Dr Ken Loh
Honorary Fellow/Associate Lecturer
Institute for Molecular Bioscience
Journal Articles
Loh, Zhixuan, Huan, Xuelu, Awate, Sunita, Schrittwieser, Markus, Renia, Laurent and Ren, Ee Chee (2022). Molecular characterization of MHC class I alpha 1 and 2 domains in Asian seabass (Lates calcarifer). International Journal of Molecular Sciences, 23 (18) 10688, 1-10. doi: 10.3390/ijms231810688
Wang, Peiqi, Hill, Timothy A., Mitchell, Justin, Fitzsimmons, Rebecca L., Xu, Weijun, Loh, Zhixuan, Suen, Jacky Y., Lim, Junxian, Iyer, Abishek and Fairlie, David P. (2022). Modifying a hydroxyl patch in glucagon-like peptide 1 produces biased agonists with unique signaling profiles. Journal of Medicinal Chemistry, 65 (17), 11759-11775. doi: 10.1021/acs.jmedchem.2c00653
Mak, Jeffrey Y. W., Wu, Kai-Chen, Gupta, Praveer K., Barbero, Sheila, McLaughlin, Maddison G., Lucke, Andrew J., Tng, Jiahui, Lim, Junxian, Loh, Zhixuan, Sweet, Matthew J, Reid, Robert C., Liu, Ligong and Fairlie, David P. (2021). HDAC7 inhibition by phenacetyl and phenylbenzoyl hydroxamates. Journal of Medicinal Chemistry, 64 (4), 2186-2204. doi: 10.1021/acs.jmedchem.0c01967
Hulme, Katina Dee, Yan, Limin, Marshall, Rebecca J., Bloxham, Conor J., Upton, Kyle R., Hasnain, Sumaira Z., Bielefeldt-Ohmann, Helle, Loh, Zhixuan, Ronacher, Katharina, Chew, Keng Yih , Gallo, Linda A. and Short, Kirsty Renfree (2020). High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier. eLife, 9 e56907, 1-20. doi: 10.7554/elife.56907
Loh, Zhixuan, Simpson, Jennifer, Ullah, Ashik, Zhang, Vivian, Gan, Wan J., Lynch, Jason P., Werder, Rhiannon B., Sikder, Al Amin, Lane, Katie, Sim, Choon Boon, Porrello, Enzo, Mazzone, Stuart B., Sly, Peter D., Steptoe, Raymond J., Spann, Kirsten M., Sukkar, Maria B., Upham, John W. and Phipps, Simon (2020). HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling. PLoS Pathogens, 16 (7) e1008651, 1-21. doi: 10.1371/journal.ppat.1008651
Simpson, Jennifer, Loh, Zhixuan, Ullah, Md Ashik, Lynch, Jason P., Werder, Rhiannon B., Collinson, Natasha, Zhang, Vivian, Dondelinger, Yves, Bertrand, Mathieu J M, Everard, Mark L., Blyth, Christopher C., Hartel, Gunter, Van Oosterhout, Antoon J., Gough, Peter J., Bertin, John, Upham, John W., Spann, Kirsten M. and Phipps, Simon (2020). Respiratory syncytial virus infection promotes necroptosis and HMGB1 release by airway epithelial cells. American Journal of Respiratory and Critical Care Medicine, 201 (11), 1358-1371. doi: 10.1164/rccm.201906-1149OC
Loh, Zhixuan, Fitzsimmons, Rebecca L., Reid, Robert C., Ramnath, Divya, Clouston, Andrew, Gupta, Praveer K., Irvine, Katharine M., Powell, Elizabeth E., Schroder, Kate, Stow, Jennifer L., Sweet, Matthew J., Fairlie, David P. and Iyer, Abishek (2019). Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic Type 2 inflammation. British Journal of Pharmacology, 176 (19) bph.14768, 3775-3790. doi: 10.1111/bph.14768
