Computational genomics

Computational genomics

Cells and organisms depend on complex networks of molecular interactions to regulate their growth, physiology, reproduction and responses to their environment. The Ragan Group generates and analyses genome-scale data to understand these molecules and their interactions under conditions of health, disease and environmental stress. Where appropriate, we develop new algorithms and software that enables us to compare and analyse very large data sets (thousands to tens-of-thousands of genomes).

Coral reef genomics

The major program underway in Group Ragan aims to understand coral bleaching on the Great Barrier Reef and other reefs worldwide. The familiar multi-coloured coral is actually a community made up of an animal host (the coral per se), the single-celled photosynthetic alga Symbiodinium, as well as bacteria, archaea and viruses. Symbiodinium produces carbon and nitrogen compounds that the coral uses as food, and in return benefits from the relative safety of living inside the coral’s cells. This symbiotic relationship can break down under conditions of environmental stress, notably elevated surface water temperature, leading to coral bleaching and possible death.

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Prof Mark Ragan

Professor Mark Ragan

Co-Division Head, Genomics of Development and Disease Division

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