Professor Bostjan Kobe

Ellis, Jonathan J. and Kobe, Boštjan (2013). Protein phosphorylation. Encyclopedia of biophysics. (pp. 2037-2040) edited by Gordon C. K. Roberts. Berlin, Germany: Springer-Verlag. doi: 10.1007/978-3-642-16712-6_184

Kobe, Bostjan and Kemp, Bruce E. (2010). Principles of kinase regulation. Handbook of Cell Signaling, 2/e. (pp. 559-563) Elsevier Inc.. doi: 10.1016/B978-0-12-374145-5.00074-7

W. Saunders, Neil F., Brinkworth, Ross I., Kemp, Bruce E. and Kobe, Bostjan (2010). Substrates of Cyclic Nucleotide-Dependent Protein Kinases. Handbook of Cell Signaling. (pp. 1489-1495) Elsevier. doi: 10.1016/b978-0-12-374145-5.00182-0

Mouradov, Dmitri, Kobe, Bostjan, Dixon, Nicholas E. and Huber, Thomas (2010). Hybrid methods for protein structure prediction. Introduction to protein structure prediction: Methods and algorithms. (pp. 265-277) edited by Huzefa Rangwala and George Karypis. Hoboken, New Jersey, USA: John Wiley and Sons, Inc.. doi: 10.1002/9780470882207.ch12

Li, Sheng, Mouradov, Dmitri, King, Gordon, Liu, Tong, Ross, Ian, Kobe, Bostjan, Woods, Virgil L. and Huber, Thomas (2009). Study of protein three-dimensional structure and dynamics determination using peptide amide hydrogen/deuterium exchange mass spectrometry (DXMS) and chemical cross-linking with mass spectrometry to constrain molecular modeling. Structural Bioinformatics. (pp. 171-206) edited by Gu, Jenny and Bourne, Phillip E.. Hoboken, N.J.: Wiley-Blackwell.

Mouradov, Dmitri, King. Gordon, Ross, Ian L., Forwood, Jade K., Hume, David A., Sinz, Andrea, Martin, Jennifer L., Kobe, Bostjan and Huber, Thomas L. (2008). Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling. Structural Proteomics: High Throughput Methods. (pp. 459-474) edited by Bostjan Kobe, Mitchell Guss and Thomas L. Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_31

Robin, G., Cowieson, N.P., Guncar, G., Forwood, J.K., Listwan, P., Hume, D.A., Kobe, B., Martin, J.L. and Huber, T.L. (2008). A general target selection method for crystallographic proteomics. Structural Proteomics: High-Throughput Methods. (pp. 27-35) edited by Kobe, B., Guss, M. and Huber, T.L.. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_2

Cowieson, N. P., Wensley, B., Robin, G., Guncar, G., Forwood, J. K., Hume, D. A., Kobe, B. and Martin, J. L. (2008). A medium or high throughput protein refolding assay. Structural Proteomics: High throughput Methods. (pp. 269-275) edited by Bostjan Kobe, Mitchell Guss and Thomas Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_17

Meng, Weining, Forwood, Jade K., Guncar, Gregor, Robin, Gautier, Cowieson, Nathan P., Listwan, Pawel, Mouradov, Dmitri, King, Gordon, Ross, lan L., Robinson, Jodie, Puri, Munish, Hill, Justine M., Kellie, Stuart, Huber, Thomas, Hume, David A., Martin, Jennifer L. and Kobe, Bostjan (2008). Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland. Structural proteomics: High-throughput methods. (pp. 577-587) edited by B. Kobe, M. Guss and T. L. Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_38

Thakur, A. S., Newman, J., Martin, J. L. and Kobe, B. (2008). Increasing protein crystallization screening success with heterogeneous nucleating agents. Structural Proteomics: High-throughput Methods. (pp. 403-409) edited by B. Kobe, M. Guss and T. Huber. USA: Humana Press.

Kobe, B. and Kemp, B. E. (2004). Principles of kinase regulation. Handbook of Cell Signaling Vol 1. (pp. 539-542) edited by R. A. Bradshaw and E. A. Dennis. USA: Academic Press.

Brinkworth, R. I., Kobe, B. and Kemp, B.L.E. (2004). Peptide substrates of cyclic nucleotide-dependent protein kinases. Handbook of Cell Signaling. (pp. 495-499) edited by R. A. Bradshaw and E. A. Dennis. USA: Academic Press. doi: 10.1016/B978-012124546-7/50563-5

Kobe, Bostjan and Kemp, Bruce E. (2003). Principles of Kinase Regulation. Handbook of Cell Signaling. (pp. 539-542) Elsevier Inc.. doi: 10.1016/B978-012124546-7/50450-2

Kobe, Bostjan, Jennings, Ian G. and Cotton, Richard G. H. (2002). Structure and Regulation of Phenylalanine Hydroxylase, and Implications for Related Enzymes. Chemistry and Biology of Pteridines and Folates. (pp. 79-84) Boston, MA: Springer US. doi: 10.1007/978-1-4615-0945-5_13

Brinkworth, R. I., Breinl, R. A. and Kobe, B. (2002). Conserved sequence motifs in protein kinase families. Recent Research Developments in Protein Folding Stability and Design. (pp. 67-77) edited by M Michael Gromiha and S Selvaraj. Trivandrum, India: Research Signpost.

Heierhorst, Jorg, Pearson, Richard, Horne, James, Bozinovski, Steven, Kobe, Bostjan and Kemp, Bruce E. (2000). Protein serine/threonine kinases. Principles of Molecular Regulation. (pp. 297-310) edited by Michael Conn P. and Anthony R. Means. Totowa, N.J., USA: Humana Press. doi: 10.1007/978-1-59259-032-2_17

Kobe, Bostjan, Gleichmann, Thomas, Teh, Trazel, Heierhorst, Jorg and Kemp, Bruce E. (1999). Crystallization of protein kinases and phosphatases. Protein phosphorylation: A practical approach. (pp. 387-422) edited by D. Grahame Hardie. Oxford, UK: Oxford University Press.

Maruta, Natsumi, Outram, Megan A. and Kobe, Bostjan (2023). Mildew RALPHs up in arms with cereals. Proceedings of the National Academy of Sciences, 120 (36). doi: 10.1073/pnas.2311817120

Li, Sulin, Manik, Mohammad K, Shi, Yun, Kobe, Bostjan and Ve, Thomas (2023). Toll/interleukin-1 receptor domains in bacterial and plant immunity. Current Opinion in Microbiology, 74 102316, 102316. doi: 10.1016/j.mib.2023.102316

McCombe, Carl L., Catanzariti, Ann‐Maree, Greenwood, Julian R., Desai, Anna M., Outram, Megan A., Yu, Daniel S., Ericsson, Daniel J., Brenner, Steven E., Dodds, Peter N., Kobe, Bostjan, Jones, David A. and Williams, Simon J. (2023). A rust‐fungus Nudix hydrolase effector decaps mRNA in vitro and interferes with plant immune pathways. New Phytologist, 239 (1), 222-239. doi: 10.1111/nph.18727

Maruta, Natsumi, Sorbello, Mitchell, Lim, Bryan Y. J., McGuinness, Helen Y., Shi, Yun, Ve, Thomas and Kobe, Bostjan (2023). TIR domain-associated nucleotides with functions in plant immunity and beyond. Current Opinion in Plant Biology, 73 102364, 102364. doi: 10.1016/j.pbi.2023.102364

Lang, Jia-Jia, Lv, You, Kobe, Bostjan, Chen, Hongfei, Tan, Yan, Chen, Limei, Wang, Xuechuan, Mi, Pengbing, Zheng, Xing and Lin, Ying-Wu (2023). Discovery of C-5 Pyrazole-Substituted Pyrrolopyridine Derivatives as Potent and Selective Inhibitors for Janus Kinase 1. Journal of Medicinal Chemistry, 66 (10), 6725-6742. doi: 10.1021/acs.jmedchem.3c00050

Tao, Le, Yang, Guangyue, Sun, Tiantian, Tao, Jie, Zhu, Chan, Yu, Huimin, Cheng, Yalan, Yang, Zongguo, Xu, Mingyi, Jiang, Yuefeng, Zhang, Wei, Wang, Zhiyi, Ma, Wenting, Wu, Liu, Xue, Dongying, Wang, Dongxue, Yang, Wentao, Zhao, Yongjuan, Horsefield, Shane, Kobe, Bostjan, Zhang, Zhe, Tang, Zongxiang, Li, Qigen, Zhai, Qiwei, Dooley, Steven, Seki, Ekihiro, Liu, Ping, Xu, Jianrong, Chen, Hongzhuan and Liu, Cheng (2023). Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1. Journal of Hepatology, 78 (4), 805-819. doi: 10.1016/j.jhep.2022.12.031

Teng, Linhong, Liang, Miao, Wang, Chenghui, Li, Yan, Urbach, Jonathan M., Kobe, Bostjan, Xing, Qikun, Han, Wentao and Ye, Naihao (2023). Exon shuffling potentiates a diverse repertoire of brown algal NB‐ARC‐TPR candidate immune receptor proteins via alternative splicing. The Plant Journal, 114 (2), 246-261. doi: 10.1111/tpj.16131

McGuinness, Helen Y., Gu, Weixi, Shi, Yun, Kobe, Bostjan and Ve, Thomas (2023). SARM1-dependent axon degeneration: nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities. The Neuroscientist, 107385842311625. doi: 10.1177/10738584231162508

Bayless, Adam M., Chen, Sisi, Ogden, Sam C., Xu, Xiaoyan, Sidda, John D., Manik, Mohammad K., Li, Sulin, Kobe, Bostjan, Ve, Thomas, Song, Lijiang, Grant, Murray, Wan, Li and Nishimura, Marc T. (2023). Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products. Science Advances, 9 (11) eade8487, 1-15. doi: 10.1126/sciadv.ade8487

Muusse, Timothy W., Lee, Morris Y.L., Kim, Hyoyoung, Parat, Marie-Odile, Nanson, Jeffrey D., Kobe, Bostjan, Vajjhala, Parimala R. and Stacey, Katryn J. (2022). Flow cytometric reporter assays provide robust functional analysis of signaling complexes. Journal of Biological Chemistry, 298 (12) 102666, 102666. doi: 10.1016/j.jbc.2022.102666

Foley, Gabriel, Mora, Ariane, Ross, Connie M., Bottoms, Scott, Sützl, Leander, Lamprecht, Marnie L., Zaugg, Julian, Essebier, Alexandra, Balderson, Brad, Newell, Rhys, Thomson, Raine E. S., Kobe, Bostjan, Barnard, Ross T., Guddat, Luke, Schenk, Gerhard, Carsten, Jörg, Gumulya, Yosephine, Rost, Burkhard, Haltrich, Dietmar, Sieber, Volker, Gillam, Elizabeth M. J. and Bodén, Mikael (2022). Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP). PL o S Computational Biology, 18 (10) e1010633, e1010633. doi: 10.1371/journal.pcbi.1010633

Wizrah, Maha S. I., Chua, Sheena M. H., Luo, Zhenyao, Manik, Mohammad K., Pan, Mengqi, Whyte, Jessica M. L., Robertson, Avril A. B., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2022). AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. Journal of Biological Chemistry, 298 (10) 102453, 102453. doi: 10.1016/j.jbc.2022.102453

Manik, Mohammad K., Shi, Yun, Li, Sulin, Zaydman, Mark A., Damaraju, Neha, Eastman, Samuel, Smith, Thomas G., Gu, Weixi, Masic, Veronika, Mosaiab, Tamim, Weagley, James S., Hancock, Steven J., Vasquez, Eduardo, Hartley-Tassell, Lauren, Kargios, Nestoras, Maruta, Natsumi, Lim, Bryan Y. J., Burdett, Hayden, Landsberg, Michael J., Schembri, Mark A., Prokes, Ivan, Song, Lijiang, Grant, Murray, DiAntonio, Aaron, Nanson, Jeffrey D., Guo, Ming, Milbrandt, Jeffrey, Ve, Thomas and Kobe, Bostjan (2022). Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling. Science, 377 (6614) eadc8969, 1-11. doi: 10.1126/science.adc8969

Hancock, Steven J., Lo, Alvin W., Ve, Thomas, Day, Christopher J., Tan, Lendl, Mendez, Alejandra A., Phan, Minh-Duy, Nhu, Nguyen Thi Khanh, Peters, Kate M., Richards, Amanda C., Fleming, Brittany A., Chang, Chyden, Ngu, Dalton H. Y., Forde, Brian M., Haselhorst, Thomas, Goh, Kelvin G. K., Beatson, Scott A., Jennings, Michael P., Mulvey, Matthew A., Kobe, Bostjan and Schembri, Mark A. (2022). Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli. PLoS Pathogens , 18 (6) e1010582, e1010582. doi: 10.1371/journal.ppat.1010582

Alquethamy, Saleh, Ganio, Katherine, Luo, Zhenyao, Hossain, Sheikh I., Hayes, Andrew J., Ve, Thomas, Davies, Mark R., Deplazes, Evelyne, Kobe, Boštjan and McDevitt, Christopher A. (2022). Structural and biochemical characterization of Acinetobacter baumannii ZnuA. Journal of Inorganic Biochemistry, 231 111787, 1-11. doi: 10.1016/j.jinorgbio.2022.111787

Maunders, Eve A., Ngu, Dalton H. Y., Ganio, Katherine, Hossain, Sheikh I., Lim, Bryan Y. J., Leeming, Michael G., Luo, Zhenyao, Tan, Aimee, Deplazes, Evelyne, Kobe, Boštjan and McDevitt, Christopher A. (2022). The impact of chromate on Pseudomonas aeruginosa molybdenum homeostasis. Frontiers in Microbiology, 13 903146, 1-19. doi: 10.3389/fmicb.2022.903146