Ramnath, Divya, Irvine, Katharine M., Lukowski, Samuel W., Horsfall, Leigh U., Loh, Zhixuan, Clouston, Andrew D., Patel, Preya J., Fagan, Kevin J., Iyer, Abishek, Lampe, Guy, Stow, Jennifer L., Schroder, Kate, Fairlie, David P., Powell, Joseph E., Powell, Elizabeth E. and Sweet, Matthew J. (2018). Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes. JCI Insight, 3 (14). doi: 10.1172/jci.insight.120274
Lynch, Jason P., Werder, Rhiannon B., Loh, Zhixuan, Sikder, Md Al Amin, Curren, Bodie, Zhang, Vivian, Rogers, Matthew J. , Lane, Katie, Simpson, Jennifer, Mazzone, Stuart B., Spann, Kirsten, Hayball, John, Diener, Kerrilyn, Everard, Mark L., Blyth, Christopher C., Forstner, Christian, Dennis, Paul G., Murtaza, Nida, Morrison, Mark, Ó Cuív, Páraic, Zhang, Ping, Haque, Ashraful, Hill, Geoffrey R., Sly, Peter D., Upham, John W. and Phipps, Simon (2017). Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a-mediated T reg expansion. The Journal of Experimental Medicine, 215 (2), 537-557. doi: 10.1084/jem.20170298
Lohman, Rink-Jan, Hamidon, Johan K., Reid, Robert C., Rowley, Jessica A., Yau, Mei-Kwan, Halili, Maria A., Nielsen, Daniel S., Lim, Junxian, Wu, Kai-Chen, Loh, Zhixuan, Do, Anh, Suen, Jacky Y., Iyer, Abishek and Fairlie, David P. (2017). Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a. Nature Communications, 8 (1) 351, 351. doi: 10.1038/s41467-017-00414-w
Simpson, Jennifer, Lynch, Jason P., Loh, Zhixuan, Zhang, Vivian, Werder, Rhiannon B., Spann, Kirsten and Phipps, Simon (2017). The Absence of Interferon-β Promotor Stimulator-1 (IPS-1) Predisposes to Bronchiolitis and Asthma-like Pathology in Response to Pneumoviral Infection in Mice. Scientific Reports, 7 (1) 2353, 2353. doi: 10.1038/s41598-017-02564-9
Arikkatt, Jaisy, Ullah, Md Ashik, Short, Kirsty Renfree, Zhang, Vivian, Gan, Wan Jun, Loh, Zhixuan, Werder, Rhiannon B., Simpson, Jennifer, Sly, Peter D., Mazzone, Stuart B., Spann, Kirsten M., Ferreira, Manuel A R., Upham, John W., Sukkar, Maria B. and Phipps, Simon (2017). RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma. eLife, 6 e21199. doi: 10.7554/eLife.21199
Lynch, Jason P., Werder, Rhiannon B., Simpson, Jennifer, Loh, Zhixuan, Zhang, Vivian, Haque, Ashraful, Spann, Kirsten, Sly, Peter D., Mazzone, Stuart B., Upham, John W. and Phipps, Simon (2016). Aeroallergen-induced IL-33 predisposes to respiratory virus–induced asthma by dampening antiviral immunity. Journal of Allergy and Clinical Immunology, 138 (5), 1326-1337. doi: 10.1016/j.jaci.2016.02.039
Ullah, Md Ashik, Revez, Joana A., Loh, Zhixuan, Simpson, Jennifer, Zhang, Vivian, Bain, Lisa, Varelias, Antiopi, Rose-John, Stefan, Blumenthal, Antje, Smyth, Mark J., Hill, Geoffrey R., Sukkar, Manuel A. R, Ferreira M. A. R. and Phipps, Simon (2015). Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation. Journal of Allergy and Clinical Immunology, 136 (4), 1065-1073. doi: 10.1016/j.jaci.2015.02.032
