| Featured projects | Duration |
|---|---|
| Immunometabolism in health and disease |
Journal Articles
Humphries, Tyrone L. R., Shen, Kunyu, Iyer, Abishek, Johnson, David W., Gobe, Glenda C., Nikolic-Paterson, David, Fairlie, David P. and Vesey, David A. (2021). PAR2-Induced Tissue Factor Synthesis by Primary Cultures of Human Kidney Tubular Epithelial Cells Is Modified by Glucose Availability. International Journal of Molecular Sciences, 22 (14) 7532, 7532. doi: 10.3390/ijms22147532
Morais, Christudas, Rajandram, Retnagowri, Blakeney, Jade S., Iyer, Abishek, Suen, Jacky Y., Johnson, David W., Gobe, Glenda C., Fairlie, David P. and Vesey, David A. (2021). Expression of protease activated receptor-2 is reduced in renal cell carcinoma biopsies and cell lines. PLoS One, 16 (3) e0248983, e0248983. doi: 10.1371/journal.pone.0248983
Iyer, Abishek, Humphries, Tyrone L. R., Owens, Evan P., Zhao, Kong-Nan, Masci, Paul P., Johnson, David W., Nikolic-Paterson, David, Gobe, Glenda C., Fairlie, David P. and Vesey, David A. (2021). PAR2 activation on human kidney tubular epithelial cells induces tissue factor synthesis, that enhances blood clotting. Frontiers in Physiology, 12 615428, 615428. doi: 10.3389/fphys.2021.615428
Das Gupta, Kaustav, Shakespear, Melanie R., Curson, James E.B., Murthy, Ambika M.V., Iyer, Abishek, Hodson, Mark P., Ramnath, Divya, Tillu, Vikas A., von Pein, Jessica B., Reid, Robert C., Tunny, Kathryn, Hohenhaus, Daniel M., Moradi, Shayli Varasteh, Kelly, Gregory M., Kobayashi, Takumi, Gunter, Jennifer H., Stevenson, Alexander J., Xu, Weijun, Luo, Lin, Jones, Alun, Johnston, Wayne A., Blumenthal, Antje, Alexandrov, Kirill, Collins, Brett M., Stow, Jennifer L., Fairlie, David P. and Sweet, Matthew J. (2020). Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2. Cell Reports, 30 (8), 2712-2728.e8. doi: 10.1016/j.celrep.2020.02.007
Rowley, Jessica A., Reid, Robert C., Poon, Eunice K. Y., Wu, Kai-Chen, Lim, Junxian, Lohman, Rink-Jan, Hamidon, Johan K., Yau, Mei-Kwan, Halili, Maria A., Durek, Thomas, Iyer, Abishek and Fairlie, David P. (2020). Potent thiophene antagonists of human complement C3a receptor with anti-inflammatory activity. Journal of Medicinal Chemistry, 63 (2) acs.jmedchem.9b00927, 529-541. doi: 10.1021/acs.jmedchem.9b00927
Wang, Xinming, Iyer, Abishek, Lyons, A. Bruce, Korner, Heinrich and Wei, Wei (2019). Emerging roles for G-protein coupled receptors in development and activation of macrophages. Frontiers in Immunology, 10 (AUG) 2031, 2031. doi: 10.3389/fimmu.2019.02031
Loh, Zhixuan, Fitzsimmons, Rebecca L., Reid, Robert C., Ramnath, Divya, Clouston, Andrew, Gupta, Praveer K., Irvine, Katharine M., Powell, Elizabeth E., Schroder, Kate, Stow, Jennifer L., Sweet, Matthew J., Fairlie, David P. and Iyer, Abishek (2019). Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic Type 2 inflammation. British Journal of Pharmacology, 176 (19) bph.14768, 3775-3790. doi: 10.1111/bph.14768
Malde, Alpeshkumar K., Hill, Timothy A., Iyer, Abishek and Fairlie, David P. (2019). Crystal structures of protein-bound cyclic peptides. Chemical Reviews, 119 (17) acs.chemrev.8b00807, 9861-9914. doi: 10.1021/acs.chemrev.8b00807
Ramnath, Divya, Irvine, Katharine M., Lukowski, Samuel W., Horsfall, Leigh U., Loh, Zhixuan, Clouston, Andrew D., Patel, Preya J., Fagan, Kevin J., Iyer, Abishek, Lampe, Guy, Stow, Jennifer L., Schroder, Kate, Fairlie, David P., Powell, Joseph E., Powell, Elizabeth E. and Sweet, Matthew J. (2018). Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes. JCI Insight, 3 (14). doi: 10.1172/jci.insight.120274
Shakespear, Melanie R., Iyer, Abishek, Cheng, Catherine Youting, Das Gupta, Kaustav, Singhal, Amit, Fairlie, David P. and Sweet, Matthew J. (2018). Lysine deacetylases and regulated glycolysis in macrophages. Trends in Immunology, 39 (6), 473-488. doi: 10.1016/j.it.2018.02.009
