 51-66. doi: 10.1016/j.biomaterials.2017.10.033

Macdonald, Sarah E., Nolan, Matthew J., Harman, Kimberley, Boulton, Kay, Hume, David A., Tomley, Fiona M., Stabler, Richard A. and Blake, Damer P. (2017). Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology. PLoS ONE, 12 (9) e0184890, 1-17. doi: 10.1371/journal.pone.0184890

Clark, Emily L., Bush, Stephen J., McCulloch, Mary E. B., Farquhar, Iseabail L., Young, Rachel, Lefevre, Lucas, Pridans, Clare, Tsang, Hiu, Wu, Chunlei, Afrasiabi, Cyrus, Watson, Mick, Whitelaw, C. Bruce, Freeman, Tom C., Summers, Kim M., Archibald, Alan L. and Hume, David A. (2017). A high resolution atlas of gene expression in the domestic sheep (Ovis aries). PLoS Genetics, 13 (9) e1006997, e1006997. doi: 10.1371/journal.pgen.1006997

Banos, G., Bramis, G., Bush, S. J., Clark, E. L., McCulloch, M. E. B., Smith, J., Schulze, G., Arsenos, G., Hume, D. A. and Psifidi, A. (2017). The genomic architecture of mastitis resistance in dairy sheep. BMC Genomics, 18 (1) 624, 1-18. doi: 10.1186/s12864-017-3982-1

Bell, J. A., Kivimäki, M., Bullmore, E. T., Steptoe, A., Carvalho, L. A., Vértes, Petra E., Cardinal, Rudolf, Richardson, Sylvia, Leday, Gwenael, Freeman, Tom, Hume, David, Regan, Tim, Wu, Zhaozong, Pariante, Carmine, Cattaneo, Annamaria, Zuszain, Patricia, Borsini, Alessandra, Stewart, Robert, Chandran, David, Souza-Teodoro, Luis Henrique, Perry, Hugh, Harrison, Neil, Janssen, Wayne Drevets, Wittenberg, Gayle M., Sun, Yu, Jones, Declan, Bullmore, Edward, Khan, Shahid, Stylianou, Annie and Henderson, Robert B. (2017). Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults. Translational Psychiatry, 7 (8) e1208, e1208-e1208. doi: 10.1038/tp.2017.155

Noguchi, Shuhei, Arakawa, Takahiro, Fukuda, Shiro, Furuno, Masaaki, Hasegawa, Akira, Hori, Fumi, Ishikawa-Kato, Sachi, Kaida, Kaoru, Kaiho, Ai, Kanamori-Katayama, Mutsumi, Kawashima, Tsugumi, Kojima, Miki, Kubosaki, Atsutaka, Manabe, Ri-ichiroh, Murata, Mitsuyoshi, Nagao-Sato, Sayaka, Nakazato, Kenichi, Ninomiya, Noriko, Nishiyori-Sueki, Hiromi, Noma, Shohei, Saijyo, Eri, Saka, Akiko, Sakai, Mizuho, Simon, Christophe, Suzuki, Naoko, Tagami, Michihira, Watanabe, Shoko, Yoshida, Shigehiro, Arner, Peter ... Hayashizaki, Yoshihide (2017). FANTOM5 CAGE profiles of human and mouse samples. Scientific Data, 4 (1) 170112, 170112. doi: 10.1038/sdata.2017.112

Rojo, Rocio, Pridans, Clare, Langlais, David and Hume, David A. (2017). Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus. Clinical Science, 131 (16), 2161-2182. doi: 10.1042/CS20170238

Summers, Kim M. and Hume, David A. (2017). Identification of the macrophage-specific promoter signature in FANTOM5 mouse embryo developmental time course data. Journal of Leukocyte Biology, 102 (4), 1081-1092. doi: 10.1189/jlb.1A0417-150RR

Bush, Stephen J., McCulloch, Mary E.B., Summers, Kim M., Hume, David A. and Clark, Emily L. (2017). Integration of quantitated expression estimates from polyA-selected and rRNA-depleted RNA-seq libraries. BMC Bioinformatics, 18 (1) 301, 1-12. doi: 10.1186/s12859-017-1714-9

Kwok, Janice, O'Shea, Marie, Hume, David A. and Lengeling, Andreas (2017). Jmjd6, a JmjC dioxygenase with many interaction partners and pleiotropic functions. Frontiers in Genetics, 8 (MAR) 32. doi: 10.3389/fgene.2017.00032

Baillie, J. Kenneth, Arner, Erik, Daub, Carsten, De Hoon, Michiel, Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Carninci, Piero, Forrest, Alistair R. R., Hayashizaki, Yoshihide, Faulkner, Geoffrey J., Wells, Christine A., Rehli, Michael, Pavli, Paul, Summers, Kim M., Hume, David A. and FANTOM Consortium (2017). Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease. PLoS Genetics, 13 (3) e1006641, 1-36. doi: 10.1371/journal.pgen.1006641

Hume, David (2017). A continuum of expanders. Fundamenta Mathematicae, 238 (2), 143-152. doi: 10.4064/fm101-11-2016

Hume, David (2017). Embedding mapping class groups into a finite product of trees. Groups, Geometry, and Dynamics, 11 (2), 613-647. doi: 10.4171/GGD/410