Ullah, Md Ashik, Loh, Zhixuan, Gan, Wan Jun, Zhang, Vivian, Yang, Huan, Li, Jian Hua, Yamamoto, Yasuhiko, Schmidt, Ann Marie, Armour, Carol L., Hughes, J. Margaret, Phipps, Simon and Sukkar, Maria B. (2014). Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation. Journal of Allergy and Clinical Immunology, 134 (2), 440-450.e3. doi: 10.1016/j.jaci.2013.12.1035
Spann, Kirsten M., Loh, Zhixuan, Lynch, Jason P., Ullah, Ashik, Zhang, Vivian, Baturcam, Engin, Werder, Rhiannon B., Khajornjiraphan, Natthida, Rudd, Penny, Loo, Yeuh-Ming, Suhrbier, Andreas, Gale Jr., Michael, Upham, John W. and Phipps, Simon (2014). IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice. American Journal of Pathology, 184 (6), 1795-1806. doi: 10.1016/j.ajpath.2014.02.026
Lynch, Jason P., Mazzone, Stuart B., Rogers, Matthew J., Arikkatt, Jaisy J., Loh, Zhixuan, Pritchard, Antonia L., Upham, John W. and Phipps, Simon (2014). The plasmacytoid dendritic cell: a cell at the cross-roads in asthma. European Respiratory Journal, 43 (1), 264-275. doi: 10.1183/09031936.00203412
Barry, Jessica, Loh, Zhixuan, Colliso, Adam, Mazzone, Stuart, Lalwani, Amit, Zhang, Vivian, Davidson, Sophia, Wybacz, Elish, Garlanda, Cecilia, Mantovani, Alberto, Mattes, Joerg, Foster, Paul S. and Phipps, Simon (2013). Absence of toll-IL-1 receptor 8/single immunoglobulin IL-1 receptor-related molecule reduces house dust mite-induced allergic airway inflammation in mice. American Journal of Respiratory Cell and Molecular Biology, 49 (3), 481-490. doi: 10.1165/rcmb.2012-0425OC
Kaiko, Gerard E., Loh, Zhixuan, Spann, Kirsten, Lynch, Jason P., Lalwani, Amit, Zheng, Zhenglong, Davidson, Sophia, Uematsu, Satoshi, Akira, Shizuo, Hayball, John, Diener, Kerrilyn R., Baines, Katherine J., Simpson, Jodie L., Foster, Paul S. and Phipps, Simon (2013). Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice. Journal of Allergy and Clinical Immunology, 131 (5), 1331-133e10. doi: 10.1016/j.jaci.2013.02.041
Davidson, Sophia, Kaiko, Gerard, Loh, Zhixuan, Lalwani, Amit, Zhang, Vivian, Spann, Kirsten, Foo, Shen Yun, Hansbro, Nicole, Uematsu, Satoshi, Akira, Shizuo, Matthaei, Klaus I., Rosenberg, Helene F., Foster, Paul S. and Phipps, Simon (2011). Plasmacytoid dendritic cells promote host defense against acute pneumovirus infection via the TLR7-MyD88-dependent signaling pathway. Journal of Immunology, 186 (10), 5938-5948. doi: 10.4049/jimmunol.1002635
Conference Papers
Ramnath, D., Irvine, K., Lukowski, S., Horsfall, L., Loh, K., Clouston, A., Patel, P., Iyer, A., Lampe, G., Stow, J., Schroder, K., Fairlie, D., Powell, J., Powell, E. and Sweet, M. (2018). RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease. International Liver Congress (ILC), Paris, France, 11-15 April, 2018. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/S0168-8278(18)31040-7
Simpson, J., Loh, Z., Zhang, , Spann, K., Upham, J. and Phipps, S. (2016). Absence of interferon-beta promotor stimulator-1 (IPS1) induces bronchiolitis and asthma-like pathology in response to pneumoviral infection. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL.
