Professor Mehdi Mobli
Affiliate Associate Professor
Institute for Molecular Bioscience
Researcher biography
Dr Mobli is a Group Leader at the UQ Centre for Advanced Imaging, where he leads a biomolecular NMR group. He has affiliate appointments at the School of Chemistry and Molecular Biosciences as well as the Institute for Molecular Bioscience. He is an expert in the field of NMR spectroscopy where he has made significant contributions in method development as well as addressing important chemical and biological questions.
He started his career as a chemical engineer at Chalmers University in his native Sweden, before moving to the University of Liverpool where he completed his doctoral studies in physical organic chemistry. During his PhD he developed a framework for predicting the NMR spectrum of small organic molecules. He continued his training in NMR spectroscopy as a post doctoral fellow at the University of Connecticut where he worked in the emerging field of stochastic data acquisition and non-Fourier processing of multidimensional NMR spectra of biomolecules, an area where he continues to make significant contributions.
After a brief stint exploring the structure and dynamics of carbohydrates at the University of Manchester he moved to Australia where he has since 2008 been working on the structural biology of peptides and proteins. His interests lie in understanding how biomolecules engage with their ligands or receptors, be they small molecules, membranes or integral membrane proteins. This research is driven by the development of advanced biochemical and biophysical methods to overcome existing limitations in structural studies by NMR spectroscopy. He was awarded an ARC Future Fellowship in 2011 to establish an independent laboratory and has to date attracted >$6M in research support. His work was recognised with the award of the Lorne Proteins Young Investigator Award in 2010 and the Sir Paul Callaghan Medal in 2013 by the Australia and New Zealand Society for Magnetic Resonance.
Publications
Books
Abraham, Raymond J. and Mobli, Mehdi (2008). Modelling H NMR Spectra of Organic Compounds: Theory, Applications and NMR Prediction Software. Chichester, UK: John Wiley and Sons. doi: 10.1002/9780470721803
Abraham, Raymond and Mobli, Mehdi (2008). Modelling 1H NMR spectra of organic compounds: Theory, applications and NMR prediction software. Chichester: Wiley.
Book Chapters
Miljenovic, Tomas Marko, Jia, Xinying and Mobli, Mehdi (2018). Nonuniform sampling in biomolecular NMR. Modern magnetic resonance. (pp. 2035-2054) edited by Graham A. Webb. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-319-28388-3_118
Mobli, Mehdi and Hoch, Jeffrey C. (2017). Fast NMR data acquisition: beyond the Fourier transform: Preface. Fast NMR data acquisition: beyond the Fourier transform. (pp. VIII-X) edited by Mehdi Mobli and Jeffrey C. Hoch. Cambridge, United Kingdom: Royal Society of Chemistry.
Mobli, Mehdi, Stern, Alan S. and Hoch, Jeffrey C. (2017). Maximum entropy reconstruction. Fast NMR data acquisition: beyond the Fourier transform. (pp. 252-266) edited by Mehdi Mobli and Jeffrey C. Hoch. Cambridge, United Kingdom: Royal Society of Chemistry.
Fry, B. G., Undheim, E. A. B., Jackson, T. N. W., Georgieva, D., Vetter, I., Calvete, J. J., Schieb, H., Cribb, B. W., Yang, D. C., Daly, N. L., Manchadi, M. L. Roy, Gutierrez, J. M., Roelants, K., Lomonte, B., Nicholson, G. M., Dziemborowicz, S., Lavergne, V., Ragnarsson, L., Rash, L. D., Mobli, M., Hodgson, W. C., Casewell, N. R., Nouwens, A., Wagstaff, S. C., Ali, S. A., Whitehead, D. L., Herzig, V., Monagle, P., Kurniawan, N. D. ... Sunagar, K. (2015). Research methods. Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery. (pp. 153-214) New York, NY, United States: Oxford University Press.
Lavergne, Vincent, Alewood, Paul F., Mobli, Mehdi and King, Glenn F. (2015). The Structural Universe of Disulfide-Rich Venom Peptides. Venoms to Drugs : Venom as a Source for the Development of Human Therapeutics. (pp. 37-79) edited by King, Glenn F.. London, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737876-00037
Maciejewski, Mark W., Mobli, Mehdi, Schuyler, Adam D., Stern, Alan S. and Hoch, Jeffrey C. (2012). Data sampling in multidimensional NMR: fundamentals and strategies. Novel sampling approaches in higher dimensional NMR. (pp. 49-77) edited by Martin Billeter and Vladislav Orekhov. Heidelberg, Germany: Springer. doi: 10.1007/128_2011_185
Hoch, Jeffrey C., Maciejewski, Mark W., Mobli, Mehdi, Schyler, Adam D. and Stern, Alan S. (2012). Nonuniform sampling in multidimensional NMR. EMagRes. (pp. 1-2) London, United Kingdom: John Wiley & Sons. doi: 10.1002/9780470034590.emrstm1239
Mobli, Mehdi, Hoch, Jeffrey C. and King, Glenn F. (2011). Fast acquisition methods in multidimensional NMR. Biomolecular NMR spectroscopy. (pp. 305-337) edited by Andrew J. Dingley and Steven M. Pascal. Amsterdam , Netherlands: IOS Press. doi: 10.3233/978-1-60750-695-9-305
Hoch, Jeffrey C., Stern, Alan S. and Mobli, Mehdi (2011). Maximum Entropy Reconstruction. eMagRes. (pp. 1-6) United Kingdom: John Wiley and Sons. doi: 10.1002/9780470034590.emrstm0299.pub2
King, Glenn F and Mehdi Mobli (2010). Determination of peptide and protein structures using NMR Spectroscopy. Comprehensive natural products II: Chemistry and biology. (pp. 280-325) edited by Lewis Mander and Hung-Wen Liu. Oxford, England: Elsevier Science & Technology Books. doi: 10.1016/B978-008045382-8.00653-5
Hoch, Jeffrey C. and Mobli, Mehdi (2009). Maximum Entropy: Multidimensional Methods. EMagRes. (pp. 1-8) United Kingdom: John Wiley & Sons. doi: 10.1002/9780470034590.emrstm1158
