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Dr Kate Stacey

Affiliate Research Fellow
Institute for Molecular Bioscience
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Researcher biography

Following my PhD on transcriptional regulation in macrophages I went in 1996 to the University of Cambridge on a CJ Martin Fellowship to work in a molecular parasitology laboratory. I returned to the Institute for Molecular Bioscience at the University of Queensland in 1998 where I continued work on immune cell responses to foreign DNA. I was awarded an ARC Future Fellowship in 2009 to move to the School of Chemistry and Molecular Bioscience, where I also lecture in immunology

Publications

Book Chapters (7)
Journal Articles (71)
Conference Papers (12)

Book Chapters

Plugging the leak in Dengue shock
Assessment of inflammasome formation by flow cytometry
Methods for delivering DNA to intracellular receptors
Discrimination of self and non-self DNAs
Phosphorothioate backbone modification changes the pattern of responses to CpG
Growth and differentiation of murine macrophages
The regulation of urokinase plasminogen activator gene expression in macrophages

Journal Articles

Membrane vesicles from Pseudomonas aeruginosa activate the non-canonical inflammasome through caspase-5 in human monocytes
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
Caspase-1 is an apical caspase leading to caspase-3 cleavage in the AIM2 inflammasome response, independent of caspase-8
Bacterial membrane vesicles transport their DNA cargo into host cells
Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling
The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways
Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6
Cryo-EM structure of caspase-8 tandem DED filament reveals assembly and regulation mechanisms of the death-inducing signaling complex
Programmed death-1 ligand 2-mediated regulation of the PD-L1 to PD-1 axis is essential for establishing CD4+ T cell immunity
Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages
Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages
Correcting the NLRP3 inflammasome deficiency in macrophages from autoimmune NZB mice with exon skipping antisense oligonucleotides
Strain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli.
Response to comment on "Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity" and "Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination"
The inflammasome adaptor ASC induces procaspase-8 death effector domain filaments
Response to Comment on "Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice".
Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity
Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.
A novel pathway of cell death in response to cytosolic DNA in Drosophila cells
A novel flow cytometric method to assess inflammasome formation
The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge
Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly
Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
Molecular mechanism for p202-mediated specific inhibition of aim2 inflammasome activation
Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection
Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival
Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction
DEC-205 is a cell surface receptor for CpG oligonucleotides
The mammalian PYHIN gene family: Phylogeny, evolution and expression
Intramacrophage survival of uropathogenic Escherichia coli: differences between diverse clinical isolates and between mouse and human macrophages
B cells do not take up bacterial DNA: An essential role for antigen in exposure of DNA to toll-like receptor-9
The immunostimulatory activity of phosphorothioate CpG oligonucleotides is affected by distal sequence changes
Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis
A clear link between endogenous retroviral LTR activity and Hodgkin's lymphoma
A visual framework for sequence analysis using n-grams and spectral rearrangement
TLR-9-independent effects of inhibitory oligonucleotides on macrophages responses to S. typhimurium
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: Alternatively activated STAT1 negatively regulates TLR signaling in macrophages
Plasmodium strain determines dendritic cell function essential for survival from malaria
PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages
CpG DNA activates survival in murine macrophages through TLR9 and the phosphatidylinositol 3-kinase-Akt pathway
Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice
DNA Motifs Suppressing TLR9 Responses
Cutting edge: Species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified ohgonucleotides
The phasevarion: A genetic system controlling coordinated, random switching of expression of multiple genes
LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action
Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity
Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides
The molecular basis for the lack of immunostimulatory activity of vertebrate DNA
Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages
G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages
Macrophage activation by immunostimulatory DNA
Phosphorothioate backbone modification modulates macrophage activation by CpG DNA1
Regulation of the urokinase plasminogen activator gene in macrophages by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell surface receptor
Immunostimulatory DNA as an adjuvant in vaccination against Leishmania major
Regulation of the plasminogen activator inhibitor-2 (PAI-2) gene in murine macrophages. Demonstration of a novel pattern of responsiveness to bacterial endotoxin
The actions of bacterial DNA on murine macrophages
Bacterial/CpG DNA down-modulates colony stimulating factor-1 receptor surface expression on murine bone marrow-derived macrophages with concomitant growth arrest and factor-independent survival
Mechanisms of regulation of the MacMarcks gene in macrophages by bacterial lipopolysaccharide
Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating Factor 1/c-fms Signaling
Involvement of Ets, rel and Sp1-like proteins in lipopolysaccharide-mediated activation of the HIV-1 LTR in macrophage
IFN-γ primes macrophage responses to bacterial DNA
Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2
Macrophages ingest and are activated by bacterial DNA
Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor
RNA synthesis inhibition stabilises urokinase mRNA in macrophages
Electroporation and dna-dependent cell-death in murine macrophages
The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin
Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig
Effects of female sex hormones on lipid metabolism in the uterine epithelium of the mouse

Conference Papers

NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages
Inflammasome function in autoimmunity
Molecular arrangement and activation of procaspases-1 and-8 at inflammasomes
Cytosolic DNA, HIN-200 proteins and inflammasome activation
Evolution of cell death responses to cytosolic DNA
Inflammatory response sculpting by neutrophil inflammasomes
Functional significance of evolutionary divergence in Toll-like receptor-regulated gene expression in human versus mouse
Regulation and function of toll-like receptor 9 in macrophages
A detection system for viral dsDNA?
Cellular activation and apoptosis in response to transfected dsDNA - A novel foreign nucleic acid detection system
Immunostimulatory DNA promotes factor independent survival of macrophages
CpG DNA effects macrophage CSF-1 receptor cell surface expression, proliferation and survival