Simpson, J., Loh, Z., Zhang, V, Spann, K., Upham, J. and Phipps, S. (2016). ABSENCE OF INTERFERON-beta PROMOTOR STIMULATOR-1 (IPS1) INDUCES BRONCHIOLITIS AND AN ASTHMA-LIKE PATHOLOGY IN RESPONSE TO PNEUMOVIRAL INFECTION. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL.
Werder, R. B., Lynch, J., Simpson, J., Loh, Z., Zhang, V., Spann, K., Sly, P., Mazzone, S., Upham, J. and Phipps, S. (2016). Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening Type I and III interferon production. 4th Annual Meeting of The International Cytokine and Interferon Society (ICIS), San Francisco, CA, United States, October 16 - 19 2016. London, United Kingdom: Academic Press.
Werder, R., Lynch, J., Simpson, J., Loh, Z., Zhang, V., Spann, K., Sly, P., Mazzone, S., Upham, J. and Phipps, S. (2016). Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening type I and III interferon production. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200
Lynch, J. P., Werder, R., Rogers, M., Lane, K., Loh, Z., Diener, K., Colonna, M., Forstner, C., Dennis, P., Hayball, J., Hill, G., Haque, A., Spann, K., Mazzone, S., Uphaem, J. and Phipps, S. (2016). Semaphorin 4A-Dependent Treg Cell Expansion by Plasmacytoid Dc Confers Protection Against Severe Viral Bronchiolitis and Subsequent Asthma. 4th Annual Meeting of The International Cytokine and Interferon Society (ICIS), San Francisco, United States, 16-19 October 2016. London, United Kingdom: Academic Press. doi: 10.1016/j.cyto.2016.07.021
Lynch, J., Rogers, M., Lane, K., Werder, R., Loh, Z., Diener, K., Hayball, J., Hill, G., Haque, A., Spann, K., Mazzone, S., Upham, J. and Phipps, S. (2016). Uncoupling of the Pdc-Treg Crosstalk During Early-Life Pneumovirus Infection Underlies Long-Lived Treg Dysfunction and Asthma Development. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL. doi: 10.1111/resp.12755_3
Lynch, J., Rogers, M., Lane, K., Werder, R., Loh, Z., Diener, K., Hayball, J., Hill, G., Haque, A., Spann, K., Mazzone, S., Upham, J. and Phipps, S. (2015). PDC EXPANSION OF NTREG LIMITS SEVERE PNEUMOVIRUS-INDUCED BRONCHIOLITIS AND ATTENUATES THE ONSET OF VIRUS-PROVOKED ASTHMA. Thoracic Society Australia New Zealand Australian New Zealand Society Respiratory Science Annual Scientific Meeting 2015, Queensland Australia, Mar 27-Apr 01, 2015. HOBOKEN: WILEY-BLACKWELL.
Werder, R., Lynch, J., Simpson, J., Loh, Z., Zhang, , Spann, K., Sly, P., Mazzone, S., Upham, J. and Phipps, S. (2015). AEROALLERGEN-INDUCED IL-33 PREDISPOSES TO RESPIRATORY VIRUS-INDUCED ASTHMA BY DAMPENING TYPE I AND III INTERFERON PRODUCTION. Thoracic Society Australia New Zealand Australian New Zealand Society Respiratory Science Annual Scientific Meeting 2015, Queensland Australia, Mar 27-Apr 01, 2015. HOBOKEN: WILEY-BLACKWELL.