Liu, Liping, Lucas, Richard M., Nanson, Jeffrey D., Li, Yan, Whitfield, Jason, Curson, James E. B., Tuladhar, Neeraj, Alexandrov, Kirill, Mobli, Mehdi, Sweet, Matthew J., Kobe, Bostjan, Stow, Jennifer and Luo, Lin (2022). The transmembrane adaptor SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs. Journal of Biological Chemistry, 298 (5) 101857, 101857. doi: 10.1016/j.jbc.2022.101857

Shi, Yun, Kerry, Philip S., Nanson, Jeffrey D., Bosanac, Todd, Sasaki, Yo, Krauss, Raul, Saikot, Forhad K., Adams, Sarah E., Mosaiab, Tamim, Masic, Veronika, Mao, Xianrong, Rose, Faith, Vasquez, Eduardo, Furrer, Marieke, Cunnea, Katie, Brearley, Andrew, Gu, Weixi, Luo, Zhenyao, Brillault, Lou, Landsberg, Michael J., DiAntonio, Aaron, Kobe, Bostjan, Milbrandt, Jeffrey, Hughes, Robert O. and Ve, Thomas (2022). Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Molecular Cell, 82 (9), 1643-1659.e10. doi: 10.1016/j.molcel.2022.03.007

Scholz, Jean L., Eleftherianos, Ioannis and Kobe, Bostjan (2022). Editorial: Evolution of Innate Immunity in Eukarya: Advances and Implications. Frontiers in Immunology, 13 879429, 879429. doi: 10.3389/fimmu.2022.879429

Nimma, Surekha, Gu, Weixi, Manik, Mohammad K., Ve, Thomas, Nanson, Jeffrey D. and Kobe, Bostjan (2022). Crystal structure of the Toll/interleukin‐1 receptor (TIR) domain of IL‐1R10 provides structural insights into TIR domain signaling. FEBS Letters, 596 (7), 886-897. doi: 10.1002/1873-3468.14288

Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166

Maruta, Natsumi, Burdett, Hayden, Lim, Bryan Y. J., Hu, Xiahao, Desa, Sneha, Manik, Mohammad Kawsar and Kobe, Bostjan (2022). Structural basis of NLR activation and innate immune signalling in plants. Immunogenetics, 74 (1), 5-26. doi: 10.1007/s00251-021-01242-5

Loreto, Andrea, Angeletti, Carlo, Gu, Weixi, Osborne, Andrew, Nieuwenhuis, Bart, Gilley, Jonathan, Arthur-Farraj, Peter, Merlini, Elisa, Amici, Adolfo, Luo, Zhenyao, Hartley-Tassell, Lauren, Ve, Thomas, Desrochers, Laura M, Wang, Qi, Kobe, Bostjan, Orsomando, Giuseppe and Coleman, Michael P (2021). Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1. eLife, 10 e72823. doi: 10.7554/elife.72823

Nimma, Surekha, Gu, Weixi, Maruta, Natsumi, Li, Yan, Pan, Mengqi, Saikot, Forhad Karim, Lim, Bryan Y. J., McGuinness, Helen Ying, Zaoti, Zannati Ferdous, Li, Sulin, Desa, Sneha, Manik, Mohammad Kawsar, Nanson, Jeffrey D. and Kobe, Bostjan (2021). Structural evolution of TIR-domain signalosomes. Frontiers in Immunology, 12 784484, 1-10. doi: 10.3389/fimmu.2021.784484

Sasaki, Yo, Zhu, Jian, Shi, Yun, Gu, Weixi, Kobe, Bostjan, Ve, Thomas, DiAntonio, Aaron and Milbrandt, Jeffrey (2021). Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. Experimental Neurology, 345 113842, 113842. doi: 10.1016/j.expneurol.2021.113842

Chua, Sheena M. H., Wizrah, Maha S. I., Luo, Zhenyao, Lim, Bryan Y. J., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2021). Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets. Journal of Biological Chemistry, 297 (4) 101091. doi: 10.1016/j.jbc.2021.101091

Gu, Weixi, Luo, Zhenyao, Vonrhein, Clemens, Jia, Xinying, Ve, Thomas, Nanson, Jeffrey D. and Kobe, Bostjan (2021). Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing. Acta Crystallographica. Section F: Structural Biology Communications, 77 (10), 364-373. doi: 10.1107/s2053230x21006786

Župan, Marina L., Luo, Zhenyao, Ganio, Katherine, Pederick, Victoria G., Neville, Stephanie L., Deplazes, Evelyne, Kobe, Boštjan and McDevitt, Christopher A. (2021). Conformation of the solute-binding protein AdcAII influences zinc uptake in Streptococcus pneumoniae. Frontiers in Cellular and Infection Microbiology, 11 729981, 1-15. doi: 10.3389/fcimb.2021.729981

Hopkins, Eleanor L., Gu, Weixi, Kobe, Bostjan and Coleman, Michael P. (2021). A novel NAD signaling mechanism in axon degeneration and its relationship to innate immunity. Frontiers in Molecular Biosciences, 8 703532, 1-16. doi: 10.3389/fmolb.2021.703532

Outram, Megan A., Sung, Yi‐Chang, Yu, Daniel, Dagvadorj, Bayantes, Rima, Sharmin A., Jones, David A., Ericsson, Daniel J., Sperschneider, Jana, Solomon, Peter S., Kobe, Bostjan and Williams, Simon J. (2021). The crystal structure of SnTox3 from the necrotrophic fungus Parastagonospora nodorum reveals a unique effector fold and provides insight into Snn3 recognition and pro‐domain protease processing of fungal effectors. New Phytologist, 231 (6) nph.17516, 1-15. doi: 10.1111/nph.17516

Lee, Chin Hong, Hawker, Nathaniel P., Peters, Jonathan R., Lonhienne, Thierry G. A., Gursanscky, Nial R., Matthew, Louisa, Brosnan, Christopher A., Mann, Christopher W. G., Cromer, Laurence, Taochy, Christelle, Ngo, Quy A., Sundaresan, Venkatesan, Schenk, Peer M., Kobe, Bostjan, Borges, Filipe, Mercier, Raphael, Bowman, John L. and Carroll, Bernard J. (2021). Defective embryo and meristems genes are required for cell division and gamete viability in Arabidopsis. PL o S Genetics, 17 (5) e1009561, 1-31. doi: 10.1371/journal.pgen.1009561

Clabbers, Max T. B., Holmes, Susannah, Muusse, Timothy W., Vajjhala, Parimala R., Thygesen, Sara J., Malde, Alpeshkumar K., Hunter, Dominic J. B., Croll, Tristan I., Flueckiger, Leonie, Nanson, Jeffrey D., Rahaman, Md. Habibur, Aquila, Andrew, Hunter, Mark S., Liang, Mengning, Yoon, Chun Hong, Zhao, Jingjing, Zatsepin, Nadia A., Abbey, Brian, Sierecki, Emma, Gambin, Yann, Stacey, Katryn J., Darmanin, Connie, Kobe, Bostjan, Xu, Hongyi and Ve, Thomas (2021). MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography. Nature Communications, 12 (1) 2578, 1-14. doi: 10.1038/s41467-021-22590-6

Sung, Yi‐Chang, Outram, Megan A., Breen, Susan, Wang, Chen, Dagvadorj, Bayantes, Winterberg, Britta, Kobe, Bostjan, Williams, Simon J. and Solomon, Peter S. (2021). PR1‐mediated defence via C‐terminal peptide release is targeted by a fungal pathogen effector. New Phytologist, 229 (6), 3467-3480. doi: 10.1111/nph.17128

Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron and Ve, Thomas (2021). SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration. Neuron, 109 (7), 1-19. doi: 10.1016/j.neuron.2021.02.009

Oyarzun, Patricio, Kashyap, Manju, Fica, Victor, Salas-Burgos, Alexis, Gonzalez-Galarza, Faviel F., McCabe, Antony, Jones, Andrew R., Middleton, Derek and Kobe, Bostjan (2021). A proteome-wide immunoinformatics tool to accelerate T-cell epitope discovery and vaccine design in the context of emerging infectious diseases: an ethnicity-oriented approach. Frontiers in Immunology, 12 598778, 1-25. doi: 10.3389/fimmu.2021.598778

Luo, Zhenyao, Morey, Jacqueline R., Deplazes, Evelyne, Motygullina, Alina, Tan, Aimee, Ganio, Katherine, Neville, Stephanie L., Eleftheriadis, Nikolaos, Isselstein, Michael, Pederick, Victoria G., Paton, James C., Cordes, Thorben, Harmer, Jeffrey R., Kobe, Bostjan and McDevitt, Christopher A. (2021). A trap-door mechanism for zinc acquisition by Streptococcus pneumoniae AdcA. mBio, 12 (1) e01958-20, 1-14. doi: 10.1128/mBio.01958-20

Struwe, Michel A., Kalimuthu, Palraj, Luo, Zhenyao, Zhong, Qifeng, Ellis, Daniel, Yang, Jing, Khadanand, K.C., Harmer, Jeffrey R., Kirk, Martin L., McEwan, Alastair G., Clement, Bernd, Bernhardt, Paul V., Kobe, Bostjan and Kappler, Ulrike (2021). Active site architecture reveals coordination sphere flexibility and specificity determinants in a group of closely related molybdoenzymes. Journal of Biological Chemistry, 296 100672, 1-16. doi: 10.1016/j.jbc.2021.100672

Zhong, Qifeng, Kobe, Bostjan and Kappler, Ulrike (2020). Molybdenum enzymes and how they support virulence in pathogenic bacteria. Frontiers in Microbiology, 11 615860, 1-23. doi: 10.3389/fmicb.2020.615860

Sun, Chenghai, Luo, Zhenyao, Zhang, Wenlu, Tian, Wenya, Peng, Haidong, Lin, Zhi, Deng, Zixin, Kobe, Bostjan, Jia, Xinying and Qu, Xudong (2020). Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines. Nature Communications, 11 (1) 6251, 1-10. doi: 10.1038/s41467-020-20022-5

Azar, Daniel F., Haas, Meryl, Fedosyuk, Sofiya, Rahaman, Md. Habibur, Hedger, Andrew, Kobe, Bostjan and Skern, Tim (2020). Vaccinia virus immunomodulator A46: destructive interactions with MAL and MyD88 shown by negative-stain electron microscopy. Structure, 28 (12), 1271-1287.e5. doi: 10.1016/j.str.2020.09.007

Sun, Yeping, Kobe, Bostjan and Qi, Jianxun (2020). Targeting multiple epitopes on the spike protein: a new hope for COVID-19 antibody therapy. Signal Transduction and Targeted Therapy, 5 (1) 208, 208. doi: 10.1038/s41392-020-00320-6

Hancock, Steven J., Phan, Minh-Duy, Luo, Zhenyao, Lo, Alvin W., Peters, Kate M., Nhu, Nguyen Thi Khanh, Forde, Brian M., Whitfield, Jason, Yang, Ji, Strugnell, Richard A., Paterson, David L., Walsh, Timothy R., Kobe, Bostjan, Beatson, Scott A. and Schembri, Mark A. (2020). Comprehensive analysis of IncC plasmid conjugation identifies a crucial role for the transcriptional regulator AcaB. Nature Microbiology, 5 (11), 1340-1348. doi: 10.1038/s41564-020-0775-0

Shewell, Lucy K., Day, Christopher J., Jen, Freda E.-C., Haselhorst, Thomas, Atack, John M., Reijneveld, Josephine F., Everest-Dass, Arun, James, David B. A., Boguslawski, Kristina M., Brouwer, Stephan, Gillen, Christine M., Luo, Zhenyao, Kobe, Bostjan, Nizet, Victor, von Itzstein, Mark, Walker, Mark J., Paton, Adrienne W., Paton, James C., Torres, Victor J. and Jennings, Michael P. (2020). All major cholesterol-dependent cytolysins use glycans as cellular receptors. Science Advances, 6 (21) EAAZ4926, eaaz4926. doi: 10.1126/sciadv.aaz4926

Lai, Jhih‐Siang, Rost, Burkhard, Kobe, Bostjan and Bodén, Mikael (2020). Evolutionary model of protein secondary structure capable of revealing new biological relationships. Proteins: Structure, Function, and Bioinformatics, 88 (9) prot.25898, 1251-1259. doi: 10.1002/prot.25898

Luo, Zhenyao, Neville, Stephanie L., Campbell, Rebecca, Morey, Jacqueline R., Menon, Shruti, Thomas, Mark, Eijkelkamp, Bart A., Ween, Miranda P., Huston, Wilhelmina M., Kobe, Bostjan and McDevitt, Christopher A. (2019). The structure and metal binding properties of Chlamydia trachomatis YtgA. Journal of Bacteriology, 202 (1) e00580. doi: 10.1128/jb.00580-19

Horsefield, Shane, Burdett, Hayden, Zhang, Xiaoxiao, Manik, Mohammad K., Shi, Yun, Chen, Jian, Qi, Tiancong, Gilley, Jonathan, Lai, Jhih-Siang, Rank, Maxwell X., Casey, Lachlan W., Gu, Weixi, Ericsson, Daniel J., Foley, Gabriel, Hughes, Robert O., Bosanac, Todd, von Itzstein, Mark, Rathjen, John P., Nanson, Jeffrey D., Boden, Mikael, Dry, Ian B., Williams, Simon J., Staskawicz, Brian J., Coleman, Michael P., Ve, Thomas, Dodds, Peter N. and Kobe, Bostjan (2019). NAD+ cleavage activity by animal and plant TIR domains in cell death pathways. Science, 365 (6455), 793-799. doi: 10.1126/science.aax1911

Burdett, Hayden, Bentham, Adam R., Williams, Simon J., Dodds, Peter N., Anderson, Peter A., Banfield, Mark J. and Kobe, Bostjan (2019). The plant “resistosome”: structural insights into immune signaling. Cell Host and Microbe, 26 (2), 193-201. doi: 10.1016/j.chom.2019.07.020

Burdett, Hayden, Kobe, Bostjan and Anderson, Peter A. (2019). Animal NLRs continue to inform plant NLR structure and function. Archives of Biochemistry and Biophysics, 670, 58-68. doi: 10.1016/j.abb.2019.05.001