Arzhantseva, Goulnara N., Cashen, Christopher H., Gruber, Dominik and Hume, David (2017). Characterizations of Morse quasi-geodesics via superlinear divergence and sublinear contraction. Documenta Mathematica, 22 (2017), 1193-1224. doi: 10.25537/dm.2017v22.1193-1224

Cordes, Matthew and Hume, David (2017). Stability and the Morse boundary:. Journal of the London Mathematical Society, 95 (3), 963-988. doi: 10.1112/jlms.12042

Stevens, Mark, Vervelde, Lonneke and Hume, David (2016). Professor Pete Kaiser 1964-2016. Avian Pathology, 45 (6), 683-684. doi: 10.1080/03079457.2016.1251745

Psifidi, Androniki, Banos, Georgios, Matika, Oswald, Desta, Takele T., Bettridge, Judy, Hume, David A., Dessie, Tadelle, Christley, Rob, Wigley, Paul, Hanotte, Olivier and Kaiser, Pete (2016). Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes. Genetics Selection Evolution, 48 (1) 74. doi: 10.1186/s12711-016-0252-7

Pridans, Clare, Davis, Gemma M., Sauter, Kristin A., Lisowski, Zofia M., Corripio-Miyar, Yolanda, Raper, Anna, Lefevre, Lucas, Young, Rachel, McCulloch, Mary E., Lillico, Simon, Milne, Elspeth, Whitelaw, Bruce and Hume, David A. (2016). A Csf1r-EGFP transgene provides a novel marker for monocyte subsets in sheep. Journal of Immunology, 197 (6), 2297-2305. doi: 10.4049/jimmunol.1502336

Sauter, Kristin A., Waddell, Lindsey A., Lisowski, Zofia M., Young, Rachel, Lefevre, Lucas, Davis, Gemma M., Clohisey, Sara M., McCulloch, Mary, Magowan, Elizabeth, Mabbott, Neil A., Summers, Kim M. and Hume, David A. (2016). Macrophage colony-stimulating factor (CSF1) controls monocyte production and maturation and the steady-state size of the liver in pigs. American Journal of Physiology - Gastrointestinal and Liver Physiology, 311 (3), G533-G547. doi: 10.1152/ajpgi.00116.2016

Alexander, Kylie Anne, Raggatt, Liza-Jane, Millard, Susan, Batoon, Lena, Wu, Andy Chiu-Ku, Chang, Ming-Kang, Hume, David Arthur and Pettit, Allison Robyn (2016). Resting and injury-induced inflamed periosteum contain multiple macrophage subsets that are located at sites of bone growth and regeneration. Immunology and Cell Biology, 95 (1), 7-16. doi: 10.1038/icb.2016.74

Kaur, Simranpreet, Raggatt, Liza Jane, Batoon, Lena, Hume, David Arthur, Levesque, Jean-Pierre and Pettit, Allison Robyn (2016). Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches. Seminars in Cell and Developmental Biology, 61, 12-21. doi: 10.1016/j.semcdb.2016.08.009

Karagianni, A. E., Kapetanovic, R., Summers, K. M., Mcgorum, B. C., Hume, D. A. and Pirie, R. S. (2016). Comparative transcriptome analysis of equine alveolar macrophages. Equine Veterinary Journal, 49 (3), 375-382. doi: 10.1111/evj.12584

Hu, Tuanjun, Wu, Zhiguang, Vervelde, Lonneke, Rothwell, Lisa, Hume, David A. and Kaiser, Pete (2016). Functional annotation of the T-cell immunoglobulin mucin family in birds. Immunology, 148 (3), 287-303. doi: 10.1111/imm.12607

Hume, David A., Summers, Kim M. and Rehli, Michael (2016). Transcriptional regulation and macrophage differentiation. Microbiology Spectrum, 4 (3) MCHD-0024-2015, 1-19. doi: 10.1128/microbiolspec.MCHD-0024-2015

Vitak, Nazarii, Hume, David A., Chappell, Keith J., Sester, David P. and Stacey, Katryn J. (2016). Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages. Developmental and Comparative Immunology, 59, 145-152. doi: 10.1016/j.dci.2016.01.023

Wu, Zhiguang, Hu, Tuanjun, Rothwell, Lisa, Vervelde, Lonneke, Kaiser, Pete, Boulton, Kay, Nolan, Matthew J., Tomley, Fiona M., Blake, Damer P. and Hume, David A. (2016). Analysis of the function of IL-10 in chickens using specific neutralising antibodies and a sensitive capture ELISA. Developmental and Comparative Immunology, 63, 206-212. doi: 10.1016/j.dci.2016.04.016

Jubb, Alasdair W., Young, Robert S., Hume, David A. and Bickmore, Wendy A. (2016). Enhancer turnover is associated with a divergent transcriptional response to glucocorticoid in mouse and human macrophages. Journal of Immunology, 196 (2), 813-822. doi: 10.4049/jimmunol.1502009