Iyer, Abishek, Xu, Weijun, Reid, Robert C and Fairlie, David P (2018). Chemical approaches to modulating complement-mediated diseases. Journal of Medicinal Chemistry, 61 (8), 3253-3276. doi: 10.1021/acs.jmedchem.7b00882
Lohman, Rink-Jan, Hamidon, Johan K., Reid, Robert C., Rowley, Jessica A., Yau, Mei-Kwan, Halili, Maria A., Nielsen, Daniel S., Lim, Junxian, Wu, Kai-Chen, Loh, Zhixuan, Do, Anh, Suen, Jacky Y., Iyer, Abishek and Fairlie, David P. (2017). Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a. Nature Communications, 8 (1) 351, 351. doi: 10.1038/s41467-017-00414-w
Do, Anh, Reid, Robert C., Lohman, Rink-Jan, Sweet, Matthew J., Fairlie, David P. and Iyer, Abishek (2017). An HDAC6 inhibitor confers protection and selectively inhibits B-cell infiltration in DSS-induced colitis in mice. The Journal of Pharmacology and Experimental Therapeutics, 360 (1), 140-151. doi: 10.1124/jpet.116.236711
Ariffin, Juliana K., das Gupta, Kaustav, Kapetanovic, Ronan, Iyer, Abishek, Reid, Robert C., Fairlie, David P. and Sweet, Matthew J. (2016). Histone deacetylase inhibitors promote mitochondrial reactive oxygen species production and bacterial clearance by human macrophages. Antimicrobial Agents and Chemotherapy, 60 (3), 1521-1529. doi: 10.1128/AAC.01876-15
Lohman, Rink-Jan, Iyer, Abishek, Fairlie, Thomas J., Cotterell, Adam, Gupta, Praveer, Reid, Robert C., Vesey, David A., Sweet, Matthew J. and Fairlie, David P. (2016). Differential anti-inflammatory activity of HDAC inhibitors in human macrophages and rat arthritis. Journal of Pharmacology and Experimental Therapeutics, 356 (2), 387-396. doi: 10.1124/jpet.115.229328
Kaustav Das Gupta, Melanie Shakespear R., Iyer, Abishek, Fairlie, David P. and Sweet, Matthew J. (2016). Histone deacetylases in monocyte/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseases. Clinical and Translational Immunology, 5 (1) e62, e62. doi: 10.1038/cti.2015.46
Iyer, Abishek, Brown, Lindsay, Whitehead, Jonathan P., Prins, Johannes B. and Fairlie, David P. (2015). Nutrient and immune sensing are obligate pathways in metabolism, immunity and disease. The FASEB Journal. doi: 10.1096/fj.15-271155
Hohenhaus, Daniel M., Schaale, Kolja, Le Cao, Kim-Anh, Seow, Vernon, Iyer, Abishek, Fairlie, David P. and Sweet, Matthew J. (2013). An mRNA atlas of G protein-coupled receptor expression during primary human monocyte/macrophage differentiation and lipopolysaccharide-mediated activation identifies targetable candidate regulators of inflammation. Immunobiology, 218 (11), 1345-1353. doi: 10.1016/j.imbio.2013.07.001
Seow, Vernon, Lim, Junxian, Iyer, Abishek, Suen, Jacky Y., Ariffin, Juliana K., Hohenhaus, Daniel M., Sweet, Matthew J. and Fairlie, David P. (2013). Inflammatory Responses Induced by Lipopolysaccharide Are Amplified in Primary Human Monocytes but Suppressed in Macrophages by Complement Protein C5a. Journal of Immunology, 191 (8), 4308-4316. doi: 10.4049/jimmunol.1301355
Lim, Junxian, Iyer, Abishek, Liu, Ligong, Suen, Jacky Y., Lohman, Rink-Jan, Seow, Vernon, Yau, Mei-Kwan, Brown, Lindsay and Fairlie, David P. (2013). Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism. The FASEB Journal, 27 (12), 4757-4767. doi: 10.1096/fj.13-232702
Shakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013). Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 (35), 25362-25374. doi: 10.1074/jbc.M113.496281
Liu, Junxian, Iyer, Abishek, Suen, Jacky Y., Seow, Vernon, Reid, Robert C., Brown, Lindsay and Fairlie, David P. (2013). C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling. The FASEB Journal, 27 (2), 822-831. doi: 10.1096/fj.12-220582
Iyer, Abishek, Lim, Junxian, Poudyal, Hemant, Reid, Robert C., Suen, Jacky Y., Webster, Julie, Prins, Johannes B., Whitehead, Jonathan P., Fairlie, David P. and Brown, Lindsay (2012). An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats. Diabetes, 61 (9), 2320-2329. doi: 10.2337/db11-1179