Dowling, Jennifer K., Tate, Michelle E., Bourke, Nollaig M., Bitto, Natalie, Lauterbach, Mario A., Cheung, Shane, Ve, Thomas, Kobe, Bostjan, Golenbock, Douglas and Mansell, Ashley (2019). The single nucleotide polymorphism Mal-D96N mice provide new insights into functionality of Mal in TLR immune responses. The Journal of Immunology, 202 (8), ji1800501-2396. doi: 10.4049/jimmunol.1800501

Newman, Toby E., Lee, Jungmin, Williams, Simon J., Choi, Sera, Halane, Morgan K., Zhou, Jun, Solomon, Peter, Kobe, Bostjan, Jones, Jonathan D. G., Segonzac, Cécile and Sohn, Kee Hoon (2019). Autoimmunity and effector recognition in Arabidopsis thaliana can be uncoupled by mutations in the RRS1-R immune receptor. New Phytologist, 222 (2), 954-965. doi: 10.1111/nph.15617

Wan, Li, Koeck, Markus, Williams, Simon J., Ashton, Anthony R., Lawrence, Gregory J., Sakakibara, Hitoshi, Kojima, Mikiko, Böttcher, Christine, Ericsson, Daniel J., Hardham, Adrienne R., Jones, David A., Ellis, Jeffrey G., Kobe, Bostjan and Dodds, Peter N. (2019). Structural and functional insights into the modulation of the activity of a flax cytokinin oxidase by flax rust effector AvrL567-A. Molecular Plant Pathology, 20 (2), 211-222. doi: 10.1111/mpp.12749

Nanson, Jeffrey D., Kobe, Bostjan and Ve, Thomas (2019). Death, TIR, and RHIM: Self-assembling domains involved in innate immunity and cell-death signaling. Journal of Leukocyte Biology, 105 (2), 363-375. doi: 10.1002/JLB.MR0318-123R

Stewart, Louisa J., Thaqi, Denis, Kobe, Bostjan, McEwan, Alastair G., Waldron, Kevin J. and Djoko, Karrera Y. (2019). Handling of nutrient copper in the bacterial envelope. Metallomics, 11 (1), 50-63. doi: 10.1039/c8mt00218e

O'Carroll, Ailís, Chauvin, Brieuc, Brown, James W.P., Meagher, Ava, Coyle, Joanne, Schill, Jurgen, Bhumkhar, Akshay, Hunter, Dominic J.B., Ve, Thomas, Kobe, Bostjan, Sierecki, Emma and Gambin, Yann (2018). Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88. BMC Biology, 16 (149) 149, 149. doi: 10.1186/s12915-018-0611-7

Wiedorn, Max O., Oberthür, Dominik, Bean, Richard, Schubert, Robin, Werner, Nadine, Abbey, Brian, Aepfelbacher, Martin, Adriano, Luigi, Allahgholi, Aschkan, Al-Qudami, Nasser, Andreasson, Jakob, Aplin, Steve, Awel, Salah, Ayyer, Kartik, Bajt, Saša, Barák, Imrich, Bari, Sadia, Bielecki, Johan, Botha, Sabine, Boukhelef, Djelloul, Brehm, Wolfgang, Brockhauser, Sandor, Cheviakov, Igor, Coleman, Matthew A., Cruz-Mazo, Francisco, Danilevski, Cyril, Darmanin, Connie, Doak, R. Bruce, Domaracky, Martin ... Barty, Anton (2018). Megahertz serial crystallography. Nature Communications, 9 (1) 4025, 4025. doi: 10.1038/s41467-018-06156-7

Kummari, Lalith K., Butler, Mark S., Furlong, Emily, Blundell, Ross, Nouwens, Amanda, Silva, Alberto B., Kappler, Ulrike, Fraser, James A., Kobe, Bostjan, Cooper, Matthew A. and Robertson, Avril A.B. (2018). Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles. Bioorganic and Medicinal Chemistry, 26 (20), 5408-5419. doi: 10.1016/j.bmc.2018.09.004

Luo, Zhenyao, Pederick, Victoria G., Paton, James C., McDevitt, Christopher A. and Kobe, Bostjan (2018). Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae. FEBS letters, 592 (13), 2341-2350. doi: 10.1002/1873-3468.13122

Nanson, Jeffrey D., Rahaman, Habibur, Ve, Thomas and Kobe, Bostjan (2018). Regulation of signaling by cooperative assembly formation in mammalian innate immunity signalosomes by molecular mimics. Seminars in Cell and Developmental Biology, 99, 96-114. doi: 10.1016/j.semcdb.2018.05.002

Cotrim, Camila A., Soares, Jose Sergio M., Kobe, Bostjan and Menossi, Marcelo (2018). Crystal structure and insights into the oligomeric state of UDP-glucose pyrophosphorylase from sugarcane. PloS One, 13 (3) 0193667, 1-13. doi: 10.1371/journal.pone.0193667

Ryan, Timothy M., Trewhella, Jill, Murphy, James M., Keown, Jeremy R., Casey, Lachlan, Pearce, F. Grant, Goldstone, David C., Chen, Kelan, Luo, Zhenyao, Kobe, Bostjan, McDevitt, Christopher A., Watkin, Serena A., Hawley, Adrian M., Mudie, Stephen T., Boban, Vesna Samardzic and Kirby, Nigel (2018). An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis. Journal of Applied Crystallography, 51 (1), 97-111. doi: 10.1107/S1600576717017101

Li, Jie, Watterson, Daniel, Chang, Chiung-Wen, Che, Xiao-Yan, Li, Xiao-Quan, Ericsson, Daniel J., Qiu, Li-Wen, Cai, Jian-Piao, Chen, Jing, Fry, Scott R., Cheung, Stacey T. M., Cooper, Matthew A., Young, Paul R. and Kobe, Bostjan (2018). Structural and functional characterization of a cross-reactive dengue virus neutralizing antibody that recognizes a cryptic epitope. Structure, 26 (1), 51-59. doi: 10.1016/j.str.2017.11.017

de Barros, Andrea C, Takeda, Agnes A S, Dreyer, Thiago R, Velazquez-Campoy, Adrian, Kobe, Boštjan and Fontes, Marcos R M (2017). DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, 146, 87-96. doi: 10.1016/j.biochi.2017.11.013

Zhang, Xiaoxiao, Farah, Nadya, Rolston, Laura, Ericsson, Daniel J., Catanzariti, Ann-Maree, Bernoux, Maud, Ve, Thomas, Bendak, Katerina, Chen, Chunhong, Mackay, Joel P., Lawrence, Gregory J., Hardham, Adrienne, Ellis, Jeffrey G., Williams, Simon J., Dodds, Peter N., Jones, David A. and Kobe, Bostjan (2017). Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P. Molecular Plant Pathology, 19 (5), 1196-1209. doi: 10.1111/mpp.12597

Hughes, Mark M., Lavrencic, Peter, Coll, Rebecca C., Ve, Thomas, Ryan, Dylan G., Williams, Niamh C., Menon, Deepthi, Mansell, Ashley, Board, Philip G., Mobli, Mehdi, Kobe, Bostjan and O'Neill, Luke A. J. (2017). Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling. Proceedings of the National Academy of Sciences, 114 (32), E6480-E6489. doi: 10.1073/pnas.1701868114

Ve, Thomas, Vajjhala, Parimala, Hedger, Andrew, Croll, Tristan, DiMaio, Frank, Horsefield, Shane, Yu, Xiong, Lavrencic, Peter, Hassan, Zahid, Morgan, Garry P., Mansell, Ashley, Mobli, Mehdi, O'Carroll, Ailis, Chauvin, Brieuc, Gambin, Yann, Sierecki, Emma, Landsberg, Michael J., Stacey, Katryn, Egelman, Edward H. and Kobe, Bostjan (2017). Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling. Nature Structural and Molecular Biology, 24 (9), 743-751. doi: 10.1038/nsmb.3444

Breen, Susan, Williams, Simon J., Outram, Megan, Kobe, Bostjan and Solomon, Peter S. (2017). Emerging insights into the functions of pathogenesis-related protein 1. Trends in Plant Science, 22 (10), 871-879. doi: 10.1016/j.tplants.2017.06.013

Chitty, Jessica L., Blake, Kirsten L., Blundell, Ross D., Koh, Y. Q. Andre E., Thompson, Merinda, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kappler, Ulrike, Williams, Simon J., Kobe, Bostjan and Fraser, James A. (2017). Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design. Journal of Biological Chemistry, 292 (28), 11829-11839. doi: 10.1074/jbc.M117.787994

Vajjhala, Parimala R., Ve, Thomas, Bentham, Adam, Stacey, Katryn J. and Kobe, Bostjan (2017). The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways. Molecular Immunology, 86, 23-37. doi: 10.1016/j.molimm.2017.02.012

Nimma, Surekha, Ve, Thomas, Williams, Simon J. and Kobe, Bostjan (2017). Towards the structure of the TIR-domain signalosome. Current Opinion In Structural Biology, 43, 122-130. doi: 10.1016/j.sbi.2016.12.014

Chitty, Jessica L., Tatzenko, Tayla L. , Williams, Simon J., Koh, Y. Q. Andre E., Corfield, Elizabeth C., Butler, Mark S., Robertson, Avril A. B., Cooper, Matthew A., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2017). GMP synthase is required for virulence factor production and infection by cryptococcus neoformans. Journal of Biological Chemistry, 292 (7), 3049-3059. doi: 10.1074/jbc.M116.767533

Patrick, Ralph, Kobe, Bostjan, Lê Cao, Kim-Anh and Bodén, Mikael (2017). PhosphoPICK-SNP: quantifying the effect of amino acid variants on protein phosphorylation. Bioinformatics, 33 (12), 1773-1781. doi: 10.1093/bioinformatics/btx072

Miljenović, Tomas, Jia, Xinying, Lavrencic, Peter, Kobe, Bostjan and Mobli, Mehdi (2017). A non-uniform sampling approach enables studies of dilute and unstable proteins. Journal of Biomolecular NMR, 68 (2), 1-9. doi: 10.1007/s10858-017-0091-z

Zhang, Xiaoxiao, Bernoux, Maud, Bentham, Adam R., Newman, Toby E., Ve, Thomas, Casey, Lachlan W., Raaymakers, Tom M., Hu, Jian, Croll, Tristan I., Schreiber, Karl J., Staskawicz, Brian J., Anderson, Peter A., Sohn, Kee Hoon, Williams, Simon J., Dodds, Peter N. and Kobe, Bostjan (2017). Multiple functional self-association interfaces in plant TIR domains. Proceedings of the National Academy of Sciences, 114 (10), E2046-E2052. doi: 10.1073/pnas.1621248114

De Oliveira, David M. P., Hartley-Tassell, Lauren, Everest-Dass, Arun, Day, Christopher J., Dabbs, Rebecca A., Ve, Thomas, Kobe, Bostjan, Nizet, Victor, Packer, Nicolle H., Walker, Mark J., Jennings, Michael P. and Sanderson-Smith, Martina L. (2017). Blood group antigen recognition via the group A Streptococcal M protein mediates host colonization. MBio, 8 (1) e02237-16, e02237-16. doi: 10.1128/mBio.02237-16

Williams, Simon J., Yin, Ling, Foley, Gabriel, Casey, Lachlan W., Outram, Megan A., Ericsson, Daniel J., Lu, Jiang, Boden, Mikael, Dry, Ian B. and Kobe, Bostjan (2016). Structure and function of the TIR domain from the grape NLR protein RPV1. Frontiers in Plant Science, 7 (DECEMBER2016) 1850, 1850. doi: 10.3389/fpls.2016.01850

Casey, Lachlan W., Lavrencic, Peter, Bentham, Adam R., Cesari, Stella, Ericsson, Daniel J., Croll, Tristan, Turk, Dušan, Anderson, Peter A., Mark, Alan E., Dodds, Peter N., Mobli, Mehdi, Kobe, Bostjan and Williams, Simon J. (2016). The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins. Proceedings of the National Academy of Sciences, 113 (45), 12856-12861. doi: 10.1073/pnas.1609922113

Patrick, Ralph, Horin, Coralie, Kobe, Bostjan, Cao, Kim-Anh Le and Bodén, Mikael (2016). Prediction of kinase-specific phosphorylation sites through an integrative model of protein context and sequence. Biochimica et Biophysica Acta, 1864 (11), 1599-1608. doi: 10.1016/j.bbapap.2016.08.001

Breen, Susan, Williams, Simon J., Winterberg, Britta, Kobe, Bostjan and Solomon, Peter S. (2016). Wheat PR-1 proteins are targeted by necrotrophic pathogen effector proteins. Plant Journal, 88 (1), 13-25. doi: 10.1111/tpj.13228

Blundell, Ross D., Williams, Simon J., Arras, Samantha D. M., Chitty, Jessica L., Blake, Kirsten L., Ericsson, Daniel J., Tibrewal, Nidhi, Rohr, Jurgen, Koh, Y. Q. Andre, Kappler, Ulrike, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kobe, Bostjan and Fraser, James A. (2016). Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformans. ACS Infectious Diseases, 2 (9), 651-663. doi: 10.1021/acsinfecdis.6b00121

Bentham, Adam, Burdett, Hayden, Anderson, Peter A., Williams, Simon J. and Kobe, Bostjan (2016). Animal NLRs provide structural insights into plant NLR function. Annals of Botany, 119 (5), 689-702. doi: 10.1093/aob/mcw171

Schreiber, Karl J., Bentham, Adam, Williams, Simon J., Kobe, Bostjan and Staskawicz, Brian J. (2016). Multiple domain associations within the Arabidopsis immune receptor RPP1 regulate the activation of programmed cell death. PLoS Pathogens, 12 (7) e1005769, e1005769. doi: 10.1371/journal.ppat.1005769

