Dr Edward Gilding
Research Fellow
Institute for Molecular Bioscience
+61 7 344 36301
Book Chapters
Jackson, Mark A. and Gilding, Edward K. (2015). Cyclotides in a biotechnological context: opportunities and challenges. Plant cyclotides. (pp. 305-333) edited by David J. Craik. Amsterdam, Netherlands: Academic Press. doi: 10.1016/bs.abr.2015.09.010
Liu, Guoquan, Gilding, Edward and Godwin, Ian D. (2014). Genetic Transformation and Breeding. Genetics, Genomics and Breeding of Sorghum. (pp. 251-283) edited by Yi-Hong Wang and Chittaranjan Kole. Boca Raton: CRC Press. doi: 10.1201/b17153
Prentis, Peter J., Gilding, Edward K., Pavasovic, Ana, Frere, Celine H. and Godwin, Ian D. (2013). Molecular markers in plant improvement. Molecular markers in plants. (pp. 67-78) edited by Robert J. Henry. Ames, IA, United States: John Wiley and Sons. doi: 10.1002/9781118473023.ch5
Journal Articles
Bajpai, Abhishek, Jackson, Mark A., Huang, Yen-Hua, Yap, Kuok, Du, Qingdan, Chau, Tevin Chui-Ying, Craik, David J. and Gilding, Edward K. (2023). Nematicidal Activity of Cyclotides: Toxicity Against Caenorhabditis elegans. Journal of Natural Products, 86 (5), 1222-1229. doi: 10.1021/acs.jnatprod.2c01124
Jackson, Mark A., Xie, Jing, Nguyen, Linh T. T., Wang, Xiaohan, Yap, Kuok, Harvey, Peta J., Gilding, Edward K. and Craik, David J. (2023). Plant-based production of an orally active cyclotide for the treatment of multiple sclerosis. Transgenic Research, 32 (1-2), 121-133. doi: 10.1007/s11248-023-00341-1
Campbell, B.C., Van Haeften, S., Massel, K., Milic, A., Al Kouba, J., Addison-Smith, B., Gilding, E.K., Beggs, P.J. and Davies, J.M. (2023). Metabarcoding airborne pollen from subtropical and temperate eastern Australia over multiple years reveals pollen aerobiome diversity and complexity. Science of the Total Environment, 862 160585, 1-11. doi: 10.1016/j.scitotenv.2022.160585
Jackson, Mark A., Chan, Lai Yue , Harding, Maxim D., Craik, David J. and Gilding, Edward K. (2022). Rational domestication of a plant-based recombinant expression system expands its biosynthetic range. Journal of Experimental Botany, 73 (18), 6103-6114. doi: 10.1093/jxb/erac273
Dang, Tien T., Huang, Yen-Hua, Ott, Stanislav, Harvey, Peta J., Gilding, Edward K., Tombling, Benjamin J., Chan, Lai Y., Kaas, Quentin, Claridge-Chang, Adam and Craik, David J. (2022). The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila. Journal of Biological Chemistry, 298 (10) 102413, 1-11. doi: 10.1016/j.jbc.2022.102413
Xie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina and Durek, Thomas (2022). Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox. Journal of Biological Chemistry, 298 (8) 102218, 1-12. doi: 10.1016/j.jbc.2022.102218
Doffek, Benjamin, Huang, Yvonne, Huang, Yen-Hua, Chan, Lai Yue, Gilding, Edward K., Jackson, Mark A. and Craik, David J. (2022). Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farming. Phytochemistry, 195 113053, 113053. doi: 10.1016/j.phytochem.2021.113053
Tombling, Benjamin J., Lammi, Carmen, Lawrence, Nicole, Gilding, Edward K., Grazioso, Giovanni, Craik, David J. and Wang, Conan K. (2021). Bioactive cyclization optimizes the affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) peptide inhibitor. Journal of Medicinal Chemistry, 64 (5) acs.jmedchem.0c01766, 2523-2533. doi: 10.1021/acs.jmedchem.0c01766