Journal Articles
Rahaman, Md. Habibur, Thygesen, Sara J., Maxwell, Michael J., Kim, Hyoyoung, Mudai, Prerna, Nanson, Jeffrey D., Jia, Xinying, Vajjhala, Parimala R., Hedger, Andrew, Vetter, Irina, Haselhorst, Thomas, Robertson, Avril A. B., Dymock, Brian, Ve, Thomas, Mobli, Mehdi, Stacey, Katryn J. and Kobe, Bostjan (2024). o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. Journal of Enzyme Inhibition and Medicinal Chemistry, 39 (1) 2313055, 2313055. doi: 10.1080/14756366.2024.2313055
Ramanujam, Venkatraman, Crawford, Theo, Cristofori-Armstrong, Ben, Deuis, Jennifer, Jia, Xinying, Maxwell, Michael, Jami, Sina, Ma, Linlin, Vetter, Irina and Mobli, Mehdi (2024). Structural basis of the bivalency of the TRPV1 agonist DkTx. Angewandte Chemie International Edition, 63 (3) e202314621, 1-8. doi: 10.1002/anie.202314621
Ramanujam, Venkatraman, Crawford, Theo, Cristofori‐Armstrong, Ben, Deuis, Jennifer R., Jia, Xinying, Maxwell, Michael J., Jami, Sina, Ma, Linlin, Vetter, Irina and Mobli, Mehdi (2024). Structural basis of the bivalency of the TRPV1 agonist DkTx. Angewandte Chemie, 136 (3), 1-8. doi: 10.1002/ange.202314621
Jia, Xinying, Chin, Yanni K.-Y., Zhang, Alan H., Crawford, Theo, Zhu, Yifei, Fletcher, Nicholas L., Zhou, Zihan, Hamilton, Brett R., Stroet, Martin, Thurecht, Kristofer J. and Mobli, Mehdi (2023). Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation. Communications Chemistry, 6 (1) 48, 1-10. doi: 10.1038/s42004-023-00841-5
Tran, Poanna, Crawford, Theo, Ragnarsson, Lotten, Deuis, Jennifer R., Mobli, Mehdi, Sharpe, Simon J., Schroeder, Christina I. and Vetter, Irina (2023). Structural conformation and activity of spider-derived inhibitory cystine knot peptide Pn3a are modulated by pH. ACS Omega, 8 (29), 26276-26286. doi: 10.1021/acsomega.3c02664
Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2
Cao, Qiushi, Ge, Cheng, Wang, Xuejie, Harvey, Peta J., Zhang, Zixuan, Ma, Yuan, Wang, Xianghong, Jia, Xinying, Mobli, Mehdi, Craik, David J., Jiang, Tao, Yang, Jinbo, Wei, Zhiqiang, Wang, Yan, Chang, Shan and Yu, Rilei (2023). Designing antimicrobial peptides using deep learning and molecular dynamic simulations. Briefings in Bioinformatics, 24 (2) bbad058, 1-13. doi: 10.1093/bib/bbad058
Kuschert, Sarah, Stroet, Martin, Chin, Yanni Ka-Yan, Conibear, Anne Claire, Jia, Xinying, Lee, Thomas, Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Güntert, Peter, Rosengren, Karl Johan, Mark, Alan Edward and Mobli, Mehdi (2023). Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR. Magnetic Resonance, 4 (1), 57-72. doi: 10.5194/mr-4-57-2023
Maxwell, Michael J., Thekkedam, Chris, Lamboley, Cedric, Chin, Yanni K.-Y., Crawford, Theo, Smith, Jennifer J., Liu, Junyu, Jia, Xinying, Vetter, Irina, Laver, Derek R., Launikonis, Bradley S., Dulhunty, Angela, Undheim, Eivind A. B. and Mobli, Mehdi (2023). A bivalent remipede toxin promotes calcium release via ryanodine receptor activation. Nature Communications, 14 (1) 1036, 1-13. doi: 10.1038/s41467-023-36579-w
Bartling, Christian R. O., Alexopoulou, Flora, Kuschert, Sarah, Chin, Yanni K.-Y., Jia, Xinying, Sereikaite, Vita, Özcelik, Dennis, Jensen, Thomas M., Jain, Palash, Nygaard, Mads M., Harpsøe, Kasper, Gloriam, David E., Mobli, Mehdi and Strømgaard, Kristian (2023). Comprehensive peptide cyclization examination yields optimized APP scaffolds with improved affinity toward Mint2. Journal of Medicinal Chemistry, 66 (4), 3045-3057. doi: 10.1021/acs.jmedchem.2c02017
Liu, Junyu, Maxwell, Michael, Cuddihy, Thom, Crawford, Theo, Bassetti, Madeline, Hyde, Cameron, Peigneur, Steve, Tytgat, Jan, Undheim, Eivind A.B. and Mobli, Mehdi (2023). ScrepYard: an online resource for disulfide-stabilised tandem repeat peptides. Protein Science, 32 (2) e4566, 1-12. doi: 10.1002/pro.4566
Peck, Yoshimi, Pickering, Darren, Mobli, Mehdi, Liddell, Michael J., Wilson, David T., Ruscher, Roland, Ryan, Stephanie, Buitrago, Geraldine, McHugh, Connor, Love, Nicholas C., Pinlac, Theresa, Haertlein, Michael, Kron, Michael A., Loukas, Alex and Daly, Norelle L. (2023). Solution structure of the N-terminal extension domain of a Schistosoma japonicum asparaginyl-tRNA synthetase. Journal of Biomolecular Structure and Dynamics, 1-11. doi: 10.1080/07391102.2023.2241918
Mohanty, Biswaranjan, Orts, Julien, Wang, Geqing, Nebl, Stefan, Alwan, Wesam S., Doak, Bradley C., Williams, Martin L., Heras, Begoña, Mobli, Mehdi and Scanlon, Martin J. (2022). Methyl probes in proteins for determining ligand binding mode in weak protein–ligand complexes. Scientific Reports, 12 (1) 11231, 1-10. doi: 10.1038/s41598-022-13561-y
Healy, Michael D., Sacharz, Joanna, McNally, Kerrie E., McConville, Calum, Tillu, Vikas A., Hall, Ryan J., Chilton, Molly, Cullen, Peter J., Mobli, Mehdi, Ghai, Rajesh, Stroud, David A. and Collins, Brett M. (2022). Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins. Structure, 30 (12), 1590-1602.e6. doi: 10.1016/j.str.2022.10.001
Liu, Liping, Lucas, Richard M., Nanson, Jeffrey D., Li, Yan, Whitfield, Jason, Curson, James E. B., Tuladhar, Neeraj, Alexandrov, Kirill, Mobli, Mehdi, Sweet, Matthew J., Kobe, Bostjan, Stow, Jennifer and Luo, Lin (2022). The transmembrane adaptor SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs. Journal of Biological Chemistry, 298 (5) 101857, 101857. doi: 10.1016/j.jbc.2022.101857