Loh, Z., Ullah, A., Zhang, V., Lynch, J., Werder, R., Simpson, J., Upham, J., Mazzone, S., Spann, K. and Phipps, S. (2015). Interferon Regulatory Factor 7 Protects Against Pneumovirus-Induced Airway Smooth Muscle Growth in Early Life. TSANZ 2015 Annual Scientific Meeting, Gold Coast, QLD Australia, 28 March - 1 April 2015. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12494_7
Ullah, Ashik M., Pharm, M., Revez, J., Loh, Z., Simpson, J., Zhang, V, Bain, L., Varelias, A., Rose-John, S., Blumenthal, A., Smyth, M., Hill, G., Sukkar, M., Ferreira, M. and Phipps, S. (2015). Il-6R Blockade Attenuates Experimental Allergic Asthma Associated with Activation of the Il-6 Trans-Signalling Pathway. Annual Scientific Meeting 2015 of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Gold Coast, QLD Australia, 27 March - 1 April 2015. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12494_9
Ullah, M. A., Revez, J., Loh, Z., Simpson, J., Zhang,, Bain, L., Varelias, A., Rose-John, S., Blumenthal, A., Smyth, M., Hill, G., Sukkar, M., Ferreira, M. A. and Phipps, S. (2015). IL-6R blockade attenuates experimental allergic asthma associated with activation of the IL-6 trans-signalling pathway. Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Barcelona, Spain, 6-10 June 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.
Lynch, J. P., Werder, R. B., Rogers, M. J., Lane, K., Loh, Z., Simpson, J., Diener, K., Hayball, J., Zhang, P., Swiecki, M., Colonna, M., Haque, A., Spann, K., Mazzone, S. B., Hill, G. R., Upham, J. W. and Phipps, S. (2014). pDC expansion of nTreg limits severe Pneumovirus-induced bronchiolitis and attenuates the onset of virus-provoked asthma. Thoracic Society Australia New Zealand Australian New Zealand Society Respiratory Science Annual Scientific Meeting 2015, Queensland Australia, Mar 27-Apr 01, 2015. HOBOKEN: WILEY-BLACKWELL.
Lynch, J., Werder, R. B., Simpson, J., Loh, Z., Zhang, V., Sly, P. D., Mazzone, S., Upham, J. W. and Phipps, S. (2014). Anti-IL-33 ameliorates asthma onset and progression in response to virus and allergen co-exposure. Abstracts of the British Society for Immunology Annual Congress, Brighton, United Kingdom, 1–4 December 2014. Chichester, West Sussex United Kingdom: Wiley-Blackwell Publishing.
Werder, Rhiannon B., Lynch, Jason P., Simpson, Jennifer, Loh, Ken, Zhang, Vivian, Spann, Kirsten, Sly, Peter D., Mazzone, Stuart, Upham, John W. and Phipps, Simon (2014). Critical role for IL-33 in the onset and progression of experimental asthma induced by concomitant virus infection and allergen exposure. 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne, VIC, Australia, October 26 - 29, 2014. London, United Kingdom: Academic Press. doi: 10.1016/j.cyto.2014.07.203
Ullah, M. A., Loh, Z., Gan, W. J., Zhang, V., Lynch, J., Eacharath, J., Hughes, J. M., Armour, C. L., Phipps, S. and Sukkar, M. B. (2013). Hmgb1-Rage Axis Mediates House Dust Mite Induced Allergic Sensitization and Airway Inflammation. 2013 Annual Scientific Meetings of The Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science, Darwin, NT Australia, 22 - 27 March 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12045
Ullah, MD Ashik, Gan, Wan J., Loh, Zhixuan, Zhang, Vivian, Hughes, J. Margaret, Armour, Carol L., Phipps, Simon and Sukkar, Maria B. (2012). The activation of the receptor for advanced glycation end products (RAGE) contributes to the induction of Hdm-specific T(h)2 responses. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2012 Annual Scientific Meetings, Canberra, ACT, Australia, 30 March - 4 April 2012. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1843.2012.02142.x
Thesis
Loh, Zhixuan (2016). The role of interferon regulatory factor 3 and 7 in virus-induced bronchiolitis and the onset of asthma. PhD Thesis, School of Biomedical Sciences, The University of Queensland. doi: 10.14264/uql.2016.238