Psifidi, A., Fife, M., Howell, J., Matika, O., van Diemen, P. M., Kuo, R., Smith, J., Hocking, P. M., Salmon, N., Jones, M. A., Hume, D. A., Banos, G., Stevens, M. P. and Kaiser, P. (2016). The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens. BMC Genomics, 17 (293) 293. doi: 10.1186/s12864-016-2612-7

Stutchfield, Benjamin M., Antoine, Daniel J., Mackinnon, Alison C., Gow, Deborah J., Bain, Calum C., Hawley, Catherine A., Hughes, Michael J., Francis, Benjamin, Wojtacha, Davina, Man, Tak Y., Dear, James W., Devey, Luke R., Mowat, Alan M., Pollard, Jeffrey W., Park, B. Kevin, Jenkins, Stephen J., Simpson, Kenneth J., Hume, David A., Wigmore, Stephen J. and Forbes, Stuart J. (2015). CSF1 restores innate immunity after liver injury in mice and serum levels indicate outcomes of patients with acute liver failure. Gastroenterology, 149 (7), 1896-1909. doi: 10.1053/j.gastro.2015.08.053

Robert, Christelle, Kapetanovic, Ronan, Beraldi, Dario, Watson, Mick, Archibald, Alan L. and Hume, David A. (2015). Identification and annotation of conserved promoters and macrophage-expressed genes in the pig genome. BMC Genomics, 16 (1) 970, 970.1-970.17. doi: 10.1186/s12864-015-2111-2

Modhiran, Naphak, Watterson, Daniel, Muller, David A., Panetta, Adele K., Sester, David P., Liu, Lidong, Hume, David A., Stacey, Katryn J. and Young, Paul R. (2015). Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity. Science Translational Medicine, 7 (304) 304ra142, 1-10. doi: 10.1126/scitranslmed.aaa3863

Hume, David A. (2015). The many alternative faces of macrophage activation. Frontiers in Immunology, 6 (JUL) 370. doi: 10.3389/fimmu.2015.00370

Rodero, Mathieu P., Poupel, Lucie, Loyher, Pierre-Louis, Hamon, Pauline, Licata, Fabrice, Pessel, Charlotte, Hume, David A., Combadière, Christophe and Boissonnas, Alexandre (2015). Immune surveillance of the lung by migrating tissue monocytes. eLife, 4 (JULY 2015) e07847, 1-23. doi: 10.7554/eLife.07847

Hume, David (2015). Direct embeddings of relatively hyperbolic groups with optimal ℓp compression exponent. Journal fur die Reine und Angewandte Mathematik, 2015 (703), 147-172. doi: 10.1515/crelle-2013-0040

Hume, David (2015). Plant breeding: UK bioscientists push for crop policy. Nature, 521 (7553), 423-423. doi: 10.1038/521423c

Aitken, Stuart, Magi, Shigeyuki, Alhendi, Ahmad M. N., Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Daub, Carsten O., Arner, Erik, Carninci, Piero, Forrest, Alistair R. R., Hayashizaki, Yoshihide, Khachigian, Levon M., Okada-Hatakeyama, Mariko, Semple, Colin A., FANTOM Consortium, Forrest, Alistair R. R., Sandelin, Albin, Daub, Carsten O., Wells, Christine, Hume, David A., Arner, Erik, Kawaji, Hideya, Summers, Kim M., Vitting-Seerup, Kristoffer, Carninci, Piero, Andersson, Robin, Hayashizaki, Yoshihide and Yumoto, Noriko (2015). Transcriptional dynamics reveal critical roles for non-coding RNAs in the immediate-early response. PLoS Computational Biology, 11 (4) e1004217, e1004217. doi: 10.1371/journal.pcbi.1004217

Joshi, Anagha, Pooley, Christopher, Freeman, Tom C., Lennartsson, Andreas, Babina, Magda, Schmidl, Christian, Geijtenbeek, Teunis, Michoel, Tom, Severin, Jessica, Itoh, Masayoshi, Lassmann, Timo, Kawaji, Hideya, Hayashizaki, Yoshihide, Carninci, Piero, Forrest, Alistair R. R., Rehli, Michael and Hume, David A. (2015). Technical advance: Transcription factor, promoter, and enhancer utilization in human myeloid cells. Journal of Leukocyte Biology, 97 (5), 985-995. doi: 10.1189/jlb.6TA1014-477RR

Ford, Catriona A., Petrova, Sofia, Pound, John D., Voss, Jorine J.L.P., Melville, Lynsey, Paterson, Margaret, Farnworth, Sarah L., Gallimore, Awen M., Cuff, Simone, Wheadon, Helen, Dobbin, Edwina, Ogden, Carol Anne, Dumitriu, Ingrid E., Dunbar, Donald R., Murray, Paul G., Ruckerl, Dominik, Allen, Judith E., Hume, David A., Van Rooijen, Nico, Goodlad, John R., Freeman, Tom C. and Gregory, Christopher D. (2015). Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Current Biology, 25 (5), 577-588. doi: 10.1016/j.cub.2014.12.059