Couñago, Rafael M., Chen, Nathan H., Chang, Chiung-Wen, Djoko, Karrera Y., McEwan, Alastair G. and Kobe, Bostjan (2016). Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region. Nucleic Acids Research, 44 (14), 6981-6993. doi: 10.1093/nar/gkw543

de Barros, Andrea C., Takeda, Agnes A.S., Dreyer, Thiago R., Velazquez-Campoy, Adrian, Kobe, Bostjan and Fontes, Marcos R.M. (2016). Structural and calorimetric studies demonstrate that Xeroderma pigmentosum type G (XPG) can be imported to the nucleus by a classical nuclear import pathway via a monopartite NLS sequence. Journal of Molecular Biology, 428 (10), 2120-2131. doi: 10.1016/j.jmb.2016.01.019

Christie, Mary, Chang, Chiung-Wen, Róna, Gergely, Smith, Kate M., Stewart, Alastair G, Takeda, Agnes A. S., Fontes, Marcos R. M., Stewart, Murray, Vértessy, Beáta G., Forwood, Jade K. and Kobe, Bostjan (2016). Structural biology and regulation of protein import into the nucleus. Journal of Molecular Biology, 428 (10), 2060-2090. doi: 10.1016/j.jmb.2015.10.023

Chang, Chiung-Wen, Counago, Rafael Miguez, Williams, Simon J., Boden, Mikael and Kobe, Bostjan (2016). Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-alpha (vol 14, pg 1144, 2013). Traffic, 17 (6), 704-704. doi: 10.1111/tra.12395

Ullah, M. Obayed, Sweet, Matthew J., Mansell, Ashley, Kellie, Stuart and Kobe, Bostjan (2016). TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target. Journal of Leukocyte Biology, 100 (1), 27-45. doi: 10.1189/jlb.2RI1115-531R

Darmanin, Connie, Strachan, Jamie, Adda, Christopher G., Ve, Thomas, Kobe, Bostjan and Abbey, Brian (2016). Protein crystal screening and characterization for serial femtosecond nanocrystallography. Scientific Reports, 6 (1) 25345, 25345.1-25345.8. doi: 10.1038/srep25345

Zhang, Xiaoxiao, Nguyen, Neal, Breen, Susan, Outram, Megan A., Dodds, Peter N., Kobe, Bostjan, Solomon, Peter S. and Williams, Simon J. (2016). Production of small cysteine-rich effector proteins in Escherichia coli for structural and functional studies. Molecular Plant Pathology, 18 (1), 141-151. doi: 10.1111/mpp.12385

You, Lv, Kandale, Ajit, Wun, Shun Jie, McGeary, Ross P., Williams, Simon J., Kobe, Bostjan, Sieber, Volker, Schembri, Mark A., Schenk, Gerhard and Guddat, Luke W. (2016). Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discovery. Febs Journal, 283 (7), 1184-1196. doi: 10.1111/febs.13672

Bernoux, Maud, Burdett, Hayden, Williams, Simon J., Zhang, Xiaoxiao, Chen, Chunhong, Newell, Kim, Lawrence, Gregory J., Kobe, Bostjan, Ellis, Jeffrey G., Anderson, Peter A. and Dodds, Peter N. (2016). Comparative analysis of the flax immune receptors L6 and L7 suggests an equilibrium-based switch activation model. Plant Cell, 28 (1), 146-159. doi: 10.1105/tpc.15.00303

Oyarzun, Patricio and Kobe, Bostjan (2016). Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and production. Human Vaccines and Immunotherapeutics, 12 (3), 763-767. doi: 10.1080/21645515.2015.1094595

Deplazes, Evelyne, Begg, Stephanie L., van Wonderen, Jessica H., Campbell, Rebecca, Kobe, Bostjan, Paton, James C., MacMillan, Fraser, McDevitt, Christopher A. and O'Mara, Megan L. (2015). Characterizing the conformational dynamics of metal-free PsaA usingmolecular dynamics simulations and electron paramagnetic resonance spectroscopy. Biophysical Chemistry, 207, 51-60. doi: 10.1016/j.bpc.2015.08.004

Luo, Zhenyao, Morey, Jacqueline R., McDevitt, Christopher A. and Kobe, Bostjan (2015). Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA. Acta Crystallographica: Section F Structural Biology Communications, 71 (12), 1459-1464. doi: 10.1107/S2053230X15021330

Oyarzun, P. and Kobe, B. (2015). Computer-aided design of T-cell epitope-based vaccines: addressing population coverage. International Journal of Immunogenetics, 42 (5), 313-321. doi: 10.1111/iji.12214

Chang, Chiung-Wen, Tran, Elizabeth N. H., Ericsson, Daniel J., Casey, Lachlan W., Lonhienne, Thierry, Benning, Friederike, Morona, Renato and Kobe, Bostjan (2015). Structural and biochemical analysis of a single amino-acid mutant of WzzBSF that alters Lipopolysaccharide O-antigen chain length in Shigella flexneri. PLoS One, 10 (9) e0138266, e0138266. doi: 10.1371/journal.pone.0138266

Kobe, Bostjan, Ve, Thomas and Williams, Simon J. (2015). Fusion-protein-assisted protein crystallization. Acta Crystallographica. Section F Structural Biology Communications, 71 (7), 861-869. doi: 10.1107/S2053230X15011061

Cork, Amanda J., Ericsson, Daniel J., Law, Ruby H. P., Casey, Lachlan W., Valkov, Eugene, Bertozzi, Carlo, Stamp, Anna, Jovcevski, Blagojce, Aquilina, J. Andrew, Whisstock, James C., Walker, Mark J. and Kobe, Bostjan (2015). Stability of the octameric structure affects plasminogen-binding capacity of Streptococcal enolase. PLoS One, 10 (3) e0121764, 1-18. doi: 10.1371/journal.pone.0121764

Begg, Stephanie L., Eijkelkamp, Bart A., Luo, Zhenyao, Couñago, Rafael M., Morey, Jacqueline R., Maher, Megan J., Ong, Cheryl-lynn Y., McEwan, Alastair G., Kobe, Bostjan, O'Mara, Megan L., Paton, James C. and McDevitt, Christopher A. (2015). Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nature Communications, 6 (6418) 6418, 1-11. doi: 10.1038/ncomms7418

Bajaj, Megha, Mamidyala, Sreeman K., Zuegg, Johannes, Begg, Stephanie L., Ween, Miranda P., Luo, Zhenyao, Huang, Johnny Xiao, McEwan, Alastair G., Kobe, Bostjan, Paton, James C., McDevitt, Christopher A. and Cooper, Matthew A. (2015). Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach. ACS Chemical Biology, 10 (6), 1511-1520. doi: 10.1021/cb501032x

Williams, Simon J., Ve, Thomas and Kobe, Bostjan (2015). A linker strategy for the production and crystallization of Toll/interleukin-1 receptor/resistance protein domain complexes. Protein Engineering, Design and Selection, 28 (5), 137-145. doi: 10.1093/protein/gzv013

Thakar, Nilay Y., Ovchinnikov, Dmitry A., Hastie, Marcus L., Kobe, Bostjan, Gorman, Jeffrey J. and Wolvetang, Ernst J. (2015). TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation.. Molecular Biology of the Cell, 26 (5), 993-1006. doi: 10.1091/mbc.E14-08-1290

Oyarzun, Patricio, Ellis, Jonathan J., Gonzalez-Galarza, Faviel F., Jones, Andrew R, Middleton, Derek, Boden, Mikael and Kobe, Bostjan (2015). A bioinformatics tool for epitope-based vaccine design that accounts for human ethnic diversity: Application to emerging infectious diseases.. Vaccine, 33 (10), 1267-1273. doi: 10.1016/j.vaccine.2015.01.040

Ve, Thomas, Williams, Simon J. and Kobe, Bostjan (2014). Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains.. Apoptosis, 20 (2), 250-261. doi: 10.1007/s10495-014-1064-2

Roona, Gergely, Borsos, Mate, Ellis, Jonathan J., Mehdi, Ahmed M., Christie, Mary, Koornyei, Zsuzsanna, Neubrandt, Mate, Tooth, Judit, Bozooky, Zoltan, Buday, Laszlo, Madaraasz, Emilia, Bodaen, Mikael, Kobe, Bostjan and Veertessy, Beata G. (2014). Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation. Cell Cycle, 13 (22), 3551-3564. doi: 10.4161/15384101.2014.960740

Dyrka, Witold, Lamacchia, Marina, Durrens, Pascal, Kobe, Bostjan, Daskalov, Asen, Paoletti, Matthieu, Sherman, David J. and Saupe, Sven J. (2014). Diversity and variability of NOD-like receptors in fungi. Genome Biology and Evolution, 6 (12), 3137-3158. doi: 10.1093/gbe/evu251

Obayed Ullah, M., Valkov, Eugene, Ve, Thomas, Williams, Simon, Mas, Caroline, Mansell, Ashley and Kobe, Bostjan (2014). Recombinant production of functional full-length and truncated human TRAM/TICAM-2 adaptor protein involved in toll-like receptor and interferon signaling. Protein Expression and Purification, 106, 31-40. doi: 10.1016/j.pep.2014.09.019

Patrick, Ralph, Lê Cao, Kim-Anh, Kobe, Bostjan and Bodén, Mikael (2014). PhosphoPICK: modelling cellular context to map kinase-substrate phosphorylation events. Bioinformatics, 31 (3), 382-389. doi: 10.1093/bioinformatics/btu663

Róna, Gergely, Borsos, Máté, Kobe, Bostjan and Vértessy, Beáta G. (2014). Factors influencing nucleo-cytoplasmic trafficking: which matter? Response to Alvisi & Jans' comment on Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights. Acta Crystallographica. Section D: Biological Crystallography, 70 (10), 2777-2778. doi: 10.1107/S1399004714020501

Sohn, Kee Hoon, Segonzac, Cecile, Rallapalli, Ghanasyam, Sarris, Panagiotis F., Woo, Joo Yong, Williams, Simon J., Newman, Toby E., Paek, Kyung Hee, Kobe, Bostjan and Jones, Jonathan D. G. (2014). The nuclear immune receptor RPS4 is required for RRS1SLH1-dependent constitutive defense activation in Arabidopsis thaliana.. PLoS Genetics, 10 (10), e1004655. doi: 10.1371/journal.pgen.1004655

Verstak, Brett, Stack, Julianne, Ve, Thomas, Mangan, Matthew, Hjerrild, Kathryn, Jeon, Jannah, Stahl, Rainer, Latz, Eicke, Gay, Nick, Kobe, Bostjan, Bowie, Andrew G. and Mansell, Ashley (2014). The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4. Journal of Leukocyte Biology, 96 (3), 427-436. doi: 10.1189/jlb.2A0913-487R

Williams, Simon J., Sohn, Kee Hoon, Wan, Li, Bernoux, Maud, Sarris, Panagiotis, Segonzac, Cecile, Ve, Thomas, Ma, Yan, Saucet, Simon B., Ericsson, Daniel J., Casey, Lachlan W., Lonhienne, Thierry, Winzor, Donald J., Zhang, Xiaoxiao, Coerdt, Anne, Parker, Jane E., Dodds, Peter N., Kobe, Bostjan and Jones, Jonathan D. G. (2014). Structural basis for assembly and function of a heterodimeric plant immune receptor. Science, 344 (6181), 299-303. doi: 10.1126/science.1247357

Chang, Chiung-Wen, Williams, Simon J., Couñago, Rafael Miguez and Kobe, Bostjan (2014). Structural basis of interaction of bipartite nuclear localization signal from Agrobacterium VirD2 with rice importin-alpha. Molecular Plant, Advance Access (6), 1-10. doi: 10.1093/mp/ssu014

Plumptre, Charles D., Eijkelkamp, Bart A., Morey, Jacqueline R., Behr, Felix, Couñago, Rafael M., Ogunniyi, Abiodun D., Kobe, Bostjan, O'Mara, Megan L., Paton, James C. and McDevitt, Christopher A. (2014). AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae. Molecular Microbiology, 91 (4), 834–851-834–851. doi: 10.1111/mmi.12504

Batten, Stuart R., Kobe, Bostjan and Guddat, Luke (2014). International Year of Crystallography. Australian Journal of Chemistry, 67 (12), 1718-1719. doi: 10.1071/CH14557

Casey, Lachlan W., Mark, Alan E. and Kobe, Bostjan (2014). Small-Angle X-Ray Scattering for the Discerning Macromolecular Crystallographer. Australian Journal of Chemistry, 67 (12), 1786-1792. doi: 10.1071/CH14396

Couñago, Rafael M., Ween, Miranda P., Begg, Stephanie L., Bajaj, Megha, Zuegg, Johannes, O'Mara, Megan L., Cooper, Matthew A., McEwan, Alastair G., Paton, James C., Kobe, Bostjan and McDevitt, Christopher A. (2014). Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology, 10 (1), 35-41. doi: 10.1038/nCHeMBIO.1382

Roman, Noelia, Christie, Mary, Swarbrick, Crystall M. D., Kobe, Bostjan and Forwood, Jade K. (2013). Structural characterisation of the nuclear import receptor importin alpha in complex with the bipartite NLS of Prp20. PLoS One, 8 (12) e82038, e82038.1-e82038.6. doi: 10.1371/journal.pone.0082038

Rona, G., Marfori, M., Borsos, M., Scheer, I., Takacs, E., Toth, J., Babos, F., Magyar, A., Erdei, A., Bozoky, Z., Buday, L., Kobe, B. and Vertessy, B.G. (2013). Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: Structural and mechanistic insights. Acta Crystallographica Section D: Biological Crystallography, 69 (12), 2495-2505. doi: 10.1107/S0907444913023354

Ullah, M. Obayed, Ve, Thomas, Mangan, Matthew, Alaidarous, Mohammed, Sweet, Matthew J., Mansell, Ashley and Kobe, Bostjan (2013). The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins. Acta Crystallographica Section D: Biological Crystallography, 69 (12), 2420-2430. doi: 10.1107/S0907444913022385