Pustovalova, Yulia, Delaglio, Frank, Craft, D. Levi, Arthanari, Haribabu, Bax, Ad, Billeter, Martin, Bostock, Mark J., Dashti, Hesam, Hansen, D. Flemming, Hyberts, Sven G., Johnson, Bruce A., Kazimierczuk, Krzysztof, Lu, Hengfa, Maciejewski, Mark, Miljenović, Tomas M., Mobli, Mehdi, Nietlispach, Daniel, Orekhov, Vladislav, Powers, Robert, Qu, Xiaobo, Robson, Scott Anthony, Rovnyak, David, Wagner, Gerhard, Ying, Jinfa, Zambrello, Matthew, Hoch, Jeffrey C., Donoho, David L. and Schuyler, Adam D. (2021). NUScon: a community-driven platform for quantitative evaluation of nonuniform sampling in NMR. Magnetic Resonance, 2 (2), 843-861. doi: 10.5194/mr-2-843-2021
Sharma, Gagan, Braga, Carolyne B., Chen, Kai-En, Jia, Xinying, Ramanujam, Venkatraman, Collins, Brett M., Rittner, Roberto and Mobli, Mehdi (2021). Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1. Current Research in Structural Biology, 3, 179-186. doi: 10.1016/j.crstbi.2021.07.003
Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron and Ve, Thomas (2021). SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration. Neuron, 109 (7), 1-19. doi: 10.1016/j.neuron.2021.02.009
Huerlimann, Roger, Maes, Gregory E., Maxwell, Michael J., Mobli, Mehdi, Launikonis, Bradley S., Jerry, Dean R. and Wade, Nicholas M. (2020). Multi-species transcriptomics reveals evolutionary diversity in the mechanisms regulating shrimp tail muscle excitation-contraction coupling. Gene, 752 144765, 144765. doi: 10.1016/j.gene.2020.144765
Sharma, Gagan, Deuis, Jennifer R., Jia, Xinying, Mueller, Alexander, Vetter, Irina and Mobli, Mehdi (2020). Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Nav1.7 inhibitor. Biochemical Pharmacology, 181 114148, 114148. doi: 10.1016/j.bcp.2020.114148
Elliott, Alysha G., Huang, Johnny X., Neve, Søren, Zuegg, Johannes, Edwards, Ingrid A., Cain, Amy K., Boinett, Christine J., Barquist, Lars, Lundberg, Carina Vingsbo, Steen, Jason, Butler, Mark S., Mobli, Mehdi, Porter, Kaela M., Blaskovich, Mark A. T., Lociuro, Sergio, Strandh, Magnus and Cooper, Matthew A. (2020). An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria. Nature Communications, 11 (1) 3184, 3184. doi: 10.1038/s41467-020-16950-x
Pineda, Sandy S., Chin, Yanni K.-Y., Undheim, Eivind A. B., Senff, Sebastian, Mobli, Mehdi, Dauly, Claire, Escoubas, Pierre, Nicholson, Graham M., Kaas, Quentin, Guo, Shaodong, Herzig, Volker, Mattick, John S. and King, Glenn F. (2020). Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene. Proceedings of the National Academy of Sciences, 117 (21) A41, 201914536-11408. doi: 10.1073/pnas.1914536117
Mueller, Alexander, Dekan, Zoltan, Kaas, Quentin, Agwa, Akello J., Starobova, Hana, Alewood, Paul F., Schroeder, Christina I., Mobli, Mehdi, Deuis, Jennifer R. and Vetter, Irina (2020). Mapping the molecular surface of the analgesic NaV1.7-selective peptide Pn3a reveals residues essential for membrane and channel interactions. ACS Pharmacology and Translational Science. doi: 10.1021/acsptsci.0c00002
Ramanujam, Venkatraman, Shen, Yang, Ying, Jinfa and Mobli, Mehdi (2020). Residual dipolar couplings for resolving cysteine bridges in disulfide-rich peptides. Frontiers in Chemistry, 7 889, 1-13. doi: 10.3389/fchem.2019.00889
Elnahriry, Khaled A., Wai, Dorothy C.C., Krishnarjuna, Bankala, Badawy, Noha N., Chittoor, Balasubramanyam, MacRaild, Christopher A., Williams-Noonan, Billy J., Surm, Joachim M., Chalmers, David K., Zhang, Alan H., Peigneur, Steve, Mobli, Mehdi, Tytgat, Jan, Prentis, Peter and Norton, Raymond S. (2019). Structural and functional characterisation of a novel peptide from the Australian sea anemone Actinia tenebrosa. Toxicon, 168, 104-112. doi: 10.1016/j.toxicon.2019.07.002
Jia, Xinying, Crawford, Theo, Zhang, Alan H. and Mobli, Mehdi (2019). A new vector coupling ligation-independent cloning with sortase a fusion for efficient cloning and one-step purification of tag-free recombinant proteins. Protein Expression and Purification, 161, 1-7. doi: 10.1016/j.pep.2019.04.004
Zhang, Alan H., Edwards, Ingrid A., Mishra, Biswa P., Sharma, Gagan, Healy, Michael D., Elliott, Alysha, Blaskovich, Mark A. T., Cooper, Matthew A., Collins, Brett M., Jia, Xinying and Mobli, Mehdi (2019). Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs. Frontiers in Chemistry, 7 (MAR) 238, 238. doi: 10.3389/fchem.2019.00238
Chandra, Mintu, Chin, Yanni K.-Y., Mas, Caroline, Feathers, J. Ryan, Paul, Blessy, Datta, Sanchari, Chen, Kai-En, Jia, Xinying, Yang, Zhe, Norwood, Suzanne J., Mohanty, Biswaranjan, Bugarcic, Andrea, Teasdale, Rohan D., Henne, W. Mike, Mobli, Mehdi and Collins, Brett M. (2019). Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities. Nature Communications, 10 (1) 1528, 1528. doi: 10.1038/s41467-019-09355-y
Motygullina, Alina E., Mobli, Mehdi and Harmer, Jeffrey R. (2019). Optimizing the transformation of HYSCORE data using the maximum entropy algorithm. Journal of Magnetic Resonance, 301, 30-39. doi: 10.1016/j.jmr.2019.02.002
Crawford, Theo, Fletcher, Nicholas, Veitch, Margaret, Gonzalez Cruz, Jazmina L., Pett, Nicola, Brereton, Ian, Wells, James W., Mobli, Mehdi and Tesiram, Yasvir (2019). Bacillus anthracis Protective Antigen Shows High Specificity for a UV Induced Mouse Model of Cutaneous Squamous Cell Carcinoma. Frontiers in Medicine, 6 (FEB) 22, 22. doi: 10.3389/fmed.2019.00022
Kwan, Ann H., Mobli, Mehdi, Schirra, Horst J., Wilson, Jennifer C. and Jones, Oliver A. H. (2019). Video with impact: access to the world's Magnetic-Resonance experts for the scientific-education community. Journal of Chemical Education, 96 (1), 159-164. doi: 10.1021/acs.jchemed.8b00523