Garceau, Valerie, Balic, Adam, Garcia-Morales, Carla, Sauter, Kristin A., McGrew, Mike J., Smith, Jacqueline, Vervelde, Lonneke, Sherman, Adrian, Fuller, Troy E., Oliphant, Theodore, Shelley, John A., Tiwari, Raksha, Wilson, Thomas L., Chintoan-Uta, Cosmin, Burt, Dave W., Stevens, Mark P., Sang, Helen M. and Hume, David A. (2015). The development and maintenance of the mononuclear phagocyte system of the chick is controlled by signals from the macrophage colony-stimulating factor receptor. BMC Biology, 13 (1) 12, 12.1-12.17. doi: 10.1186/s12915-015-0121-9

Schultze, Joachim L., Freeman, Tom, Hume, David A. and Latz, Eicke (2015). A transcriptional perspective on human macrophage biology. Seminars in Immunology, 27 (1), 44-50. doi: 10.1016/j.smim.2015.02.001

Caprace, Pierre-Emmanuel and Hume, David (2015). Orthogonal forms of Kac-moody groups are acylindrically hyperbolic. Annales de l'Institut Fourier, 65 (6), 2613-2640. doi: 10.5802/aif.2998

Garcia-Morales, Carla, Nandi, Sunil, Zhao, Debiao, Sauter, Kristin A., Vervelde, Lonneke, McBride, Derek, Sang, Helen M., Clinton, Mike and Hume, David A. (2015). Cell-autonomous sex differences in gene expression in chicken bone marrow-derived macrophages. Journal of Immunology, 194 (5), 2338-2344. doi: 10.4049/jimmunol.1401982

Nanjiani, Ian, Hume, David, Fitzpatrick, Julie and Murray, John (2015). 'Recognised veterinary practice' in the context of clinical field trials. Veterinary Record, 176 (21), 552-552. doi: 10.1136/vr.h2718

Warr, Amanda, Robert, Christelle, Hume, David, Archibald, Alan, Deeb, Nader and Watson, Mick (2015). Exome sequencing: current and future perspectives. G3: Genes, Genomes, Genetics, 5 (8), 1543-1550. doi: 10.1534/g3.115.018564

Schmid, Michael, Smith, Jacqueline, Burt, David W., Aken, Bronwen L., Antin, Parker B., Archibald, Alan L., Ashwell, Chris, Blackshear, Perry J., Boschiero, Clarissa, Brown, C. Titus, Burgess, Shane C., Cheng, Hans H., Chow, William, Coble, Derrick J., Cooksey, Amanda, Crooijmans, Richard P. M. A., Damas, Joana, Davis, Richard V.N., De Koning, Dirk-Jan, Delany, Mary E., Derrien, Thomas, Desta, Takele T., Dunn, Ian C., Dunn, Matthew, Ellegren, Hans, Eöry, Lél, Erb, Ionas, Farré, Marta, Fasold, Mario ... Zhou, Huaijun (2015). Third Report on Chicken Genes and Chromosomes 2015:. Cytogenetic and Genome Research, 145 (2), 78-179. doi: 10.1159/000430927

Warr, Amanda, Robert, Christelle, Hume, David, Archibald, Alan L., Deeb, Nader and Watson, Mick (2015). Identification of low-confidence regions in the pig reference genome (Sscrofa10.2). Frontiers in Genetics, 6 (NOV) 338. doi: 10.3389/fgene.2015.00338

Gow, Deborah J, Sauter, Kristin A., Pridans, Clare, Moffat, Lindsey, Sehgal, Anuj, Stutchfield, Ben M., Raza, Sobia, Beard, Philippa M., Tsai, Yi Ting, Bainbridge, Graeme, Boner, Pamela L., Fici, Greg, Garcia-Tapia, David, Martin, Roger A., Oliphant, Theodore, Shelly, John A., Tiwari, Raksha, Wilson, Thomas L., Smith, Lee B., Mabbott, Neil A. and Hume, David A. (2014). Characterisation of a novel fc conjugate of macrophage colony-stimulating factor. Molecular Therapy, 22 (9), 1580-1592. doi: 10.1038/mt.2014.112

Hume, David A. and Freeman, Tom C. (2014). Transcriptomic analysis of mononuclear phagocyte differentiation and activation. Immunological Reviews, 262 (1), 74-84. doi: 10.1111/imr.12211

Moffat, L., Rothwell, L., Garcia-Morales, C., Sauter, K. A., Kapetanovic, R., Gow, D. J. and Hume, D. A. (2014). Development and characterisation of monoclonal antibodies reactive with porcine CSF1R (CD115). Developmental and Comparative Immunology, 47 (1), 123-128. doi: 10.1016/j.dci.2014.07.001

Garcia-Morales, Carla, Rothwell, Lisa, Moffat, Lindsey, Garceau, Valerie, Balic, Adam, Sang, Helen M., Kaiser, Pete and Hume, David A. (2014). Production and characterisation of a monoclonal antibody that recognises the chicken CSF1 receptor and confirms that expression is restricted to macrophage-lineage cells. Developmental and Comparative Immunology, 42 (2), 278-285. doi: 10.1016/j.dci.2013.09.011

Sauter, Kristin A., Pridans, Clare, Sehgal, Anuj, Bain, Calum C., Scott, Charlotte, Moffat, Lindsey, Rojo, Rocío, Stutchfield, Ben M., Davies, Claire L., Donaldson, David S., Renault, Kathleen, McColl, Barry W., Mowat, Alan M., Serrels, Alan, Frame, Margaret C., Mabbott, Neil A. and Hume, David A. (2014). The MacBlue Binary Transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration. PLoS ONE, 9 (8) e105429, 1-12. doi: 10.1371/journal.pone.0105429