Dang, Tien T., Chan, Lai Y., Tombling, Benjamin J., Harvey, Peta J., Gilding, Edward K. and Craik, David J. (2021). In planta discovery and chemical synthesis of bracelet cystine knot peptides from Rinorea bengalensis. Journal of Natural Products, 84 (2), 395-407. doi: 10.1021/acs.jnatprod.0c01065
Campbell, B. C., Al Kouba, J., Timbrell, V., Noor, M. J., Massel, K., Gilding, E. K., Angel, N., Kemish, B., Hugenholtz, P., Godwin, I. D. and Davies, J. M. (2020). Tracking seasonal changes in diversity of pollen allergen exposure: targeted metabarcoding of a subtropical aerobiome. Science of the Total Environment, 747 141189, 141189. doi: 10.1016/j.scitotenv.2020.141189
Jackson, Mark A., Nguyen, Linh T. T., Gilding, Edward K., Durek, Thomas and Craik, David J. (2020). Make it or break it: plant AEPs on stage in biotechnology. Biotechnology Advances, 45 107651, 107651. doi: 10.1016/j.biotechadv.2020.107651
Qu, Haiou, Jackson, Mark A., Yap, Kuok, Harvey, Peta J., Gilding, Edward K. and Craik, David J. (2020). Production of a structurally validated cyclotide in rice suspension cells is enabled by a supporting biosynthetic enzyme. Planta, 252 (6) 97, 97. doi: 10.1007/s00425-020-03505-z
Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Israel, Mathilde R., Harvey, Peta J., Poth, Aaron G., Rehm, Fabian B. H., Stow, Jennifer L., Robinson, Samuel D., Yap, Kuok, Brown, Darren L., Hamilton, Brett R., Andersson, David, Craik, David J., Vetter, Irina and Durek, Thomas (2020). Neurotoxic peptides from the venom of the giant Australian stinging tree. Science Advances, 6 (38) eabb8828, 1-10. doi: 10.1126/sciadv.abb8828
Du, Qingdan, Chan, Lai Y., Gilding, Edward K., Henriques, Sónia Troeira, Condon, Nicholas D., Ravipati, Anjaneya S., Kaas, Quentin, Huang, Yen-Hua and Craik, David J. (2020). Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus. Journal of Biological Chemistry, 295 (32), jbc.RA120.012627-10925. doi: 10.1074/jbc.ra120.012627
Oguis, Georgianna K., Gilding, Edward K., Huang, Yen-Hua, Poth, Aaron G., Jackson, Mark A. and Craik, David J. (2020). Insecticidal diversity of butterfly pea (Clitoria ternatea) accessions. Industrial Crops and Products, 147 112214, 112214. doi: 10.1016/j.indcrop.2020.112214
Du, Junqiao, Yap, Kuok, Chan, Lai Yue, Rehm, Fabian B. H., Looi, Fong Yang, Poth, Aaron G., Gilding, Edward K., Kaas, Quentin, Durek, Thomas and Craik, David J. (2020). A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors. Nature Communications, 11 (1) 1575, 1-11. doi: 10.1038/s41467-020-15418-2
Smithies, Bronwyn J., Huang, Yen-Hua, Jackson, Mark A., Yap, Kuok, Gilding, Edward K., Harris, Karen S., Anderson, Marilyn A. and Craik, David J. (2020). Circular permutation of the native enzyme-mediated cyclization position in cyclotides. ACS Chemical Biology, 15 (4) acschembio.9b00996, 962-969. doi: 10.1021/acschembio.9b00996
van der Burg, Chloé A., Pavasovic, Ana, Gilding, Edward K., Pelzer, Elise S., Surm, Joachim M., Smith, Hayden L., Walsh, Terence P. and Prentis, Peter J. (2020). The rapid regenerative response of a model sea anemone species Exaiptasia pallida is characterised by tissue plasticity and highly coordinated cell communication. Marine Biotechnology, 22 (2), 285-307. doi: 10.1007/s10126-020-09951-w