Brinson, Robert G., Marino, John P., Delaglio, Frank, Arbogast, Luke W., Evans, Ryan M., Kearsley, Anthony, Gingras, Geneviève, Ghasriani, Houman, Aubin, Yves, Pierens, Gregory K., Jia, Xinying, Mobli, Mehdi, Grant, Hamish G., Keizer, David W., Schweimer, Kristian, Ståhle, Jonas, Widmalm, Göran, Zartler, Edward R., Lawrence, Chad W., Reardon, Patrick N., Cort, John R., Xu, Ping, Ni, Feng, Yanaka, Saeko, Kato, Koichi, Parnham, Stuart R., Tsao, Desiree, Blomgren, Andreas, Rundlöf, Torgny ... Wikström, Mats (2019). Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics. mAbs, 11 (1), 94-105. doi: 10.1080/19420862.2018.1544454
Mobli, M. and Miljenovic, Tomas M. (2019). Framework for and evaluation of bursts in random sampling of multidimensional NMR experiments. Journal of Magnetic Resonance, 300, 103-113. doi: 10.1016/j.jmr.2019.01.014
Maxwell, Michael, Undheim, Eivind A. B. and Mobli, Mehdi (2018). Secreted cysteine-rich repeat proteins "SCREPs": a novel multi-domain architecture. Frontiers in Pharmacology, 9 (NOV) 01333, 1333. doi: 10.3389/fphar.2018.01333
Tian, Wenya, Sun, Chenghai, Zheng, Mei, Harmer, Jeffrey R., Yu, Mingjia, Zhang, Yanan, Peng, Haidong, Zhu, Dongqing, Deng, Zixin, Chen, Shi-Lu, Mobli, Mehdi, Jia, Xinying and Qu, Xudong (2018). Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids. Nature Communications, 9 (1) 4428, 4428. doi: 10.1038/s41467-018-06528-z
Herzig, Volker, de Araujo, Aline, Greenwood, Kathryn, Chin, Yanni, Windley, Monique, Chong, Youmie, Muttenthaler, Markus, Mobli, Mehdi, Audsley, Neil, Nicholson, Graham, Alewood, Paul and King, Glenn (2018). Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides. Biomedicines, 6 (3) 90, 90. doi: 10.3390/biomedicines6030090
Richards, Kay L., Milligan, Carol J., Richardson, Robert J., Jancovski, Nikola, Grunnet, Morten, Jacobson, Laura H., Undheim, Eivind A. B., Mobli, Mehdi, Chow, Chun Yuen, Herzig, Volker, Csoti, Agota, Panyi, Gyorgy, Reid, Christopher A., King, Glenn F. and Petrou, Steven (2018). Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death. Proceedings of the National Academy of Sciences, 115 (34), 201804764-E8085. doi: 10.1073/pnas.1804764115
Brust, Andreas, Wang, Ching-I. A., Daly, Norelle L., Kennerly, Joe, Sadeghi, Mahsa, Christie, Macdonald J., Lewis, Richard J., Mobli, Mehdi and Alewood, Paul F. (2018). Corrigendum to: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter (Angewandte Chemie International Edition, (2013), 52, 46, (12020-12023), 10.1002/anie.201304660). Angewandte Chemie - International Edition, 57 (19), 5203-5203. doi: 10.1002/anie.201803138
Zhang, Alan H., Sharma, Gagan, Undheim, Eivind A. B., Jia, Xinying and Mobli, Mehdi (2018). A complicated complex: ion channels, voltage sensing, cell membranes and peptide inhibitors. Neuroscience Letters, 679, 35-47. doi: 10.1016/j.neulet.2018.04.030
Lonhienne, Thierry, Garcia, Mario D., Pierens, Gregory, Mobli, Mehdi, Nouwens, Amanda and Guddat, Luke W. (2018). Structural insights into the mechanism of inhibition of AHAS by herbicides. Proceedings of the National Academy of Sciences of the United States of America, 115 (9), E1945-E1954. doi: 10.1073/pnas.1714392115
Hughes, Mark M., Lavrencic, Peter, Coll, Rebecca C., Ve, Thomas, Ryan, Dylan G., Williams, Niamh C., Menon, Deepthi, Mansell, Ashley, Board, Philip G., Mobli, Mehdi, Kobe, Bostjan and O'Neill, Luke A. J. (2017). Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling. Proceedings of the National Academy of Sciences, 114 (32), E6480-E6489. doi: 10.1073/pnas.1701868114
Ve, Thomas, Vajjhala, Parimala, Hedger, Andrew, Croll, Tristan, DiMaio, Frank, Horsefield, Shane, Yu, Xiong, Lavrencic, Peter, Hassan, Zahid, Morgan, Garry P., Mansell, Ashley, Mobli, Mehdi, O'Carroll, Ailis, Chauvin, Brieuc, Gambin, Yann, Sierecki, Emma, Landsberg, Michael J., Stacey, Katryn, Egelman, Edward H. and Kobe, Bostjan (2017). Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling. Nature Structural and Molecular Biology, 24 (9), 743-751. doi: 10.1038/nsmb.3444
Franke, Bastian, James, Amy M., Mobli, Mehdi, Colgrave, Michelle L., Mylne, Joshua S. and Rosengren, K. Johan (2017). Two proteins for the price of one: structural studies of the dual-destiny protein preproalbumin with sunflower trypsin inhibitor-1. The Journal of Biological Chemistry, 292 (30), 12398-12411. doi: 10.1074/jbc.M117.776955
Wingerd, Joshua S., Mozar, Christine A., Ussing, Christine A., Murali, Swetha S., Chin, Yanni K. -Y., Cristofori-Armstrong, Ben, Durek, Thomas, Gilchrist, John, Vaughan, Christopher W., Bosmans, Frank, Adams, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Christie, Macdonald J. and Rash, Lachlan D. (2017). The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.. Scientific Reports, 7 (1) 974, 974. doi: 10.1038/s41598-017-01129-0
Mobli, Mehdi, Undheim, Eivind A.B. and Rash, Lachlan D. (2017). Modulation of ion channels by cysteine-rich peptides: from sequence to structure. Advances in Pharmacology, 79, 199-223. doi: 10.1016/bs.apha.2017.03.001
Rahnama, Sassan, Deuis, Jennifer R., Cardoso, Fernanda C., Ramanujam, Venkatraman, Lewis, Richard J., Rash, Lachlan D., King, Glenn F., Vetter, Irina and Mobli, Mehdi (2017). The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant. PLoS One, 12 (3) e0173551, e0173551. doi: 10.1371/journal.pone.0173551
Chassagnon, Irene R., McCarthy, Claudia A., Chin, Yanni K.-Y., Pineda, Sandy S., Keramidas, Angelo, Mobli, Mehdi, Pham, Vi, De Silva, T. Michael, Lynch, Joseph W., Widdop, Robert E., Rash, Lachlan D. and King, Glenn F. (2017). Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a. Proceedings from the National Academy of Sciences of the United States of America, 114 (14), 3750-3755. doi: 10.1073/pnas.1614728114
Miljenović, Tomas, Jia, Xinying, Lavrencic, Peter, Kobe, Bostjan and Mobli, Mehdi (2017). A non-uniform sampling approach enables studies of dilute and unstable proteins. Journal of Biomolecular NMR, 68 (2), 1-9. doi: 10.1007/s10858-017-0091-z
