Dr Amy Hanna
Research Fellow
Institute for Molecular Bioscience
Book Chapter
Hanna, A.D., Sharp, L.J. and Hamilton, S.L. (2016). Ryanodine Receptor Channelopathies in Skeletal and Cardiac Muscle. Ion Channels in Health and Disease. (pp. 53-84) London, United Kingdom: Academic Press. doi: 10.1016/b978-0-12-802002-9.00003-0
Journal Articles
Bojko, Barbara, Vasiljevic, Tijana, Boyaci, Ezel, Roszkowska, Anna, Kraeva, Natalia, Ibarra Moreno, Carlos A, Koivu, Annabel, Wąsowicz, Marcin, Hanna, Amy, Hamilton, Susan, Riazi, Sheila and Pawliszyn, Janusz (2021). Untargeted metabolomics profiling of skeletal muscle samples from malignant hyperthermia susceptible patients. Canadian Journal of Anaesthesia, 68 (6), 761-772. doi: 10.1007/s12630-020-01895-y
Hanna, Amy D., Lee, Chang Seok, Babcock, Lyle, Wang, Hui, Recio, Joseph and Hamilton, Susan L. (2021). Pathological mechanisms of vacuolar aggregate myopathy arising from a Casq1 mutation. The FASEB Journal, 35 (5) e21349, 1-20. doi: 10.1096/fj.202001653RR
Babcock, Lyle W., Hanna, Amy D., Agha, Nadia H. and Hamilton, Susan L. (2020). MyoSight-semi-automated image analysis of skeletal muscle cross sections. Skeletal Muscle, 10 (1) 33, 1-11. doi: 10.1186/s13395-020-00250-5
Wang, Hui J., Lee, Chang Seok, Yee, Rachel Sue Zhen, Groom, Linda, Friedman, Inbar, Babcock, Lyle, Georgiou, Dimitra K., Hong, Jin, Hanna, Amy D., Recio, Joseph, Choi, Jong Min, Chang, Ting, Agha, Nadia H., Romero, Jonathan, Sarkar, Poonam, Voermans, Nicol, Gaber, M. Waleed, Jung, Sung Yun, Baker, Matthew L., Pautler, Robia G., Dirksen, Robert T., Riazi, Sheila and Hamilton, Susan L. (2020). Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation. Nature Communications, 11 (1) 5099, 1-20. doi: 10.1038/s41467-020-18865-z
Vanden Abeele, Fabien, Lotteau, Sabine, Ducreux, Sylvie, Dubois, Charlotte, Monnier, Nicole, Hanna, Amy, Gkika, Dimitra, Romestaing, Caroline, Noyer, Lucile, Flourakis, Matthieu, Tessier, Nolwenn, Al-Mawla, Ribal, Chouabe, Christophe, Lefai, Etienne, Lunardi, Joël, Hamilton, Susan, Fauré, Julien, Van Coppenolle, Fabien and Prevarskaya, Natalia (2019). TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia. Genetics in Medicine, 21 (2), 441-450. doi: 10.1038/s41436-018-0066-9
Hanna, Amy D., Lam, Alexander, Thekkedam, Chris, Willemse, Hermia, Dulhunty, Angela F. and Beard, Nicole A. (2017). The anthracycline metabolite doxorubicinol abolishes RyR2 sensitivity to physiological changes in luminal Ca2+ through an interaction with calsequestrin. Molecular Pharmacology, 92 (5), 576-587. doi: 10.1124/mol.117.108183
Lee, Chang Seok, Hanna, Amy D., Wang, Hui, Dagnino-Acosta, Adan, Joshi, Aditya D., Knoblauch, Mark, Xia, Yan, Georgiou, Dimitra K., Xu, Jianjun, Long, Cheng, Amano, Hisayuki, Reynolds, Corey, Dong, Keke, Martin, John C., Lagor, William R., Rodney, George G., Sahin, Ergun, Sewry, Caroline and Hamilton, Susan L. (2017). A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nature Communications, 8 (1) 14659, 1-15. doi: 10.1038/ncomms14659
