Dr Jean Jin
Postdoctoral Research Fellow
Institute for Molecular Bioscience
+61 7 334 62377
Book Chapter
Dutertre, Sebastien, Undheim, Eivind, Pineda, Sandy S., Jin, Ai-Hua (Jean), Lavergne, Vincent, Fry, Bryan G., Lewis, Richard J., Alewood, Paul F. and King, Glenn F. (2015). Venoms-Based Drug Discovery: Proteomic and Transcriptomic Approaches. In King, Glenn F (Ed.), Venoms to Drugs (pp. 80-96) London, United Kingdom: Royal Society of Chemistry. doi:10.1039/9781849737876-00080
Journal Articles
Dekan, Zoltan, Sianati, Setareh, Yousuf, Arsalan, Sutcliffe, Katy J., Gillis, Alexander, Mallet, Christophe, Singh, Paramjit, Jin, Aihua H., Wang, Anna M., Mohammadi, Sarasa A., Stewart, Michael, Ratnayake, Ranjala, Fontaine, Frank, Lacey, Ernest, Piggott, Andrew M., Du, Yan P., Canals, Meritxell, Sessions, Richard B., Kelly, Eamonn, Capon, Robert J., Alewood, Paul F. and Christie, MacDonald J. (2019) A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor. Proceedings of the National Academy of Sciences, 116 44: 22353-22358. doi:10.1073/pnas.1908662116
Jin, Ai-Hua, Muttenthaler, Markus, Dutertre, Sebastien, Himaya, S.W.A., Kaas, Quentin, Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2019) Conotoxins: chemistry and biology. Chemical Reviews, . doi:10.1021/acs.chemrev.9b00207
Jin, Ai-hua, Cristofori-Armstrong, Ben, Rash, Lachlan D., Román González, Sergio Agustín, Espinosa, Roberto Arreguín, Lewis, Richard J., Alewood, Paul F. and Vetter, Irina (2019) Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels. Biochemical Pharmacology, 164 342-348. doi:10.1016/j.bcp.2019.04.025
Jin, Ai-Hua, Dutertre, Sébastien, Dutt, Mriga, Lavergne, Vincent, Jones, Alun, Lewis, Richard and Alewood, Paul (2019) Transcriptomic-proteomic correlation in the predation-evoked venom of the cone snail, Conus imperialis. Marine Drugs, 17 3: 177. doi:10.3390/md17030177
Dutt, Mriga, Dutertre, Sébastien, Jin, Ai-Hua, Lavergne, Vincent, Alewood, Paul and Lewis, Richard (2019) Venomics reveals venom complexity of the piscivorous cone snail, Conus tulipa. Marine Drugs, 17 1: 71. doi:10.3390/md17010071
Jin, Ai-Hua, Dekan, Zoltan, Smout, Michael J., Wilson, David, Dutertre, Sébastien, Vetter, Irina, Lewis, Richard J., Loukas, Alex, Daly, Norelle L. and Alewood, Paul F. (2017) Conotoxin Φ-MiXXVIIA from the superfamily G2 employs a novel cysteine framework that mimics granulin and displays anti-apoptotic activity. Angewandte Chemie, 129 47: 15169-15172. doi:10.1002/ange.201708927
Jin, Ai-Hua, Dekan, Zoltan, Smout, Michael J., Wilson, David, Dutertre, Sébastien, Vetter, Irina, Lewis, Richard J., Loukas, Alex, Daly, Norelle L. and Alewood, Paul F. (2017) Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity. Angewandte Chemie (International ed. in English), 56 47: 14973-14976. doi:10.1002/anie.201708927
Touchard, Axel, Brust, Andreas, Cardoso, Fernanda C., Chin, K.-Y., Herzig, Volker, Jin, Ai-Hua, Dejean, Alain, Alewood, Paul F., King, Glenn F., Orivel, Jérôme and Escoubas, Pierre (2016) Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus. Biochimica et Biophysica Acta, 1860 11 Part A: 2553-2562. doi:10.1016/j.bbagen.2016.07.027
Prashanth, J. R., Dutertre, S., Jin, A. H., Lavergne, V., Hamilton, B., Cardoso, F. C., Griffin, J., Venter, D. J., Alewood, P. F. and Lewis, R. J. (2015) The role of defensive ecological interactions in the evolution of conotoxins. Molecular Ecology, 25 2: 598-615. doi:10.1111/mec.13504
Himaya S.W.A., Jin, Ai-Hua, Dutertre, Sebastien, Giacomotto, Jean, Mohialdeen, Hoshyar, Vetter, Irina, Alewood, Paul F. and Lewis, Richard J. (2015) Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus. Journal of Proteome Research, 14 10: 4372-4381. doi:10.1021/acs.jproteome.5b00630
Jin, Ai-Hua, Israel, Mathilde R., Inserra, Marco, Smith, Jennifer J., Lewis, Richard J., Alewood, Paul F., Vetter, Irina and Dutertre, Sebastien (2015) δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proceedings of the Royal Society B: Biological Sciences, 282 1811: 1-8. doi:10.1098/rspb.2015.0817
Mueller, Alexander, Starobova, Hana, Inserra, Marco C., Jin, Ai-Hua, Deuis, Jennifer R., Dutertre, Sebastien, Lewis, Richard J., Alewood, Paul F., Daly, Norelle L. and Vetter, Irina (2015) α-conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors. Biochemical Pharmacology, 94 2: 155-163. doi:10.1016/j.bcp.2015.01.011