Wan, Jingjing, Mobli, Mehdi, Brust, Andreas, Muttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Castro, Joel, Vetter, Irina, Huang, Johnny X., Nilsson, Mathias, Brierley, Stuart M., Cooper, Matthew A., Lewis, Richard J. and Alewood, Paul F. (2017). Synthesis of multivalent [Lys8]-oxytocin dendrimers that inhibit visceral nociceptive responses. Australian Journal of Chemistry, 70 (2), 162-171. doi: 10.1071/CH16407
Vetter, Irina, Deuis, Jennifer, Mueller, Alexander, Israel, Mathilde R., Hana Starobova, Zhang, Alan, Rash, Lachlan D. and Mobli, Mehdi (2016). NaV1.7 as a pain target – from gene to pharmacology. Pharmacology and Therapeutics, 172, 73-100. doi: 10.1016/j.pharmthera.2016.11.015
Casey, Lachlan W., Lavrencic, Peter, Bentham, Adam R., Cesari, Stella, Ericsson, Daniel J., Croll, Tristan, Turk, Dušan, Anderson, Peter A., Mark, Alan E., Dodds, Peter N., Mobli, Mehdi, Kobe, Bostjan and Williams, Simon J. (2016). The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins. Proceedings of the National Academy of Sciences, 113 (45), 12856-12861. doi: 10.1073/pnas.1609922113
Mohanty, Biswaranjan, Williams, Martin L., Doak, Bradley C., Vazirani, Mansha, Ilyichova, Olga, Wang, Geqing, Bermel, Wolfgang, Simpson, Jamie S., Chalmers, David K., King, Glenn F., Mobli, Mehdi and Scanlon, Martin J. (2016). Determination of ligand binding modes in weak protein–ligand complexes using sparse NMR data. Journal of Biomolecular NMR, 66 (3), 195-208. doi: 10.1007/s10858-016-0067-4
Lau, Carus H.Y., King, Glenn F and Mobli, Mehdi (2016). Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels. Scientific Reports, 6 (1) 34333, 34333. doi: 10.1038/srep34333
Mobli, Mehdi, Maciejewski, Mark W, Schuyler, Adam D, Stern, Alan S and Hoch, Jeffrey C (2016). Correction: Sparse sampling methods in multidimensional NMR. Physical Chemistry Chemical Physics, 18 (28), 19482-19482. doi: 10.1039/c6cp90157c
Undheim, Eivind A., Mobli, Mehdi and King, Glenn F. (2016). Toxin structures as evolutionary tools: Using conserved 3D folds to study the evolution of rapidly evolving peptides. Bioessays, 38 (6), 539-548. doi: 10.1002/bies.201500165
Deuis, Jennifer R, Dekan, Zoltan, Inserra, Marco C., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Craik, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Schroeder, Christina I., Henriques, Sónia Troeira and Vetter, Irina (2016). Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8. Journal of Biological Chemistry, 291 (22), 11829-11842. doi: 10.1074/jbc.M116.721662
Wan, Jingjing, Brust, Andreas, Bhola, Rebecca F., Jha, Prerna, Mobli, Mehdi, Lewis, Richard J., Christie, Macdonald J. and Alewood, Paul F. (2016). Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers. Journal of Peptide Science, 22 (5), 280-289. doi: 10.1002/psc.2857
Klint, Julie K., Chin, Yanni K. -Y. and Mobli, Mehdi (2015). Rational engineering defines a molecular switch that is essential for activity of spider-venom peptides against the analgesics target na(v)1.7. Molecular Pharmacology, 88 (6), 1002-1010. doi: 10.1124/mol.115.100784
Saez, Natalie J., Deplazes, Evelyne, Cristofori-Armstrong, Ben, Chassagnon, Irene R., Lin, Xiaozhen, Mobli, Mehdi, Mark, Alan E., Rash, Lachlan D. and King, Glenn F. (2015). Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a. British Journal of Pharmacology, 172 (20), 4985-4995. doi: 10.1111/bph.13267
Undheim, Eivind A. B., Grimm, Lena L., Low, Chek -Fong, Morgenstern, David, Herzig, Volker, Zobel-Thropp, Pamela, Pineda, Sandy Steffany, Habib, Rosaline, Dziemborowicz, Slawomir, Fry, Bryan G., Nicholson, Graham M., Binford, Greta J., Mobli, Mehdi and King, Glenn F. (2015). Weaponization of a hormone: convergent recruitment of hyperglycemic hormone into the venom of arthropod predators. Structure, 23 (7) 3184, 1283-1292. doi: 10.1016/j.str.2015.05.003
Mobli, Mehdi (2015). Reducing seed dependent variability of non-uniformly sampled multidimensional NMR data. Journal of Magnetic Resonance, 256, 60-69. doi: 10.1016/j.jmr.2015.04.003
Sawyer, Anne L., Landsberg, Michael J., Ross, Ian L., Kruse, Olaf, Mobli, Mehdi and Hankamer, Ben (2015). Solution structure of the RNA-binding cold shock domain of the Chlamydomonas reinhardtii NAB1 protein and insights into RNA recognition. Biochemical Journal, 469 (1), 97-106. doi: 10.1042/BJ20150217
Nogueira, Maria Luiza C., Sforca, Mauricio Luis, Chin, Yanni K. -Y., Mobli, Mehdi, Handler, Aaron, Gorbatyuk, Vitaliy Y., Robson, Scott A., King, Glenn F., Gueiros-Filho, Frederico J. and de Mattos Zeri, Ana Carolina (2015). Backbone and side chain NMR assignments of Geobacillus stearothermophilus ZapA allow identification of residues that mediate the interaction of ZapA with FtsZ. Biomolecular NMR Assignments, 9 (2), 387-391. doi: 10.1007/s12104-015-9615-1
Klint, Julie K., Smith, Jennifer J., Vetter, Irina, Rupasinghe, Darshani B., Er, Sing Yan, Senff, Sebastian, Herzig, Volker, Mobli, Mehdi, Lewis, Richard J., Bosmans, Frank and King, Glenn F. (2015). Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach. British Journal of Pharmacology, 172 (10), 2445-2458. doi: 10.1111/bph.13081
Ma, Cong, Mobli, Mehdi, Yang, Xiao, Keller, Andrew N., King, Glenn F. and Lewis, Peter J. (2015). RNA polymerase-induced remodelling of NusA produces a pause enhancement complex. Nucleic Acids Research, 43 (5), 2829-2840. doi: 10.1093/nar/gkv108
Bende, Niraj S., Dziemborowicz, Slawomir, Herzig, Volker, Ramanujam, Venkatraman, Brown, Geoffrey W., Bosmans, Frank, Nicholson, Graham M., King, Glenn F. and Mobli, Mehdi (2015). The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop. FEBS Journal, 282 (5), 904-920. doi: 10.1111/febs.13189