Alaidarous, Mohammed Abdullah, Ve, Thomas, Casey, Lachlan, Valkov, Eugene, Ericsson, Daniel, Obayed, Ullah, M., Schembri, Mark A., Mansell, Ashley, Sweet, Matthew J. and Kobe, Bostjan (2013). Mechanism of bacterial interference with TLR4 signaling by Brucella TIR-domain-containing protein TcpB. Journal of Biological Chemistry, 289 (2), 654-668. doi: 10.1074/jbc.M113.523274

Wan, Li, Zhang, Xiaoxiao, Williams, Simon J., Ve, Thomas, Bernoux, Maud, Sohn, Kee Hoon, Jones, Jonathan D. G., Dodds, Peter N. and Kobe, Bostjan (2013). Crystallization and preliminary X-ray diffraction analyses of the TIR domains of three TIR-NB-LRR proteins that are involved in disease resistance in Arabidopsis thaliana. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (11), 1275-1280. doi: 10.1107/S1744309113026614

Chang, Chiung-Wen, Counago, Rafael Miguez, Williams, Simon J., Boden, Mikael and Kobe, Bostjan (2013). Distinctive conformation of minor site-specific nuclear localization signals bound to importin-α. Traffic, 14 (11), 1144-1154. doi: 10.1111/tra.12098

Alaidarous, Mohammed, Ve, Thomas, Ullah, M. Obayed, Valkov, Eugene, Mansell, Ashley, Schembri, Mark A., Sweet, Matthew J. and Kobe, Bostjan (2013). Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of the TIR domain from the Brucella melitensis TIR-domain-containing protein TcpB. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (10), 1167-1170. doi: 10.1107/S1744309113024408

Wan, Li, Williams, Simon J., Zhang, Xiaoxiao, Ericsson, Daniel J., Koeck, Markus, Dodds, Peter N., Ellis, Jeffrey G. and Kobe, Bostjan (2013). Crystallization and preliminary X-ray diffraction analysis of the flax cytokinin oxidase LuCKX1.1. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (10), 1094-1096. doi: 10.1107/S1744309113023142

Ve, Thomas, Williams, Simon J., Catanzariti, Ann-Maree, Rafiqi, Maryam, Rahman, Motiur, Ellis, Jeffrey G., Hardham, Adrienne R., Jones, David A., Anderson, Peter A., Dodds, Peter N. and Kobe, Bostjan (2013). Structures of the flax-rust effector AvrM reveal insights into the molecular basis of plant-cell entry and effector-triggered immunity. Proceedings of the National Academy of Sciences of the United States of America, 110 (43), 17594-17599. doi: 10.1073/pnas.1307614110

Blundell, Ross D., Williams, Simon J., Morrow, Carl A., Ericsson, Daniel J., Kobe, Bostjan and Fraser, James A. (2013). Purification, crystallization and preliminary X-ray analysis of adenylosuccinate synthetase from the fungal pathogen Cryptococcus neoformans. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (Pt. 9), 1033-1036. doi: 10.1107/S1744309113021921

Henningham, Anna, Ericsson, Daniel J., Langer, Karla, Casey, Lachlan W., Jovcevski, Blagojce, Singh Chhatwal, G., Aquilina, J. Andrew, Batzloff, Michael R., Kobe, Bostjan and Walker, Mark J. (2013). Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus. mBio, 4 (4) e00509-13. doi: 10.1128/mBio.00509-13

Ullah, M. Obayed, Ve, Thomas, Dkhar, Jameris, Alaidarous, Mohammed, Ericsson, Daniel J., Sweet, Matthew J., Mansell, Ashley and Kobe, Bostjan (2013). Crystallization and X-ray diffraction analysis of the N-terminal domain of the Toll-like receptor signalling adaptor protein TRIF/TICAM-1. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (7), 766-770. doi: 10.1107/S174430911301419X

Chen, Nathan H., Couñago, Rafael M., Djoko, Karrera Y., Jennings, Michael P., Apicella, Michael A., Kobe, Bostjan and McEwan, Alastair G. (2013). A glutathione-dependent detoxification system is required for formaldehyde resistance and optimal survival of Neisseria meningitidis in biofilms. Antioxidants and Redox Signaling, 18 (7), 743-755. doi: 10.1089/ars.2012.4749

Oyarzun, Patricio, Ellis, Jonathan J., Boden, Mikael and Kobe, Bostjan (2013). PREDIVAC: CD4+T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity. BMC Bioinformatics, 14 (1) 52, 52. doi: 10.1186/1471-2105-14-52

Chang, Chiung-Wen, Counago, Rafael Miguez, Williams, Simon J., Boden, Mikael and Kobe, Bostjan (2013). The distribution of different classes of nuclear localization signals (NLSs) in diverse organisms and the utilization of the minor NLS-binding site in plant nuclear import factor importin-α. Plant Signaling and Behavior, 8 (10), e25976.1-e25976.6. doi: 10.4161/psb.25976

Mehdi, Ahmed M., Sehgal, Muhammad Shoaib B., Kobe, Bostjan, Bailey, Timothy L. and Boden, Mikael (2013). DLocalMotif: a discriminative approach for discovering local motifs in protein sequences. Bioinformatics, 29 (1), 39-46. doi: 10.1093/bioinformatics/bts654

Chen, Kai-En, Richards, Ayanthi A., Caradoc-Davies, Tom T., Vajjhala, Parimala R., Robin, Gautier, Lua, Linda H. L., Hill, Justine M., Schroder, Kate, Sweet, Matthew J., Kellie, Stuart, Kobe, Bostjan and Martin, Jennifer (2013). The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. Acta Crystallographica Section D: Biological Crystallography, 69 (5), 774-784. doi: 10.1107/S0907444913001558

Chang, Chiung-Wen, Counago, Rafael Lemos Miguez, Williams, Simon J., Boden, Mikael and Kobe, Bostjan (2012). Crystal structure of rice importin-alpha and structural basis of its interaction with plant-specific nuclear localization signals. Plant Cell, 24 (12), 5074-5088. doi: 10.1105/tpc.112.104422

Ravensdale, Michael, Bernoux, Maud, Ve, Thomas, Kobe, Bostjan, Thrall, Peter H., Ellis, Jeffrey G. and Dodds, Peter N. (2012). Intramolecular interaction influences binding of the flax L5 and L6 resistance proteins to their AvrL567 ligands. PloS Pathogens, 8 (11) e1003004, e1003004. doi: 10.1371/journal.ppat.1003004

Morrow, Carl A., Valkov, Eugene, Stamp, Anna, Chow, Eve W. L., Lee, I. Russel, Wronski, Ania, Williams, Simon J., Hill, Justine M., Djordjevic, Julianne T., Kappler, Ulrke, Kobe, Bostjan and Fraser, James A. (2012). De novo GTP biosynthesis is critical for virulence of the fungal pathogen cryptococcus neoformans. PLoS Pathogens, 8 (10) e1002957, e1002957. doi: 10.1371/journal.ppat.1002957

Ve, Thomas, Gay, Nicholas J., Mansell, Ashley, Kobe, Bostjan and Kellie, Stuart (2012). Adaptors in toll-like receptor signaling and their potential as therapeutic targets. Current Drug Targets, 13 (11), 1360-1374. doi: 10.2174/138945012803530260

Ericsson, Daniel J., Standish, Alistair, Kobe, Bostjan and Morona, Renata (2012). Wzy-dependent bacterial capsules as potential drug targets. Current Drug Targets, 13 (11), 1421-1431. doi: 10.2174/138945012803530279

Counago, Rafael M., McDevitt, Christopher A., Ween, Miranda P. and Kobe, Bostjan (2012). Prokaryotic substrate-binding proteins as targets for antimicrobial therapies. Current Drug Targets, 13 (11), 1400-1410. doi: 10.2174/138945012803530170

de Barros, Andrea C., Takeda, Agnes A. S., Chang, Chiung-Wen, Kobe, Bostjan and Fontes, Marcos R. M. (2012). Structural basis of nuclear import of flap endonuclease 1 (FEN1). Acta Crystallographica Section D: Biological Crystallography, 68 (7), 743-750. doi: 10.1107/S0907444912010281

Kobe, Bostjan and Boden, Mikael (2012). Computational modelling of linear motif-mediated protein interactions. Current Topics in Medicinal Chemistry, 12 (14), 1553-1561. doi: 10.2174/156802612802652439

Patrick, Ralph, Cao, Kim-Anh L., Davis, Melissa, Kobe, Bostjan and Bodén, Mikael (2012). Mapping the stabilome: a novel computational method for classifying metabolic protein stability. BMC Systems Biology, 6 (1) 60, 60.1-60.15. doi: 10.1186/1752-0509-6-60

Chen, Kai-En, Richards, Ayanthi A., Arrifin, Juliana K., Ross, Ian L., Sweet, Matthew J., Kellie, Stuart, Kobe, Bostjan and Martin, Jennifer L. (2012). The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer. Acta Crystallographica Section D: Biological Crystallography, 68 (6), 637-648. doi: 10.1107/S0907444912006592

Marfori, Mary, Lonhienne, Thierry G., Forwood, Jade K. and Kobe, Bostjan (2012). Structural basis of high-affinity nuclear localization signal interactions with importin-alpha. Traffic, 13 (4), 532-548. doi: 10.1111/j.1600-0854.2012.01329.x

Henningham, Anna, Chiarot, Emiliano, Gillen, Christine M., Cole, Jason N., Rohde, Manfred, Fulde, Marcus, Ramachandran, Vidiya, Cork, Amanda J., Hartas, Jon, Magor, Graham, Djordjevic, Steven P., Cordwell, Stuart J., Kobe, Bostjan, Sriprakash, Kabada S., Nizet, Victor, Chhatwal, G. S., Margarit, Immaculada Y. R., Batzloff, Michael R. and Walker, Mark J. (2012). Conserved anchorless surface proteins as group A streptococcal vaccine candidates. Journal of Molecular Medicine, 90 (10), 1197-1207. doi: 10.1007/s00109-012-0897-9

Watterson, Daniel, Kobe, Bostjan and Young, Paul R. (2012). Residues in domain III of the dengue virus envelope glycoprotein involved in cell-surface glycosaminoglycan binding. Journal of General Virology, 93 (1), 72-82. doi: 10.1099/vir.0.037317-0

Ve, Thomas, Williams, Simon J., Stamp, Anna, Valkov, Eugene, Dodds, Peter N., Anderson, Peter A. and Kobe, Bostjan (2011). Crystallization and X-ray diffraction analysis of the C-terminal domain of the flax rust effector protein AvrM. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 67 (12), 1603-1607. doi: 10.1107/S1744309111037675

McDevitt, Christopher A., Ogunniyi, Abiodun D., Valkov, Eugene, Lawrence, Michael C., Kobe, Bostjan, McEwan, Alastair G. and Paton, James C. (2011). A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathogens, 7 (11) e1002357, e1002357.1-e1002357.9. doi: 10.1371/journal.ppat.1002357

Kobe, Bostjan (2011). Structural mix-n-match reveals molecular secrets of platelets. Blood, 118 (19), 5065-5066. doi: 10.1182/blood-2011-09-379859

Marfori, Mary, Kobe, Bostjan and Forwood, Jade K. (2011). Ligand-induced conformational changes within a hexameric acyl-CoA thioesterase. Journal of Biological Chemistry, 286 (41), 35643-35649. doi: 10.1074/jbc.M111.225953

Valkov, Eugene, Stamp, Anna, DiMaio, Frank, Baker, David, Verstak, Brett, Roversi, Pietro, Kellie, Stuart, Sweet, Matthew J., Mansell, Ashley, Gay, Nicholas J., Martin, Jennifer L. and Kobe, Bostjan (2011). Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. Proceedings of the National Academy of Sciences of the United States of America, 108 (36), 14879-14884. doi: 10.1073/pnas.1104780108

Takeda, Agnes A. S., de Barros, Andrea C., Chang, Chiung-Wen, Kobe, Boštjan and Fontes, Marcos R. M. (2011). Structural basis of importin-alpha-mediated nuclear transport for Ku70 and Ku80. Journal of Molecular Biology, 412 (2), 226-234. doi: 10.1016/j.jmb.2011.07.038

Marfori, Mary, Mynott, Andrew, Ellis, Jonathan J., Mehdi, Ahmed M., Saunders, Neil F. W., Curmi, Paul M., Forwood, Jade K., Bodén, Mikael and Kobe, Bostjan (2011). Molecular basis for specificity of nuclear import and prediction of nuclear localization. Biochimica et Biophysica Acta (BBA): Molecular Cell Research, 1813 (9), 1562-1577. doi: 10.1016/j.bbamcr.2010.10.013

Williams, Simon J., Sornaraj, Pradeep, deCourcy-Ireland, Emma, Menz, R. Ian, Kobe, Bostjan, Ellis, Jeffrey G., Dodds, Peter N. and Anderson, Peter A. (2011). An autoactive mutant of the M flax rust resistance protein has a preference for binding ATP, whereas wild-type M protein binds ADP. Molecular Plant-Microbe Interactions, 24 (8), 897-906. doi: 10.1094/MPMI-03-11-0052

Ellis, Jonathan J. and Kobe, Bostjan (2011). Predicting protein kinase specificity : Predikin update and performance in the DREAM4 challenge. PLoS One, 6 (7) e21169, e21169-1-e21169-7. doi: 10.1371/journal.pone.0021169

Maco, B, Ross, IL, Landsberg, MJ, Mouradov, D, Saunders, NFW, Hankamer, B and Kobe, B (2011). Proteomic and electron microscopy survey of large assemblies in macrophage cytoplasm. Molecular and Cellular Proteomics, 10 (6) M111.008763, M111.008763. doi: 10.1074/mcp.M111.008763

Mehdi, Ahmed M., Sehgal, Muhammad Shoaib B., Kobe, Bostjan, Bailey, Timothy L. and Boden, Mikael (2011). A probabilistic model of nuclear import of proteins. Bioinformatics, 27 (9) btr121, 1239-1246. doi: 10.1093/bioinformatics/btr121

Mynott, Andrew V., Harrop, Stephen J., Brown, Louise J., Breit, Samuel N., Kobe, Bostjan and Curmi, Paul M. G. (2011). Crystal structure of importin-alpha bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4. The FEBS Journal, 278 (10), 1662-1675. doi: 10.1111/j.1742-4658.2011.08086.x

Bemoux, Maud, Ve, Thomas, Williams, Simon, Warren, Christopher, Hatters, Danny, Valkov, Eugene, Zhang, Xiaoxiao, Ellis, Jeffrey G., Kobe, Bostjan and Dodds, Peter N. (2011). Structural and functional analysis of a plant resistance protein TIR Domain reveals interfaces for self-association, signaling, and autoregulation. Cell Host and Microbe, 9 (3), 200-211. doi: 10.1016/j.chom.2011.02.009

Ve, Thomas, Williams, Simon, Valkov, Eugene, Ellis, Jeffrey G., Dodds, Peter N. and Kobe, Bostjan (2011). Crystallization, X-ray diffraction analysis and preliminary structure determination of the TIR domain from the flax resistance protein L6. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 67 (2), 237-240. doi: 10.1107/S1744309110051006

Pitson, S. and Kobe, B. (2010). Science meets Parliament 2010. Australian Biochemist, 41 (2), 40-41.