Mesripour, Azadeh, Iyer, Abishek and Brown, Lindsay (2012). Mineralocorticoid receptors mediate cardiac remodelling in morphine-dependent rats. Basic and Clinical Pharmacology and Toxicology, 111 (2), 75-80. doi: 10.1111/j.1742-7843.2012.00860.x
Gupta, Praveer, Reid, Robert C., Iyer, Abishek, Sweet, Matthew J. and Fairlie, David (2012). Towards isozyme-selective HDA inhibitors for interrogating disease. Current Topics in Medicinal Chemistry, 12 (14), 1479-1499. doi: 10.2174/156802612802652420
Iyer, Abishek, Fairlie, David P. and Brown, Lindsay (2012). Lysine acetylation in obesity, diabetes and metabolic disease. Immunology and Cell Biology, 90 (1), 39-46. doi: 10.1038/icb.2011.99
Iyer, Abishek, Woodruff, Trent M., Wu, Mike C. L., Stylianou, Con, Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and Brown, Lindsay (2011). Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats. Journal of Cardiovascular Pharmacology, 58 (5), 479-486. doi: 10.1097/FJC.0b013e31822a7a09
Iyer, Abishek, Kauter, Kathleen, Alam, Md. Ashraful, Hwang, Sung Hee, Morisseau, Christophe, Hammock, Bruce D. and Brown, Lindsay (2011). Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats. Experimental Diabetes Research, 2012 758614, 758614.1-758614.11. doi: 10.1155/2012/758614
Iyer, Abishek, Kauter, Kathleen and Brown, Lindsay (2011). Gender differences in metabolic syndrome - A key research issue. Endocrine, Metabolic and Immune Disorders - Drug Targets, 11 (3), 182-188. doi: 10.2174/187153011796429808
Panchal, S. K., Poudyal, H., Iyer, A., Nazer, R., Alam, A., Diwan, V., Kauter, K., Sernia, C., Campbell, F., Ward, L., Gobe, G., Fenning, A. and Brown, L. (2011). Erratum: High-carbohydrate, High-fat Diet–induced Metabolic Syndrome and Cardiovascular Remodeling in Rats. Journal of Cardiovascular Pharmacology, 57 (5). doi: 10.1097/FJC.0b013e31821b1379
Panchal, Sunil K., Poudyal, Hemant, Iyer, Abishek, Nazer, Reeza, Alam, Ashraful, Diwan, Vishal, Kautner, Kathleen, Sernia, Conrad, Campbell, Fiona, Ward, Leigh, Gobe, Glenda, Fenning, Andrew and Brown, Lindsay (2011). High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats. Journal of Cardiovascular Pharmacology, 57 (5), 611-624. doi: 10.1097/FJC.0b013e3181feb90a
Chan, Vincent, Fenning, Andrew, Levick, Scott P., Loch, David, Chunduri, Prasad, Iyer, Abishek, Teo, Yi Ling, Hoey, Andrew, Wilson, Kathleen, Burstow, Darryl and Brown, Lindsay (2011). Cardiovascular changes during maturation and ageing in male and female spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 57 (4), 469-478. doi: 10.1097/FJC.0b013e3182102c3b
Patel, Jatin, Matnor, Nur Azim, Iyer, Abishek and Brown, Lindsay (2011). A regenerative antioxidant protocol of vitamin E and α-lipoic acid ameliorates cardiovascular and metabolic changes in fructose-fed rats. Evidence Based Complementary and Alternative Medicine, 2011 120801, 120801-1-120801-8. doi: 10.1155/2011/120801
Chan, Vincent, Fenning, Andrew, Iyer, Abishek, Hoey, Andrew and Brown, Lindsay (2011). Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats. Current Pharmaceutical Biotechnology, 12 (3), 429-436. doi: 10.2174/138920111794480552
Iyer, Abishek and Brown, Lindsay (2011). Fermented wheat germ extract (avemar) in the treatment of cardiac remodeling and metabolic symptoms in rats. Evidence-Based Complementary and Alternative Medicine, 2011 (Article # 508957) 508957, 1-10. doi: 10.1093/ecam/nep090
Rickman, Celestine, Iyer, Aabishek, Chan, Vincent and Brown, Lindsay (2010). Green tea attenuates cardiovascular remodeling and metabolic symptoms in high carbohydrate-fed rats. Current Pharmaceutical Biotechnology, 11 (8), 881-886. doi: 10.2174/138920110793261980
Iyer, Abishek, Chan, Vincent and Brown, Lindsay (2010). The DOCA-salt hypertensive rate as a rat model of cardiovascular oxidative stress and inflammatory stress. Current Cardiology Reviews, 6 (4), 291-297. doi: 10.2174/157340310793566109