Mobli, Mehdi and Hoch, Jeffrey C. (2015). Erratum to "Nonuniform sampling and non-Fourier signal processing methods in multidimensional NMR" [Prog. Nucl. Magn. Reson. Spectrosc. 83 (2014) 21-41]. Progress in Nuclear Magnetic Resonance Spectroscopy, 86-87, 80-80. doi: 10.1016/j.pnmrs.2015.02.001
Wan, Jingjing, Huang, Johnny X., Vetter, Irina, Mobli, Mehdi, Lawson, Joshua, Tae, Han-Shen, Abraham, Nikita, Paul, Blessy, Cooper, Matthew A., Adams, David J., Lewis, Richard J. and Alewood, Paul F. (2015). α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors. Journal of the American Chemical Society, 137 (9), 3209-3212. doi: 10.1021/jacs.5b00244
Mobli, Mehdi and Hoch, Jeffrey C. (2014). Nonuniform sampling and non-Fourier signal processing methods in multidimensional NMR. Progress in Nuclear Magnetic Resonance Spectroscopy, 83, 21-41. doi: 10.1016/j.pnmrs.2014.09.002
Wang, Geqing, MacRaild, Christopher A., Mohanty, Biswaranjan, Mobli, Mehdi, Cowieson, Nathan P., Anders, Robin F., Simpson, Jamie S., McGowan, Sheena, Norton, Raymond S. and Scanlon, Martin J. (2014). Molecular insights into the interaction between plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide. PLoS One, 9 (10) e109674, 1-12. doi: 10.1371/journal.pone.0109674
Nakka, K. K., Tesiram, Y. A., Brereton, I. M., Mobli, M. and Harmer, J. R. (2014). Non-uniform sampling in EPR-optimizing data acquisition for HYSCORE spectroscopy. Physical Chemistry Chemical Physics, 16 (31), 16378-16382. doi: 10.1039/c4cp02172j
Bende, Niraj S., Dziemborowicz, Sławomir, Mobli, Mehdi, Herzig, Volker, Gilchrist, John, Wagner, Jordan, Nicholson, Graham M., King, Glenn F and Bosmans, Frank (2014). A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a. Nature Communications, 5 (1) 4350, 4350. doi: 10.1038/ncomms5350
Klint, Julie K., Berecki, Géza, Durek, Thomas, Mobli, Mehdi, Knapp, Oliver, King, Glenn F., Adams, David J., Alewood, Paul F. and Rash, Lachlan D. (2014). Isolation, synthesis and characterization of omega-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels. Biochemical Pharmacology, 89 (2), 276-286. doi: 10.1016/j.bcp.2014.02.008
Bobby, Romel, Robustelli, Paul, Kralicek, Andrew V., Mobli, Mehdi, King, Glenn F., Grotzinger, Joachim and Dingley, Andrew J. (2014). Functional implications of large backbone amplitude motions of the glycoprotein 130-binding epitope of interleukin-6. FEBS Journal, 281 (10), 2471-2483. doi: 10.1111/febs.12800
Dekan, Zoltan, Mobli, Mehdi, Pennington, Michael W., Fung, Eileen, Nemeth, Elizabeta and Alewood, Paul F. (2014). Total synthesis of human hepcidin through regioselective disulfide-bond formation by using the safety-catch cysteine protecting group 4,4'-dimethylsulfinylbenzhydryl. Angewandte Chemie International Edition, 53 (11), 2931-2934. doi: 10.1002/anie.201310103
Hoch, Jeffrey C., Maciejewski, Mark W., Mobli, Mehdi, Schuyler, Adam D. and Stern, Alan S. (2014). Nonuniform sampling and maximum entropy reconstruction in multidimensional NMR. Accounts of Chemical Research, 47 (2), 708-717. doi: 10.1021/ar400244v
Gui, Junhong, Liu, Boyi, Cao, Guan, Lipchik, Andrew M., Perez, Minervo, Dekan, Zoltan, Mobli, Mehdi, Daly, Norelle L., Alewood, Paul F., Parker, Laurie L., King, Glenn F., Zhou, Yufeng, Jordt, Sven-Eric and Nitabach, Michael N. (2014). A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1–S4 gating domain. Current Biology, 24 (5), 473-483. doi: 10.1016/j.cub.2014.01.013
Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2. Angewandte Chemie International Edition, 53 (4), 1017-1020. doi: 10.1002/anie.201308898
Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angewandte Chemie, 126 (4), 1035-1038. doi: 10.1002/ange.201308898
Jia, Xinying, Schulte, Leigh, Loukas, Alex, Pickering, Darren, Pearson, Mark, Mobli, Mehdi, Jones, Alun, Rosengren, Karl J., Daly, Norelle L., Gobert, Geoffrey N., Jones, Malcolm K., Craik, David J. and Mulvenna, Jason (2014). Solution structure, membrane interactions and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni. Journal of Biological Chemistry, 289 (10), 1-26. doi: 10.1074/jbc.M113.531558
Jensen, Jonas E., Cristofori-Armstrong, Ben, Anangi, Raveendra, Rosengren, K. Johan, Lau, Carus H. Y., Mobli, Mehdi, Brust, Andreas, Alewood, Paul F., King, Glenn F. and Rash, Lachlan D. (2014). Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores. Journal of Medicinal Chemistry, 57 (21), 9195-9203. doi: 10.1021/jm501400p
Dantas De Araujo, Aline, Mobli, Mehdi, Castro, Joel, Harrington, Andrea M., Vetter, Irina, Dekan, Zoltan, Muttenthale, Markus, Wan, JingJing, Lewis, Richard J., King, Glenn F., Brierley, Stuart M. and Alewood, Paul F. (2014). Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications, 5 (1) 3165, 3165.1-3165.12. doi: 10.1038/ncomms4165
Ghai, Rajesh, Mobli, Mehdi and Collins, Brett M. (2014). Measuring interactions of FERM domain-containing sorting nexin proteins with endosomal lipids and cargo molecules. Methods in Enzymology, 534, 331-349. doi: 10.1016/B978-0-12-397926-1.00019-6
Dantas De Araujo, Aline, Herzig, Volker, Windley, Monique J., Dziemborowicz, Slawomir, Mobli, Mehdi, Nicholson, Graham M., Alewood, Paul F. and King, Glenn F. (2013). Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?. Antioxidants and Redox Signaling, 19 (16), 1976-1980. doi: 10.1089/ars.2013.5365