Li, Enpeng, Hasjim, Jovin, Gilding, Edward K., Godwin, Ian D., Li, Cheng and Gilbert, Robert G. (2019). The role of pullulanase in starch biosynthesis, structure, and thermal properties by studying sorghum with increased pullulanase activity. Starch, 71 (9-10) 1900072, 1900072. doi: 10.1002/star.201900072
Harris, Karen S., Guarino, Rosemary F., Dissanayake, Ravindu S., Quimbar, Pedro, McCorkelle, Owen C., Poon, Simon, Kaas, Quentin, Durek, Thomas, Gilding, Edward K., Jackson, Mark A., Craik, David J., van der Weerden, Nicole L., Anders, Robin F. and Anderson, Marilyn A. (2019). A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein. Scientific Reports, 9 (1) 10820, 10820. doi: 10.1038/s41598-019-47273-7
Oguis, Georgianna K., Gilding, Edward K., Jackson, Mark A. and Craik, David J. (2019). Butterfly pea (Clitoria ternatea), a cyclotide-bearing plant with applications in agriculture and medicine. Frontiers in Plant Science, 10 645, 645. doi: 10.3389/fpls.2019.00645
Jackson, Mark A., Yap, Kuok, Poth, Aaron G., Gilding, Edward K., Swedberg, Joakim E., Poon, Simon, Qu, Haiou, Durek, Thomas, Harris, Karen, Anderson, Marilyn A. and Craik, David J. (2019). Rapid and scalable plant-based production of a potent plasmin inhibitor peptide. Frontiers in Plant Science, 10 602, 602. doi: 10.3389/fpls.2019.00602
Rehm, Fabian B. H., Jackson, Mark A., De Geyter, Ewout, Yap, Kuok, Gilding, Edward K., Durek, Thomas and Craik, David J. (2019). Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization. Proceedings of the National Academy of Sciences, 116 (16), 7831-7836. doi: 10.1073/pnas.1901807116
Liu, Guoquan, Gilding, Edward K., Kerr, Edward D., Schulz, Benjamin L., Tabet, Basam, Hamaker, Bruce R. and Godwin, Ian D. (2019). Increasing protein content and digestibility in sorghum grain with a synthetic biology approach. Journal of Cereal Science, 85, 27-34. doi: 10.1016/j.jcs.2018.11.001
Jackson, M. A., Gilding, E. K., Shafee, T., Harris, K. S., Kaas, Q., Poon, S., Yap, K., Jia, H., Guarino, R., Chan, L. Y., Durek, T., Anderson, M. A. and Craik, D. J. (2018). Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases. Nature Communications, 9 (1) 2411, 2411. doi: 10.1038/s41467-018-04669-9
Poon, Simon, Harris, Karen S, Jackson, Mark A, McCorkelle, Owen C, Gilding, Edward K, Durek, Thomas, van der Weerden, Nicole L, Craik, David J and Anderson, Marilyn A (2017). Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta. Journal of experimental botany, 69 (3), 633-641. doi: 10.1093/jxb/erx422
Liu, Guoquan, Lamont, Kyle C., Ahmad, Norazlina, Tomkins, Alison, Mudge, Stephen R., Gilding, Edward K. and Godwin, Ian D. (2017). The functionality of α-kafirin promoter and α-kafirin signal peptide. Plant Cell, Tissue and Organ Culture, 128 (1), 133-143. doi: 10.1007/s11240-016-1093-3
Campbell, Bradley C., Gilding, Edward K., Mace, Emma S., Tai, Shuaishuai, Tao, Yongfu, Prentis, Peter J., Thomelin, Pauline, Jordan, David R. and Godwin, Ian D. (2016). Domestication and the storage starch biosynthesis pathway: signatures of selection from a whole sorghum genome sequencing strategy. Plant Biotechnology Journal, 14 (12), 2240-2253. doi: 10.1111/pbi.12578
Harris, Karen S., Durek, Thomas, Kaas, Quentin, Poth, Aaron G., Gilding, Edward K., Conlan, Brendon F., Saska, Ivana, Daly, Norelle L., Van Der Weerden, Nicole L., Craik, David J. and Anderson, Marilyn A. (2015). Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase. Nature Communications, 6 (10199) 10199, 10199. doi: 10.1038/ncomms10199
