Nuclear hormone receptor and epigenetic regulation of cancer and metabolic disease

Hormone signalling: how cells, tissues and organs communicate in health and disease.

To maintain the correct functioning of the body, and respond to many different challenges and demands of daily life, the human body needs to communicate and transmit messages over long distances to many different organs, tissues and cells. To do this, humans and animals utilize chemicals known as hormones that are produced and/or released from organs and glands (the endocrine system) into the bloodstream. Organs and tissue in the endocrine system include the thyroid gland, ovaries, testes, and adrenal glands.

The Muscat Group focuses on the steroid hormone superfamily. These hormone signalling molecules traverse the circulatory system identifying target tissues and entering the cell binding to Nuclear Receptors. The Hormone and Nuclear Receptors control the expression of specific genes in time and space.

The effects of the steroid hormone family, for example, estrogen, testosterone, thyroid hormone, Vit A and D, are mediated by the Nuclear Receptor hormone dependent regulatory proteina that bind genes, and acts as hormone inducible modulators of gene expression. The Nuclear Receptor proteins act as a conduit that translates hormonal and physiological signals into gene regulation. There are 48 nuclear receptors (NRs) in humans.

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Prof George Muscat


Professor George Muscat
Group Leader, Genomics of Development and Disease Division

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  • Professor George Muscat

    Group Leader, Cell Biology and Molecular Medicine Division
    Professorial Research Fellow - GL
    Institute for Molecular Bioscience