Kirkby, Brenda, Roman, Noelia, Kobe, Bostjan, Kellie, Stuart and Forwood, Jade K. (2010). Functional and structural properties of mammalian acyl-coenzyme A thioesterases. Progress in Lipid Research, 49 (4), 366-377. doi: 10.1016/j.plipres.2010.04.001

Forwood, JK, Lange, A, Zachariae, U, Marfori, M, Preast, C, Grubmuller, H, Stewart, M, Corbett, AH and Kobe, B (2010). Quantitative structural analysis of Importin-β flexibility: Paradigm for solenoid protein structures. Structure, 18 (9), 1171-1183. doi: 10.1016/j.str.2010.06.015

Morrow, CA, Stamp, A, Valkov, E, Kobe, B and Fraser, JA (2010). Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66 (9), 1104-1107. doi: 10.1107/S1744309110031659

Yang, Sny, Takeda, AAS, Fontes, MRM, Harris, JM, Jans, DA and Kobe, B (2010). Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening. Journal of Biological Chemistry, 285 (26), 19935-19946. doi: 10.1074/jbc.M109.079574

Allsopp, Luke P., Totsika, Makrina, Tree, Jai J., Ulett, Glen C., Mabbett, Amanda N., Wells, Timothy J., Kobe, Bostjan, Beatson, Scott A. and Schembri, Mark A. (2010). UpaH is a newly identified autotransporter protein that contributes to biofilm formation and bladder colonization by uropathogenic Escherichia coli CFT073. Infection and Immunity, 78 (4), 1659-1669. doi: 10.1128/IAI.01010-09

Catanzariti, Ann-Maree, Dodds, Peter N., Ve, Thomas, Kobe, Bostjan, Ellis, Jeffrey G. and Staskawicz, Brian J. (2010). The AvrM Effector from flax rust has a structured C-terminal domain and interacts directly with the M resistance protein. Molecular Plant-Microbe Interactions, 23 (1), 49-57. doi: 10.1094/MPMI-23-1-0049

Kampmann, T., Yennamalli, R., Campbell, P., Stoermer, M. J., Fairlie, D. P., Kobe, B. and Young, P. R. (2009). In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses. Antiviral Research, 84 (3), 234-241. doi: 10.1016/j.antiviral.2009.09.007

Kobe, B., Guncar, G., Buchholz, R., Huber, T. L. and Maco, B. (2009). The many faces of platelet glycoprotein Ib alpha - thrombin interaction. Current Protein and Peptide Science, 10 (6), 551-558. doi: 10.2174/138920309789630570

King, Gordon J., Chen, Kai-En, Robin, Gautier, Forwood, Jade K., Heras, Begoña, Thakur, Anil S., Kobe, Bostjan, Blomberg, Simon P. and Martin, Jennifer L. (2009). Interaction between plate make and protein in protein crystallisation screening. PLoS One, 4 (11) e7851, x-x. doi: 10.1371/journal.pone.0007851

O'Connell, A, Robin, G, Kobe, B and Botella, JR (2009). Biochemical characterization of arabidopsis developmentally regulated G-proteins (DRGs). PROTEIN EXPRESSION AND PURIFICATION, 67 (2), 88-95. doi: 10.1016/j.pep.2009.05.009

Lonhienne, Thierry G., Forwood, Jade K., Marfori, Mary, Robin, Gautier, Kobe, Bostjan and Carroll, Bernard J. (2009). Importin-B is a GDP-to-GTP exchange factor of Ran: Implications for the mechanism of nuclear import. Journal of Biological Chemistry, 284 (34), 22549-22558. doi: 10.1074/jbc.M109.019935

Cork, A. J., Jergic, S., Hammerschmidt, S., Kobe, B., Pancholi, V., Benesch, J. L. P., Robinson, C. V., Dixon, N. E., Aquilina, J. A. and Walker, M. J. (2009). Defining the structural basis of human plasminogen binding by streptococcal surface enolase. Journal of Biological Chemistry, 284 (25), 17129-17137. doi: 10.1074/jbc.M109.004317

Roman, Noelia, Kirkby, Brenda, Marfori, Mary, Kobe, Bostjan and Forwood, Jade K. (2009). Crystallization of the flexible nuclear import receptor importin-beta in the unliganded state. Acta Crystallographica Section F: Structural Biology and Crystallization Communications Online, 65 (6), 625-628. doi: 10.1107/S1744309109016820

Yennamalli, Ragothaman, Subbarao, Naidu, Kampmann, Thorsten, McGeary, Ross P., Young, Paul R. and Kobe, Bostjan (2009). Identification of novel target sites and an inhibitor of the dengue virus E protein. Journal of Computer-Aided Molecular Design, 23 (6), 333-341. doi: 10.1007/s10822-009-9263-6

Kobe, Bostjan, Guncar, Gregor, Buchholz, Rebecca, Huber, Thomas, Maco, Bohumil, Cowieson, Nathan, Martin, Jennifer L., Marfori, Mary and Forwood, Jade K. (2008). Crystallography and protein-protein interactions: Biological interfaces and crystal contacts. Biochemical Society Transactions, 36 (6), 1438-1441. doi: 10.1042/BST0361438

Forwood, Jade K., Lonhienne, Thierry G., Marfori, Mary, Robin, Gautier, Meng, Weining, Guncar, Gregor, Liu, Sai M., Stewart, Murray, Carroll, Bernard J. and Kobe, Bostjan (2008). Kap95p binding induces the switch loops of RanGDP to adopt the GTP-bound conformation: Implications for nuclear import complex assembly dynamics. Journal of Molecular Biology, 383 (4), 772-782. doi: 10.1016/j.jmb.2008.07.090

Cowieson, Nathan P., Kobe, Bostjan and Martin, Jennifer L. (2008). United we stand: combining structural methods. Current Opinion in Structural Biology, 18 (5), 617-622. doi: 10.1016/j.sbi.2008.07.004

Miyahara, A., Hirani, T., Oakes, M., Kereszt, A., Kobe, B., Djordjevic, M.A. and Gresshoff, P. M. (2008). Soybean Nodule Autoregulation Receptor Kinase Phosphorylates Two Kinase-associated Protein Phosphatases in Vitro. Journal of Biological Chemistry, 283 (37), 25381-25391. doi: 10.1074/jbc.M800400200

Thakur, Anil S, Newman, Janet, Martin, Jennifer L and Kobe, Bostjan (2008). Increasing protein crystallization screening success with heterogeneous nucleating agents. Methods in molecular biology (Clifton, N.J.), 426, 403-409. doi: 10.1007/978-1-60327-058-8_26

Androulakis, S., Schmidberger, J., Bate, M. A., DeGori, R., Beitz, A., Keong, C., Cameron, B., McGowan, S., Porter, C. J., Harrison, A., Hunter, J., Martin, J. L., Kobe, B., Dobson, R. C. J., Parker, M. W., Whisstock, J. C., Gray, J., Treloar, A., Groenewegen, D., Dickson, N. and Buckle, A. M. (2008). Federated repositories of X-ray diffraction images. Acta Crystallographica Section D: Biological Crystallography, 64 (7), 810-814. doi: 10.1107/S0907444908015540

King, G. J., Jones, A., Kobe, B., Huber, T., Mouradov, D., Hume, D. A. and Ross, I. L. (2008). Identification of Disulfide-containing chemical cross-links in proteins using MALDI-TOF/TOF-MAss spectrometry. Analytical Chemistry, 80 (13), 5036-5043. doi: 10.1021/ac702277q

Cowieson, Nathan P., King, Gordon, Cookson, David, Ross, Ian, Huber, Thomas, Hume, David A., Kobe, Bostjan and Martin, Jennifer L. (2008). Cortactin adopts a globular conformation and bundles actin into sheets. The Journal of Biological Chemistry, 283 (23), 16187-16193. doi: 10.1074/jbc.M708917200

Saunders, N., Brinkworth, R.I., Huber, T. L., Kemp, B.E. and Kobe, B. (2008). Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated database of phosphorylation sites. BMC Bioinformatics, 9 (245) 245, 1-11. doi: 10.1186/1471-2105-9-245

Frith, Martin C., Saunders, Neil F. W., Kobe, Bostjan and Bailey, Timothy L. (2008). Discovering sequence motifs with arbitrary insertions and deletions. PLoS Computational Biology, 4 (5) e1000071, e1000071.1-e1000071.12. doi: 10.1371/journal.pcbi.1000071

Lonic, A., Barry, E.F., Quach, C., Kobe, B., Saunders, N. and Guthridge, M.A. (2008). Fibroblast growth factor receptor 2 phosphorylation on Serine 779 couples to 14-3-3 and regulates cell survival and proliferation. Molecular & Cellular Biology, 28 (10), 3372-3385. doi: 10.1128/MCB.01837-07

Cowieson, Nathan P., Miles, Andrew J., Robin, Gautier, Forwood, Jade K., Kobe, Bostjan, Martin, Jennifer L. and Wallace, B. A. (2008). Evaluating protein: Protein complex formation using synchrotron radiation circular dichroism spectroscopy. Proteins: Structure Function Bioinformatics, 70 (4), 1142-1146. doi: 10.1002/prot.21631

Mueller, D., Kampmann, T., Yennamalli, R., Young, P.R., Kobe, B. and Mark, A. E. (2008). Histidine protonation and the activation of viral fusion proteins. Biochemical Society Transactions, 36 (1), 43-45. doi: 10.1042/BST0360043

Kobe, Bostjan, Guss, Mitchell and Huber, Thomas (2008). Structural proteomics: high-throughput methods. Preface. Methods in molecular biology (Clifton, N.J.), 426, v-vi. doi: 10.1007/978-1-60327-058-8

Saunders, Neil F. W. and Kobe, Bostjan (2008). The Predikin webserver: improved prediction of protein kinase peptide specificity using structural information. Nucleic Acids Research, 36 (suppl 2), W286-W290. doi: 10.1093/nar/gkn279

Thakur, A., Robin, G., Guncar, G., Saunders, N., Newman, J., Martin, J. L. and Kobe, B. (2007). Improved Success of Sparse Matrix Protein Crystallization Screening with Heterogeneous Nucleating Agents. PLoS ONE, 2 (10) e1091, e1091-1-e1091-6. doi: 10.1371/journal.pone.0001091

Wang, C., Guncar, G., Forwood, J., Teh, T., Catanzariti, A., Lawrence, G., Loughlin, F., Mackay, J., Schirra, H., Anderson, P., Ellis, J., Dodds, P. and Kobe, B. (2007). Crystal structures of flax rust avirulence proteins AvrL567-A and -D reveal details of the structural basis for flax disease resistance specificity. Plant Cell, 19 (9), 2898-2912. doi: 10.1105/tpc.107.053611

Forwood, J., Thakur, A., Guncar, G., Marfori, M., Mouradov, D., Meng, W., Robinson, J., Huber, T., Kellie, S., Martin, J. L., Hume, D. and Kobe, B. (2007). Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation. Proceedings of The National Academy of Sciences of The United States of America, 104 (25), 10382-10387. doi: 10.1073/pnas.0700974104

Guncar, G., Wang, C., Forwood, J., Teh, T., Catanzariti, A., Ellis, J., Dodds, P. and Kobe, B (2007). The use of Co2+ for crystallization and structure determination, using a conventional monochromatic X-ray source, of flax rust avirulence protein. Acta Crystallographica Section F-structural Biology And Crystallization Communications, 63 (3), 209-213. doi: 10.1107/S1744309107004599

Schmidt, S., Williams, S., Wang, C., Sornaraj, P., James, B., Kobe, B., Dodds, P., Ellis, J. and Anderson, P. (2007). Purification of the M flax-rust resistance protein expressed in Pichia pastoris. Plant Journal, 50 (6), 1107-1117. doi: 10.1111/j.1365-313X.2007.03104.x

Bogoyevitch, Marie A. and Kobe, Bostjan (2006). Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiology and Molecular Biology Reviews, 70 (4), 1061-1095. doi: 10.1128/MMBR.00025-06

Dodds, P. N., Lawrence, G. J., Cantanzariti, A. M., Teh, T., Wang, C. I. A., Ayliffe, M. A., Kobe, B. and Ellis, J. G. (2006). Direct protein interaction underlies gene-for-gene specificity and coevolution of the flax resistance genes and flax rust avirulence genes. Proceedings of the National Academy of Science of the United States of America, 103 (23), 8888-8893. doi: 10.1073/pnas.0602577103

Cowieson, Nathan P., Wensley, Beth, Listwan, Pawel, Hume, David A., Kobe, Bostjan and Martin, Jennifer L. (2006). An automatable screen for the rapid identification of proteins amenable to refolding. Proteomics, 6 (6), 1750-1757. doi: 10.1002/pmic.200500056