Gilding, Edward K., Jackson, Mark A., Poth, Aaron G., Henriques, Sonia Troeira, Prentis, Peter J., Mahatmanto, Tunjung and Craik, David J. (2015). Gene coevolution and regulation lock cyclic plant defence peptides to their targets. New Phytologist, 210 (2), 717-730. doi: 10.1111/nph.13789
Liu, Guoquan, Gilding, Edward K and Godwin, Ian D (2015). A robust tissue culture system for sorghum [Sorghum bicolor (L.) Moench]. South African Journal of Botany, 98, 157-160. doi: 10.1016/j.sajb.2015.03.179
Shim, Youn Young, Young, Lester W., Arnison, Paul G., Gilding, Edward and Reaney, Martin J. T. (2015). Proposed systematic nomenclature for orbitides. Journal of Natural Products, 78 (4), 645-652. doi: 10.1021/np500802p
Campbell, Bradley C., Gilding, Edward K., Timbrell, Victoria, Guru, Preethi, Loo, Dorothy, Zennaro, Danila, Mari, Adriano, Solley, Graham, Hill, Michelle M., Godwin, Ian D. and Davies, Janet M. (2015). Total transcriptome, proteome, and allergome of Johnson grass pollen, which is important for allergic rhinitis in subtropical regions. Journal of Allergy and Clinical Immunology, 135 (1), 133-142. doi: 10.1016/j.jaci.2014.06.034
Cremer, Julia E., Bean, Scott R., Tilley, Michael M., Ioerger, Brian P., Ohm, Jae B., Kaufman, Rhett C., Wilson, Jeff D., Innes, David J., Gilding, Edward K. and Godwin, Ian D. (2014). Grain sorghum proteomics: integrated approach toward characterization of endosperm storage proteins in kafirin allelic variants. Journal of Agricultural and Food Chemistry, 62 (40), 9819-9831. doi: 10.1021/jf5022847
Mace, Emma, Tai, Shuaishuai, Innes, David, Godwin, Ian, Hu, Wushu, Campbell, Bradley, Gilding, Edward, Cruickshank, Alan, Prentis, Peter, Wang, Jun and Jordan, David (2014). The plasticity of NBS resistance genes in sorghum is driven by multiple evolutionary processes. BMC Plant Biology, 14 (1) 253, 253.1-253.14. doi: 10.1186/s12870-014-0253-z
Amin, Shorash, Prentis, Peter J., Gilding E.K. and Pavasovic, Ana (2014). Assembly and annotation of a non-model gastropod (Nerita melanotragus) transcriptome: a comparison of de novo assemblers. BMC Research Notes, 7 (488) 488, 1-8. doi: 10.1186/1756-0500-7-488
Cremer, Julie E., Liu, Liman, Bean, Scott R., Ohm, Jae-Bom, Tilley, Michael, Wilson, Jeff D., Kaufman, Rhett C., Vu, Thanh H., Gilding, Edward K., Godwin, Ian D. and Wang, Donghai (2014). Impacts of kafirin allelic diversity, starch content, and protein digestibility on ethanol conversion efficiency in grain sorghum. Cereal Chemistry, 91 (3), 218-227. doi: 10.1094/CCHEM-04-13-0068-R
Mace, Emma S., Tai, Shuaishuai, Gilding, Edward K., Li, Yanhong, Prentis, Peter J., Bian, Lianle, Campbell, Bradley C., Hu, Wushu, Innes, David J., Han, Xuelian, Cruickshank, Alan, Dai, Changming, Frere, Celine, Zhang, Haikuan, Hunt, Colleen H., Wang, Xianyuan, Shatte, Tracey, Wang, Miao, Su, Zhe, Li, Jun, Lin, Xiaozhen, Godwin, Ian D., Jordan, David R. and Wang, Jun (2013). Whole-genome sequencing reveals untapped genetic potential in Africa's indigenous cereal crop sorghum. Nature Communications, 4 (1) 2320, 2320.1-2320.8. doi: 10.1038/ncomms3320
Liu, Guoquan, Gilding, Edward K. and Godwin, Ian D. (2013). Additive effects of three auxins and copper on sorghum in vitro root induction. In Vitro Cellular & Developmental Biology-Plant, 49 (2), 191-197. doi: 10.1007/s11627-012-9488-2