Brust, Andreas, Wang, Ching-I. A., Daly, Norelle L., Kennerly, Joe, Sadeghi, Mahsa, Christie, Macdonald J., Lewis, Richard J., Mobli, Mehdi and Alewood, Paul F. (2013). Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter. Angewandte Chemie (International Edition), 52 (46), 12020-12023. doi: 10.1002/anie.201304660
Hardy, Margaret C., Daly, Norelle L., Mobli, Mehdi, Morales, Rodrigo A. V. and King, Glenn F. (2013). Isolation of an orally active insecticidal toxin from the venom of an Australian tarantula. PLoS ONE, 8 (9), e73136.1-e73136.12. doi: 10.1371/journal.pone.0073136
Smirnova, Ekaterina, Shanbhag, Riya, Kurabi, Arwa, Mobli, Mehdi, Kwan, Jamie J. and Donaldson, Logan W. (2013). Solution structure and peptide binding of the PTB domain from the AIDA1 postsynaptic signaling scaffolding protein. PLoS ONE, 8 (6) e65605, e65605.1-e65605.8. doi: 10.1371/journal.pone.0065605
Klint, Julie K., Senff, Sebastian, Saez, Natalie J., Seshadri, Radha, Lau, Ho Yee, Bende, Nira J., Undheim, Eivind A. B., Rash, Lachlan D., Mobli, Mehdi and King, Glenn F. (2013). Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli. PLoS One, 8 (5) e63865, e63865.1-e63865.12. doi: 10.1371/journal.pone.0063865
Bende, Niraj S., Kang, Eunji, Herzig, Volker, Bosmans, Frank, Nicholson, Graham M., Mobli, Mehdi and King, Glenn F. (2013). The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels. Biochemical Pharmacology, 85 (10), 1542-1554. doi: 10.1016/j.bcp.2013.02.030
Dantas de Araujo, Aline, Mobli, Mehdi, King, Glenn F. and Alewood, Paul F. (2012). Cyclization of peptides by using selenolanthionine bridges. Angewandte Chemie International Edition, 51 (41), 10298-10302. doi: 10.1002/anie.201204229
Mobli, Mehdi, Maciejewski, Mark W., Schuyler, Adam D., Stern, Alan S. and Hoch, Jeffrey C. (2012). Sparse sampling methods in multidimensional NMR. Physical Chemistry Chemical Physics, 14 (31), 10835-10843. doi: 10.1039/c2cp40174f
Anangi, Raveendra, Rash, Lachlan D., Mobli, Mehdi and King, Glenn F. (2012). Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3. Marine Drugs, 10 (7), 1605-1618. doi: 10.3390/md10071605
Jensen, Jonas E., Mobli, Mehdi, Brust, Andreas, Alewood, Paul F., King, Glenn F. and Rash, Lachlan D. (2012). Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3. Marine Drugs, 10 (7), 1511-1527. doi: 10.3390/md10071511
Galea, Charles A., Mobli, Mehdi, McNeil, Kerrie A., Mulhern, Terrence D., Wallace, John C., King, Glenn F., Forbes, Briony E. and Norton, Raymond S. (2012). Insulin-like growth factor binding protein 2: NMR analysis and structural characterization of the N-terminal domain. Biochimie, 94 (3), 608-616. doi: 10.1016/j.biochi.2011.09.012
Mobli, Mehdi, Morgenstern, David, King, Glenn F., Alewood, Paul F. and Muttenthaler, Markus (2011). Site-specific pKa determination of selenocysteine residues in selenovasopressin using 77Se NMR. Angewandte Chemie (International Edition), 50 (50), 11952-11955. doi: 10.1002/anie.201104169
Saez, Natalie J., Mobli, Mehdi, Bieri, Michael, Chassagnon, Irene R., Malde, Alpeshkumar K., Gamsjaeger, Roland, Mark, Alan E., Gooley, Paul R., Rash. Lachlan D. and King, Glenn F. (2011). A dynamic pharmacophore drives the interaction between psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a. Molecular Pharmacology, 80 (5), 796-808. doi: 10.1124/mol.111.072207
Ghai, Rajesh, Mobli, Mehdi, Norwood, Suzanne J., Bugarcic, Andrea, Teasdale, Rohan D., King, Glenn F. and Collins, Brett M. (2011). Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases. Proceedings of the National Academy of Sciences of the United States of America, 108 (19), 7763-7768. doi: 10.1073/pnas.1017110108
Bieri, Michael, Kwan, Ann H., Mobli, Mehdi, King, Glenn F., Mackay, Joel P. and Gooley, Paul R. (2011). Macromolecular NMR spectroscopy for the non-spectroscopist: Beyond macromolecular structure determination. Febs Journal, 278 (5), 704-715. doi: 10.1111/j.1742-4658.2011.08005.x
Kwan, Ann H., Mobli, Mehdi, Gooley, Paul R., King, Glenn F. and Mackay, Joel P. (2011). Macromolecular NMR spectroscopy for the non-spectroscopist. Febs Journal, 278 (5), 687-703. doi: 10.1111/j.1742-4658.2011.08004.x
Ng, Chai Ann, Hunter, Mark J., Perry, Matthew D., Mobli, Mehdi, Ke, Ying, Kuchel, Philip W., King, Glenn F., Stock, Daniela and Vandenberg, Jamie I. (2011). The N-terminal tail of hERG contains an amphipathic alpha-helix that regulates channel deactivation. PLoS One, 6 (1) e16191, e16191.1-e16191.9. doi: 10.1371/journal.pone.0016191
Vetter, Irina, Davis, Jasmine L., Rash, Lachlan D., Anangi, Raveendra, Mobli, Mehdi, Alewood, Paul F., Lewis, Richard J. and King, Glenn F. (2011). Venomics: A new paradigm for natural products-based drug discovery. Amino Acids, 40 (1), 15-28. doi: 10.1007/s00726-010-0516-4
Mobli, Mehdi and King, Glenn F. (2010). NMR methods for determining disulfide-bond connectivities. Toxicon, 56 (6), 849-854. doi: 10.1016/j.toxicon.2010.06.018
Morales, Rodrigo A. V., Daly, Norelle L., Vetter, Irina, Mobli, Mehdi, Napier, Ian A., Craik, David J., Lewis, Richard J., Christie, MacDonald J., King, Glenn F., Alewood, Paul F. and Durek, Thomas (2010). Chemical synthesis and structure of the prokineticin Bv8. ChemBioChem, 11 (13), 1882-1888. doi: 10.1002/cbic.201000330
Mobli, Mehdi, Stern, Alan S., Bermel, Wolfgang, King, Glenn F. and Hoch, Jeffrey C. (2010). A non-uniformly sampled 4D HCC(CO)NH-TOCSY experiment processed using maximum entropy for rapid protein sidechain assignment. Journal of Magnetic Resonance, 204 (1), 160-164. doi: 10.1016/j.jmr.2010.02.012
King, Glenn F. and Mobli, Mehdi (2010). Derivation of Peptide and Protein Structure using NMR Spectroscopy. Comprehensive Natural Products Ii: Chemistry and Biology, Vol 9: Modern Methods in Natural Products Chemistry, 9, 279-325.