Raza, Sobia, Barnett, Mark W., Barnett-Itzhaki, Zohar, Amit, Ido, Hume, David A. and Freeman, Tom C. (2014). Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators. Journal of Leukocyte Biology, 96 (2), 167-183. doi: 10.1189/jlb.6HI0313-169R

Sauter, Kristin A., Pridans, Clare, Sehgal, Anuj, Tsai, Yi Ting, Bradford, Barry M., Raza, Sobia, Moffat, Lindsey, Gow, Deborah J., Beard, Philippa M., Mabbott, Neil A., Smith, Lee B. and Hume, David A. (2014). Pleiotropic effects of extended blockade of CSF1R signaling in adult mice. Journal of Leukocyte Biology, 96 (2), 265-274. doi: 10.1189/jlb.2A0114-006R

Robert, Christelle, Fuentes-Utrilla, Pablo, Troup, Karen, Loecherbach, Julia, Turner, Frances, Talbot, Richard, Archibald, Alan L., Mileham, Alan, Deeb, Nader, Hume, David A. and Watson, Mick (2014). Design and development of exome capture sequencing for the domestic pig (Sus scrofa). BMC Genomics, 15 (1) 550. doi: 10.1186/1471-2164-15-550

Mooney, Jane E., Summers, Kim M., Gongora, Milena, Grimmond, Sean M., Campbell, Julie H., Hume, David A. and Rolfe, Barbara E. (2014). Transcriptional switching in macrophages associated with the peritoneal foreign body response. Immunology and Cell Biology, 92 (6), 518-526. doi: 10.1038/icb.2014.19

Hall, David P., MacCormick, Ian J. C., Phythian-Adams, Alex T., Rzechorzek, Nina M., Hope-Jones, David, Cosens, Sorrel, Jackson, Stewart, Bates, Matthew G. D., Collier, David J., Hume, David A., Freeman, Thomas, Thompson, A. A. Roger and Baillie, John Kenneth (2014). Network analysis reveals distinct clinical syndromes underlying acute mountain sickness. PLoS ONE, 9 (1) e81229, e81229. doi: 10.1371/journal.pone.0081229

Pridans, Clare, Lillico, Simon, Whitelaw, Bruce and Hume, David A. (2014). Lentiviral vectors containing mouse Csf1r control elements direct macrophage-restricted expression in multiple species of birds and mammals. Molecular Therapy - Methods and Clinical Development, 1 14010, 14010. doi: 10.1038/mtm.2014.10

Balic, Adam, Garcia-Morales, Carla, Vervelde, Lonneke, Gilhooley, Hazel, Sherman, Adrian, Garceau, Valerie, Gutowska, Maria W., Burt, David W., Kaiser, Pete, Hume, David A. and Sang, Helen M. (2014). Visualisation of chicken macrophages using transgenic reporter genes: insights into the development of the avian macrophage lineage. Development, 141 (16), 3255-3265. doi: 10.1242/dev.105593

Jenkins, Stephen J. and Hume, David A. (2014). Homeostasis in the mononuclear phagocyte system. Trends in Immunology, 35 (8), 358-367. doi: 10.1016/j.it.2014.06.006

Pridans, Clare, Sauter, Kristin A., Baer, Kristin, Kissel, Holger and Hume, David A. (2013). CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function. Scientific Reports, 3 (1) 3013. doi: 10.1038/srep03013

Jenkins, Stephen J., Ruckerl, Dominik, Thomas, Graham D., Hewitson, James P., Duncan, Sheelagh, Brombacher, Frank, Maizels, Rick M., Hume, David A. and Allen, Judith E. (2013). IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1. Journal of Experimental Medicine, 210 (11), 2477-2491. doi: 10.1084/jem.20121999

Karagianni, Anna E., Kapetanovic, Ronan, McGorum, Bruce C., Hume, David A. and Pirie, Scott R. (2013). The equine alveolar macrophage: functional and phenotypic comparisons with peritoneal macrophages. Veterinary Immunology And Immunopathology, 155 (4), 219-228. doi: 10.1016/j.vetimm.2013.07.003

Mabbott, Neil A., Baillie, J. K., Brown, Helen, Freeman, Tom C. and Hume, David A. (2013). An expression atlas of human primary cells: inference of gene function from coexpression networks. BMC Genomics, 14 (1) 632. doi: 10.1186/1471-2164-14-632

Hume, David and Sisto, Alessandro (2013). Embedding universal covers of graph manifolds in products of trees. Proceedings of the American Mathematical Society, 141 (10), 3337-3340. doi: 10.1090/S0002-9939-2013-11669-2

Kapetanovic, Ronan, Fairbairn, Lynsey, Downing, Alison, Beraldi, Dario, Sester, David P., Freeman, Tom C., Tuggle, Christopher K., Archibald, Alan L. and Hume, David A. (2013). The impact of breed and tissue compartment on the response of pig macrophages to lipopolysaccharide. Bmc Genomics, 14 (1) 581. doi: 10.1186/1471-2164-14-581