Pedrotti, Simona, Giudice, Jimena, Dagnino-Acosta, Adan, Knoblauch, Mark, Singh, Ravi K, Hanna, Amy, Mo, Qianxing, Hicks, John, Hamilton, Susan and Cooper, Thomas A (2015). The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function. Human Molecular Genetics, 24 (8), 2360-74. doi: 10.1093/hmg/ddv003
Lee, Chang Seok, Dagnino-Acosta, Adan, Yarotskyy, Viktor, Hanna, Amy, Lyfenko, Alla, Knoblauch, Mark, Georgiou, Dimitra K, Poché, Ross A, Swank, Michael W, Long, Cheng, Ismailov, Iskander I, Lanner, Johanna, Tran, Ted, Dong, KeKe, Rodney, George G, Dickinson, Mary E, Beeton, Christine, Zhang, Pumin, Dirksen, Robert T and Hamilton, Susan L (2015). Ca2+ permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca2+ signaling to sustain muscle function. Skeletal muscle, 5 4, 1-16. doi: 10.1186/s13395-014-0027-1
Hanna, Amy D., Lam, Alex, Thekkedam, Chris, Gallant, Esther M., Beard, Nicole A. and Dulhunty, Angela F. (2014). Cardiac ryanodine receptor activation by a high Ca²⁺ store load is reversed in a reducing cytoplasmic redox environment. Journal of Cell Science, 127 (Pt 20), 4531-4541. doi: 10.1242/jcs.156760
Hanna, Amy D., Lam, Alex, Tham, Steffi, Dulhunty, Angela F. and Beard, Nicole A. (2014). Adverse effects of doxorubicin and its metabolic product on cardiac RyR2 and SERCA2A. Molecular Pharmacology, 86 (4), 438-49. doi: 10.1124/mol.114.093849
Lee, Chang Seok, Georgiou, Dimitra K., Dagnino-Acosta, Adan, Xu, Jianjun, Ismailov, Iskander I., Knoblauch, Mark, Monroe, Tanner O., Ji, RuiRui, Hanna, Amy D., Joshi, Aditya D., Long, Cheng, Oakes, Joshua, Ted Tran, , Corona, Benjamin T., Lorca, Sabina, Ingalls, Christopher P., Narkar, Vihang A., Lanner, Johanna T., Bayle, J. Henri, Durham, William J. and Hamilton, Susan L. (2014). Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function. Journal of Biological Chemistry, 289 (37), 25556-25570. doi: 10.1074/jbc.m114.586289
Dulhunty, Angela F., Beard, Nicole A. and Hanna, Amy D. (2012). Regulation and dysregulation of cardiac ryanodine receptor (RyR2) open probability during diastole in health and disease. Journal of General Physiology, 140 (2), 87-92. doi: 10.1085/jgp.201210862
Dulhunty, Angela F., Wium, Elize, Li, Linwei, Hanna, Amy D., Mirza, Shamaruh, Talukder, Sadik, Ghazali, Nuur A.A. and Beard, Nicole A. (2012). Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output. Clinical and Experimental Pharmacology and Physiology, 39 (5), 477-84. doi: 10.1111/j.1440-1681.2012.05704.x
Hanna, Amy D., Janczura, Marie, Cho, Eric, Dulhunty, Angela F. and Beard, Nicole A. (2011). Multiple actions of the anthracycline daunorubicin on cardiac ryanodine receptors. Molecular Pharmacology, 80 (3), 538-549. doi: 10.1124/mol.111.073478
Wei, Lan, Hanna, Amy D., Beard, Nicole A. and Dulhunty, Angela F. (2009). Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle. Cell Calcium, 45 (5), 474-84. doi: 10.1016/j.ceca.2009.03.006