Mouradov, D., Craven, A., Forwood, J. K., Flanagan, J. U., Garcia-Castellanos, R., Gomis-Ruth, F. X., Hume, D. A., Martin, J. L., Kobe, B. and Huber, T. (2006). Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking. Protein Engineering Design & Selection, 19 (1), 9-16. doi: 10.1093/protein/gzi070

Brinkworth, Ross I., Munn, Alan L. and Kobe, Bostjan (2006). Protein kinases associated with the yeast phosphoproteome. Bmc Bioinformatics, 7 (47) 47, 47. doi: 10.1186/1471-2105-7-47

Serek, R., Forwood, J. K., Hume, D. A., Martin, J. L. and Kobe, B. (2006). Crystallization of the C-terminal domain of the mouse brain cytosolic long-chain acyl-CoA thioesterase. Acta Crystallographica Section F-structural Biology And Crystallization Communications, 62, 133-135. doi: 10.1107/S17443091060000030

Kurz, M., Cowieson, N. P., Robin, G., Hume, D. A., Martin, J. L., Kobe, B. and Listwan, P. (2006). Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins. Protein Expression And Purification, 50 (1), 68-73. doi: 10.1016/j.pep.2006.05.006

Puri, M., Robin, G., Cowieson, N., Forwood, J. K., Listwan, P., Hu, S. H., Guncar, G., Huber, T., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2006). Focusing in on structural genomics: The University of Queensland structural biology pipeline. Biomolecular Engineering, 23 (6), 281-289. doi: 10.1016/j.bioeng.2006.09.002

Kampmann, Thorsten, Meuller, Daniela S., Mark, Alan E., Young, Paul R. and Kobe, Bostjan (2006). The role of histidine residues in low-pH-mediated viral membrane fusion. Structure, 14 (10), 1481-1487. doi: 10.1016/j.str.2006.07.011

Kobe, Bostjan, Kampmann, Thorsten, Forwood, Jade K., Listwan, Pawel and Brinkworth, Ross I. (2005). Substrate specifity of protein kinases and computational prediction of substrates. Biochimica et Biophysica Acta, 1754 (1-2), 200-209. doi: 10.1016/j.bbapap.2005.07.036

Fontes, M. R. M., Teh, T., Riell, R. D., Park, S. B., Standaert, R. E. and Kobe, B. (2005). Crystallization and preliminary X-ray diffraction analysis of importin-alpha acomplexed with NLS peptidomimetics. Biochimica Et Biophysica Acta-proteins And Proteomics, 1750 (1), 9-13. doi: 10.1016/j.bbapap.2005.03.014

Ren, Gang, Wang, Juan, Brinkworth, Ross, Winsor, Barbara, Kobe, Bostjan and Munn, Alan L. (2005). Verprolin cytokinesis function mediated by the Hof one trap domain. Traffic, 6 (7), 575-593. doi: 10.1111/j.1600-0854.2005.00300.x

Listwan, P, Cowieson, N, Kurz, M, Hume, DA, Martin, JL and Kobe, B (2005). Modification of recombinatorial cloning for small affinity tag fusion protein construct generation. Analytical Biochemistry, 346 (2), 327-329. doi: 10.1016/j.ab.2005.06.016

Cowieson, N. P., Listwan, P., Kurz, M., Aagaard, A., Ravasi, T., Wells, C. A., Huber, T. L., Hume, D. A., Kobe, B. and Martin, J. L. (2005). Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system. Journal of Structural and Functional Genomics, 6 (1), 13-20. doi: 10.1007/s10969-005-0462-7

Aagaard, A., Listwan, P., Cowieson, N. P., Huber, T. L., Ravasi, T., Wells, C. A., Flanagan, J. U., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2005). An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1. Structure, 13 (2), 309-317. doi: 10.1016/j.str.2004.12.013

Lay, C. S., Wilson, K. A., Kobe, B., Kemp, B. E., Drummer, H. E. and Poumbourios, P. (2004). Expression and biochemical analysis of the entire HIV-2 gp41 ectodomain: determinants of stability map to N- and C-terminal sequences outside the 6-helix bundle core. Febs Letters, 567 (2-3), 183-188. doi: 10.1016/j.febslet.2004.04.054

Huber, T. L. and Kobe, B. (2004). Comment on 'Protein isoelectric point as a predictor for increased crystallization screening efficiency'. Bioinformatics, 20 (14), 2169-2170. doi: 10.1093/bioinformatics/bth452

Listwan, P., Martin, J. L., Kobe, B. and Cowieson, N. P. (2004). Methods for high-throughput protein expression, purification and structure determination adapted for structural genomics. Australian Biochemist, 35 (2), 43-46.

Kobe, Bostjan (2004). Structural and Functional Genomics. Australian Biochemist, 35 (2)

Fontes, R. M., Teh, T., Toth, G., John, A.I., Pavo, I. D. A., Jans, D. A. and Kobe, B. (2003). Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-a. Biochemical Journal, 375 (2), 339-349. doi: 10.1042/BJ20030510

Wooh, J. W., Kidd, R. D., Martin, J. L. and Kobe, B. (2003). Comparison of three commercial sparse-matrix crystallization screens. Acta Crystallographica Section D: Biological Crystallography, 59 (4), 769-772. doi: 10.1107/S0907444903002919

Smyth, Douglas R., Mrozkiewicz, Marek K., McGrath, William J., Listwan, Pawel and Kobe, Bostjan (2003). Crystal structures of fusion proteins with large-affinity tags. Protein Science, 12 (7), 1313-1322. doi: 10.1110/ps.0243403

Fontes, R. Marcos, Teh, Trazel, Jans, David A., Brinkworth, Ross I. and Kobe, Bostjan (2003). Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-α. Journal of Biological Chemistry, 278 (30), 27981-27987. doi: 10.1074/jbc.M303275200

Brinkworth, R. I., Breinl, R. A. and Kobe, B. (2003). Structural basis and prediction of substrate specificity in protein serine/threonine kinases. Proceedings of The National Academy of Sciences of The United States of America, 100 (1), 74-79. doi: 10.1073/pnas.0134224100

Kobe, B. (2003). Great Expectations: Structural Biology Amidst World Politics. Australian Biochemist, 34 (1), 24-27.

Kobe, Bostjan (2002). Intramolecular autoregulatory sequences in proteins. Croatica Chemica Acta, 75 (3), 805-816.

Brinkworth, R. I., Horne, J. and Kobe, B. (2002). A computational analysis of substrate binding strength by phosphorylase kinase and protein kinase A. Journal of Molecular Recognition, 15 (2), 104-111. doi: 10.1002/jmr.563

Horne, J., Jennings, I. G., Teh, T., Gooley, P. R. and Kobe, B. (2002). Structural characterization of the N-terminal autoregulatory sequence of phenylalanine hydroxylase. Protein Science, 11 (8), 2041-2047. doi: 10.1110/ps.4560102

Kajava, A. V. and Kobe, B. (2002). Assessment of the ability to model proteins with leucine-rich repeats in light of the latest structural information. Protein Science, 11 (5), 1082-1090. doi: 10.1110/ps.4010102

Kobe, Bostjan and Kajava, Andrey V. (2001). The leucine-rich repeat as a protein recognition motif. Current Opinion In Structural Biology, 11 (6), 725-732. doi: 10.1016/S0959-440X(01)00266-4

Kobe, B. (2001). Crystallization and crystal structure determination of ribomuclease A-ribonuclease inhibitor protein complex. Methods in Molecular Biology, 160, 201-211. doi: 10.1385/1-59259-233-3:201

Walsh, C. R., Hume, D. A., Kobe, B. and Martin, J. L. (2001). Structural genomics: Protein structures for the masses?. Australian Biochemist, 32 (2), 13-16.

Jennings, I. G., Teh, T. and Kobe, B. (2001). Essential role of the N-terminal autoregulatory sequence in the regulation of phenylalanine hydroxylase. Febs Letters, 488 (3), 196-200. doi: 10.1016/S0014-5793(00)02426-1

Blanchard, H., Fontes, R. M, Hammet, A., Pike, B. L., Teh, T., Gleichmann, T., Gooley, P. R., Kobe, B. and Heierhorst, J. (2001). Crystallization and preliminary X-ray diffraction studies of FHA domains of Dun1 and Rad53 protein kinases. Acta Crystallographica Section D: Biological Crystallography, 57 (3), 459-461. doi: 10.1107/S0907444901002116

Catimel, B., Teh, T., Fontes, M. R. M., Jennings, I. G., Jans, D. A., Howlett, G. J., Nice, E. C. and Kobe, B. (2001). Biophysical characterization of interactions involving importin-alpha during nuclear import. Journal of Biological Chemistry, 276 (36), 34189-34198. doi: 10.1074/jbc.M103531200

Maerz, Anne L., Center, Rob J., Kemp, Bruce E., Kobe, Bostjan and Poumbourios, Pantelis (2000). Functional implications of the human T-lymphotropic virus type 1 transmembrane glycoprotein helical hairpin structure. Journal of Virology, 74 (14), 6614-6621. doi: 10.1128/JVI.74.14.6614-6621.2000

Jennings, IG, Cotton, RGH and Kobe, B (2000). Structural interpretation of mutations in phenylalanine hydroxylase protein aids in identifying genotype-phenotype correlations in phenylketonuria. European Journal of Human Genetics, 8 (9), 683-696. doi: 10.1038/sj.ejhg.5200518

Jennings, IG, Cotton, RGH and Kobe, B (2000). Functional analysis, using in vitro mutagenesis, of amino acids located in the phenylalanine hydroxylase active site. Archives of Biochemistry And Biophysics, 384 (2), 238-244. doi: 10.1006/abbi.2000.2111

Hammet, A, Pike, BL, Mitchelhill, KI, Teh, T, Kobe, B, House, CM, Kemp, BE and Heierhorst, J (2000). FHA domain boundaries of the Dun1p and Rad53p cell cycle checkpoint kinases. Febs Letters, 471 (2-3), 141-146. doi: 10.1016/S0014-5793(00)01392-2

Montgomery, J, Ilg, T, Thompson, JK, Kobe, B and Handman, E (2000). Identification and predicted structure of a leucine-rich repeat motif shared by Leishmania major proteophosphoglycan and Parasite Surface Antigen 2. Molecular And Biochemical Parasitology, 107 (2), 289-295. doi: 10.1016/S0166-6851(00)00186-9

Fontes, MRM, Teh, T and Kobe, B (2000). Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha. Journal of Molecular Biology, 297 (5), 1183-1194. doi: 10.1006/jmbi.2000.3642

Kobe, B and Kajava, AV (2000). When protein folding is simplified to protein coiling: the continuum of solenoid protein structures. Trends in Biochemical Sciences, 25 (10), 509-515. doi: 10.1016/S0968-0004(00)01667-4

Kobe, B, Jennings, IG, House, CM, Michell, BJ, Goodwill, KE, Santarsiero, BD, Stevens, RC, Cotton, RGH and Kemp, BE (1999). Structural basis of autoregulation of phenylalanine hydroxylase. Nature Structural Biology, 6 (5), 442-448. doi: 10.1038/8247

Teh, T, Tiganis, T and Kobe, B (1999). Crystallization of importin alpha, the nuclear-import receptor. Acta Crystallographica Section D: Biological Crystallography, 55 (2), 561-563. doi: 10.1107/S0907444998012943

Poumbourios, P, Center, RJ, Wilson, KA, Kemp, BE and Kobe, B (1999). Evolutionary conservation of the membrane fusion machine. Iubmb Life, 48 (2), 151-156. doi: 10.1080/713803503

Kobe, B and Kemp, BE (1999). Active site-directed protein regulation. Nature, 402 (6760), 373-376. doi: 10.1038/46478

Kobe, B, Gleichmann, T, Horne, J, Jennings, IG, Scotney, PD and Teh, T (1999). Turn up the HEAT. Structure, 7 (5), R91-R97. doi: 10.1016/S0969-2126(99)80060-4

Kobe, B, Center, RJ, Kemp, BE and Poumbourios, P (1999). Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins. Proceedings of The National Academy of Sciences of The United States of America, 96 (8), 4319-4324. doi: 10.1073/pnas.96.8.4319

Kobe, B (1999). Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha. Nature Structural Biology, 6 (4), 388-397. doi: 10.1038/7625

Smith, Barbara S., Kobe, Bostjan, Kurumbail, Ravi, Buchanan, Susan K., Venkatramani, Lalitha, van der Helm, Dick and Deisenhofer, Johann (1998). Crystallization and preliminary X-ray analysis of ferric enterobactin receptor FepA, an integral membrane protein from Escherichia coli. Acta crystallographica: Section D, Biological crystallography, 54 (4), 697-699. doi: 10.1107/S0907444997020222

Center, RJ, Kobe, B, Wilson, KA, Teh, T, Howlett, GJ, Kemp, BE and Poumbourios, P (1998). Crystallization of a trimeric human T cell leukemia virus type 1 gp21 ectodomain fragment as a chimera with maltose-binding protein. Protein Science, 7 (7), 1612-1619. doi: 10.1002/pro.5560070715

Kobe, B (1998). Open up review system. Nature, 396 (6711), 509-509. doi: 10.1038/24969

Kemp, B. E., Kobe, B. and Heierhorst, J. (1998). Protein phosphorylation: In-charge and networking!. Australian Biochemist, 29, 11-13.

Kobe, B. (1997). Erratum: Leucines on a roll (Nature Structural Biology (1996) 3:12 (977- 980)). Nature Structural Biology, 4 (4). doi: 10.1038/nsb0497-327

Kobe, B, Jennings, IG, House, CM, Feil, SC, Michell, BJ, Tiganis, T, Parker, MW, Cotton, RGH and Kemp, BE (1997). Regulation and crystallization of phosphorylated and dephosphorylated forms of truncated dimeric phenylalanine hydroxylase. Protein Science, 6 (6), 1352-1357. doi: 10.1002/pro.5560060626

Kobe, B, Heierhorst, J and Kemp, BE (1997). Intrasteric regulation of protein kinases. Signal Transduction In Health And Disease, 31, 29-40.