Jacquelin, Sébastien, Licata, Fabrice, Dorgham, Karim, Hermand, Patricia, Poupel, Lucie, Guyon, Elodie, Deterre, Philippe, Hume, David A., Combadière, Christophe and Boissonnas, Alexandre (2013). CX3CR1 reduces Ly6Chigh-monocyte motility within and release from the bone marrow after chemotherapy in mice. Blood, 122 (5), 674-683. doi: 10.1182/blood-2013-01-480749

Doig, Tamasin N., Hume, David A., Theocharidis, Thanasis, Goodlad, John R., Gregory, Christopher D. and Freeman, Tom C. (2013). Coexpression analysis of large cancer datasets provides insight into the cellular phenotypes of the tumour microenvironment. BMC Genomics, 14 (1) 469. doi: 10.1186/1471-2164-14-469

Fairbairn, Lynsey, Kapetanovic, Ronan, Beraldi, Dario, Sester, David P., Tuggle, Chris K., Archibald, Alan L. and Hume, David A. (2013). Comparative analysis of monocyte subsets in the pig. Journal of Immunology, 190 (12), 6389-6396. doi: 10.4049/jimmunol.1300365

Shakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013). Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 (35), 25362-25374. doi: 10.1074/jbc.M113.496281

Dave, Richa K., Dinger, Marcel E., Andrew, Megan, Askarian-Amiri, Marjan, Hume, David A. and Kellie, Stuart (2013). Regulated expression of PTPRJ/CD148 and an antisense long noncoding RNA in macrophages by proinflammatory stimuli. PLoS One, 8 (6) e68306, e68306.1-e68306.13. doi: 10.1371/journal.pone.0068306

Yona, Simon, Kim, Ki-Wook, Wolf, Yochai, Mildner, Alexander, Varol, Diana, Breker, Michal, Strauss-Ayali, Dalit, Viukov, Sergey, Guilliams, Martin, Misharin, Alexander, Hume, DavidA., Perlman, Harris, Malissen, Bernard, Zelzer, Elazar and Jung, Steffen (2013). Erratum: Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis [Immunity 38 (2013) 79-91]. Immunity, 38 (5), 1073-1079. doi: 10.1016/j.immuni.2013.05.008

Dawson, Harry D., Loveland, Jane E., Pascal, Geraldine, Gilbert, James G. R., Uenishi, Hirohide, Mann, Katherine M., Sang, Yongming, Zhang, Jie, Carvalho-Silva, Denise, Hunt, Toby, Hardy, Matthew, Hu, Zhiliang, Zhao, Shu-Hong, Anselmo, Anna, Shinkai, Hiroki, Chen, Celine, Badaoui, Bouabid, Berman, Daniel, Amid, Clara, Kay, Mike, Lloyd, David, Snow, Catherine, Morozumi, T., Cheng, Ryan Pei-Yen, Bystrom, Megan, Kapetanovic, Ronan, Schwartz, John C., Kataria, Ranjit, Astley, Matthew ... Tuggle, Christopher K. (2013). Structural and functional annotation of the porcine immunome. BMC Genomics, 14 (1) 332, 332.1-332.16. doi: 10.1186/1471-2164-14-332

Hume, David A., Mabbott, Neil, Raza, Sobia and Freeman, Tom C. (2013). Can DCs be distinguished from macrophages by molecular signatures?. Nature Immunology, 14 (3), 187-189. doi: 10.1038/ni.2516

Gow, Deborah J., Garceau, Valerie, Pridans, Clare, Gow, Adam G., Simpson, Kerry E., Gunn-Moore, Danielle and Hume, David A. (2013). Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). Cytokine, 61 (2), 630-638. doi: 10.1016/j.cyto.2012.11.014

Yona, Simon, Kim, Ki-Wook, Wolf, Yochai, Mildner, Alexander, Varol, Diana, Breker, Michal, Strauss-Ayali, Dalit, Viukov, Sergey, Guilliams, Martin, Misharin, Alexander, Hume, David A., Perlman, Harris, Malissen, Bernard, Zelzer, Elazar and Jung, Steffen (2013). Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity, 38 (1), 79-91. doi: 10.1016/j.immuni.2012.12.001

Sauter, Kristin A., Bouhlel, M. Amine, O'Neal, Julie, Sester, David P., Tagoh, Hiromi, Ingram, Richard M. I, Pridans, Clare, Bonifer, Constanze and Hume, David A. (2013). The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus. PLoS One, 8 (1) e54935, e54935. doi: 10.1371/journal.pone.0054935

Gow, Deborah J., Garceau, Valerie, Kapetanovic, Ronan, Sester, David P., Fici, Greg J., Shelly, John A., Wilson, Thomas L. and Hume, David A. (2012). Cloning and expression of porcine Colony Stimulating Factor-1 (CSF-1) and Colony Stimulating Factor-1 Receptor (CSF-1R) and analysis of the species specificity of stimulation by CSF-1 and Interleukin 34. Cytokine, 60 (3), 793-805. doi: 10.1016/j.cyto.2012.08.008