Kroon, Paul A., Iyer, Abishek, Chunduri, Prasad, Chan, Vincent and Brown, Lindsay (2010). The cardiovascular nutrapharmacology of resveratrol: Pharmacokinetics, molecular mechanisms and therapeutic potential. Current Medicinal Chemistry, 17 (23), 2442-2455. doi: 10.2174/092986710791556032
Iyer, Abishek and Brown, Lindsay (2010). Lipid mediators and inflammation leading to insulin resistance and type 11 diabetes. Drug Discovery Today: Disease Mechanisms, 7 (3-4), e191-e197. doi: 10.1016/j.ddmec.2010.12.001
Iyer, Abishek, Fenning, Andrew, Lim, Junxian, Le, Giang T, Reid, Robert C, Halili, Maria A, Fairlie, David P and Brown, Lindsay (2010). Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats. British Journal of Pharmacology, 159 (7), 1408-1417. doi: 10.1111/j.1476-5381.2010.00637.x
Iyer, Abishek, Fairlie, David P., Prins, Johannes B., Hammock, Bruce D. and Brown, Lindsay (2010). Inflammatory lipid mediators in adipocyte function and obesity. Nature Reviews Endocrinology, 6 (2), 71-82. doi: 10.1038/nrendo.2009.264
Iyer, A, Panchal, S, Poudyal, H and Brown, L (2009). Potential Health Benefits of Indian Spices in the Symptoms of the Metabolic Syndrome: A Review. Indian Journal of Biochemistry & Biophysics, 46 (6), 467-481.
O'Brien, Daniel, Chunduri, Prasad, Iyer, Abishek and Brown, Lindsay (2009). L-Carnitine attenuates cardiac remodelling rather than vascular remodelling in deoxycorticosterone acetate-salt hypertensive rats. Basic & Clinical Pharmacology & Toxicology, 106 (4), 296-301. doi: 10.1111/j.1742-7843.2009.00480.x
Iyer, A. and Brown, L. (2009). Is Mycophenolate more than just an Immunosuppressant? - An Overview. INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, 46 (1), 25-30.
Patel, Jatin, Iyer, Abishek and Brown, Lindsay (2009). Evaluation of the chronic complications of diabetes in a high fructose diet in rats. Indian Journal of Biochemistry & Biophysics, 46 (1), 66-72.
Conference Papers
Fairlie, David, Reid, Robert, Rowley, Jessica, Wu, Kai-Chen, Yau, Mei-Kwan, Lim, Junxian and Iyer, Abishek (2019). Heterocycles for switching GPCR ligand conformation and activity. National Meeting of the American-Chemical-Society (ACS), Orlando Fl, 31 March-4 April 2019. Washington, DC USA: American Chemical Society.
Ramnath, D., Irvine, K., Lukowski, S., Horsfall, L., Loh, K., Clouston, A., Patel, P., Iyer, A., Lampe, G., Stow, J., Schroder, K., Fairlie, D., Powell, J., Powell, E. and Sweet, M. (2018). RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease. International Liver Congress (ILC), Paris, France, 11-15 April, 2018. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/S0168-8278(18)31040-7
Owens, E., Iyer, A., Morais, C., Lohman, R., Suen, J., Johnson, D., Nikolic-Paterson, D., Gobe, G., Fairlie, D. and Vesey, D. (2016). Protease activated-receptor-2 induced inflammation and fibrosis is mediated in part through activation of transforming growth factor-beta signalling. The 15th Asian Pacific Congress of Nephrology (APCN) and 52nd ANZSN ASM, Perth Western Australia, 17–21 September 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12887
Fairlie, David P. , Yau, Mei-Kwan , Hamidon, Johan K. , Singh, Ranee , Lim, Junxian , Suen, Jacky Y. , Rowley, Jessica A. , Lohman, Rink-Jan , Stoermer, Martin J. , Iyer, Abishek and Reid, Robert C. (2015). Downsizing Proteins Without Losing Potency or Function. American Peptide Symposium 2015, Orlando , Florida, United States, 20-25 June 2015. American Peptide Society. doi: 10.17952/24APS.2015.016
Data Collection
Iyer, Abishek, Humphries, Tyrone LR, Owens, Evan P, Zhao, Kong-Nan, Masci, Paul P, Gobe, Glenda C, Johnson, David W, Paterson, David Nikolic, Fairlie, David P and Vesey, David A (2019). Supplementary Figure S1. The University of Queensland. (Dataset) doi: 10.14264/uql.2019.810
Thesis
Iyer, Abishek (2011). Modulation of the immune sytem in the metabolic syndrome. PhD Thesis, School of Biomedical Sciences, The University of Queensland.