Gilding, Edward K., Frere, Celine H., Cruickshank, Alan, Rada, Anna K., Prentis, Peter J., Mudge, Agnieszka M., Mace, Emma S., Jordan, David R. and Godwin, Ian D. (2013). Allelic variation at a single gene increases food value in a drought-tolerant staple cereal. Nature Communications, 4 (1) 1483, 1483.1-1483.5. doi: 10.1038/ncomms2450
Frere, Celine H., Prentis, Peter J., Gilding, Edward K., Mudge, Agnieszka M., Cruickshank, Alan and Godwin, Ian D. (2011). Lack of low frequency variants masks patterns of non-neutral evolution following domestication. PLoS One, 6 (8 Article # e23041) e23041, e23041-1-e23041-5. doi: 10.1371/journal.pone.0023041
Gilding, Edward K. and Marks, M. David (2010). Analysis of purified glabra3-shapeshifter trichomes reveals a role for NOECK in regulating early trichome morphogenic events. Plant Journal, 64 (2), 304-317. doi: 10.1111/j.1365-313X.2010.04329.x
Marks, M. David, Wenger, Jonathan P., Gilding, Edward, Jilk, Ross and Dixon, Richard A. (2009). Transcriptome analysis of Arabidopsis wild-type and gl3-sst sim trichomes identifies four additional genes required for trichome development. Molecular Plant, 2 (4), 803-822. doi: 10.1093/mp/ssp037
Marks, M. David, Betancur, Lissete, Gilding, Edward, Chen, Fang, Bauer, Stefan, Wenger, Jonathan P., Dixon, Richard A. and Haigler, Candace H. (2008). A new method for isolating large quantities of Arabidopsis trichomes for transcriptome, cell wall and other types of analyses. The Plant Journal, 56 (3), 483-492. doi: 10.1111/j.1365-313X.2008.03611.x
Lewis, Janet M., Mackintosh, Caroline A., Shin, Sanghyun, Gilding, Edward, Kravchenko, Sasha, Baldridge, Gerald, Zeyen, Richard and Muehlbauer, Gary J. (2008). Overexpression of the maize Teosinte Branched1 gene in wheat suppresses tiller development. Plant Cell Reports, 27 (7), 1217-1225. doi: 10.1007/s00299-008-0543-8
Marks, M. David, Gilding, Edward and Wenger, Jonathon P. (2007). Genetic interaction between glabra3-shapeshifter and siamese in Arabidopsis thaliana converts trichome precursors into cells with meristematic activity. The Plant Journal, 52 (2), 352-361. doi: 10.1111/j.1365-313X.2007.03243.x
Conference Papers
Campbell, B., Al Kouba, J., Noor, M., Timbrell,, Gilding, E., Angel, N., Kemish, B., Massel, K., Hugenholz, P., Godwin, and Davies, J. M. (2019). Temporal changes in molecular aerobiome diversity by applying DNA metabarcode sequencing across the pollen season. Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI), Lisbon, Portugal, 1-5 June 2019. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.
Craik, D., Oguis, G. K., Smithies, B., Qu, H., Gilding, E. K. and Jackson, M. A. (2016). Design and plant-based production of therapeutic cyclic peptides. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Oxford, United Kingdom: John Wiley & Sons.
Campbell, B., Gilding, E., Lomas, V., Guru, P., Loo, D., Solley, G., Mari, A., Hill, M., Godwin, I. and Davies, J. M. (2013). The allergome, proteome and transcriptome of pollen from the prominent subtropical Johnson grass (Sorghum halepense). World Allergy and Asthma Congress of the European Academy of Allergy and Clinical Immunology and World Allergy Organization, Milan, Italy, 22 - 26 June 2013. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing Ltd.. doi: 10.1111/all.12247