Freeman, Tom C., Ivens, Alasdair, Baillie, J. Kenneth, Beraldi, Dario, Barnett, Mark W., Dorward, David, Downing, Alison, Fairbairn, Lynsey, Kapetanovic, Ronan, Raza, Sobia, Tomoiu, Andru, Alberio, Ramiro, Wu, Chunlei, Su, Andrew I., Summers, Kim M., Tuggle, Christopher K., Archibald, Alan L. and Hume, David A. (2012). A gene expression atlas of the domestic pig. BMC Biology, 10 (9) 90. doi: 10.1186/1741-7007-10-90

Ahanda, Marie-Laure Endale, Fritz, Eric R., Estelle, Jordi, Hu, Zhi-Liang, Madsen, Ole, Groenen, Martien A. M., Beraldi, Dario, Kapetanovic, Ronan, Hume, David A., Rowland, Robert R. R., Lunney, Joan K., Rogel-Gaillard, Claire, Reecy, James M. and Giuffra, Elisabetta (2012). Prediction of altered 3 '-UTR miRNA-binding sites from RNA-seq data: the swine leukocyte antigen complex (SLA) as a model region. Plos One, 7 (11), e48607.1-e48607.11. doi: 10.1371/journal.pone.0048607

Hume, David A. (2012). Plenary perspective: the complexity of constitutive and inducible gene expression in mononuclear phagocytes. Journal of Leukocyte Biology, 92 (3), 433-444. doi: 10.1189/jlb.0312166

Schroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A. and Sweet, Matthew J. (2012). Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the USA, 109 (16), E944-E953. doi: 10.1073/pnas.1110156109

Kapetanovic, Ronan, Fairbairn, Lynsey, Beraldi, Dario, Sester, David P., Archibald, Alan L., Tuggle, Christopher K. and Hume, David A. (2012). Pig bone marrow-derived macrophages resemble human macrophages in their response to bacterial lipopolysaccharide. The Journal of Immunology, 188 (7), 3382-3394. doi: 10.4049/jimmunol.1102649

Hume, David A. and MacDonald, Kelli P. A. (2012). Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. Blood, 119 (8), 1810-1820. doi: 10.1182/blood-2011-09-379214

Bradford, Barry M., Sester, David P., Hume, David A. and Mabbott, Neil A. (2011). Defining the anatomical localisation of subsets of the murine mononuclear phagocyte system using integrin alpha X (Itgax, CD11c) and colony stimulating factor 1 receptor (Csf1r, CD115) expression fails to discriminate dendritic cells from macrophages. Immunobiology, 216 (11), 1228-1237. doi: 10.1016/j.imbio.2011.08.006

Hume, David A. (2011). Editorial. Immunobiology, 216 (11), 1163-1. doi: 10.1016/j.imbio.2011.08.010

Robert, Christelle, Lu, Xiang, Law, Andrew, Freeman, Tom C. and Hume, David A. (2011). Macrophages.com: an on-line community resource for innate immunity research. Immunobiology, 216 (11), 1203-1211. doi: 10.1016/j.imbio.2011.07.025

Baillie, J. Kenneth, Barnett, Mark W., Upton, Kyle R., Gerhardt, Daniel J., Richmond, Todd A., De Sapio, Fioravante, Brennan. Paul M., Rizzu, Patrizia, Smith, Sarah, Fell, Mark, Talbot, Richard T., Gustincich, Stefano, Freeman, Thomas C., Mattick, John S., Hume, David A., Heutink, Peter, Carninci, Piero, Jeddeloh, Jeffrey A. and Faulkner, Geoffrey J. (2011). Somatic retrotransposition alters the genetic landscape of the human brain. Nature, 479 (7374), 534-537. doi: 10.1038/nature10531

Alikhan, Maliha A., Jones, Christina V., Williams, Timothy M., Beckhouse, Anthony G., Fletcher , Anne L., Kett, Michelle M., Sakkal, Samy, Samuel, Chrishan S., Ramsay, Robert G., Deane, James A., Wells, Christine A., Little, Melissa H., Hume, David A. and Ricardo, Sharon D. (2011). Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses. The American Journal of Pathology, 179 (3), 1243-1256. doi: 10.1016/j.ajpath.2011.05.037

Alexander, Kylie A., Chang, Ming K., Maylin, Erin R., Kohler, Thomas, Meuller, Ralph, Wu, Andy C., van Rooijen, Nico, Sweet, Matthew J ., Hume, David A., Raggatt, Liza J. and Pettit, Allison R. (2011). Osteal tissue macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model. Journal of Bone And Mineral Research, 26 (7), 1517-1532. doi: 10.1002/jbmr.354

Fairbairn, Lynsey, Kapetanovic, Ronan, Sester, David P. and Hume, David A. (2011). The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease. Journal of Leukocyte Biology, 89 (6), 855-871. doi: 10.1189/jlb.1110607

Thomas, James A., Pope, Caroline, Wojtacha, Davina, Robson, Andrew J., Gordon-Walker, Timothy T., Hartland, Stephen, Ramachandran, Prakash, Van Deemter, Marielle, Hume, David A., Iredale, John P. and Forbes, Stuart J. (2011). Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function. Hepatology, 53 (6), 2003-2015. doi: 10.1002/hep.24315