Jin, Ai-Hua, Vetter, Irina, Himaya, Siddhihalu W. A., Alewood, Paul F., Lewis, Richard J. and Dutertre, Sébastien (2015) Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom. Proteomics, 15 23-24: 4030-4040. doi:10.1002/pmic.201500220
Dutertre, Sebastien, Jin, Ai-Hua, Alewood, Paul F. and Lewis, Richard J. (2014) Intraspecific variations in Conus geographus defence-evoked venom and estimation of the human lethal dose. Toxicon, 91 135-144. doi:10.1016/j.toxicon.2014.09.011
Prashanth, Jutty Rajan, Brust, Andreas, Jin, Ai-Hua, Alewood, Paul F., Dutertre, Sebastien and Lewis, Richard J. (2014) Cone snail venomics: From novel biology to novel therapeutics. Future Medicinal Chemistry, 6 15: 1659-1675. doi:10.4155/FMC.14.99
Dutertre, Sébastien, Jin, Ai-Hua, Vetter, Irina, Hamilton, Brett, Sunagar, Kartik, Lavergne, Vincent, Dutertre, Valentin, Fry, Bryan G., Antunes, Agostinho, Venter, Deon J., Alewood, Paul F. and Lewis, Richard J. (2014) Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. Nature Communications, 5 3521: 1-9. doi:10.1038/ncomms4521
Jin, Ai-Hua, Vetter, Irina, Dutertre, Sébastien, Abraham, Nikita, Emidio, Nayara B., Inserra, Marco, Murali, Swetha S., Christie, MacDonald J., Alewood, Paul F. and Lewis, Richard J. (2014) MrIC, a novel alpha-conotoxin agonist in the presence of PNU at endogenous alpha-7 nicotinic acetylcholine receptors. Biochemistry, 53 1: 1-3. doi:10.1021/bi400882s
Prashanth, Jutty Rajan, Brust, Andreas, Jin, Ai-Hua, Alewood, Paul F., Dutertre, Sébastien and Lewis, Richard J. (2014) Erratum: Cone snail venomics: From novel biology to novel therapeutics (Future Medicinal Chemistry (2014) 6:15 (1659-1675)). Future Medicinal Chemistry, 6 18: . doi:10.4155/fmc.14.159
Jin, Ai-Hua, Dutertre, Sébastien, Kaas, Quentin, Lavergne, Vincent, Kubala, Petra, Lewis, Richard J. and Alewood, Paul F. (2013) Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. Molecular and Cellular Proteomics, 12 12: 3824-3833. doi:10.1074/mcp.M113.030353
Lavergne, Vincent, Dutertre, Sebastien, Jin, Ai-hua, Lewis, Richard J., Taft, Ryan J. and Alewood, Paul F. (2013) Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies. Bmc Genomics, 14 1: 708.1-708.11. doi:10.1186/1471-2164-14-708
Dutertre, Sebastien, Jin, Ai-Hua (Jean), Kaas, Quentin, Jones, Alun, Alewood, Paul F. and Lewis, Richard J. (2013) Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Molecular and Cellular Proteomics, 12 2: 312-329. doi:10.1074/mcp.M112.021469
Napier, I. A., Klimis, H., Rycroft, B. K., Jin, A. H., Alewood, P. F., Motin, L., Adams, D. J. and Christie, M. J. (2012) Intrathecal alpha-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain. Neuropharmacology, 62 7: 2202-2207. doi:10.1016/j.neuropharm.2012.01.016
Vink, S., Jin, A. H., Poth, K. J., Head, G. A. and Alewood, P. F. (2012) Natriuretic peptide drug leads from snake venom. Toxicon, 59 4: 434-445. doi:10.1016/j.toxicon.2010.12.001
Kaas, Quentin, Yu, Rilei, Jin, Ai-Hua, Dutertre, Sebastien and Craik, David J. (2012) ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research, 40 D1: D325-D330. doi:10.1093/nar/gkr886
Jin, Ai-Hua, Daly, N. L., Nevin, S. T., Wang, C. I. A., Dutertre, S., Lewis, R. J., Adams, D. J., Craik, D. J. and Alewood, P. F. (2008) Molecular engineering of conotoxins: The importance of loop size to alpha-conotoxin structure and function. Journal of Medicinal Chemistry, 51 18: 5575-5584. doi:10.1021/jm800278k
Jin, Ai-Hua, Brandstaetter, Hemma, Nevin, Simon T., Tan, Chia Chia, Clark, Richard J., Adams, David J., Alewood, Paul F., Craik, David J. and Daly, Norelle L. (2007) Structure of alpha-conotoxin BuIA: Influences of disulfide connectivity on structural dynamics. BMC Structural Biology, 7 28: 1-13. doi:10.1186/1472-6807-7-28
Conference Papers
Jin, Ai-hua, Dutertre, Sébastien, Kaas, Quentin, Lewis, Richard J. and Alewood, Paul F. (2012). Transcriptomic and peptidomic characterisation of the Conus marmoreus venom: Insights on conopeptide diversity and venomic processing. In: 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, (144-145). 8-13 July 2012. doi:10.1016/j.toxicon.2012.04.099
Dutertre, Sébastien, Jin, Ai-hua, Alewood, Paul F. and Lewis, Richard J. (2012). The venom of Conus geographus revisited. In: 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, (145-145). 8-13 July 2012. doi:10.1016/j.toxicon.2012.04.100
Thesis
Jin, Aihua Jean (2006). Cysteine-rich bioactive peptides A structural and biological characterisation of toxins and bioactive peptides PhD Thesis, Institute for Molecular Bioscience, University of Queensland.