Mobli, M., Dantas de Araujo, A., Lambert, L. K., Pierens, G. K., Windley, M. J., Nicholson, G. M., Alewood, P. F. and King, G. E. (2009). Direct Visualization of Disulfide Bonds through Diselenide Proxies Using Se-77 NMR Spectroscopy. Angewandte Chemie International Edition, 48 (49), 9312-9314. doi: 10.1002/anie.200905206
Pierens, G. K., Mobli, M. and Vegh, V. (2009). Effective Protocol for Database Similarity Searching of Heteronuclear Single Quantum Coherence Spectra. Analytical Chemistry, 81 (22), 9329-9335. doi: 10.1021/ac901616t
Kurabi, A, Brener, S, Mobli, M, Kwan, J. J. and Donaldson, L. W. (2009). A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import. Journal of Molecular Biology, 392 (5), 1168-1177. doi: 10.1016/j.jmb.2009.08.004
Maciejewski, Mark W., Qui, Harry Z., Rujan, Iulian, Mobli, Mehdi and Hoch, Jeffrey C. (2009). Nonuniform sampling and spectral aliasing. Journal of Magnetic Resonance, 199 (1), 88-93. doi: 10.1016/j.jmr.2009.04.006
Mobli, Mehdi and Hoch, Jeffrey C. (2008). Maximum entropy spectral reconstruction of nonuniformly sampled data. Concepts in Magnetic Resonance Part A, 32A (6), 436-448. doi: 10.1002/cmr.a.20126
Mobli, Mehdi, Nilsson, Mathias and Almond, Andrew (2008). The structural plasticity of heparan sulfate NA-domains and hence their role in mediating multivalent interactions is confirmed by high-accuracy 15N-NMR relaxation studies. Glycoconjugate Journal, 25 (5), 401-414. doi: 10.1007/s10719-007-9081-9
Mobli, Mehdi, Maciejewski, Mark W., Gryk, Michael R. and Hoch, Jeffrey C. (2007). Automatic maximum entropy spectral reconstruction in NMR. Journal of Biomolecular NMR, 39 (2), 133-139. doi: 10.1007/s10858-007-9180-8
Abraham, Raymond J. and Mobli, Mehdi (2007). An NMR, IR and theoretical investigation of 1H Chemical Shifts and hydrogen bonding in phenols. Magnetic resonance in chemistry, 45 (10), 865-877. doi: 10.1002/mrc.2060
Mobli, Mehdi, Maciejewski, Mark W., Gryk, Michael R. and Hoch, Jeffrey C. (2007). An automated tool for maximum entropy reconstruction of biomolecular NMR spectra. Nature Methods, 4 (6), 467-468. doi: 10.1038/nmeth0607-467
Mobli, Mehdi and Almond, Andrew (2007). N-Acetylated amino sugars: the dependence of NMR 3J(HNH2)-couplings on conformation, dynamics and solvent. Organic and biomolecular chemistry, 5 (14), 2243-2251. doi: 10.1039/b705761j
Mobli, Mehdi, Stern, Alan S. and Hoch, Jeffrey C. (2006). Spectral reconstruction methods in fast NMR: Reduced dimensionality, random sampling and maximum entropy. Journal of magnetic resonance, 182 (1), 96-105. doi: 10.1016/j.jmr.2006.06.007
Jordan, John B., Kovacs, Helena, Wang, Yuefeng, Mobli, Mehdi, Luo, Rensheng, Anklin, Clemens, Hoch, Jeffrey C. and Kriwacki, Richard W. (2006). Three-Dimensional 13C-Detected CH3-TOCSY Using Selectively Protonated Proteins: Facile Methyl Resonance Assignment and Protein Structure Determination. Journal of the American Chemical Society, 128 (28), 9119-9128. doi: 10.1021/ja058587a
Abraham, Raymond J., Mobli, Mehdi, Ratti, Joyce, Sancassan, Fernando and Smith, Timothy A. D. (2006). Conformational analysis, Part 41. A modelling and LIS/NMR investigation of the conformations of ,alpa and beta -unsaturated carbonyl compounds. Journal of physical organic chemistry, 19 (6), 384-392. doi: 10.1002/poc.1092
Mobli, Mehdi and Abraham, Raymond J. (2005). Quantum vs. classical models of the nitro group for proton chemical shift calculations and conformational analysis. Journal of Computational Chemistry, 26 (4), 389-398. doi: 10.1002/jcc.20177
Abraham, Raymond J., Bardsley, Ben, Mobli, Mehdi and Smith, Richard J. (2005). H chemical shifts in NMR. Part 21 - Prediction of the 1H chemical shifts of molecules containing the ester group: a modelling and ab initio investigation. Magnetic Resonance in Chemistry, 43 (1), 3-15. doi: 10.1002/mrc.1491
Abraham, Raymond J. and Mobli, Mehdi (2004). The prediction of 1H NMR chemical shifts in organic compounds. Spectroscopy Europe, 16 (4)
Abraham, Raymond J., Mobli, Mehdi and Smith, Richard J. (2004). 1H chemical shifts in NMR. Part 20 - Anisotropic and steric effects in halogen substituent chemical shifts (SCS), a modelling and ab initio investigation. Magnetic resonance in chemistry, 42 (5), 436-444. doi: 10.1002/mrc.1369
Abraham, Raymond J., Mobli, Medhi and Smith, Richard J. (2003). 1H chemical shifts in NMR: Part 19. Carbonyl anisotropies and steric effects in aromatic aldehydes and ketones. Magnetic Resonance in Chemistry, 41 (1), 26-36. doi: 10.1002/mrc.1125
Conference Papers
Franke, B., James, A., Mobli, M., Mylne, J. S. and Rosengren, K. J. (2016). Structural Features of An Unusual Sun-Flower Proalbumin Protein That Gives Rise to a Small Cyclic Peptide and a Seed Storage Protein. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. HOBOKEN: Wiley.
Schroeder, Christina I., Deuis, Jennifer, Henriques, Sonia Troeria, Dekan, Zoltan, Inserra, Marco, Mobli, Mehdi and Vetter, Irina (2016). Rational design and synthesis of a novel membrane binding NaV1.8 selective inhibitor with in vivo activity in pain models. 60th Annual Meeting of the Biophysical Society, Los Angeles, CA, United States, 27 Feb - 2 Mar 2016. CAMBRIDGE: CELL PRESS. doi: 10.1016/j.bpj.2015.11.247
Schroeder, Christina, Henriques, Sonia, Mobli, Mehdi, Chaousis, Stephanie, Walsh, Phillip, Thongyoo, Panumart and Craik, David (2015). Delineating toxin:lipid:ion channel interactions for rationally sodium channel inhibitors design. 29th Annual Symposium of the Protein Society, Barcelona Spain, Jul 22-25, 2015. Hoboken, United States: Wiley-Blackwell Publishing. doi: 10.1002/pro.2823
Rahnama, S., Lachlan, R., Cardoso, F. C., Smith, J., Deuis, J., Vetter, I., King, G. F. and Mobli, M. (2015). Rational development of novel analgesics for the treatment of chronic pain: Structure-Function studies of an engineered Nav1.7 blocker. The 40th Lorne Conference on Protein Structure and Function, Lorne VIC, Australia, 8-12 February 2015.
Ghai, R., Mobli, M., Norwood, S. J., Bugarcic, A., Teasdale, R. D., King, G. F. and Collins, B. M. (2012). PX family proteins at the interface between intracellular trafficking and signalling. 22nd IUBMB Congress/37th FEBS Congress, Seville, Spain, 4-9 September 2012. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. doi: 10.1111/j.1742-4658.2010.08705.x
Klint, Julie, Anangi, Raveendra, Mobli, Mehdi, Knapp, Oliver, Adams, David J. and King, Glenn F. (2012). Spider-venom peptides that target the human NaV1.7 channel: Potential analgesics for the treatment of chronic pain. 7th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, 8 - 13 July 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.032
Dantas de Araujo, A. D., Herzig, V., Mobli, M., Windley, M. J., Nicholson, G. M., Alewood, P. F. and King, G. F. (2010). Understanding the role of the unusual constrained eight-membered disulfide ring of spider toxins. 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.1303
Mobli, M., Lambert, L. K., Pierens, G. K., Dantas de Araujo, A., Alewood, P. F. and King, G. F. (2008). Unequivocal direct determination of the disulfide bond connectivities in proteins using 77Se NMR. 7th Biennial Conference of the Australian and New Zealand Society for Magnetic Resonance (ANZMAG 2008), Couran Cove, Australia, 7-11 December 2008.
Data Collection
Hardy, Margaret, Daly, Norelle L., Mobli, Mehdi , Morales, Rodrigo and King, Glenn F (2013). Isolation of an orally active insecticidal toxin from the venom of an Australian tarantula (Table S1). Figshare. (Dataset) doi: 10.1371/journal.pone.0073136.s001