Hume, David A. (2011). Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity. Journal of Leukocyte Biology, 89 (4), 525-538. doi: 10.1189/jlb.0810472

Roberts, Tara L., Dunn, Jasmyn A., Sweet, Matthew J., Hume, David A. and Stacey, Katryn J. (2011). The immunostimulatory activity of phosphorothioate CpG oligonucleotides is affected by distal sequence changes. Molecular Immunology, 48 (8), 1027-1034. doi: 10.1016/j.molimm.2011.01.011

Hume, D. A., Whitelaw, C. B. A. and Archibald, A. L. (2011). The future of animal production: improving productivity and sustainability. Journal of Agricultural Science, 149 (S1), 9-16. doi: 10.1017/S0021859610001188

Van Zuylen, Wendy J., Garceau, Valerie, Idris, Adi, Schroder, Kate, Irvine, Katharine M., Lattin, Jane E., Ovchinnikov, Dmitry A., Perkins, Andrew C., Cook, Andrew D., Hamilton, John A., Hertzog, Paul J., Stacey, Katryn J., Kellie, Stuart, Hume, David A. and Sweet, Matthew J. (2011). Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis. PLoS One, 6 (1) e15723, e15723-1-e15723-13. doi: 10.1371/journal.pone.0015723

MacDonald, Kelli P. A., Palmer, James S., Cronau, Stephen, Seppanen, Elke Jane, Olver, Stuart, Raffelt, Neil C., Kuns, Rachel, Pettit, Allison R., Clouston, Andrew, Wainwright, Brandon J., Branstetter, Dan, Smith, Jeffrey, Paxton, Raymond J., Cerretti, Douglas Pat, Bonham, Lynn, Hill, Geoffrey R. and Hume, David A. (2010). An antibody against the colony-stimulating factor 1 receptor (CSF1R) depletes the resident subset of monocytes and tissue and tumor-associated macrophages but does not inhibit inflammation. Blood, 116 (19), 3955-3963. doi: 10.1182/blood-2010-02-266296

Summers, Kim M., Raza, Sobia, van Nimwegen, Erik, Freeman, Thomas C. and Hume, David A. (2010). Co-expression of FBN1 with mesenchyme-specific genes in mouse cell lines: implications for phenotypic variability in Marfan syndrome. European Journal of Human Genetics, 18 (11), 1209-1215. doi: 10.1038/ejhg.2010.91

Mabbott, Neil A., Baillie, J. Kenneth, Hume, David A. and Freeman, Tom C. (2010). Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations. Immunobiology, 215 (9-10), 724-736. doi: 10.1016/j.imbio.2010.05.012

Gow, Deborah J., Sester, David P. and Hume, David A. (2010). CSF-1, IGF-1, and the control of postnatal growth and development. Journal of Leukocyte Biology, 88 (3), 475-481. doi: 10.1189/jlb.0310158

Kubosaki, A, Lindgren, G, Tagami, M, Simon, C, Tomaru, Y, Miura, H, Suzuki, T, Arner, E, Forrest, ARR, Irvine, KM, Schroder, K, Hasegawa, Y, Kanamori-Katayama, M, Rehli, M, Hume, DA, Kawai, J, Suzuki, M, Suzuki, H and Hayashizaki, Y (2010). The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells. Molecular Immunology, 47 (14), 2295-2302. doi: 10.1016/j.molimm.2010.05.289

Hume, David A., Summers, Kim M., Raza, Sobia, Baillie, J. Kenneth and Freeman, Thomas C. (2010). Functional clustering and lineage markers: insights into cellular differentiation and gene function from large-scale microarray studies of purified primary cell populations. Genomics, 95 (6), 328-338. doi: 10.1016/j.ygeno.2010.03.002

Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. (2010). Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology, 87 (6), 1103-1114. doi: 10.1189/jlb.0509363

Ovchinnikov, Dmitry A., DeBats, Claire E. E., Sester, David P., Sweet, Matthew J. and Hume, David A. (2010). A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic mice. Journal of Leukocyte Biology, 87 (5), 815-822. doi: 10.1189/jlb.0809557

Garceau, Valerie, Smith, Jacqueline, Paton, Ian R., Davey, Megan, Fares, Mario A., Sester, David P., Burt, David W. and Hume, David A. (2010). Avian colony-stimulating factor 1 (CSF-1), interleukin-34 (IL-34), and CSF-1 receptor genes and gene products. Journal of Leukocyte Biology, 87 (5), 753-764. doi: 10.1189/jlb.0909624

Geissmann, Frederic, Gordon, Siamon, Hume, David A., Mowat, Allan M. and Randolph, Gwendalyn J. (2010). Unravelling mononuclear phagocyte heterogeneity. Nature Reviews Immunology, 10 (6), 453-460. doi: 10.1038/nri2784

Ripoll, Vera M., Kadioglu, Aras, Cox, Roger, Hume, David A. and Denny, Paul (2010). Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to Streptococcus pneumoniae. Journal of Leukocyte Biology, 87 (4), 735-741. doi: 10.1189/jlb.0509359

Professor David Hume

Researcher biography

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Book

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Journal Articles