Xu, P, Mitchelhill, KI, Kobe, B, Kemp, BE and Zot, HG (1997). The myosin-I-binding protein Acan125 binds the SH3 domain and belongs to the superfamily of leucine-rich repeat proteins. Proceedings of The National Academy of Sciences of The United States of America, 94 (8), 3685-3690. doi: 10.1073/pnas.94.8.3685

Heierhorst, Jörg, Kobe, Bostjan, Feil, Susanne C., Parker, Michael W., Benian, Guy M., Weiss, Klaudiusz R. and Kemp, Bruce E. (1996). Ca2+ /S100 regulation of giant protein kinases. Nature, 380 (6575), 636-639. doi: 10.1038/380636a0

Kobe, Bostjan (1996). Leucines on a roll. Nature Structural Biology, 3 (12), 977-980. doi: 10.1038/nsb1296-977

Kemp, B. E., Barden, J. A., Kobe, B., House, C. and Parker, M. W. (1996). Intrasteric regulation of calmodulin-dependent protein kinases. Advances in Pharmacology, 36 (C), 221-249. doi: 10.1016/S1054-3589(08)60584-0

Kobe, B, Heierhorst, J, Feil, SC, Parker, MW, Benian, GM, Weiss, KR and Kemp, BE (1996). Giant protein kinases: Domain interactions and structural basis of autoregulation. Embo Journal, 15 (24), 6810-6821. doi: 10.1002/j.1460-2075.1996.tb01072.x

Kobe, B and Deisenhofer, J (1996). Mechanism of ribonuclease inhibition by ribonuclease inhibitor protein based on the crystal structure of its complex with ribonuclease A. Journal of Molecular Biology, 264 (5), 1028-1043. doi: 10.1006/jmbi.1996.0694

Kobe, Bostjan and Deisenhofer, Johann (1995). Proteins with leucine-rich repeats. Current Opinion in Structural Biology, 5 (3), 409-416. doi: 10.1016/0959-440X(95)80105-7

Kobe, Bostjan and Deisenhofer, Johann (1995). A structural basis of the interactions between leucine-rich repeats and protein ligands. Nature, 374 (6518), 183-186. doi: 10.1038/374183a0

Kobe, Bestjan, Ma, Zhiquan and Deisenhofer, Johann (1994). Complex between bovine ribonuclease A and porcine ribonuclease inhibitor crystallizes in a similar unit cell as free ribonuclease inhibitor. Journal of Molecular Biology, 241 (2), 288-291. doi: 10.1006/jmbi.1994.1502

Kobe, Bostjan and Deisenhofer, Johann (1994). The leucine-rich repeat: a versatile binding motif. Trends In Biochemical Sciences, 19 (10), 415-421. doi: 10.1016/0968-0004(94)90090-6

Rizo, Josep, Blanco, Francisco J., Kobe, Bostjan, Bruch, Martha D. and Gierasch, Lila M. (1993). Conformational behavior of Escherichia coli OmpA signal peptides in membrane mimetic environments. Biochemistry, 32 (18), 4881-4894. doi: 10.1021/bi00069a025

Kobe, Bostjan and Deisenhofer, Johann (1993). Crystallization and preliminary X-ray analysis of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Journal of Molecular Biology, 231 (1), 137-140. doi: 10.1006/jmbi.1993.1263

Kobe, Bostjan and Deisenhofer, Johann (1993). Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Nature, 366 (6457), 751-756. doi: 10.1038/366751a0

Kobe, B., Kobe, J., Smee, D. F., Jerman-Blazic-Dzonova, B. and Solmajer, T. (1992). Use of distance geometry approach for the in vitro antiviral activity evaluation of N-bridgehead C-nucleosides. European Journal of Medicinal Chemistry, 27 (3), 259-266. doi: 10.1016/0223-5234(92)90010-X

Faming, Z., Kobe, B., Stewart, C. B., Rutter, W. J. and Goldsmith, E. J. (1991). Structural evolution of an enzyme specificity. The structure of rat carboxypeptidase A2 at 1.9-A resolution. The Journal of Biological Chemistry, 266 (36), 24606-24612.

Pan, M., Hedger, A., Nanson, J., Pospich, S., Ve, T. V. E. A., Raunser, S., Landsberg, M. and Kobe, B. (2022). Structural basis of TIR-domain assembly formation in TRAM- and TRIF- dependent TLR signalling. 2022 American Crystallographic Association Meeting, Portland, OR USA, 29 July-3 August 2022. Hoboken, NJ USA: Wiley-Blackwell Publishing. doi: 10.1107/s2053273322093196

Chen, J., Zhang, X., Burdett, H., Rank, M. X., Ve, T., Rathjen, J., Kobe, B. and Dodds, P. N. (2019). Self-association and an intact NADase active site are required for plant TIR domain immune signaling. 18th Congress of International Society for Molecular Plant Microbe Interactions (IS-MPMI), Glasgow, Scotland, 14-18 July, 2019. St. Paul, MN, United States: American Phytopathological Society. doi: 10.1094/MPMI-32-10-S1.1

Burdett, H., Rank, M. X., Chen, J., Zhang, X., Shi, Y., Ve, T., Dodds, P. N. and Kobe, B. (2019). Structural and Biochemical Analysis of Plant TIR NAD plus Cleavage Activity. 18th Congress of International Society for Molecular Plant Microbe Interactions (IS-MPMI), Glasgow, Scotland, 14-18 July, 2019. St. Paul, MN, United States: American Phytopathological Society. doi: 10.1094/MPMI-32-10-S1.213

Rank, M. X., Kobe, B., Burdett, H., Horsefield, S., Manik, M. K., Zhang, X. and Shi, Y. (2019). Interaction and structural study between plant TIR-containing NLRs and EDS1 immune regulatory complex. 18th Congress of International Society for Molecular Plant Microbe Interactions (IS-MPMI), Glasgow, Scotland, 14-18 July, 2019. St. Paul, MN, United States: American Phytopathological Society. doi: 10.1094/MPMI-32-10-S1.1

Kobe, B., Burdett, H., Zhang, X., Chen, J., Rank, M. X., Horsefield, S., Manik, M. K., Shi, Y., Qi, T., Dry, I. B., Williams, S. J., Staskawicz, B. J., Ve, T. and Dodds, P. N. (2019). Animal TIR domains inform the molecular and structural basis of signaling by plant NLR TIR domains. 18th Congress of International Society for Molecular Plant Microbe Interactions (IS-MPMI), Glasgow, Scotland, 14-18 July, 2019. St. Paul, MN, United States: American Phytopathological Society. doi: 10.1094/MPMI-32-10-S1.1

de Mattos Fontes, Marcos Roberto, de Barros, Andrea, Bernardes, Natalia, Takeda, Agnes, Dreyer, Thiago, Bertolini, Maria Celia and Kobe, Bostjan (2018). Crystallographic and calorimetric studies with nuclear transport of DNA repair proteins. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1107/S2053273318092434

O'Carroll, Allis, Ve, Thomas, Moustaqil, Mehdi, Giles, Nichole, Bhumkar, Akshay, Hunter, Dominic, Kobe, Bostjan, Sierecki, Emma and Gambin, Yann (2017). Prion - like protein polymerisation underlies signal transduction in innate immunity: the emergence of a universal mechanism ?. Annual Meeting of the American-Society-for-Pharmacology-and-Experimental-Therapeutics (ASPET) at Experimental Biology Meeting, Chicago, IL USA, Apr 22-26, 2017. Bethesda, MD, USA: Federation of American Societies for Experimental Biology.

Jeon, Yujung, Ross, Ian, Landsberg, Michael, Hankamer, Ben and Kobe, Bostjan (2017). Structural characterization of pseudo-dihyroorotase domain in yeast URA2. XXIV IUCr Congress, Hyderabad, India, 21-28 August 2017. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1107/s2053273317090325

Horsefield, Shane Michael, Ve, Thomas, Zhang, Xiaoxiao, Casey, Lachlan and Kobe, Bostjan (2017). Structural characterisation of SARM in axon degeneration and cell death. IUCr Congress, Hyderabad, India, 21-28 August 2017. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1107/S205327331708740X

Jeon, Yujung, Ross, Ian, Landsberg, Michael, Schultz, Ben, Hankamer, Ben and Kobe, Bostjan (2016). Structural characterization of dihydroorotase domain in yeast CAD multienzyme. 30th European Crystallographic Meeting, Basel, Switzerland, 28 August - 1 September 2016. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273316096807

Yennamalli, RM, Kobe, B, Mark, AE, Young, PR and Subbarao, N (2009). Dengue viral envelope protein and histidine protonation. XVIII National Conference of Indian Virological Society, Post Graduate Institute of Medical Education and Research, Chandigarh, India., 11–13 December 2008. HISAR: Indian Virological Society.

Gresshoff, P. M., Indrasumunar, A., Miyahara, A., Nontachaiyapoom, S., Biswas, B., Lin, Y-H., Lin, M-H, Reid, D., Callahan, D., Capon, R., Zhang, H., Jiang, Q., Hirani, T., Kobe, B., Men, A., Scott, P., Kereszt, A., Miyagi, M., Li, D., Chan, P-K., Roessner, U., Djordjevic, M. A., Kinkema, M. and Ferguson, B. (2009). Functional genomic analysis of systemic cell division regulation in legumes. International Symposium on Induced Mutations in Plants, Vienna, Austria, 2–15 August 2008. Vienna, Austria: Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture.

Brooking, Charles, Shouldice, Stephen R., Robin, Gautier, Kobe, Bostjan, Martin, Jennifer L. and Hunter, Jane (2009). Comparing METS and OAI-ORE for encapsulating scientific data products: A protein crystallography case study. IEEE International Conference on e-Science and Grid Computing [e-Science], Oxford, U.K., 9-11 December 2009. Los Alamitos, CA, U.S.A.: Institute for Electrical and Electronic Engineers (IEEE). doi: 10.1109/e-Science.2009.29

Yennamalli Madhava R, R., Kampmann, T., Subbarao, N., Kobe, B. and Young, P. R. (2006). In silico screening and structure based drug design for the envelope protein of flaviviruses. 5th International Conference on Bioinformatics, New Delhi, India, 18-20 Dec, 2006.

Forwood, J K, Mouradov, D. A., Guncar, G, Mafori, M., Serek, R. A., Martin, J L, Huber, T L and Kobe, B (2006). Two hot dogs are better than one: Structural and biochemical insights into mammalian long-chain acyl-COA hydrolase. ComBio 2006, Brisbane, 24-28 Sept, 2006.

Guncar, G, Forwood, J K, Mouradov, D. A., Serek, R. A., Mafori, M., Huber, T L, Martin, J L and Kobe, B (2006). Exit on the other side please; crystal structure of the ACOT7 C-terminal domain. ComBio 2006, Brisbane, 24-28 Sept, 2006.

King, G. F., Jones, A., Cowieson, N. P., Huber, T. L., Kobe, B. and Ross, I. L. (2006). Rapid identification of DTSSP crosslinked peptides using LCMALDI Tof-Tof mass spectrometry. ComBio 2006, Brisbane, Australia, 24-28 Sept, 2006. Kent Town, Australia: Australian Society for Biochemistry and Molecular Biology.

Robin, G, Cowieson, N P, Forwood, J K, Guncar, G, Listwan, P., Huber, T L, Kobe, B and Martin, J L (2006). University of Queensland structural genomics pipeline. ComBio 2006, Brisbane, 24-28 Sept, 2006.

Saunders, F W, Brinkworth, R. I., Huber, T L and Kobe, B (2006). Prediction of protein kinase substrates using sequence-structure information. ComBio 2006, Brisbane, 24-28 Sept, 2006.

Kampmann, T., Muller,, Robinson, J., Mark, A, Young, P R and Kobe, B (2006). The mechanism of vira membrane fusion and identification of novel antiviral lead compounds. 31st Lorne Conference on Protein Structure & Function, Lorne, Victoria, Australia, 5-9 Feb, 2006.

Young, P. R., Chappell, K. J., Stoermer, M. J., Fairlie, D., Kampmann, T. and Kobe, B. (2006). Multiple targets for antiviral inhibitors. 7th Asia Pacific Congress of Virology, New Delhi, 13-15 Nov, 2006.

Yennamalli Madhava R, R., Kampmann, T., Subbarao, N., Kobe, B and Young, P R (2006). In silico screening and structure based drug design for the envelope protein of flaviviruses. 7th Asia Pacific Congress of Virology, New Delhi, 13-15 Nov, 2006.

Kampmann, T., Yennamalli, R., Stoermer, M., Kobe, B. and Young, P. (2005). Development of antiviral drugs targeting the flaviviruses fusion mechanism. 30th FEBS Congress - 9th IUBMB Conference, Budapest, Hungary, 2-7tJuly 2005. Oxford, England: Blackwell Publishing. doi: 10.1111/j.1742-4658.2005.4739_15.x

Fontes, M. R. M., Takeda, A. A. S., Teh, T., Standaert, R. F. and Kobe, B. (2005). Structural studies with the importin alpha complexed with nuclear localization sequence peptidomimetics. Int Union Biochem Molecular Biol 50th Anniversary Symposium, Budapest, Hungary, 2nd - 7th July, 2005. Oxford, U.K.: Blackwell. doi: 10.1111/j.1742-4658.2005.4739_14.x

Kampmann, T., Yennamalli Madhava R, R., Stoermer, M. J., Kobe, B. and Young, P. R. (2005). Development of antiviral drugs targeting the flavivirus fusion mechanism. 30th Lorne Conference on Protein Structure & Function, Lorne, 6-10 Feb, 2005.

Kampmann, T., Yennamalli Madhava R, R., Stoermer, M.

Professor Bostjan Kobe

Researcher biography

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